CN110520524A - 靶向肿瘤微环境的嵌合抗原受体t细胞 - Google Patents

靶向肿瘤微环境的嵌合抗原受体t细胞 Download PDF

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CN110520524A
CN110520524A CN201880025361.8A CN201880025361A CN110520524A CN 110520524 A CN110520524 A CN 110520524A CN 201880025361 A CN201880025361 A CN 201880025361A CN 110520524 A CN110520524 A CN 110520524A
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M·V·毛斯
B·崔
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General Hospital Corp
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CN201880025361.8A 2017-04-14 2018-04-16 靶向肿瘤微环境的嵌合抗原受体t细胞 Pending CN110520524A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762485670P 2017-04-14 2017-04-14
US62/485,670 2017-04-14
US201862629593P 2018-02-12 2018-02-12
US62/629,593 2018-02-12
PCT/US2018/027783 WO2018191748A1 (en) 2017-04-14 2018-04-16 Chimeric antigen receptor t cells targeting the tumor microenvironment

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US (2) US12378297B2 (enExample)
EP (1) EP3609914B1 (enExample)
JP (2) JP7505885B2 (enExample)
CN (1) CN110520524A (enExample)
AU (3) AU2018251206A1 (enExample)
CA (1) CA3059444A1 (enExample)
WO (1) WO2018191748A1 (enExample)

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CN111971053A (zh) * 2018-02-12 2020-11-20 综合医院公司 靶向肿瘤微环境的嵌合抗原受体
CN115491358A (zh) * 2021-06-17 2022-12-20 复星凯特生物科技有限公司 一种靶向b7-h3和folr1双打靶点car t的制备及应用
WO2023274386A1 (zh) * 2021-07-01 2023-01-05 宁波茂行生物医药科技有限公司 靶向egfr的通用型car-t细胞及其制备方法
CN119708251A (zh) * 2023-09-27 2025-03-28 北京大学 一种利用cd27逆转t和car-t细胞pd1信号的工程化细胞方法
WO2025092689A1 (zh) * 2023-10-30 2025-05-08 苏州沙砾生物科技有限公司 一种表达多特异性抗原结合蛋白的细胞及其应用
WO2025140683A1 (zh) * 2023-12-29 2025-07-03 北京鼎成肽源生物技术有限公司 表达趋化因子10和白介素15的工程化免疫细胞

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US12378297B2 (en) 2017-04-14 2025-08-05 The General Hospital Corporation Chimeric antigen receptor T cells targeting the tumor microenvironment
CN109970864A (zh) * 2017-12-28 2019-07-05 上海细胞治疗研究院 一种双向激活共刺激分子受体及其用途
US20220177524A1 (en) * 2018-07-26 2022-06-09 Nanjing Legend Biotech Co., Ltd. Nef-containing t cells and methods of producing thereof
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TW202110873A (zh) 2019-04-30 2021-03-16 美商聖堤生物科技股份有限公司 嵌合受體及其使用方法
WO2020232247A1 (en) 2019-05-14 2020-11-19 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
EP3747904A1 (en) * 2019-06-03 2020-12-09 Universität Regensburg Cd25-specific chimeric antigen receptors and their uses
MX2022001711A (es) * 2019-08-09 2022-05-10 A2 Biotherapeutics Inc Receptores en la superficie celular que responden a la perdida de heterocigosidad.
EP4063387A4 (en) * 2019-11-22 2023-08-02 Nantong Yichen Biopharma. Co. Ltd. PSMA ANTIBODIES AND ITS USE
CN115052887B (zh) 2019-12-11 2026-03-31 A2生物治疗公司 基于lilrb1的嵌合抗原受体
CN111235113A (zh) * 2020-01-21 2020-06-05 南京北恒生物科技有限公司 包含嵌合抗原受体的免疫细胞及其用途
GB202008688D0 (en) * 2020-06-09 2020-07-22 Cancer Research Tech Ltd Chimeric antigen receptor cell
IL298999A (en) 2020-06-11 2023-02-01 Provention Bio Inc Methods and compositions for the prevention of type 1 diabetes
CA3188867A1 (en) 2020-08-20 2022-02-24 Xueyin Wang Compositions and methods for treating ceacam positive cancers
IL300500A (en) 2020-08-20 2023-04-01 A2 Biotherapeutics Inc Preparations and methods for the treatment of mesothelin positive cancer
JP2023550148A (ja) * 2020-11-20 2023-11-30 シンシア・イノベーション・インコーポレイテッド がん免疫治療に用いられる武装二重ｃａｒ－ｔ組成物及び方法
JP2024520444A (ja) 2021-05-24 2024-05-24 プロヴェンション・バイオ・インコーポレイテッド １型糖尿病を治療するための方法
TWI823402B (zh) * 2021-07-21 2023-11-21 長聖國際生技股份有限公司 多特異性單域抗體嵌合抗原受體及t細胞銜接體、核酸、其表達細胞、其用途以及治療癌症之醫藥組合物
WO2023077068A1 (en) * 2021-10-28 2023-05-04 Skunkworx Bio, Inc. Novel binding agents related to glycoprotein-a
WO2024192289A2 (en) * 2023-03-14 2024-09-19 The Wistar Institute Of Anatomy And Biology Tri-specific t-cell engagers and methods of use in cancer therapeutics
WO2024196794A2 (en) * 2023-03-17 2024-09-26 The Children's Hospital Of Philadelphia Compositions and methods for interneuron mediated delivery of cytotoxic agents to the brain
WO2025076471A2 (en) * 2023-10-04 2025-04-10 Ohio State Innovation Foundation Modulating the tumor immune microenvironment via targeting regulatory t cells (tregs) with chimeric antigen receptor (car) t cell therapy
KR20260016890A (ko) * 2024-07-24 2026-02-04 서울대학교산학협력단 안전하며 효과적인 유전자세포치료 시스템

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