CA3054837A1 - Methods for preventing and treating heart disease - Google Patents

Methods for preventing and treating heart disease Download PDF

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Publication number
CA3054837A1
CA3054837A1 CA3054837A CA3054837A CA3054837A1 CA 3054837 A1 CA3054837 A1 CA 3054837A1 CA 3054837 A CA3054837 A CA 3054837A CA 3054837 A CA3054837 A CA 3054837A CA 3054837 A1 CA3054837 A1 CA 3054837A1
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CA
Canada
Prior art keywords
seq
variable region
chain variable
light chain
heavy chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3054837A
Other languages
English (en)
French (fr)
Inventor
Anthony Rosenzweig
Jason D. Roh
David J. Glass
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Beth Israel Deaconess Medical Center Inc
Original Assignee
Novartis AG
Beth Israel Deaconess Medical Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG, Beth Israel Deaconess Medical Center Inc filed Critical Novartis AG
Publication of CA3054837A1 publication Critical patent/CA3054837A1/en
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3054837A 2017-03-24 2018-03-20 Methods for preventing and treating heart disease Pending CA3054837A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762476054P 2017-03-24 2017-03-24
US62/476,054 2017-03-24
PCT/US2018/023390 WO2018175460A1 (en) 2017-03-24 2018-03-20 Methods for preventing and treating heart disease

Publications (1)

Publication Number Publication Date
CA3054837A1 true CA3054837A1 (en) 2018-09-27

Family

ID=62028095

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3054837A Pending CA3054837A1 (en) 2017-03-24 2018-03-20 Methods for preventing and treating heart disease

Country Status (12)

Country Link
US (3) US10982000B2 (enExample)
EP (1) EP3600415B1 (enExample)
JP (2) JP7339159B2 (enExample)
KR (2) KR102628323B1 (enExample)
CN (2) CN110461359B (enExample)
AU (1) AU2018240117B2 (enExample)
CA (1) CA3054837A1 (enExample)
DK (1) DK3600415T3 (enExample)
FI (1) FI3600415T3 (enExample)
IL (1) IL269083B2 (enExample)
PT (1) PT3600415T (enExample)
WO (1) WO2018175460A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7339159B2 (ja) 2017-03-24 2023-09-05 ノバルティス アーゲー 心疾患の予防および治療方法
US20220242956A1 (en) * 2019-05-30 2022-08-04 Acceleron Pharma Inc. Actrii-binding proteins and uses thereof
WO2021222322A1 (en) * 2020-04-28 2021-11-04 Acceleron Pharma Inc. Actrii proteins and use in treating post-capillary pulmonary hypertension
CN111870685B (zh) * 2020-07-16 2022-11-29 上海市同仁医院 运动相关多肽在制备防治缺血性心脏病药物中的应用
EP4200017A1 (en) * 2020-08-20 2023-06-28 Regeneron Pharmaceuticals, Inc. Methods for preventing and treating cardiac dysfunction and covid-19 with activin a antagonists
CA3265879A1 (en) * 2022-08-26 2024-02-29 Versanis Bio, Inc. ACTRII FIXED SINGLE-DOSE ANTIBODY TREATMENTS
TW202513591A (zh) * 2023-08-01 2025-04-01 大陸商來凱醫藥科技(上海)有限公司 抗acvr2b抗體及其用途
WO2025183966A1 (en) 2024-02-28 2025-09-04 Versanis Bio, Inc. Actrii antibodies with extended half life

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Also Published As

Publication number Publication date
CN110461359B (zh) 2025-01-21
JP7339159B2 (ja) 2023-09-05
JP2020511502A (ja) 2020-04-16
DK3600415T3 (da) 2025-12-01
US10982000B2 (en) 2021-04-20
PT3600415T (pt) 2025-11-24
US20210309749A1 (en) 2021-10-07
CN110461359A (zh) 2019-11-15
AU2018240117A1 (en) 2019-09-19
AU2018240117B2 (en) 2024-12-05
KR20190131096A (ko) 2019-11-25
RU2019129858A (ru) 2021-03-23
US20200031940A1 (en) 2020-01-30
KR20240014600A (ko) 2024-02-01
IL269083B1 (en) 2024-08-01
FI3600415T3 (fi) 2025-12-05
IL269083B2 (en) 2024-12-01
US20240158514A1 (en) 2024-05-16
EP3600415A1 (en) 2020-02-05
JP2023100919A (ja) 2023-07-19
EP3600415B1 (en) 2025-09-17
RU2019129858A3 (enExample) 2022-03-24
US11834508B2 (en) 2023-12-05
IL269083A (en) 2019-11-28
WO2018175460A1 (en) 2018-09-27
KR102628323B1 (ko) 2024-01-22
CN119971025A (zh) 2025-05-13

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