CN110520127B - 作为gpr6的调节剂的经哌啶基取代的杂芳族羧酰胺和经哌嗪基取代的杂芳族羧酰胺 - Google Patents

作为gpr6的调节剂的经哌啶基取代的杂芳族羧酰胺和经哌嗪基取代的杂芳族羧酰胺 Download PDF

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CN110520127B
CN110520127B CN201880024073.0A CN201880024073A CN110520127B CN 110520127 B CN110520127 B CN 110520127B CN 201880024073 A CN201880024073 A CN 201880024073A CN 110520127 B CN110520127 B CN 110520127B
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piperidin
cyano
phenyl
difluorophenoxy
carboxamide
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CN110520127A (zh
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J·格林
M·霍普金斯
B·琼斯
A·A·吉尔亚诺夫
J·库勒
H·蒙恩斯城
S·墨菲
T·尼克西
孙会凯
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Takeda Pharmaceutical Co Ltd
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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CN201880024073.0A 2017-03-26 2018-03-26 作为gpr6的调节剂的经哌啶基取代的杂芳族羧酰胺和经哌嗪基取代的杂芳族羧酰胺 Active CN110520127B (zh)

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US201762476846P 2017-03-26 2017-03-26
US201762476786P 2017-03-26 2017-03-26
US62/476,846 2017-03-26
US62/476,786 2017-03-26
PCT/US2018/024249 WO2018183145A1 (en) 2017-03-26 2018-03-26 Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of gpr6

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CN110520127B true CN110520127B (zh) 2023-05-16

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