CA3059444A1 - Chimeric antigen receptor t cells targeting the tumor microenvironment - Google Patents

Chimeric antigen receptor t cells targeting the tumor microenvironment Download PDF

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Publication number
CA3059444A1
CA3059444A1 CA3059444A CA3059444A CA3059444A1 CA 3059444 A1 CA3059444 A1 CA 3059444A1 CA 3059444 A CA3059444 A CA 3059444A CA 3059444 A CA3059444 A CA 3059444A CA 3059444 A1 CA3059444 A1 CA 3059444A1
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car
cell
seq
cells
antibody
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English (en)
French (fr)
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Marcela V. Maus
Bryan CHOI
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General Hospital Corp
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General Hospital Corp
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K2239/47—Brain; Nervous system
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/622—Single chain antibody (scFv)
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CA3059444A 2017-04-14 2018-04-16 Chimeric antigen receptor t cells targeting the tumor microenvironment Pending CA3059444A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762485670P 2017-04-14 2017-04-14
US62/485,670 2017-04-14
US201862629593P 2018-02-12 2018-02-12
US62/629,593 2018-02-12
PCT/US2018/027783 WO2018191748A1 (en) 2017-04-14 2018-04-16 Chimeric antigen receptor t cells targeting the tumor microenvironment

Publications (1)

Publication Number Publication Date
CA3059444A1 true CA3059444A1 (en) 2018-10-18

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CA3059444A Pending CA3059444A1 (en) 2017-04-14 2018-04-16 Chimeric antigen receptor t cells targeting the tumor microenvironment

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US (2) US12378297B2 (enExample)
EP (2) EP4759318A2 (enExample)
JP (2) JP7505885B2 (enExample)
CN (1) CN110520524A (enExample)
AU (3) AU2018251206A1 (enExample)
CA (1) CA3059444A1 (enExample)
WO (1) WO2018191748A1 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018132427A1 (en) 2017-01-10 2018-07-19 The General Hospital Corporation Targeted t cells with cytotoxicity toward immunosuppressive cells
EP4759318A2 (en) 2017-04-14 2026-06-17 The General Hospital Corporation Chimeric antigen receptor t cells targeting the tumor microenvironment
CN109970864A (zh) * 2017-12-28 2019-07-05 上海细胞治疗研究院 一种双向激活共刺激分子受体及其用途
ES3068176T3 (en) * 2018-02-12 2026-05-28 Massachusetts Gen Hospital Chimeric antigen receptor t cells targeting the tumor microenvironment
TW202020146A (zh) * 2018-07-26 2020-06-01 大陸商南京傳奇生物科技有限公司 含nef之t細胞及其產生方法
WO2020092455A2 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Car t cell transcriptional atlas
EP3947689A4 (en) * 2019-03-27 2023-03-29 National Research Council of Canada ANTIGEN BINDING AGENTS SPECIFIC TO BINDING THE RECEPTOR VARIANT III OF THE EPIDERMAL GROWTH FACTOR
JP7711945B2 (ja) 2019-04-30 2025-07-23 センティ バイオサイエンシズ インコーポレイテッド キメラ受容体及びその使用方法
JP7137696B2 (ja) 2019-05-14 2022-09-14 プロヴェンション・バイオ・インコーポレイテッド １型糖尿病を予防するための方法および組成物
EP3747904A1 (en) * 2019-06-03 2020-12-09 Universität Regensburg Cd25-specific chimeric antigen receptors and their uses
EP4010377A4 (en) * 2019-08-09 2023-09-06 A2 Biotherapeutics, Inc. CELL SURFACE RECEPTORS THAT RESPOND TO LOSS OF HETEROZYGOSIS
US12702708B2 (en) 2019-08-21 2026-08-11 Innovative Cellular Therapeutics Holdings, Ltd. Presenting cell and use thereof in cell therapy
CN113677704B (zh) * 2019-11-22 2024-03-26 南通壹宸生物医药科技有限公司 Psma抗体及其应用
WO2021119489A1 (en) 2019-12-11 2021-06-17 A2 Biotherapeutics, Inc. Lilrb1-based chimeric antigen receptor
CN111235113A (zh) * 2020-01-21 2020-06-05 南京北恒生物科技有限公司 包含嵌合抗原受体的免疫细胞及其用途
GB202008688D0 (en) * 2020-06-09 2020-07-22 Cancer Research Tech Ltd Chimeric antigen receptor cell
KR20230092863A (ko) 2020-06-11 2023-06-26 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
EP4097486A4 (en) 2020-08-20 2023-09-06 A2 Biotherapeutics, Inc. COMPOSITIONS AND METHODS FOR TREATING CEACAM POSITIVE CANCER
WO2022040454A1 (en) 2020-08-20 2022-02-24 A2 Biotherapeutics, Inc. Compositions and methods for treating mesothelin positive cancers
US11433100B2 (en) 2020-08-20 2022-09-06 A2 Biotherapeutics, Inc. Compositions and methods for treating ceacam positive cancers
JP2023550148A (ja) * 2020-11-20 2023-11-30 シンシア・イノベーション・インコーポレイテッド がん免疫治療に用いられる武装二重ｃａｒ－ｔ組成物及び方法
MX2023013851A (es) 2021-05-24 2023-12-08 Provention Bio Inc Metodos para el tratamiento de diabetes tipo 1.
CN115491358B (zh) * 2021-06-17 2024-09-06 复星凯特生物科技有限公司 一种靶向b7-h3和folr1双打靶点car t的制备及应用
WO2023274386A1 (zh) * 2021-07-01 2023-01-05 宁波茂行生物医药科技有限公司 靶向egfr的通用型car-t细胞及其制备方法
TWI823402B (zh) * 2021-07-21 2023-11-21 長聖國際生技股份有限公司 多特異性單域抗體嵌合抗原受體及t細胞銜接體、核酸、其表達細胞、其用途以及治療癌症之醫藥組合物
WO2023077068A1 (en) * 2021-10-28 2023-05-04 Skunkworx Bio, Inc. Novel binding agents related to glycoprotein-a
CN116535518A (zh) * 2022-08-03 2023-08-04 深圳市先康达生命科学有限公司 一种IL-15与DnTRII结合的融合蛋白及其应用
WO2024192289A2 (en) * 2023-03-14 2024-09-19 The Wistar Institute Of Anatomy And Biology Tri-specific t-cell engagers and methods of use in cancer therapeutics
WO2024196794A2 (en) * 2023-03-17 2024-09-26 The Children's Hospital Of Philadelphia Compositions and methods for interneuron mediated delivery of cytotoxic agents to the brain
CN119708251A (zh) * 2023-09-27 2025-03-28 北京大学 一种利用cd27逆转t和car-t细胞pd1信号的工程化细胞方法
CN122295360A (zh) * 2023-10-04 2026-06-26 俄亥俄州创新基金会 经由用嵌合抗原受体(car) t细胞疗法靶向调节性t细胞(treg)来调节肿瘤免疫微环境
WO2025092689A1 (zh) * 2023-10-30 2025-05-08 苏州沙砾生物科技有限公司 一种表达多特异性抗原结合蛋白的细胞及其应用
WO2025140683A1 (zh) * 2023-12-29 2025-07-03 北京鼎成肽源生物技术有限公司 表达趋化因子10和白介素15的工程化免疫细胞
WO2026020041A1 (en) * 2024-07-17 2026-01-22 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
WO2026022768A1 (ko) * 2024-07-24 2026-01-29 (주)티카로스 안전하며 효과적인 유전자세포치료 시스템

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
US4737462A (en) 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
US4518584A (en) 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
CA2222231A1 (en) 1995-06-07 1996-12-19 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth of tumors
CA2326389C (en) 1998-04-21 2007-01-23 Micromet Gesellschaft Fur Biomedizinische Forschung Mbh Novel cd19xcd3 specific polypeptides and uses thereof
EP1478648B1 (en) 2002-02-01 2014-04-30 ARIAD Pharmaceuticals, Inc. Phosphorus-containing compounds and uses thereof
US20050136035A1 (en) * 2003-06-03 2005-06-23 Derek Ko Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site
US10155038B2 (en) 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
CA2735456C (en) 2008-08-26 2021-11-16 City Of Hope Method and compositions for enhanced anti-tumor effector functioning of t cells
US9349368B1 (en) * 2010-08-05 2016-05-24 Google Inc. Generating an audio notification based on detection of a triggering event
EP3459560B1 (en) * 2011-04-08 2021-02-24 The United States of America, as represented by The Secretary, Department of Health and Human Services Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer
US20130280220A1 (en) 2012-04-20 2013-10-24 Nabil Ahmed Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes
KR20150029714A (ko) 2012-07-13 2015-03-18 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 이중특이적 항체의 공-도입에 의한 ｃａｒ 세포의 활성 증강
SG11201505896YA (en) 2013-02-20 2015-09-29 Novartis Ag Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
IL298125A (en) * 2013-02-26 2023-01-01 Memorial Sloan Kettering Cancer Center Preparations and methods for immunotherapy
US20160015749A1 (en) * 2013-03-05 2016-01-21 Baylor College Of Medicine Engager cells for immunotherapy
US20160017058A1 (en) 2013-03-14 2016-01-21 The California Institute For Biomedical Research Bispecific antibodies and uses thereof
ES2769574T3 (es) 2013-03-15 2020-06-26 Michael C Milone Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva
AU2014298373B2 (en) 2013-08-01 2019-12-05 Ludwig Institute For Cancer Research Ltd Anti-GARP protein and uses thereof
JP6665102B2 (ja) 2014-02-21 2020-03-13 セレクティスＣｅｌｌｅｃｔｉｓ 制御性ｔ細胞をインサイチューで阻害するための方法
RU2017102769A (ru) * 2014-07-29 2018-08-28 Пфайзер Инк. EGFRvIII СПЕЦИФИЧЕСКИЕ ХИМЕРНЫЕ АНТИГЕННЫЕ РЕЦЕПТОРЫ ДЛЯ ИММУНОТЕРАПИИ РАКА
ES2738705T3 (es) 2014-09-19 2020-01-24 Hope City Linfocitos T de receptor de antígeno quimérico coestimulante que se dirigen a IL13R 2
PL3212225T3 (pl) * 2014-10-31 2026-03-30 The Trustees Of The University Of Pennsylvania Sposoby i kompozycje zmodyfikowanych limfocytów t
HRP20240357T1 (hr) 2014-12-24 2024-06-07 Autolus Limited Stanica
US10647778B2 (en) 2015-02-09 2020-05-12 University Of Florida Research Foundation, Incorporated Bi-specific chimeric antigen receptor and uses thereof
EP3297672B1 (en) * 2015-05-21 2021-09-01 Harpoon Therapeutics, Inc. Trispecific binding proteins and methods of use
AU2016274989A1 (en) * 2015-06-12 2017-11-02 Immunomedics, Inc. Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs
WO2017040324A1 (en) 2015-08-28 2017-03-09 The Trustees Of The University Of Pennsylvania Methods and compositions for cells expressing a chimeric intracellular signaling molecule
CA2999070A1 (en) * 2015-09-17 2017-03-23 Novartis Ag Car t cell therapies with enhanced efficacy
CN105796597A (zh) 2016-03-11 2016-07-27 江苏三特生物科技有限公司 携带pd-l1和ctla-4抗体基因的car-t细胞在肿瘤免疫上的应用
US20190112380A1 (en) 2016-03-29 2019-04-18 University Of Southern California Chimeric antigen receptors targeting cancer
WO2017173091A1 (en) 2016-03-30 2017-10-05 Musc Foundation For Research Development Methods for treatment and diagnosis of cancer by targeting glycoprotein a repetitions predominant (garp) and for providing effective immunotherapy alone or in combination
US9567399B1 (en) * 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
CN109562126A (zh) * 2016-06-24 2019-04-02 美商生物细胞基因治疗有限公司 嵌合抗原受体(car)、组合物及其使用方法
US20190307799A1 (en) 2016-09-23 2019-10-10 The Regents Of The University Of Michigan Engineered lymphocytes
AU2017347686A1 (en) 2016-10-19 2019-05-02 Cellectis Cell death inducing chimeric antigen receptors
US20200095301A1 (en) 2016-12-14 2020-03-26 The Board Of Trustees Of The Leland Stanford Junior University Il-13 superkine: immune cell targeting constructs and methods of use thereof
WO2018132427A1 (en) 2017-01-10 2018-07-19 The General Hospital Corporation Targeted t cells with cytotoxicity toward immunosuppressive cells
US20190375815A1 (en) 2017-01-31 2019-12-12 Novartis Ag Treatment of cancer using chimeric t cell receptor proteins having multiple specificities
CN110520523A (zh) * 2017-03-29 2019-11-29 台北医学大学 具抗原专一性的t细胞及其用途
EP4759318A2 (en) 2017-04-14 2026-06-17 The General Hospital Corporation Chimeric antigen receptor t cells targeting the tumor microenvironment
CN107326014B (zh) 2017-07-31 2019-09-24 时力生物科技（北京）有限公司 一种双特异性嵌合抗原受体修饰的t淋巴细胞及其制备方法和应用
WO2019079034A1 (en) 2017-10-17 2019-04-25 The General Hospital Corporation METHODS AND COMPOSITIONS RELATING TO GENETICALLY MODIFIED REGULATORY T LYMPHOCYTES
ES3068176T3 (en) 2018-02-12 2026-05-28 Massachusetts Gen Hospital Chimeric antigen receptor t cells targeting the tumor microenvironment
WO2022046935A2 (en) 2020-08-26 2022-03-03 The Regents Of The University Of California Methods and compositions for treating glioblastoma
EP4426723A4 (en) 2021-11-04 2025-12-17 Massachusetts Gen Hospital ANTI-MESOTHELIN CAR T-CELL SECRETING TEAMS AND METHODS FOR THEM USE
CN119365202A (zh) 2022-04-15 2025-01-24 总医院有限公司 包含结合cd33的t细胞接合抗体分子的结合cd70的car-t细胞

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