CN110384651B - Essence for repairing allergic skin and treating eczema - Google Patents
Essence for repairing allergic skin and treating eczema Download PDFInfo
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- CN110384651B CN110384651B CN201910838825.3A CN201910838825A CN110384651B CN 110384651 B CN110384651 B CN 110384651B CN 201910838825 A CN201910838825 A CN 201910838825A CN 110384651 B CN110384651 B CN 110384651B
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- 208000010668 atopic eczema Diseases 0.000 title claims abstract description 58
- 201000004624 Dermatitis Diseases 0.000 title claims abstract description 32
- 230000000172 allergic effect Effects 0.000 title claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 36
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 34
- 241000414067 Inonotus obliquus Species 0.000 claims abstract description 27
- 241000037826 Polygonatum kingianum Species 0.000 claims abstract description 25
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 17
- 229960000458 allantoin Drugs 0.000 claims abstract description 17
- 239000008367 deionised water Substances 0.000 claims abstract description 16
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 16
- 239000002488 antieczema agent Substances 0.000 claims abstract description 11
- 239000003906 humectant Substances 0.000 claims abstract description 8
- 239000002131 composite material Substances 0.000 claims abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 41
- 238000003756 stirring Methods 0.000 claims description 31
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 22
- 230000001804 emulsifying effect Effects 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 20
- 241000237536 Mytilus edulis Species 0.000 claims description 16
- 235000020638 mussel Nutrition 0.000 claims description 16
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 15
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 15
- 229920002498 Beta-glucan Polymers 0.000 claims description 15
- 239000004386 Erythritol Substances 0.000 claims description 15
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 15
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 15
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 15
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 15
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 15
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 15
- 235000019414 erythritol Nutrition 0.000 claims description 15
- 229940009714 erythritol Drugs 0.000 claims description 15
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 15
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 15
- 238000004140 cleaning Methods 0.000 claims description 12
- 238000007599 discharging Methods 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 12
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 11
- 238000001816 cooling Methods 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 239000003755 preservative agent Substances 0.000 claims description 7
- 230000002335 preservative effect Effects 0.000 claims description 7
- 239000003973 paint Substances 0.000 claims description 2
- 229940074410 trehalose Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 17
- 230000032683 aging Effects 0.000 abstract description 9
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 4
- 230000008439 repair process Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 61
- 235000011187 glycerol Nutrition 0.000 description 13
- 230000003020 moisturizing effect Effects 0.000 description 9
- 230000037303 wrinkles Effects 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 239000002994 raw material Substances 0.000 description 8
- 238000004659 sterilization and disinfection Methods 0.000 description 8
- 238000003860 storage Methods 0.000 description 8
- 230000037394 skin elasticity Effects 0.000 description 7
- 230000008859 change Effects 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 230000009759 skin aging Effects 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 210000002510 keratinocyte Anatomy 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000002884 skin cream Substances 0.000 description 4
- 206010050637 Skin tightness Diseases 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 238000004020 luminiscence type Methods 0.000 description 2
- HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 241000723185 Cyathea Species 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000003390 bioluminescence detection Methods 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention relates to the technical field of skin care products, and provides essence for repairing allergic skin and treating eczema, aiming at the problems of skin with reduced water absorption capacity and poor skin care effect caused by aging, wherein the technical scheme is as follows: the composite material comprises the following components in percentage by mass: 13.9 to 25.4 percent of humectant; 4.6 to 5.8 percent of anti-eczema agent; 1 to 3 percent of polygonatum kingianum extract; 1% -3% of inonotus obliquus extract; the balance being deionized water. By adding polygonatum kingianum extract and inonotus obliquus extract and matching in a specific ratio, free radicals are eliminated, aging is slowed down, the skin is protected to keep young, the skin is improved substantially, and the skin is not simply filled with substances to restore the elasticity of the skin but is completely reduced by eliminating the free radicals to cause aging of the skin; the essence has a good effect of treating eczema by adding the anti-eczema agent; allantoin is utilized to achieve a good effect of repairing skin allergy, so that the essence can repair allergic skin well.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to essence for repairing allergic skin and treating eczema.
Background
With the development of society, people have higher and higher pursuits for life, and in order to delay skin aging and better keep youthful appearance, skin care products are commonly used for protecting the skin.
Skin care products generally have the functions of moisturizing and moisturizing, and the elasticity and luster of skin are increased through moisturizing, so that the skin looks younger, but with skin aging, the water absorption capacity is greatly reduced, wrinkles are difficult to cover, the general moisturizing and moisturizing needs to embody the skin care effect based on the water absorption capacity of the skin, and the skin care effect is poor for the skin with the reduced water absorption capacity caused by aging, so that the skin care products have room for improvement.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide the essence for repairing allergic skin and treating eczema, and the essence has the advantage of delaying skin aging.
In order to achieve the purpose, the invention provides the following technical scheme:
the essence for repairing allergic skin and treating eczema comprises the following components in percentage by mass:
13.9 to 25.4 percent of humectant
4.6 to 5.8 percent of anti-eczema agent
1 to 3 percent of polygonatum kingianum extract;
1% -3% of inonotus obliquus extract;
the balance being deionized water.
By adopting the technical scheme, the polygonatum kingianum extract and the inonotus obliquus extract are added and matched in a specific proportion, so that wrinkles are effectively resisted from generating, the wrinkles are faded, free radicals are eliminated, the aging is slowed down, the skin is protected to keep young, the skin is essentially improved, and the skin is not simply filled with substances to restore the elasticity of the skin but is reduced by eliminating the free radicals to cause the aging of the skin to be vigorous, so that the skin is delicate and smooth;
the essence has a good eczema treatment effect by adding the anti-eczema agent;
the moisturizer is added, so that the skin of the essence is relatively smooth after use, and the free radicals are eliminated to relieve aging from the root and supplement moisture to the skin at the same time, so that the skin is more tender and elastic.
The invention is further configured to: the paint also comprises the following components in percentage by mass:
0.5 to 1.5 percent of preservative.
By adopting the technical scheme, the preservative is added, so that the essence is not easy to deteriorate, the quality guarantee period is long, and the quality of the skin cream is guaranteed.
The invention is further configured to: the humectant comprises one or more of glycerol, butanediol, sodium hyaluronate, allantoin, trehalose, beta-glucan and erythritol.
By adopting the technical scheme, the moisturizing effect is better, no conflict exists between the moisturizing effect and the moisturizing effect, and the skin care effect is ensured.
The invention is further configured to: the humectant comprises the following components in percentage by mass:
2% -4% of glycerol;
4% -5% of butanediol;
0.3 to 0.9 percent of sodium hyaluronate;
0.1 to 0.3 percent of allantoin;
trehalose 0.5% -1.2%;
2% -5% of beta-glucan;
5% -8% of erythritol.
By adopting the technical scheme, the moisturizing effect is better, allantoin is utilized to play a better effect of repairing skin allergy, and the essence can repair allergic skin better.
The invention is further configured to: the anti-eczema agent comprises one or two of extract of mussel and extract of Cyathea leaf .
By adopting the technical scheme, the anti-eczema effect is better, and meanwhile, the clam lunea leaf extract also has the effect of eliminating free radicals, so that the anti-aging effect of the essence is better.
The invention is further configured to: the anti-eczema agent comprises the following components in percentage by mass:
0.1% -0.3% of mussel extract;
4.5 to 5.5 percent of clam leaf extract.
By adopting the technical scheme, the clam extract of the leaf of the lunea, the extract of the polygonatum kingianum and the extract of the inonotus obliquus are matched in a specific proportion, so that the effect of eliminating free radicals is better.
The invention is further configured to: the preservative comprises one or two of p-hydroxyacetophenone and hexanediol.
Through adopting above-mentioned technical scheme for the antiseptic effect preferred, and conflict-free, guarantee the cycle of depositing of essence.
The invention is further configured to: the preservative comprises the following components in percentage by mass:
0.2 to 0.7 percent of p-hydroxyacetophenone;
0.3 to 0.8 percent of hexanediol.
By adopting the technical scheme, the anti-corrosion effect is better, the using amount is less, and the anti-corrosion period is longer.
The invention is further configured to: the preparation method of the essence for repairing allergic skin and treating eczema comprises the following steps:
s1, cleaning equipment;
s2, adding p-hydroxyacetophenone, deionized water, glycerol, butanediol, sodium hyaluronate and allantoin into an emulsifying pot, heating to 80-90 ℃, and uniformly stirring to form an A-phase mixture;
s3, cooling the phase A mixture to 30-40 ℃, sequentially adding trehalose, hexanediol, beta-glucan, a mussel extract, erythritol, a mussel lunea leaf extract, a polygonatum kingianum extract and an inonotus obliquus extract into an emulsifying pot one by one, and uniformly stirring to form essence for repairing allergic skin and treating eczema;
And S4, filtering and discharging.
By adopting the technical scheme, the clam leaf of luneberry extract, the polygonatum kingianum extract and the inonotus obliquus extract are added at the temperature of 30-40 ℃ to avoid the inactivation of the clam leaf of luneberry extract, the polygonatum kingianum extract and the inonotus obliquus extract, so that the effect of eliminating free radicals is ensured, and the anti-aging effect of the essence is further ensured.
In conclusion, the invention has the following beneficial effects:
1. by adding polygonatum kingianum extract and inonotus obliquus extract and matching in a specific ratio, the wrinkle generation is effectively resisted, wrinkles are reduced, free radicals are eliminated, the aging is slowed down, the skin is protected to keep young, the skin is essentially improved, the skin is not simply filled with substances to restore the elasticity of the skin, but the free radicals are eliminated to reduce the vigor of skin aging, so that the skin is delicate and smooth;
2. the essence has a good effect of treating eczema by adding the anti-eczema agent;
3. the moisturizer is added, so that the skin of the essence is relatively smooth after use, and the moisture is supplemented to the skin while the free radicals are eliminated to radically slow down aging, so that the skin is more tender and elastic;
4. The combination of the clam leaf extract, the polygonatum kingianum extract and the inonotus obliquus extract according to a specific proportion ensures that the effect of eliminating free radicals is better.
Drawings
Fig. 1 is a schematic flow chart of a preparation method of the essence for repairing allergic skin and treating eczema in the present invention.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples.
In the following examples and comparative examples:
p-hydroxyacetophenone is carnatone sold by Denzhi Co., Ltd.
As the glycerin, glycerin sold by Malassen Co., Ltd is used.
The butanediol is 1, 3 butanediol sold by Guangzhou daily oil science and technology company.
Sodium hyaluronate is sold by Shandong Furuida Co., Ltd.
Allantoin is available from the Clariant Co., Ltd.
Trehalose is available from the crystal vitamin peptide company Limited.
As the hexanediol, hexanediol available from Dexinxin Co., Ltd was used.
As the beta-glucan, there can be used glucan sold by Onlida Co.
The extract of Yibei is sold by Seiko Co., Ltd.
Erythritol is sold by Mitsubishi chemical company, Inc.
The extract of clam LUYE is 391 LUYE LUYE extract sold by Yongyuan biology GmbH.
The Polygonatum kingianum extract is sold by England Biometrics Ltd.
The Inonotus obliquus extract is obtained from Inonotus obliquus sold by Harbin Guandong Physcomitas.
Example 1
Referring to fig. 1, the preparation method of the essence comprises the following steps:
s1, cleaning equipment is as follows:
various devices are cleaned by clean water and then are washed by deionized water at 100 ℃ for disinfection.
S2, adding 79.5kg of water, 2kg of glycerin, 4kg of butanediol, 0.3kg of sodium hyaluronate and 0.1kg of allantoin into an emulsifying pot, heating to 80 ℃, rotating at the speed of 60r/min, stirring until all the raw materials are completely dissolved, and then stirring for 3min to form a phase A mixture.
S3, cooling the phase A mixture to 30 ℃, sequentially adding 0.5kg of trehalose, 2kg of beta-glucan, 5kg of erythritol, 0.1kg of mussel extract, 4.5kg of clam leaf extract, 1kg of polygonatum kingianum extract and 1kg of inonotus obliquus extract into an emulsifying pot one by one, rotating at a speed of 55r/min, and stirring for 8min to uniformly form essence for repairing allergic skin and treating eczema;
S4, filtering and discharging, which specifically comprises the following steps:
the essence is filtered by a filter screen and then discharged into a storage bucket.
Example 2
Referring to fig. 1, the preparation method of the essence comprises the following steps:
s1, cleaning equipment is as follows:
various devices are cleaned by clean water and then are washed by deionized water at 100 ℃ for disinfection.
S2, adding 71.2kg of water, 3kg of glycerin, 5kg of butanediol, 0.6kg of sodium hyaluronate and 0.2kg of allantoin into an emulsifying pot, heating to 85 ℃, rotating at the speed of 60r/min, stirring until all the raw materials are completely dissolved, and then stirring for 3min to form a phase A mixture.
S3, cooling the phase A mixture to 35 ℃, sequentially adding 0.8kg of trehalose, 3.5kg of beta-glucan, 6.5kg of erythritol, 0.2kg of mussel extract, 5kg of clam leaf extract, 2kg of polygonatum kingianum extract and 2kg of inonotus obliquus extract into an emulsifying pot one by one, rotating at a speed of 55r/min, and stirring for 8min to uniformly stir to form essence for repairing allergic skin and treating eczema;
s4, filtering and discharging, specifically comprising the following steps:
the essence is filtered by a filter screen and then discharged into a storage bucket.
Example 3
Referring to fig. 1, the preparation method of the essence comprises the following steps:
S1, cleaning equipment is as follows:
various devices are cleaned by clean water and then are washed by deionized water at 100 ℃ for disinfection.
S2, adding 62.8kg of water, 4kg of glycerin, 6kg of butanediol, 0.9kg of sodium hyaluronate and 0.3kg of allantoin into an emulsifying pot, heating to 90 ℃, rotating at the speed of 60r/min, stirring until all the raw materials are completely dissolved, and then stirring for 3min to form a phase A mixture.
S3, cooling the phase A mixture to 40 ℃, sequentially adding 1.2kg of trehalose, 5kg of beta-glucan, 8kg of erythritol, 0.3kg of mussel extract, 5.5kg of clam leaf extract, 3kg of polygonatum kingianum extract and 3kg of inonotus obliquus extract into an emulsifying pot one by one, rotating at a speed of 55r/min, and stirring for 8min to uniformly form essence for repairing allergic skin and treating eczema;
s4, filtering and discharging, specifically comprising the following steps:
the essence is filtered by a filter screen and then discharged into a storage bucket.
Example 4
Referring to fig. 1, the preparation method of the essence comprises the following steps:
s1, cleaning equipment is as follows:
various devices are cleaned by clean water and then are washed by deionized water at 100 ℃ for disinfection.
S2, adding 68.8kg of water, 3.3kg of glycerol, 5.4kg of butanediol, 0.7kg of sodium hyaluronate and 0.2kg of allantoin into an emulsifying pot, heating to 80 ℃, rotating at the speed of 60r/min, stirring until all the raw materials are completely dissolved, and then stirring for 3min to form a phase A mixture.
S3, cooling the phase A mixture to 30 ℃, sequentially adding 0.6kg of trehalose, 4.5kg of beta-glucan, 7kg of erythritol, 0.2kg of mussel extract, 4.9kg of clam leaf extract, 2.3kg of polygonatum kingianum extract and 2.1kg of inonotus obliquus extract into an emulsifying pot one by one, rotating at a speed of 55r/min, and stirring for 8min to uniformly form essence for repairing allergic skin and treating eczema;
s4, filtering and discharging, which specifically comprises the following steps:
filtering the essence through a filter screen and then discharging the essence into a storage barrel.
Example 5
Referring to fig. 1, the preparation method of the essence comprises the following steps:
s1, cleaning equipment is as follows:
various devices are cleaned by clean water and then are washed by deionized water at 100 ℃ for disinfection.
S2, adding 68.3kg of water, 3.3kg of glycerol, 5.4kg of butanediol, 0.7kg of sodium hyaluronate and 0.2kg of allantoin into an emulsifying pot, heating to 80 ℃, rotating at the speed of 60r/min, stirring until all the raw materials are completely dissolved, and then stirring for 3min to form a phase A mixture.
S3, cooling the phase A mixture to 30 ℃, sequentially adding 0.6kg of trehalose, 4.5kg of beta-glucan, 7kg of erythritol, 0.2kg of mussel extract, 4.9kg of clam leaf extract, 2.3kg of polygonatum kingianum extract, 2.1kg of inonotus obliquus extract, 0.2kg of p-hydroxyacetophenone and 0.3kg of hexanediol into an emulsifying pot one by one, stirring at a rotating speed of 55r/min for 8min to uniformly form essence for repairing allergic skin and treating eczema;
S4, filtering and discharging, specifically comprising the following steps:
the essence is filtered by a filter screen and then discharged into a storage bucket.
Example 6
Referring to fig. 1, the preparation method of the essence comprises the following steps:
s1, cleaning equipment is as follows:
various devices are cleaned by clean water and then are washed by deionized water at 100 ℃ for disinfection.
S2, adding 67.8kg of water, 3.3kg of glycerin, 5.4kg of butanediol, 0.7kg of sodium hyaluronate and 0.2kg of allantoin into an emulsifying pot, heating to 80 ℃, rotating at the speed of 60r/min, stirring until all the raw materials are completely dissolved, and then stirring for 3min to form a phase A mixture.
S3, cooling the phase A mixture to 30 ℃, sequentially adding 0.6kg of trehalose, 4.5kg of beta-glucan, 7kg of erythritol, 0.2kg of mussel extract, 4.9kg of clam leaf extract, 2.3kg of polygonatum kingianum extract, 2.1kg of inonotus obliquus extract, 0.5kg of p-hydroxyacetophenone and 0.5kg of hexanediol into an emulsifying pot one by one, stirring at a rotating speed of 55r/min for 8min to uniformly form essence for repairing allergic skin and treating eczema;
s4, filtering and discharging, specifically comprising the following steps:
the essence is filtered by a filter screen and then discharged into a storage bucket.
Example 7
Referring to fig. 1, the preparation method of the essence comprises the following steps:
S1, cleaning equipment is as follows:
various devices are cleaned by clean water and then are washed by deionized water at 100 ℃ for disinfection.
S2, adding 67.3kg of water, 3.3kg of glycerol, 5.4kg of butanediol, 0.7kg of sodium hyaluronate and 0.2kg of allantoin into an emulsifying pot, heating to 80 ℃, rotating at the speed of 60r/min, stirring until all the raw materials are completely dissolved, and then stirring for 3min to form a phase A mixture.
S3, cooling the phase A mixture to 30 ℃, sequentially adding 0.6kg of trehalose, 4.5kg of beta-glucan, 7kg of erythritol, 0.2kg of mussel extract, 4.9kg of clam leaf extract, 2.3kg of polygonatum kingianum extract, 2.1kg of inonotus obliquus extract, 0.7kg of p-hydroxyacetophenone and 0.8kg of hexanediol in an emulsifying pot one by one, stirring at a rotating speed of 55r/min for 8min to uniformly form essence for repairing allergic skin and treating eczema;
s4, filtering and discharging, specifically comprising the following steps:
filtering the essence through a filter screen and then discharging the essence into a storage barrel.
Example 8
Referring to fig. 1, the preparation method of the essence comprises the following steps:
s1, cleaning equipment is as follows:
various devices are cleaned by clean water and then are washed by deionized water at 100 ℃ for disinfection.
S2, adding 67.7kg of water, 3.3kg of glycerin, 5.4kg of butanediol, 0.7kg of sodium hyaluronate and 0.2kg of allantoin into an emulsifying pot, heating to 80 ℃, rotating at the speed of 60r/min, stirring until all the raw materials are completely dissolved, and then stirring for 3min to form a phase A mixture.
S3, cooling the phase A mixture to 30 ℃, sequentially adding 0.6kg of trehalose, 4.5kg of beta-glucan, 7kg of erythritol, 0.2kg of mussel extract, 4.9kg of clam leaf extract, 2.3kg of polygonatum kingianum extract, 2.1kg of inonotus obliquus extract, 0.4kg of p-hydroxyacetophenone and 0.7kg of hexanediol into an emulsifying pot one by one, stirring at a rotating speed of 55r/min for 8min to uniformly form essence for repairing allergic skin and treating eczema;
s4, filtering and discharging, which specifically comprises the following steps:
the essence is filtered by a filter screen and then discharged into a storage bucket.
Comparative example 1
The difference from example 8 is that:
in step S3, the clam leaf extract is not added.
Comparative example 2
The difference from example 8 is that:
in step S3, rhizoma Polygonati extract is added.
Comparative example 3
The difference from example 8 is that:
in step S3, the Inonotus obliquus extract is removed.
Comparative example 4
The difference from example 8 is that:
in step S3, clam extract of leaf of lunea, extract of polygonatum kingianum and extract of inonotus obliquus are removed.
Experiment 1
1200 female volunteers of 30-40 years old are selected, every 100 female volunteers are taken as a group, and the skin cream of each embodiment and each comparative example is respectively applied to the face for 3 months, once in the morning and once in the evening;
after 1 week of use, after face cleaning and natural drying for 30min, testing skin moisture through a skin moisture detector Corneometer CM825, detecting skin elasticity by a skin elasticity tester Corneometer MPA580, detecting skin tightness by a skin elasticity tester Corneometer MPA580, and detecting skin wrinkles by a skin rapid three-dimensional imaging system PRIMOS;
after 3 months of use, after face cleaning and natural drying for 30min, skin moisture is tested again through a skin moisture tester Corneometer CM825, skin elasticity is tested through a skin elasticity tester Corneometer MPA580, skin tightness is tested through the skin elasticity tester Corneometer MPA580, and skin wrinkles are tested through a skin rapid three-dimensional imaging system PRIMOS;
subtracting the first detection data from the second detection data to obtain the change condition of the skin moisture content, the change condition of the skin elasticity, the change condition of the skin tightness and the change condition of skin wrinkles;
the values of the highest 5 persons and the lowest 5 persons are removed from each group, and the values of the remaining 90 persons are averaged, namely the change of the skin moisture content of the skin cream of the embodiment or the comparative example after 3 months of use and 1 week of use.
Experiment 2
120 female volunteers 30-40 years old are taken, 10 female volunteers are taken as a group, and the skin cream of each embodiment and comparative example is respectively smeared on the back of the hand for 3 months, once in the morning and once in the evening;
after 1 week of use, scraping off the keratinocyte on the back of the volunteer with a cotton swab for 10 times, putting the keratinocyte into deionized water, stirring uniformly to form a cell solution, taking a luminol reagent as a luminescent reagent, and adopting Fe2+Ion workThe catalyst is prepared by adopting a chemiluminescence measuring method and detecting the luminous intensity by a fluorescence quantitative detection device;
after 3 months of use, scraping off 10 times of the back of a volunteer's hand with a cotton swab to scrape off the keratinocytes on the surface layer, putting the keratinocytes into deionized water, stirring uniformly to form a cell solution, taking a luminol reagent as a luminescent reagent, and adopting Fe2+Ion is used as a catalyst, a chemiluminescence measuring method is adopted, and the luminous intensity is detected by a fluorescence quantitative detection device;
the difference between the luminescence intensity measured after 1 week of use and the luminescence intensity measured after 3 months of use was calculated.
Specifically, the fluorescence quantitative detection device adopts a Japanese Churitsu Electric high-sensitivity bioluminescence detection system.
Specific detection data are shown in Table 1
TABLE 1
According to the table 1, the clam leaf extract, the polygonatum kingianum extract and the inonotus obliquus extract can be added to effectively eliminate free radicals in the skin, and meanwhile, when the clam leaf extract, the polygonatum kingianum extract and the inonotus obliquus extract are matched according to a specific proportion, the effect of eliminating the free radicals in the skin is good, the root source of skin aging is fundamentally reduced, the skin is not easy to age and is always youthful, and further the moisture of the skin is increased, is more moist and compact, wrinkles are reduced, and the skin care effect is good.
The embodiments of the present invention are preferred embodiments of the present invention, and the scope of the present invention is not limited by these embodiments, so: equivalent changes made according to the structure, shape and principle of the invention shall be covered by the protection scope of the invention.
Claims (7)
1. An essence for repairing allergic skin and treating eczema is characterized in that: the composite material comprises the following components in percentage by mass:
13.9 to 25.4 percent of humectant;
4.6 to 5.8 percent of anti-eczema agent;
1 to 3 percent of polygonatum kingianum extract;
1% -3% of inonotus obliquus extract;
the balance of deionized water;
the anti-eczema agent comprises the following components in percentage by mass:
0.1 to 0.3 percent of mussel extract;
4.5 to 5.5 percent of clam leaf extract;
the mass percentage is based on the essence.
2. An essence for repairing allergic skin and treating eczema is characterized in that: the composite material comprises the following components in percentage by mass:
13.9 to 25.4 percent of humectant;
4.6 to 5.8 percent of anti-eczema agent;
1 to 3 percent of polygonatum kingianum extract;
1% -3% of inonotus obliquus extract;
the balance of deionized water;
the anti-eczema agent comprises the following components in percentage by mass:
0.1% -0.3% of mussel extract;
4.5 to 5.5 percent of clam leaf extract;
the paint also comprises the following components in percentage by mass:
0.5 to 1.5 percent of preservative;
the mass percentage is based on the essence.
3. The essence for repairing allergic skin and treating eczema according to claim 2, which is characterized in that: the humectant comprises one or more of glycerol, butanediol, sodium hyaluronate, allantoin, trehalose, beta-glucan and erythritol.
4. The essence for repairing allergic skin and treating eczema according to claim 2, which is characterized in that: the humectant comprises the following components in percentage by mass:
2% -4% of glycerol;
4% -5% of butanediol;
0.3 to 0.9 percent of sodium hyaluronate;
0.1 to 0.3 percent of allantoin;
trehalose 0.5% -1.2%;
2% -5% of beta-glucan;
5% -8% of erythritol;
the mass percentage is based on the essence.
5. The essence for repairing allergic skin and treating eczema according to claim 4, which is characterized in that: the preservative comprises one or two of p-hydroxyacetophenone and hexanediol.
6. The essence for repairing allergic skin and treating eczema according to claim 5, which is characterized in that: the preservative comprises the following components in percentage by mass:
0.2 to 0.7 percent of p-hydroxyacetophenone;
0.3 to 0.8 percent of hexanediol;
the mass percentage is based on the essence.
7. The essence for repairing allergic skin and treating eczema according to claim 6, which is characterized in that: the preparation method of the essence for repairing allergic skin and treating eczema comprises the following steps:
s1, cleaning equipment;
s2, adding p-hydroxyacetophenone, deionized water, glycerol, butanediol, sodium hyaluronate and allantoin into an emulsifying pot, heating to 80-90 ℃, and uniformly stirring to form an A-phase mixture;
s3, cooling the phase A mixture to 30-40 ℃, sequentially adding trehalose, hexanediol, beta-glucan, a mussel extract, erythritol, a mussel lunea leaf extract, a polygonatum kingianum extract and an inonotus obliquus extract into an emulsifying pot one by one, and uniformly stirring to form essence for repairing allergic skin and treating eczema;
And S4, filtering and discharging.
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| CN111991316B (en) * | 2020-09-15 | 2023-06-30 | 广州莱约生物科技有限公司 | Anti-allergy repair composition, preparation method and application thereof |
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Address after: 510000 floors 1-3, building 1, No.95, Dalai South Road, Taihe Town, Baiyun District, Guangzhou City, Guangdong Province Applicant after: Guangzhou Huanong Cosmetics Co.,Ltd. Address before: No.196, Dalai North Road, wanggangling Industrial Park, xiejiazhuang, Taihe Town, Baiyun District, Guangzhou, Guangdong 510000 Applicant before: GUANGZHOU LENNON COSMETICS Co.,Ltd. |
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Denomination of invention: Essence liquid for repairing allergic skin and treating eczema Effective date of registration: 20231013 Granted publication date: 20220610 Pledgee: Bank of China Limited by Share Ltd. Guangzhou Liwan branch Pledgor: Guangzhou Huanong Cosmetics Co.,Ltd. Registration number: Y2023980061136 |