AU2018240117B2 - Methods for preventing and treating heart disease - Google Patents

Methods for preventing and treating heart disease Download PDF

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Publication number
AU2018240117B2
AU2018240117B2 AU2018240117A AU2018240117A AU2018240117B2 AU 2018240117 B2 AU2018240117 B2 AU 2018240117B2 AU 2018240117 A AU2018240117 A AU 2018240117A AU 2018240117 A AU2018240117 A AU 2018240117A AU 2018240117 B2 AU2018240117 B2 AU 2018240117B2
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AU
Australia
Prior art keywords
seq
variable region
chain variable
heavy chain
light chain
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AU2018240117A
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AU2018240117A1 (en
Inventor
David J. Glass
Jason D. Roh
Anthony Rosenzweig
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Novartis AG
Beth Israel Deaconess Medical Center Inc
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Novartis AG
Beth Israel Deaconess Medical Center Inc
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Publication of AU2018240117A1 publication Critical patent/AU2018240117A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2018240117A 2017-03-24 2018-03-20 Methods for preventing and treating heart disease Active AU2018240117B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762476054P 2017-03-24 2017-03-24
US62/476,054 2017-03-24
PCT/US2018/023390 WO2018175460A1 (en) 2017-03-24 2018-03-20 Methods for preventing and treating heart disease

Publications (2)

Publication Number Publication Date
AU2018240117A1 AU2018240117A1 (en) 2019-09-19
AU2018240117B2 true AU2018240117B2 (en) 2024-12-05

Family

ID=62028095

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018240117A Active AU2018240117B2 (en) 2017-03-24 2018-03-20 Methods for preventing and treating heart disease

Country Status (12)

Country Link
US (3) US10982000B2 (enExample)
EP (1) EP3600415B1 (enExample)
JP (2) JP7339159B2 (enExample)
KR (2) KR20240014600A (enExample)
CN (2) CN119971025A (enExample)
AU (1) AU2018240117B2 (enExample)
CA (1) CA3054837A1 (enExample)
DK (1) DK3600415T3 (enExample)
FI (1) FI3600415T3 (enExample)
IL (1) IL269083B2 (enExample)
PT (1) PT3600415T (enExample)
WO (1) WO2018175460A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3054837A1 (en) 2017-03-24 2018-09-27 Novartis Ag Methods for preventing and treating heart disease
JP7669291B2 (ja) * 2019-05-30 2025-04-28 アクセレロン ファーマ インコーポレーテッド Ａｃｔｒｉｉ結合性タンパク質及びその使用
EP4142769A4 (en) * 2020-04-28 2024-05-15 Acceleron Pharma Inc. ACTRII PROTEINS AND USE IN THE TREATMENT OF POSTCAPILLARY PULMONARY HYPERTENSION
CN111870685B (zh) * 2020-07-16 2022-11-29 上海市同仁医院 运动相关多肽在制备防治缺血性心脏病药物中的应用
CN116249713A (zh) * 2020-08-20 2023-06-09 瑞泽恩制药公司 利用激活素a拮抗剂预防和治疗心功能不全和covid-19的方法
WO2024044782A1 (en) * 2022-08-26 2024-02-29 Versanis Bio, Inc. Actrii antibody fixed unit dose treatments
TW202513591A (zh) * 2023-08-01 2025-04-01 大陸商來凱醫藥科技（上海）有限公司 抗acvr2b抗體及其用途
WO2025183966A1 (en) 2024-02-28 2025-09-04 Versanis Bio, Inc. Actrii antibodies with extended half life

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Also Published As

Publication number Publication date
IL269083B2 (en) 2024-12-01
FI3600415T3 (fi) 2025-12-05
PT3600415T (pt) 2025-11-24
IL269083A (en) 2019-11-28
AU2018240117A1 (en) 2019-09-19
US20210309749A1 (en) 2021-10-07
EP3600415B1 (en) 2025-09-17
US11834508B2 (en) 2023-12-05
CN110461359A (zh) 2019-11-15
US10982000B2 (en) 2021-04-20
CN110461359B (zh) 2025-01-21
KR20240014600A (ko) 2024-02-01
RU2019129858A3 (enExample) 2022-03-24
JP2023100919A (ja) 2023-07-19
WO2018175460A1 (en) 2018-09-27
US20240158514A1 (en) 2024-05-16
KR102628323B1 (ko) 2024-01-22
JP2020511502A (ja) 2020-04-16
KR20190131096A (ko) 2019-11-25
EP3600415A1 (en) 2020-02-05
DK3600415T3 (da) 2025-12-01
CA3054837A1 (en) 2018-09-27
US20200031940A1 (en) 2020-01-30
IL269083B1 (en) 2024-08-01
RU2019129858A (ru) 2021-03-23
JP7339159B2 (ja) 2023-09-05
CN119971025A (zh) 2025-05-13

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