CN110279656B - Composition for relieving nasal dryness and preparation method and using method thereof - Google Patents
Composition for relieving nasal dryness and preparation method and using method thereof Download PDFInfo
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- CN110279656B CN110279656B CN201910624804.1A CN201910624804A CN110279656B CN 110279656 B CN110279656 B CN 110279656B CN 201910624804 A CN201910624804 A CN 201910624804A CN 110279656 B CN110279656 B CN 110279656B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
Abstract
The invention discloses a composition for relieving nasal dryness, which comprises a lubricant, a humectant, a penetration regulator, a microcirculation improving agent and a skin repairing agent, wherein each 100 parts by weight of the composition comprises the following components in parts by weight: 5-10 parts; humectant: 0.1 to 0.25 portion; osmotic adjusting agent: 10-15 parts; microcirculation improving agent: 0.1 part; skin repair agents: 0.1 to 0.5 portion; the balance of distilled water. The composition can fully exert the excellent lubricating and moisturizing functions, and is favorable for nasal cavity ventilation while keeping the appropriate humidity of the nasal cavity environment; meanwhile, the microcirculation improving agent and the skin repairing agent can improve tiny wound surfaces caused by dryness in nasal cavities, keep nasal mucosa complete and healthy, and improve various nasal problems. The composition disclosed by the invention is safe in components, high in practicability, scientific in prescription proportion and easy to popularize.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to a composition for relieving nasal dryness and a preparation method and a using method thereof.
Background
Rhinitis sicca is generally considered to be caused by external physical or chemical stimulation, such as mechanical stimulation of long-term dust, influence of air overheating and overdrying, and the like. The disease is a common occupational chronic rhinitis. When the rhinitis sicca is not treated in time and affects olfactory mucosa, olfactory disorder occurs, which affects intelligence development and body development, and respiratory obstruction can cause cerebral anoxia to cause dizziness and lethargy. In addition, when the mouth breathes due to poor exhalation, the throat cavity is directly stimulated to cause pharyngitis, and the lips are thickened and the teeth grow outwards to cause facial deformity.
At present, the method for treating rhinitis sicca mainly removes the cause of disease and adopts oil solution for local application and nasal drip liquid medicine. The method for removing the external causes is the most reliable, but the method without contacting with external stimulation cannot be realized in real life. Most of the currently marketed nasal cavity care products have the functions of inhibiting the growth of nasal cavity bacteria, inhibiting the secretion of inflammatory factors, contracting mucous membrane vessels, resisting allergy and the like, do not have material components effective for rhinitis sicca, and part of nasal drops with vasoconstrictor even aggravate the symptom of nasal cavity dryness.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a composition for relieving nasal dryness, and the composition has obvious improvement effects on humidity control of the environment in a nasal cavity, promotion of nasal cavity ventilation and mucous membrane integrity.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows: a composition for relieving nasal dryness comprises a lubricant, a humectant, a penetration regulator, a microcirculation improving agent and a skin repairing agent, wherein each 100 parts by weight of the composition comprises the following components in parts by weight:
lubricant: 5-10 parts;
humectant: 0.1 to 0.25 portion;
osmotic adjusting agent: 10 to 15 portions of
Microcirculation improving agent: 0.1 part;
skin repair agents: 0.1 to 0.5 portion;
the balance of distilled water.
Further, the lubricant is one or a mixture of more than two of glycerol, butanediol and medical white oil mixed in any proportion.
Further, the humectant is a mixture of one or more than two of hyaluronic acid, aloe extract and xylitol mixed in any proportion.
Further, the osmotic adjusting agent is one of sodium chloride and phosphate or a mixture of the sodium chloride and the phosphate mixed in any proportion.
Further, the microcirculation improving agent is dextran 40.
Further, one or both of allantoin and dipotassium glycyrrhizinate may be mixed at any ratio.
The invention also provides a preparation method of the composition for relieving nasal dryness, which comprises the following steps:
A. mixing lubricant, humectant, microcirculation improver and skin repairing agent, adding distilled water 50 weight parts, and stirring at normal temperature and pressure;
B. and C, adding an osmotic adjusting agent into the mixture obtained in the step A, adding distilled water to 100 parts by weight, and stirring and dissolving at normal temperature and normal pressure.
The invention also provides a using method of the composition for relieving nasal dryness, and the composition is diluted by 80-100 times with normal saline or mineral water and sprayed to nasal cavity when in use.
The invention can achieve the following beneficial effects:
1. the composition of the invention does not contain vasoconstrictor, and does not aggravate the symptoms of rhinitis sicca like the common nasal drops sold on the market.
2. By means of lubricant (glycerol, butanediol, medical grade white oil) and humectant (hyaluronic acid, Aloe extract, xylitol), the mucous membrane state of nasal cavity dryness is improved, and the nasal cavity interior is kept moist and ventilated. Adding osmotic regulator (sodium salt, phosphate), and making the composition and body fluid in isotonic environment due to the osmosis of mucosa to prevent nasal cavity mucosa from excessive edema; adding microcirculation improving agent (dextran) and skin repairing agent (allantoin and dipotassium glycyrrhizinate) to repair the tiny wound caused by dryness and make nasal cavity achieve a complete and moist healthy environment.
3. The composition has the advantages of simple preparation method, easily obtained raw materials, high practicability and scientific prescription proportion. Meanwhile, the composition does not contain a vasoconstrictor, and does not aggravate the symptoms of the rhinitis sicca like the common nasal drops sold in the market. Has the characteristics of good curative effect, safety, no toxicity, easily obtained raw materials and the like.
Detailed Description
The following examples are provided to illustrate the present invention, but are not limited thereto. The hyaluronic acid, sodium chloride, allantoin and the like used therein are commercially available products unless otherwise specified.
The invention provides a composition for relieving nasal dryness, which comprises a lubricant, a humectant, a penetration regulator, a microcirculation improving agent and a skin repairing agent, wherein each 100 parts by weight of the composition comprises the following components in parts by weight:
lubricant: 5-10 parts;
humectant: 0.1 to 0.25 portion;
osmotic adjusting agent: 10 to 15 portions of
Microcirculation improving agent: 0.1 part;
skin repair agents: 0.1 to 0.5 portion;
the balance of distilled water.
Wherein the lubricant is one or a mixture of more than two of glycerol, butanediol and medical white oil mixed in any proportion. The humectant is one or a mixture of more than two of hyaluronic acid, aloe extract and xylitol in any proportion. The osmotic adjusting agent is one of sodium chloride and phosphate or a mixture of the sodium chloride and the phosphate mixed in any proportion. The microcirculation improving agent is dextran 40. The skin repairing agent is one or a mixture of allantoin and dipotassium glycyrrhizinate in any proportion.
The invention also provides a preparation method of the composition for relieving nasal dryness, which comprises the following steps:
A. mixing lubricant, humectant, microcirculation improver and skin repairing agent, adding distilled water 50 weight parts, and stirring at normal temperature and pressure;
B. and C, adding an osmotic adjusting agent into the mixture obtained in the step A, adding distilled water to 100 parts by weight, and stirring and dissolving at normal temperature and normal pressure.
The composition of the invention is different from the common nasal drops in the prior art, which usually takes the removal of pathogeny as the research and development starting point, or common nursing products as the starting point for inhibiting the growth of bacteria in the nasal cavity, inhibiting the secretion of inflammatory factors, contracting blood vessels of the mucous membrane, resisting allergy and the like, and takes the improvement of the nasal cavity environment as the starting point, the lubricant (glycerol, butanediol, medical white oil) and the humectant (hyaluronic acid, aloe extract and xylitol) are firstly introduced for improving the nasal cavity environment, and the osmotic adjusting agent (sodium salt and phosphate), the microcirculation improving agent (dextran) and the skin repairing agent (allantoin and dipotassium glycyrrhizinate) are cooperatively matched, and the combination mode of the components is not related to other similar patent products at present, and the invention has high innovation. The invention greatly improves the comfort of the patient, and has the advantages of low cost, no side effect and easy popularization.
The present invention will be specifically described below with reference to specific examples.
Example 1
A composition for relieving nasal dryness comprises glycerol, hyaluronic acid, sodium chloride, dextran 40, dipotassium glycyrrhizinate and allantoin.
100g of the composition is prepared, and the components are weighed according to the following weight:
glycerol: 10g of a mixture;
hyaluronic acid: 0.25 g;
sodium chloride: 12g of a mixture;
dextran 40: 0.1 g;
allantoin: 0.2 g;
dipotassium glycyrrhizinate: 0.2 g;
distilled water was added to 100 g.
The preparation process of the composition comprises the following steps:
adding distilled water 50g into glycerol, hyaluronic acid, dextran 40, allantoin, and dipotassium glycyrrhizinate, stirring at normal temperature and normal pressure, adding sodium chloride 100g, stirring for 10 min, standing to obtain stock solution, and diluting with physiological saline or mineral water 100 times to obtain the final product.
Example 2
A composition for relieving nasal dryness comprises butylene glycol, aloe vera extract, sodium chloride, dextran 40, and allantoin.
100g of the composition is prepared, and the components are weighed according to the following weight:
butanediol: 5g of the total weight of the mixture;
aloe extract: 0.15 g;
sodium chloride: 15g of the total weight of the mixture;
dextran 40: 0.1 g;
allantoin: 0.1 g;
distilled water was added to 100 g.
The preparation process of the composition for relieving the nasal dryness comprises the following steps:
adding distilled water 50g into butanediol, Aloe extract, sodium chloride, dextran 40, and allantoin, stirring at normal temperature and normal pressure, adding sodium chloride 100g, stirring for 10 min, standing to obtain stock solution, diluting with normal saline or mineral water 100 times to obtain the final product, and spraying or dripping into nasal cavity.
Example 3
A composition for relieving nasal dryness comprises glycerol, butanediol, xylitol, phosphate, dextran 40, dipotassium glycyrrhizinate, and allantoin.
100 ml of the composition was prepared, and the following components were weighed out:
glycerol: 2g of the total weight of the mixture;
butanediol: 6g
Xylitol: 0.1 g;
phosphate salt: 13g of a mixture;
dextran 40: 0.1 g;
allantoin: 0.3 g;
dipotassium glycyrrhizinate: 0.2 g;
distilled water was added to 100 g.
The preparation process of the composition for relieving the nasal dryness comprises the following steps:
adding distilled water 50g into glycerol, butanediol, xylitol, phosphate, dextran 40, dipotassium glycyrrhizinate and allantoin, stirring at normal temperature and normal pressure, adding phosphate, adding distilled water to 100g, stirring for 10 min, standing to obtain stock solution, and diluting with physiological saline or mineral water 100 times to obtain the final product.
Example 4
A composition for relieving nasal dryness and obstruction comprises medical white oil, Aloe extract, hyaluronic acid, sodium chloride, dextran 40, and allantoin.
100 ml of the composition was prepared, and the following components were weighed out:
medical grade white oil: 7g of a mixture;
aloe extract: 0.1 g;
hyaluronic acid: 0.1 g;
sodium chloride: 14g of a mixture;
dextran 40: 0.1 g;
allantoin: 0.2 g;
distilled water was added to 100 g.
The preparation process of the composition for relieving the nasal dryness comprises the following steps:
firstly, adding 50g of distilled water into the medical white oil, the aloe extract, the hyaluronic acid, the sodium chloride, the dextran 40 and the allantoin, uniformly stirring at normal temperature and normal pressure, then adding the sodium chloride, adding the distilled water to 100g, stirring for 10 minutes, standing to obtain a stock solution, and diluting the stock solution by 100 times with normal saline or mineral water to obtain a finished product.
Example 5
A composition for relieving nasal dryness and obstruction comprises glycerol, xylitol, sodium chloride, dextran 40, and dipotassium glycyrrhizinate.
100g of the composition is prepared, and the components are weighed according to the following weight:
glycerol: 9g of a mixture;
xylitol: 0.18 g;
sodium chloride: 11g of a reaction solution;
dextran 40: 0.1 g;
dipotassium glycyrrhizinate: 0.1 g;
distilled water was added to 100 g.
The preparation process of the composition for relieving the nasal dryness comprises the following steps:
firstly, adding 50g of distilled water into the above-mentioned materials of glycerine, xylitol, sodium chloride, dextran 40 and dipotassium glycyrrhizinate, uniformly stirring them at normal temp. and normal pressure, adding sodium chloride, adding distilled water to 100g, stirring for 10 min, standing to obtain stock solution, diluting with physiological saline or mineral water by 100 times so as to obtain the invented product.
The using method comprises the following steps:
5 drops of the composition of any of the above examples are added to an atomizer containing physiological saline or mineral water (about 25ml) and sprayed into the nose after shaking.
The use effect is as follows:
participating volunteers with rhinitis sicca 39, 21 male and 18 female. The moisturizing effect and the feeling of use were observed by using the above-mentioned method of use, and the results of comparison are shown in the following table.
The following table compares the effect of the composition of the present invention and the common nasal drops:
| nasal drops | Moisturizing effect | Repairing effects | Feeling of use | Ventilation effect | Vasoconstrictive action | Effect for treating rhinitis sicca | Bacteriostatic action | Anti-inflammatory action | Cost of |
| Commercially available nasal drops A | In general | Is poor | In general | In general | High strength | Difference (D) | High strength | High strength | In |
| Commercial nasal care spray B | In general | Is poor | In general | In general | In general | Is poor | In general | High strength | In |
| Examples of the invention | Good taste | Good taste | Good taste | Good taste | Weak (weak) | Is preferably used | In general | In general | In |
As can be seen from the above table, the composition of the embodiment of the present invention is superior to the same type of products on the market in terms of moisturizing effect, repairing effect, feeling of use, and ventilation effect.
The described embodiments of the present invention are intended to be illustrative only and not to limit the scope of the present invention, and various other alternatives, modifications, and improvements within the scope of the present invention may be devised by those skilled in the art, and the embodiments herein are chosen and described in detail in order to better explain the principles of the present invention and the practical application, thereby enabling others skilled in the art to best understand and utilize the present invention. The present invention is not limited to the above-described embodiments, but is only limited by the claims and their full scope and equivalents.
Claims (2)
1. A composition for relieving nasal dryness, which comprises a lubricant, a humectant, a penetration regulator, a microcirculation improving agent and a skin repairing agent, and is characterized in that each 100 parts by weight of the composition comprises the following components in parts by weight:
lubricant: 5-10 parts of lubricant, wherein the lubricant is one or a mixture of more than two of glycerol, butanediol and medical white oil mixed in any proportion;
humectant: 0.1 to 0.25 portion, wherein the humectant is one or a mixture of more than two of hyaluronic acid, aloe extract and xylitol which are mixed according to any proportion;
osmotic adjusting agent: 10-15 parts of a permeation regulator, wherein the permeation regulator is sodium chloride or phosphate;
microcirculation improving agent: 0.1 part of a microcirculation improving agent, namely dextran 40;
skin repair agents: 0.1 to 0.5 portion, the skin repair agent is one of allantoin and dipotassium glycyrrhizinate or a mixture of the two mixed according to any proportion;
the balance of distilled water.
2. A method of preparing a composition for relieving nasal dryness according to claim 1, comprising the steps of:
A. mixing lubricant, humectant, microcirculation improver and skin repairing agent, adding distilled water 50 weight parts, stirring at normal temperature and normal pressure;
B. adding osmotic adjusting agent into the mixture obtained in the step A, then adding distilled water to 100 parts by weight, stirring and dissolving at normal temperature and normal pressure,
wherein the lubricant is one or a mixture of more than two of glycerol, butanediol and medical white oil mixed in any proportion;
the humectant is one or a mixture of more than two of hyaluronic acid, aloe extract and xylitol mixed in any proportion; the osmotic adjusting agent is sodium chloride or phosphate; the microcirculation improving agent is dextran 40; the skin repairing agent is one or a mixture of allantoin and dipotassium glycyrrhizinate in any proportion.
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| CN201910624804.1A CN110279656B (en) | 2019-07-11 | 2019-07-11 | Composition for relieving nasal dryness and preparation method and using method thereof |
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| CN110279656B true CN110279656B (en) | 2021-11-09 |
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|---|---|---|---|---|
| CN1312079A (en) * | 2001-02-23 | 2001-09-12 | 张士军 | Nasosinusitis treating medicine |
| US20050089480A1 (en) * | 1987-10-15 | 2005-04-28 | Vickery Brian H. | Intranasal administration of polypeptides in powdered form |
| CN103120703A (en) * | 2013-01-06 | 2013-05-29 | 王峥 | Care solution for cleaning nasal cavity and related composition |
| CN105412913A (en) * | 2015-12-17 | 2016-03-23 | 齐鲁工业大学 | Nasal cavity wetting agent |
| CN105902555A (en) * | 2016-06-22 | 2016-08-31 | 张波 | Novel nasal irrigation composition and preparation method thereof |
| CN106902075A (en) * | 2017-02-23 | 2017-06-30 | 任君刚 | A kind of water sensitive adhesiveness ointment based on non-aqueous techniques and preparation method thereof |
| CN107982277A (en) * | 2017-11-30 | 2018-05-04 | 青岛九远医疗科技有限公司 | A kind of composite antibacterial aerosol and its preparation method and application |
-
2019
- 2019-07-11 CN CN201910624804.1A patent/CN110279656B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050089480A1 (en) * | 1987-10-15 | 2005-04-28 | Vickery Brian H. | Intranasal administration of polypeptides in powdered form |
| CN1312079A (en) * | 2001-02-23 | 2001-09-12 | 张士军 | Nasosinusitis treating medicine |
| CN103120703A (en) * | 2013-01-06 | 2013-05-29 | 王峥 | Care solution for cleaning nasal cavity and related composition |
| CN105412913A (en) * | 2015-12-17 | 2016-03-23 | 齐鲁工业大学 | Nasal cavity wetting agent |
| CN105902555A (en) * | 2016-06-22 | 2016-08-31 | 张波 | Novel nasal irrigation composition and preparation method thereof |
| CN106902075A (en) * | 2017-02-23 | 2017-06-30 | 任君刚 | A kind of water sensitive adhesiveness ointment based on non-aqueous techniques and preparation method thereof |
| CN107982277A (en) * | 2017-11-30 | 2018-05-04 | 青岛九远医疗科技有限公司 | A kind of composite antibacterial aerosol and its preparation method and application |
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