CN110279656A - A kind of composition for alleviating mycteroxerosis and preparation method thereof and application method - Google Patents

A kind of composition for alleviating mycteroxerosis and preparation method thereof and application method Download PDF

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Publication number
CN110279656A
CN110279656A CN201910624804.1A CN201910624804A CN110279656A CN 110279656 A CN110279656 A CN 110279656A CN 201910624804 A CN201910624804 A CN 201910624804A CN 110279656 A CN110279656 A CN 110279656A
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composition
parts
mycteroxerosis
alleviating
skin
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CN201910624804.1A
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CN110279656B (en
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周铁丽
陈涛
曹建明
方人驰
喻凯航
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Wenzhou Medical University
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Wenzhou Medical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants

Abstract

The invention discloses a kind of for alleviating the composition of mycteroxerosis, the composition includes lubricant, moisturizer, Osmolyte regulator, microcirculation improver and skin-rehabilitating agent, it include each component of following parts by weight, lubricant: 5 parts~10 parts in the composition of every 100 parts by weight；Moisturizer: 0.1 part~0.25 part；Osmolyte regulator: 10 parts~15 parts；Microcirculation improver: 0.1 part；Skin-rehabilitating agent: 0.1 part~0.5 part；Surplus is distilled water.Composition of the invention can give full play to its outstanding lubrication moisture-keeping functions, while keeping environment in nasal cavity humidity to be suitable for, be conducive to nasal airflow；Meanwhile microcirculation improver therein, skin-rehabilitating agent can improve the small surface of a wound caused by dry in nasal cavity, keep bronchia mucosal complete health, and can improve a variety of nasal cavity problems.The safe, practical property of composition components of the invention is high, prescription proportion science, easy to spread.

Description

A kind of composition for alleviating mycteroxerosis and preparation method thereof and application method
Technical field
The present invention relates to field of medical technology, and in particular to a kind of composition and its preparation side for alleviating mycteroxerosis Method and application method.
Background technique
Rhinitis sicca is generally acknowledged that for a long time caused by by the stimulation of extraneous physically or chemically substance, such as the machine of long-term dust Tool sexual stimulus, air overheat, influence of overdrying etc..This disease is a kind of common occupational chronic rhinitis.When rhinitis sicca not It can get timely medical treatment, when influencing smell mucous membrane, just will appear dysosmia, influence intellectual development and body development, breathing resistance Plug can make cerebral anoxia and cause dizzy drowsiness.In addition unsmooth because exhaling, it is breathed with mouth, can also directly stimulate pharyngeal cavity to cause to swallow Inflammation can if things go on like this make lip thicken, and tooth is developed outward, leads to facial deformity.
Currently, the method for the treatment of rhinitis sicca mainly removes the cause of disease and local use finish collunarium medical fluid.Except going The method of boundary's cause of disease is the most firm, but the method by not contacting environmental stimuli often cannot achieve in real life.Mesh The function majority of preceding commercially available nasal nursing class product is to inhibit nasal cavity bacterial growth, inhibit Secretion of Inflammatory Factors, shrink mucous membrane The effects of blood vessel, antiallergy, there is no the material compositions for being effectively directed to rhinitis sicca, and part has vasoconstrictor Nasal drops can even aggravate the symptom of mycteroxerosis.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of for alleviating the composition of mycteroxerosis, and the combination is various Ingredient plays significant improvement result in terms of the humidity regulation of environment, promotion nasal airflow and mucosal integrity in nasal cavity.
In order to solve the above technical problems, the technical solution used in the present invention is: a kind of for alleviating the group of mycteroxerosis Object is closed, the composition includes lubricant, moisturizer, Osmolyte regulator, microcirculation improver and skin-rehabilitating agent, every 100 weight Include each component of following parts by weight in the composition of part:
Lubricant: 5 parts~10 parts；
Moisturizer: 0.1 part~0.25 part；
Osmolyte regulator: 10 parts~15 parts
Microcirculation improver: 0.1 part；
Skin-rehabilitating agent: 0.1 part~0.5 part；
Surplus is distilled water.
Further, the lubricant is one of glycerine, butanediol and medical grade white oil or two or more with arbitrary proportion Mixed mixture.
Further, the moisturizer is one of hyaluronic acid, aloe extract and xylitol or two or more arbitrarily to compare The mixture of example mixing.
Further, the Osmolyte regulator is one of sodium chloride and phosphate or the mixing mixed with the two arbitrary proportion Object.
Further, the microcirculation improver is dextran 40.
Further, the mixture that one or both of allantoin, dipotassium glycyrrhizinate are mixed with arbitrary proportion.
The present invention also provides above-mentioned for alleviating the preparation method of the composition of mycteroxerosis, includes the following steps:
A. mixed lubrication agent, moisturizer, microcirculation improver and skin-rehabilitating agent add about 50 parts by weight normal temperature and pressure of distilled water to stir It mixes uniformly；
B. Osmolyte regulator is added in the mixture of step A, later plus distilled water is to 100 parts by weight, normal temperature and pressure stirring and dissolving ?.
The present invention also provides above-mentioned for alleviating the application method of the composition of mycteroxerosis, uses physiology salt when in use Water or mineral water are sprayed on nasal cavity after carrying out 80-100 times of dilution to the composition.
The attainable beneficial effect of institute of the invention is:
1, the present composition is free of vasoconstrictor, and the disease of rhinitis sicca will not be aggravated as commercially available common nasal drops Shape.
2, by lubricant (glycerine, butanediol, medical grade white oil) and moisturizer (hyaluronic acid, aloe extract, wood Sugar alcohol), improve the mucous membrane state of mycteroxerosis, keeps the wet ventilation of nasal cavity.Osmolyte regulator (sodium salt, phosphoric acid is added Salt), due to the osmosis of mucous membrane, so that composition and internal body fluid is in isotonic environment, prevent the excessive oedema of bronchia mucosal；Add Enter microcirculation improver (dextran) and skin-rehabilitating agent (allantoin, dipotassium glycyrrhizinate), can repair dry caused small Wound makes nasal cavity reach the health environment completely moistened.
3, present composition preparation method is simple, raw material is easy to get, and practicability is high, prescription proportion science.Meanwhile the combination Object is free of vasoconstrictor, and the symptom of rhinitis sicca will not be aggravated as commercially available common nasal drops., peace good with curative effect The features such as Atoxic, raw material is easy to get.
Specific embodiment
Following case study on implementation is used to explain the present invention, and however, it is not limited to this.Wherein used hyaluronic acid, chlorination Sodium, allantoin etc. are as being commercial product without clearly stating.
The present invention provides a kind of for alleviating the composition of mycteroxerosis, and the composition includes lubricant, moisturizer, infiltration Regulator, microcirculation improver and skin-rehabilitating agent include each component of following parts by weight in the composition of every 100 parts by weight:
Lubricant: 5 parts~10 parts；
Moisturizer: 0.1 part~0.25 part；
Osmolyte regulator: 10 parts~15 parts
Microcirculation improver: 0.1 part；
Skin-rehabilitating agent: 0.1 part~0.5 part；
Surplus is distilled water.
Wherein, the lubricant is one of glycerine, butanediol and medical grade white oil or two or more mixed with arbitrary proportion The mixture of conjunction.The moisturizer is one of hyaluronic acid, aloe extract and xylitol or two or more mixed with arbitrary proportion The mixture of conjunction.The Osmolyte regulator is one of sodium chloride and phosphate or the mixture mixed with the two arbitrary proportion.Institute Stating microcirculation improver is dextran 40.The skin-rehabilitating agent is one or both of allantoin, dipotassium glycyrrhizinate with any The mixture of ratio mixing.
The present invention also provides above-mentioned for alleviating the preparation method of the composition of mycteroxerosis, includes the following steps:
A. mixed lubrication agent, moisturizer, microcirculation improver and skin-rehabilitating agent add about 50 parts by weight normal temperature and pressure of distilled water to stir It mixes uniformly；
B. Osmolyte regulator is added in the mixture of step A, later plus distilled water is to 100 parts by weight, normal temperature and pressure stirring and dissolving ?.
Composition of the invention is different from nasal drops common in the art usually setting out to remove the cause of disease as research and development Point or common nursing class product are to inhibit nasal cavity bacterial growth, inhibit Secretion of Inflammatory Factors, contraction mucous membrane blood vessel, antiallergy Etc. starting points, and to improve environment in nasal cavity as starting point, be firstly introduced lubricant (glycerine, butanediol, medical grade white oil) and Moisturizer (hyaluronic acid, aloe extract, xylitol) is used to improve environment in nasal cavity, and with Osmolyte regulator (sodium salt, phosphoric acid Salt), microcirculation improver (dextran) and skin-rehabilitating agent (allantoin, dipotassium glycyrrhizinate) cooperate with compatibility, at subassembly Mode is that other current same type patented products are not directed to, the novelty with height.The present invention substantially increases patient's Comfort level, and it is low in cost, without side-effects, easy to spread.
The present invention is specifically described with specific embodiment below.
Embodiment 1
It is a kind of for alleviating the composition of mycteroxerosis, including glycerine, hyaluronic acid, sodium chloride, dextran 40, glycyrrhizic acid Dipotassium and allantoin.
100g the composition is prepared, weighs each component by following weight:
Glycerine: 10g；
Hyaluronic acid: 0.25g；
Sodium chloride: 12g；
Dextran 40:0.1g；
Allantoin: 0.2g；
Dipotassium glycyrrhizinate: 0.2g；
Add distilled water to 100g.
The preparation process of the composition are as follows:
First add distilled water about 50g in the glycerine of weight as above, hyaluronic acid, dextran 40, allantoin, dipotassium glycyrrhizinate Normal temperature and pressure stirs evenly, and adds sodium chloride, adds to 100g with distilled water, stirs 10 minutes, is stoste after standing, when use Diluting 100 times with physiological saline or mineral water is finished product.
Embodiment 2
It is a kind of for alleviating the composition of mycteroxerosis, including butanediol, aloe extract, sodium chloride, dextran 40, allantois Element.
100g the composition is prepared, weighs each component by following weight:
Butanediol: 5g；
Aloe extract: 0.15g；
Sodium chloride: 15g；
Dextran 40:0.1g；
Allantoin: 0.1g；
Add distilled water to 100g.
The preparation process of the composition of the alleviation mycteroxerosis are as follows:
First add distilled water about 50g normal in the butanediol of weight as above, aloe extract, sodium chloride, dextran 40, allantoin Normal temperature and pressure stirs evenly, and adds sodium chloride, adds to 100g with distilled water, stirs 10 minutes, is stoste after standing, uses physiology salt It is that finished product is sprayed on or drips in nasal cavity that water or mineral water, which dilute 100 times,.
Embodiment 3
A kind of special composition for alleviating mycteroxerosis obstruction, it is by glycerine, butanediol, xylitol, phosphate, dextran 40, dipotassium glycyrrhizinate, allantoin composition.
100 milliliters of the compositions are prepared, weigh each component by following weight:
Glycerine: 2g；
Butanediol: 6g
Xylitol: 0.1g；
Phosphate: 13g；
Dextran 40:0.1g；
Allantoin: 0.3g；
Dipotassium glycyrrhizinate: 0.2g；
Add distilled water to 100g.
The preparation process of the composition of the alleviation mycteroxerosis are as follows:
First in the glycerine of weight as above, butanediol, xylitol, phosphate, dextran 40, dipotassium glycyrrhizinate, allantoin Add distilled water about 50g normal temperature and pressure to stir evenly, add phosphate, adds to 100g with distilled water, stir 10 minutes, after standing For stoste, diluting 100 times with physiological saline or mineral water is finished product.
Embodiment 4
A kind of special composition for alleviating mycteroxerosis obstruction, it is by medical grade white oil, aloe extract, hyaluronic acid, chlorination Sodium, dextran 40, allantoin.
100 milliliters of the compositions are prepared, weigh each component by following weight:
Medical grade white oil: 7g；
Aloe extract: 0.1g；
Hyaluronic acid: 0.1g；
Sodium chloride: 14g；
Dextran 40:0.1g；
Allantoin: 0.2g；
Add distilled water to 100g.
The preparation process of the composition of the alleviation mycteroxerosis are as follows:
First add in the medical grade white oil of weight as above, aloe extract, hyaluronic acid, sodium chloride, dextran 40, allantoin Distilled water about 50g normal temperature and pressure stirs evenly, and adds sodium chloride, adds to 100g with distilled water, stirs 10 minutes, be after standing Stoste, diluting 100 times with physiological saline or mineral water is finished product.
Embodiment 5
A kind of special composition for alleviating mycteroxerosis obstruction, it is by glycerine, xylitol, sodium chloride, dextran 40, Radix Glycyrrhizae Sour dipotassium composition.
100g the composition is prepared, weighs each component by following weight:
Glycerine: 9g；
Xylitol: 0.18g；
Sodium chloride: 11g；
Dextran 40:0.1g；
Dipotassium glycyrrhizinate: 0.1g；
Add distilled water to 100g.
The preparation process of the composition of the alleviation mycteroxerosis are as follows:
First add distilled water about 50g room temperature in the glycerine of weight as above, xylitol, sodium chloride, dextran 40, dipotassium glycyrrhizinate Atmospheric agitation is uniform, adds sodium chloride, adds to 100g with distilled water, stirs 10 minutes, is stoste after standing, uses physiological saline Or it is finished product that mineral water, which dilutes 100 times,.
Application method:
It takes the stoste 5 of the composition in any of the above-described embodiment to drip, is added and is atomized equipped with physiological saline or mineral water (about 25ml) Shaking up in device can be sprayed in nose.
Using effect:
39 people of rhinitis sicca volunteer of participation, wherein 21 people of male, 18 people of women.By above-mentioned application method carry out using, It observes moistening effect and using feeling, comparing result is as shown in the table.
Following table is the Contrast on effect of the present composition and common nasal drop:
Nasal drops Moistening effect Repairing effect Use feeling Ventilatory effect Vasoconstrictor effects Treat rhinitis sicca effect Bacteriostasis Antiinflammation Cost
Commercially available nasal drop A Generally It is poor Generally Generally By force Difference By force By force In
Commercially available nasal nursing is sprayed B Generally It is poor Generally Generally Generally It is poor Generally By force In
The embodiment of the present invention It is good It is good It is good It is good It is weak Preferably Generally Generally In
As can be seen from the above table, the composition of the embodiment of the present invention moistening effect, repairing effect, use feel, ventilatory effect Etc. be superior to similar-type products in the market.
Embodiment described in the invention is merely for exemplary purpose, the protection scope being not intended to limit the invention, Those skilled in the art can be made within the scope of the invention various other replacements, changes and improvements, and this specification is chosen and had Body describes these embodiments, is principle and practical application in order to better explain the present invention, to make technical field skill Art personnel can better understand and utilize the present invention.The present invention is not limited to the above embodiments, only by claims and its entirely The limitation of portion's range and equivalent.

Claims (8)

1. a kind of for alleviating the composition of mycteroxerosis, the composition includes lubricant, moisturizer, Osmolyte regulator, micro- follows Ring improver and skin-rehabilitating agent, which is characterized in that include each component of following parts by weight in the composition of every 100 parts by weight:
Lubricant: 5 parts~10 parts；
Moisturizer: 0.1 part~0.25 part；
Osmolyte regulator: 10 parts~15 parts
Microcirculation improver: 0.1 part；
Skin-rehabilitating agent: 0.1 part~0.5 part；
Surplus is distilled water.
2. according to claim 1 a kind of for alleviating the composition of mycteroxerosis, which is characterized in that the lubricant is One of glycerine, butanediol and medical grade white oil or the two or more mixtures mixed with arbitrary proportion.
3. according to claim 1 a kind of for alleviating the composition of mycteroxerosis, which is characterized in that the moisturizer is One of hyaluronic acid, aloe extract and xylitol or the two or more mixtures mixed with arbitrary proportion.
4. according to claim 1 a kind of for alleviating the composition of mycteroxerosis, which is characterized in that the osmotic adjustment Agent is sodium chloride or phosphate.
5. according to claim 1 a kind of for alleviating the composition of mycteroxerosis, which is characterized in that the microcirculation changes Kind agent is dextran 40.
6. according to claim 1 a kind of for alleviating the composition of mycteroxerosis, which is characterized in that the skin repair Agent is the mixture that one or both of allantoin, dipotassium glycyrrhizinate are mixed with arbitrary proportion.
7. described in any one of claims 1-6 for alleviating the preparation method of the composition of mycteroxerosis, which is characterized in that packet Include following steps:
A. mixed lubrication agent, moisturizer, microcirculation improver and skin-rehabilitating agent add about 50 parts by weight normal temperature and pressure of distilled water to stir It mixes uniformly；
B. Osmolyte regulator is added in the mixture of step A, later plus distilled water is to 100 parts by weight, normal temperature and pressure stirring and dissolving ?.
8. described in any one of claims 1-6 for alleviating the application method of the composition of mycteroxerosis, which is characterized in that Nasal cavity is sprayed on after carrying out 80-100 times of dilution to the composition with physiological saline or mineral water when use.
CN201910624804.1A 2019-07-11 2019-07-11 Composition for relieving nasal dryness and preparation method and using method thereof Active CN110279656B (en)

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Publication number Priority date Publication date Assignee Title
CN112773764A (en) * 2019-11-11 2021-05-11 鼻精灵(重庆)医疗科技有限公司 Nasal care lotion

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