CN110461359B - 用于预防和治疗心脏病的方法 - Google Patents

用于预防和治疗心脏病的方法 Download PDF

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Publication number
CN110461359B
CN110461359B CN201880020467.9A CN201880020467A CN110461359B CN 110461359 B CN110461359 B CN 110461359B CN 201880020467 A CN201880020467 A CN 201880020467A CN 110461359 B CN110461359 B CN 110461359B
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seq
variable region
antibody
chain variable
heavy chain
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Chinese (zh)
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CN110461359A (zh
Inventor
安东尼·罗森茨威格
杰森·D·罗赫
戴维·J·格拉斯
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Novartis AG
Beth Israel Deaconess Medical Center Inc
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Novartis AG
Beth Israel Deaconess Medical Center Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880020467.9A 2017-03-24 2018-03-20 用于预防和治疗心脏病的方法 Active CN110461359B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411979268.4A CN119971025A (zh) 2017-03-24 2018-03-20 用于预防和治疗心脏病的方法

Applications Claiming Priority (3)

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US201762476054P 2017-03-24 2017-03-24
US62/476,054 2017-03-24
PCT/US2018/023390 WO2018175460A1 (en) 2017-03-24 2018-03-20 Methods for preventing and treating heart disease

Related Child Applications (1)

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CN202411979268.4A Division CN119971025A (zh) 2017-03-24 2018-03-20 用于预防和治疗心脏病的方法

Publications (2)

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CN110461359A CN110461359A (zh) 2019-11-15
CN110461359B true CN110461359B (zh) 2025-01-21

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CN202411979268.4A Pending CN119971025A (zh) 2017-03-24 2018-03-20 用于预防和治疗心脏病的方法

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US (3) US10982000B2 (enExample)
EP (1) EP3600415B1 (enExample)
JP (2) JP7339159B2 (enExample)
KR (2) KR102628323B1 (enExample)
CN (2) CN110461359B (enExample)
AU (1) AU2018240117B2 (enExample)
CA (1) CA3054837A1 (enExample)
DK (1) DK3600415T3 (enExample)
FI (1) FI3600415T3 (enExample)
IL (1) IL269083B2 (enExample)
PT (1) PT3600415T (enExample)
WO (1) WO2018175460A1 (enExample)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
JP7339159B2 (ja) 2017-03-24 2023-09-05 ノバルティス アーゲー 心疾患の予防および治療方法
US20220242956A1 (en) * 2019-05-30 2022-08-04 Acceleron Pharma Inc. Actrii-binding proteins and uses thereof
WO2021222322A1 (en) * 2020-04-28 2021-11-04 Acceleron Pharma Inc. Actrii proteins and use in treating post-capillary pulmonary hypertension
CN111870685B (zh) * 2020-07-16 2022-11-29 上海市同仁医院 运动相关多肽在制备防治缺血性心脏病药物中的应用
EP4200017A1 (en) * 2020-08-20 2023-06-28 Regeneron Pharmaceuticals, Inc. Methods for preventing and treating cardiac dysfunction and covid-19 with activin a antagonists
CA3265879A1 (en) * 2022-08-26 2024-02-29 Versanis Bio, Inc. ACTRII FIXED SINGLE-DOSE ANTIBODY TREATMENTS
TW202513591A (zh) * 2023-08-01 2025-04-01 大陸商來凱醫藥科技（上海）有限公司 抗acvr2b抗體及其用途
WO2025183966A1 (en) 2024-02-28 2025-09-04 Versanis Bio, Inc. Actrii antibodies with extended half life

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016171948A1 (en) * 2015-04-22 2016-10-27 Alivegen Usa Inc. Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases

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CA3054837A1 (en) 2018-09-27
JP7339159B2 (ja) 2023-09-05
JP2020511502A (ja) 2020-04-16
DK3600415T3 (da) 2025-12-01
US10982000B2 (en) 2021-04-20
PT3600415T (pt) 2025-11-24
US20210309749A1 (en) 2021-10-07
CN110461359A (zh) 2019-11-15
AU2018240117A1 (en) 2019-09-19
AU2018240117B2 (en) 2024-12-05
KR20190131096A (ko) 2019-11-25
RU2019129858A (ru) 2021-03-23
US20200031940A1 (en) 2020-01-30
KR20240014600A (ko) 2024-02-01
IL269083B1 (en) 2024-08-01
FI3600415T3 (fi) 2025-12-05
IL269083B2 (en) 2024-12-01
US20240158514A1 (en) 2024-05-16
EP3600415A1 (en) 2020-02-05
JP2023100919A (ja) 2023-07-19
EP3600415B1 (en) 2025-09-17
RU2019129858A3 (enExample) 2022-03-24
US11834508B2 (en) 2023-12-05
IL269083A (en) 2019-11-28
WO2018175460A1 (en) 2018-09-27
KR102628323B1 (ko) 2024-01-22
CN119971025A (zh) 2025-05-13

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