CN110337444A - 穿越血脑屏障的纳米药物载体 - Google Patents
穿越血脑屏障的纳米药物载体 Download PDFInfo
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- CN110337444A CN110337444A CN201880010782.3A CN201880010782A CN110337444A CN 110337444 A CN110337444 A CN 110337444A CN 201880010782 A CN201880010782 A CN 201880010782A CN 110337444 A CN110337444 A CN 110337444A
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Abstract
本发明公开了一种穿越血脑屏障的纳米药物载体，所述载体能够靶向脑部病灶(脑部肿瘤或者其他神经退行性疾病)，所述穿越血脑屏障的靶向性药物载体包含全重链人铁蛋白或其功能片段重建体或突变体。其穿越血脑屏障的方式为受体介导的转胞吞作用。本发明所述的药物载体将为脑瘤或神经退行性疾病的治疗提供一种有效的纳米药物载体。
Description
PCT国内申请，说明书已公开。
Claims (14)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710109495.5A CN108503704A (zh) | 2017-02-27 | 2017-02-27 | 穿越血脑屏障的纳米药物载体 |
| CN2017101094955 | 2017-02-27 | ||
| PCT/CN2018/077295 WO2018153372A1 (zh) | 2017-02-27 | 2018-02-26 | 穿越血脑屏障的纳米药物载体 |
Publications (2)
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| CN110337444A true CN110337444A (zh) | 2019-10-15 |
| CN110337444B CN110337444B (zh) | 2024-02-20 |
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| CN201880010782.3A Active CN110337444B (zh) | 2017-02-27 | 2018-02-26 | 穿越血脑屏障的纳米药物载体 |
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| CN (2) | CN108503704A (zh) |
| WO (1) | WO2018153372A1 (zh) |
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| CN111991561A (zh) * | 2020-08-26 | 2020-11-27 | 中国科学院上海高等研究院 | 一种高效穿过血脑屏障的寡聚核苷酸/原子精细纳米团簇复合物及其制备方法以及应用 |
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| CN110179997B (zh) * | 2018-08-08 | 2020-02-14 | 昆山新蕴达生物科技有限公司 | 一种用于糖尿病治疗的纳米药物载体及其组合药物 |
| WO2021008454A1 (zh) * | 2019-07-12 | 2021-01-21 | 昆山新蕴达生物科技有限公司 | 基于铁蛋白重链亚基的药物载体 |
| CN111411120B (zh) * | 2020-04-01 | 2022-04-08 | 中国农业大学 | 一种锌离子诱导铁蛋白自组装包埋活性小分子的方法 |
| CN112321719B (zh) * | 2020-07-28 | 2023-03-17 | 磐石锦程生物科技(北京)有限公司 | 一种药物载体蛋白及其应用 |
| WO2022179536A1 (zh) * | 2021-02-25 | 2022-09-01 | 昆山新蕴达生物科技有限公司 | 铁蛋白重链亚基突变体及其应用 |
| CN115137839A (zh) * | 2021-03-30 | 2022-10-04 | 南京纳么美科技有限公司 | 靶向-共装载亲/疏水药物的铁蛋白笼纳米载体及其应用 |
| CN114832116B (zh) * | 2022-05-19 | 2024-01-26 | 沈阳药科大学 | 基于小胶质细胞表型调节和脑内铁清除的ros响应型纳米载体及其制备方法与应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991561A (zh) * | 2020-08-26 | 2020-11-27 | 中国科学院上海高等研究院 | 一种高效穿过血脑屏障的寡聚核苷酸/原子精细纳米团簇复合物及其制备方法以及应用 |
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| Publication number | Publication date |
|---|---|
| US11707527B2 (en) | 2023-07-25 |
| WO2018153372A1 (zh) | 2018-08-30 |
| CN110337444B (zh) | 2024-02-20 |
| CN108503704A (zh) | 2018-09-07 |
| US20200138960A1 (en) | 2020-05-07 |
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