CN110402145A - 用于增强免疫应答的信使核糖核酸及其使用方法 - Google Patents
用于增强免疫应答的信使核糖核酸及其使用方法 Download PDFInfo
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- CN110402145A CN110402145A CN201780080846.2A CN201780080846A CN110402145A CN 110402145 A CN110402145 A CN 110402145A CN 201780080846 A CN201780080846 A CN 201780080846A CN 110402145 A CN110402145 A CN 110402145A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K39/0005—Vertebrate antigens
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- A61K39/001164—GTPases, e.g. Ras or Rho
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/70—Multivalent vaccine
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- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20071—Demonstrated in vivo effect
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
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- Mycology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662412933P | 2016-10-26 | 2016-10-26 | |
| US62/412,933 | 2016-10-26 | ||
| US201762467034P | 2017-03-03 | 2017-03-03 | |
| US62/467,034 | 2017-03-03 | ||
| US201762490522P | 2017-04-26 | 2017-04-26 | |
| US62/490,522 | 2017-04-26 | ||
| US201762558206P | 2017-09-13 | 2017-09-13 | |
| US62/558,206 | 2017-09-13 | ||
| PCT/US2017/058585 WO2018081459A1 (en) | 2016-10-26 | 2017-10-26 | Messenger ribonucleic acids for enhancing immune responses and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110402145A true CN110402145A (zh) | 2019-11-01 |
Family
ID=60570181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780080846.2A Pending CN110402145A (zh) | 2016-10-26 | 2017-10-26 | 用于增强免疫应答的信使核糖核酸及其使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20180311343A1 (enExample) |
| EP (1) | EP3532070A1 (enExample) |
| JP (2) | JP2019532657A (enExample) |
| KR (1) | KR20190086681A (enExample) |
| CN (1) | CN110402145A (enExample) |
| AU (1) | AU2017347837A1 (enExample) |
| BR (1) | BR112019008369A2 (enExample) |
| CA (1) | CA3042015A1 (enExample) |
| IL (1) | IL266222A (enExample) |
| MX (1) | MX2019004810A (enExample) |
| RU (1) | RU2765874C2 (enExample) |
| SG (1) | SG11201903674YA (enExample) |
| WO (1) | WO2018081459A1 (enExample) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110974954A (zh) * | 2019-12-24 | 2020-04-10 | 珠海丽凡达生物技术有限公司 | 一种用于增强核酸疫苗免疫效果的脂质纳米颗粒及其制备方法 |
| CN113616793A (zh) * | 2021-08-20 | 2021-11-09 | 南方海洋科学与工程广东省实验室(湛江) | Traf6抑制剂在作为和/或制备铁死亡诱导剂中的应用 |
| CN114641315A (zh) * | 2019-11-14 | 2022-06-17 | 博阿济吉大学 | 癌症免疫疗法中的asc斑点 |
| CN115089588A (zh) * | 2022-08-22 | 2022-09-23 | 云南大学 | 达沙布韦作为e3连接酶新型配体构建protac的应用 |
| CN116209771A (zh) * | 2020-07-31 | 2023-06-02 | 联合治疗公司 | 用于改善疫苗接种的组合物和方法 |
| WO2023125974A1 (zh) * | 2021-12-31 | 2023-07-06 | 广州国家实验室 | mRNA疫苗 |
| CN119662655A (zh) * | 2023-12-04 | 2025-03-21 | 武汉厚先生物医药有限公司 | Rna分子及其组合物在肿瘤免疫治疗中的应用 |
| WO2025087250A1 (en) * | 2023-10-23 | 2025-05-01 | Abogen Biosciences (Shanghai) Co., Ltd. | Therapeutic mrna cancer vaccine targeting hpv-associated cancers |
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| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| PT3134131T (pt) | 2014-04-23 | 2022-03-24 | Modernatx Inc | Vacinas de ácidos nucleicos |
| EP4218805A1 (en) | 2015-07-21 | 2023-08-02 | ModernaTX, Inc. | Infectious disease vaccines |
| US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
| EP3328394A4 (en) | 2015-07-30 | 2019-03-13 | ModernaTX, Inc. | CONCATEMEE peptide epitope RNAs |
| WO2017031232A1 (en) | 2015-08-17 | 2017-02-23 | Modernatx, Inc. | Methods for preparing particles and related compositions |
| CA3002922A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| EP3364950A4 (en) | 2015-10-22 | 2019-10-23 | ModernaTX, Inc. | VACCINES AGAINST TROPICAL DISEASES |
| MA45209A (fr) | 2015-10-22 | 2019-04-17 | Modernatx Inc | Vaccins contre les maladies sexuellement transmissibles |
| SG11201803360UA (en) | 2015-10-22 | 2018-05-30 | Modernatx Inc | Nucleic acid vaccines for varicella zoster virus (vzv) |
| EP4349404A3 (en) | 2015-10-22 | 2024-06-19 | ModernaTX, Inc. | Respiratory virus vaccines |
| EP3386484B1 (en) | 2015-12-10 | 2022-03-30 | ModernaTX, Inc. | Compositions and methods for delivery of therapeutic agents |
| US10465190B1 (en) | 2015-12-23 | 2019-11-05 | Modernatx, Inc. | In vitro transcription methods and constructs |
| US10188749B2 (en) | 2016-04-14 | 2019-01-29 | Fred Hutchinson Cancer Research Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| IL263079B2 (en) | 2016-05-18 | 2024-05-01 | Modernatx Inc | Polynucleotides encoding relaxin |
| MA45052A (fr) | 2016-05-18 | 2019-03-27 | Modernatx Inc | Polynucléotides codant pour jagged1 pour le traitement du syndrome d'alagille |
| SG11201901941YA (en) | 2016-09-14 | 2019-04-29 | Modernatx Inc | High purity rna compositions and methods for preparation thereof |
| EP3528821A4 (en) | 2016-10-21 | 2020-07-01 | ModernaTX, Inc. | HUMAN CYTOMEGALOVIRUS VACCINE |
| WO2018089851A2 (en) | 2016-11-11 | 2018-05-17 | Modernatx, Inc. | Influenza vaccine |
| WO2018107088A2 (en) | 2016-12-08 | 2018-06-14 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
| US11384352B2 (en) | 2016-12-13 | 2022-07-12 | Modernatx, Inc. | RNA affinity purification |
| US11572389B2 (en) * | 2017-01-27 | 2023-02-07 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Vaccine compositions of herpesvirus envelope protein combinations to induce immune response |
| AU2018214556A1 (en) * | 2017-02-01 | 2019-08-15 | Modernatx, Inc. | Immunomodulatory therapeutic mRNA compositions encoding activating oncogene mutation peptides |
| JP7731656B2 (ja) * | 2017-02-01 | 2025-09-01 | モデルナティエックス インコーポレイテッド | Rna癌ワクチン |
| EP3582790A4 (en) | 2017-02-16 | 2020-11-25 | ModernaTX, Inc. | VERY POWERFUL IMMUNOGENIC COMPOSITIONS |
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| EP3595713A4 (en) | 2017-03-15 | 2021-01-13 | ModernaTX, Inc. | Respiratory syncytial virus vaccine |
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| EP3595676A4 (en) | 2017-03-17 | 2021-05-05 | Modernatx, Inc. | RNA VACCINES AGAINST ZOONOSES |
| US11905525B2 (en) | 2017-04-05 | 2024-02-20 | Modernatx, Inc. | Reduction of elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins |
| ES2952779T3 (es) | 2017-05-18 | 2023-11-06 | Modernatx Inc | ARN mensajero modificado que comprende elementos de ARN funcionales |
| EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
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| WO2019035901A1 (en) * | 2017-08-15 | 2019-02-21 | University Of Miami | COMPOSITIONS AND METHODS FOR STING PROTEIN MODULATION |
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| EP3898942A4 (en) * | 2018-12-21 | 2022-10-19 | Tiba Biotech LLC | NANOPARTICLE COMPOSITIONS FOR EFFICIENT NUCLEIC ACID DELIVERY AND METHODS OF MAKING AND USE THEREOF |
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| EP3683229A1 (en) * | 2019-01-21 | 2020-07-22 | Charité - Universitätsmedizin Berlin | Specific t cell receptors against epitopes of mutant myd88l265p protein for adoptive t cell therapy |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
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| CN115089588A (zh) * | 2022-08-22 | 2022-09-23 | 云南大学 | 达沙布韦作为e3连接酶新型配体构建protac的应用 |
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| WO2018081459A9 (en) | 2018-11-22 |
| US20180311343A1 (en) | 2018-11-01 |
| JP2022184924A (ja) | 2022-12-13 |
| US20250170235A1 (en) | 2025-05-29 |
| JP2019532657A (ja) | 2019-11-14 |
| RU2019116006A (ru) | 2020-11-27 |
| RU2019116006A3 (enExample) | 2021-07-30 |
| BR112019008369A2 (pt) | 2019-10-01 |
| CA3042015A1 (en) | 2018-05-03 |
| IL266222A (en) | 2019-06-30 |
| EP3532070A1 (en) | 2019-09-04 |
| RU2765874C2 (ru) | 2022-02-04 |
| KR20190086681A (ko) | 2019-07-23 |
| US20200261572A1 (en) | 2020-08-20 |
| AU2017347837A1 (en) | 2019-06-06 |
| MX2019004810A (es) | 2019-10-15 |
| WO2018081459A1 (en) | 2018-05-03 |
| SG11201903674YA (en) | 2019-05-30 |
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