CN1105110C - 制备4,6－二羟基嘧啶的方法 - Google Patents

制备4,6－二羟基嘧啶的方法 Download PDF

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Publication number
CN1105110C
CN1105110C CN97193112A CN97193112A CN1105110C CN 1105110 C CN1105110 C CN 1105110C CN 97193112 A CN97193112 A CN 97193112A CN 97193112 A CN97193112 A CN 97193112A CN 1105110 C CN1105110 C CN 1105110C
Authority
CN
China
Prior art keywords
formula
dihydroxypyrimidine
product obtained
solvent
formamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97193112A
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English (en)
Chinese (zh)
Other versions
CN1214044A (zh
Inventor
R·V·H·琼斯
D·J·里奇
B·S·克罗姆比
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SINZETA Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of CN1214044A publication Critical patent/CN1214044A/zh
Application granted granted Critical
Publication of CN1105110C publication Critical patent/CN1105110C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN97193112A 1996-05-17 1997-04-24 制备4,6－二羟基嘧啶的方法 Expired - Fee Related CN1105110C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9610320.5A GB9610320D0 (en) 1996-05-17 1996-05-17 Chemical process
GB9610320.5 1996-05-17

Publications (2)

Publication Number Publication Date
CN1214044A CN1214044A (zh) 1999-04-14
CN1105110C true CN1105110C (zh) 2003-04-09

Family

ID=10793853

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97193112A Expired - Fee Related CN1105110C (zh) 1996-05-17 1997-04-24 制备4,6－二羟基嘧啶的方法

Country Status (13)

Country Link
US (1) US6096892A (en:Method)
EP (1) EP0901475A1 (en:Method)
JP (1) JP2000510864A (en:Method)
CN (1) CN1105110C (en:Method)
AR (1) AR007091A1 (en:Method)
AU (1) AU2397997A (en:Method)
BR (1) BR9709096A (en:Method)
GB (1) GB9610320D0 (en:Method)
IL (1) IL126989A (en:Method)
IN (1) IN186126B (en:Method)
TW (1) TW404943B (en:Method)
WO (1) WO1997044327A1 (en:Method)
ZA (1) ZA973847B (en:Method)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2188816T5 (es) † 1996-07-03 2006-06-01 Degussa Ag Procedimiento para preparar 4,6-dihidroxipirimidina.
KR100676222B1 (ko) 1999-08-18 2007-01-30 바이엘 악티엔게젤샤프트 4,6-디클로로-5-플루오로피리미딘의 제조방법
US6608199B2 (en) 2000-07-07 2003-08-19 Syngenta Limited Synthesis of chlorinated pyrimidines
US6982331B2 (en) * 2001-06-08 2006-01-03 Syngenta Crop Protection, Inc. Synthesis of chlorinated pyrimidines
DE10140269A1 (de) * 2001-08-16 2003-02-27 Degussa Verfahren zur Herstellung von 4,6-Dihydroxypyrimidin
CN102115463B (zh) * 2010-01-05 2013-02-13 重庆紫光化工股份有限公司 4，6-二羟基嘧啶的合成方法
DE102010035012A1 (de) * 2010-08-20 2012-02-23 A. Raymond Et Cie Vorrichtung zum Halten eines Anbauteiles an einem Trägerteil sowie Anordnung mit einer derartigen Vorrichtung und mit einem Anbauteil
CN102442954B (zh) * 2011-09-06 2014-01-08 淄博万昌科技股份有限公司 利用丙烯腈副产氢氰酸制备4，6-二羟基嘧啶的方法
CN102936224A (zh) * 2012-11-29 2013-02-20 连云港市国盛化工有限公司 一种4,6-二氯嘧啶的制备方法
CN106397337B (zh) * 2015-07-27 2018-12-07 江苏扬农化工集团有限公司 一种合成4,6-二羟基嘧啶的后处理方法
CN105585192B (zh) * 2015-12-25 2018-03-09 石家庄杰克化工有限公司 一种4,6‑二羟基嘧啶生产的废水处理方法
CN106883186B (zh) * 2017-04-21 2019-03-15 重庆紫光国际化工有限责任公司 一种4,6-二羟基嘧啶的制备方法
ES2991522T3 (es) * 2018-12-28 2024-12-03 Saltigo Gmbh Procedimiento mejorado para la producción de 4,6-dihidroxipirimidina

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1200308B (de) * 1961-08-17 1965-09-09 Dresden Arzneimittel Verfahren zur Herstellung von 4, 6-Dihydroxy-pyrimidinen
FR1424940A (fr) * 1964-02-21 1966-01-14 Kyowa Hakko Kogyo Kk Procédé de production de la 4, 6-dihydroxypyrimidine
US3306900A (en) * 1964-02-21 1967-02-28 Kyowa Hakko Kogyo Kk Method for producing 4,6-dihydroxy-pyrimidine
BE798724A (fr) * 1973-04-26 1973-08-16 En Abrege Socechim Soc Et Chim Nouveaux composes chimiques
DE2523324A1 (de) * 1975-05-27 1976-12-09 Bayer Ag Pyrimidin(4,6)diyl-bis-(thiono) (thiol)phosphor-(phosphon)-saeureester, verfahren zu ihrer herstellung sowie ihre verwendung als insektizide und akarizide
AU652968B2 (en) * 1990-10-09 1994-09-15 Neurogen Corporation Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of gaba brain receptor ligands
CN1082031A (zh) * 1993-05-20 1994-02-16 郑州市孝义制药厂 磺胺间甲氧嘧啶的制备方法
ES2188816T5 (es) * 1996-07-03 2006-06-01 Degussa Ag Procedimiento para preparar 4,6-dihidroxipirimidina.

Also Published As

Publication number Publication date
AU2397997A (en) 1997-12-09
TW404943B (en) 2000-09-11
EP0901475A1 (en) 1999-03-17
BR9709096A (pt) 1999-08-03
IN186126B (en:Method) 2001-06-23
GB9610320D0 (en) 1996-07-24
IL126989A (en) 2003-04-10
JP2000510864A (ja) 2000-08-22
ZA973847B (en) 1997-11-17
IL126989A0 (en) 1999-09-22
CN1214044A (zh) 1999-04-14
US6096892A (en) 2000-08-01
WO1997044327A1 (en) 1997-11-27
AR007091A1 (es) 1999-10-13

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C06 Publication
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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: SIGENTIS CO., LTD.

Free format text: FORMER NAME OR ADDRESS: ZENECA LTD

CP03 Change of name, title or address

Address after: surrey

Patentee after: Sinzeta Ltd.

Address before: London, England, England

Patentee before: Zeneca Limited

C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee