CN105902555A - Novel nasal irrigation composition and preparation method thereof - Google Patents
Novel nasal irrigation composition and preparation method thereof Download PDFInfo
- Publication number
- CN105902555A CN105902555A CN201610460061.5A CN201610460061A CN105902555A CN 105902555 A CN105902555 A CN 105902555A CN 201610460061 A CN201610460061 A CN 201610460061A CN 105902555 A CN105902555 A CN 105902555A
- Authority
- CN
- China
- Prior art keywords
- group
- preparation
- combination agent
- osmotic pressure
- novel washing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Abstract
The invention relates to a novel nasal irrigation composition and a preparation method thereof. The novel nasal irrigation composition and the preparation method thereof are characterized in that the composition is divided into two groups, one group is an active ingredient group, the other group is an osmoregulation and pH conditioning agent group, dipotassium glycyrrhizinate and puerarin are included in the active ingredient group, NAC1 and sodium citrate are included in the osmoregulation and pH conditioning agent group, and besides dipotassium glycyrrhizinate with the effects of inhibiting bacteria, diminishing inflammations, removing toxins, resisting allergy and the like, puerarin capable of resisting hazardous substances of cigarettes is further compounded.
Description
Technical field
The present invention relates to pharmaceutical technology field, mainly a kind of Novel washing nose combination agent and
Preparation method.
Background technology
Air quality constantly declined in recent years, such as phenomenons etc. such as the hazes that constantly occurs,
Having arrived the stage that people can not be ignored, mankind's concern to body health, to respiratory tract disease
Prevention be increasingly taken seriously, the vehicle exhaust in air, floating dust, various microorganisms,
The virulence factors such as anaphylactogen, these virulence factors can increase undoubtedly various acute and chronic rhinitis,
The generation of the diseases such as sinusitis, allergic rhinitis, flu.
Main harmful substance in medicated cigarette is nicotine and tar, can pass through respiratory tract,
Nasal mucosa, skin are entered rapidly human body, nicotine and tar and are entered after human body by respiratory tract
Multiple organ is caused damage.
These harmful gas materials make nasal cavity self-cleaning function exceed self load, the self-cleaning energy of nasal cavity
Power will reduce, it is possible to by by the similar abluent possessing nasal cavity self-cleaning function
Harmful substance is disposed, to reach to prevent the effect of nose diseases, passes through nasal cavity cleaning
Reduce sending out of the diseases such as various acute and chronic rhinitis, sinusitis, allergic rhinitis, flu
Raw.
Along with popularizing of nasal endoscopes, nose diseases makes patient's health early by Transnasal endoscopy operation
Multiple, and postoperative nasal endoscopic, how to promote that art chamber mucosa recovers early, prevent art chamber from gluing
Even and Dou Kou to close be clinical problem demanding prompt solution, nasal cavity cleaning be alleviate above-mentioned postoperative
One important measures of complication.
A kind of Novel washing nose combination agent of the present invention and preparation method thereof have antibacterial, antiinflammatory,
Outside the effects such as removing toxic substances, antiallergic, the also compounding puerarin having energy antagonism cigarette harmful matter is used
In nasal cavity cleaning, antiinflammatory, the treatment and prevention of antiallergic.
Summary of the invention
To achieve these goals, the present invention is by the following technical solutions:
A kind of Novel washing nose combination agent, combination agent is divided into two groups, and one group is active component group,
Another group is osmotic pressure regulation and conjugates group, includes glycyrrhizic acid in described active component group
Dipotassium and puerarin, include NAC1, lemon in the regulation of described osmotic pressure and pH adjusting agent group
Lemon acid sodium.Its active component can be that therein one or both are applied in combination.
Described active component group concentration configuration ratio is: glycyrrhizic acid dipotassium 50-100PPM and Radix Puerariae
Element 100-200PPM；The regulation of described osmotic pressure and pH adjusting agent group allocation ratio become:
NAC12.2-3.0g, sodium citrate 0.5-0.6g；The regulation of described osmotic pressure and pH regulator
Agent group is grouped into by a kind of composition in allocation ratio or two kinds of one-tenth.
Described active component group and osmotic pressure regulation and pH adjusting agent assemble put uniformly through
Mode nasal cavity cleaning and the nasal sinuses such as flushing, spraying, collunarium.
Described sodium citrate is pH adjusting agent.
A kind of Novel washing nose combination agent preparation method:
1), after taking glycyrrhizic acid dipotassium and the dissolving of puerarin purified water of formula ratio respectively, use
Spray drying method is uniformly sprayed on NAC1, adds the sodium citrate stirring of formula ratio all
Even.
2) stirring after gained wash nose combination agent thing sterilized after preserve at normal temperatures.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, below implements to be only used for this
Bright technology contents, and whole technology contents of non-invention.
Embodiment 1
A kind of Novel washing nose combination agent is made up of following component and weight ratio:
A kind of Novel washing nose combination agent preparation method and step:
(1) after taking glycyrrhizic acid dipotassium and the dissolving of puerarin purified water of formula ratio respectively, with spraying
Seasoning is uniformly sprayed on NAC1, adds the pH adjusting agent of formula ratio.
(2) the nasal douche compositions subpackage of gained, sterilizing, preservation are prepared.
(3) warehouse-in is packed after the assay was approved.
Embodiment 2
A kind of Novel washing nose combination agent is made up of following component and weight ratio:
Glycyrrhizic acid dipotassium 50-100PPM
NAC1 2.0-3.0g
PH adjusting agent 0.5-0.6g
A kind of Novel washing nose combination agent preparation method and step:
(1), after taking the glycyrrhizic acid dipotassium purified water dissolving of formula ratio, uniformly spray with spray drying method
Spill to NAC1, add the pH adjusting agent of formula ratio.
(2) the nasal douche compositions subpackage of gained, sterilizing, preservation are prepared.
(3) warehouse-in is packed after the assay was approved.
Embodiment 3
A kind of Novel washing nose combination agent is made up of following component and weight ratio:
Puerarin 100-200PPM
NAC1 2.0-3.0g
PH adjusting agent 0.5-0.6g
A kind of Novel washing nose combination agent preparation method and step:
(1), after taking the puerarin purified water dissolving of formula ratio, uniformly spray with spray drying method
To NAC1, add the pH adjusting agent of formula ratio.
(2) the nasal douche compositions subpackage of gained, sterilizing, preservation are prepared.
(3) warehouse-in is packed after the assay was approved.
The ultimate principle of the present invention, principal character and advantage are more than shown and described, the skill of the industry
Art personnel it should be appreciated that the present invention is not restricted to the described embodiments, above-described embodiment and explanation
The principle that the present invention is simply described described in book, before without departing from spirit and scope of the invention
Putting, the present invention also has various changes and modifications, and these changes and improvements both fall within requirement and protect
In the scope of the invention protected.Claimed scope by appending claims and etc.
Effect thing defines.
Claims (4)
1. Novel washing nose combination agent and preparation method thereof, it is characterised in that: combination agent is divided
Being two groups, one group is active component group, and another group is osmotic pressure regulation and conjugates group,
Include glycyrrhizic acid dipotassium and puerarin in described active component group, the regulation of described osmotic pressure and
NAC1, sodium citrate is included in pH adjusting agent group.
2. a kind of Novel washing nose combination agent stated according to claim 1 and preparation method thereof, its
It is characterised by: described active component group concentration configuration ratio is: glycyrrhizic acid dipotassium 50-100PPM
With puerarin 100-200PPM；The regulation of described osmotic pressure and pH adjusting agent group allocation ratio
Become: NAC12.2-3.0g, sodium citrate 0.5-0.6g；Described osmotic pressure regulation and
PH adjusting agent group is grouped into by a kind of composition in allocation ratio or two kinds of one-tenth.
3. a kind of Novel washing nose combination agent stated according to claim 1 and preparation method thereof,
It is characterized in that: described active component group and osmotic pressure regulation and pH adjusting agent assemble and put
Uniformly through mode nasal cavity cleaning and nasal sinuses such as flushing, spraying, collunariums.
4. a kind of Novel washing nose combination agent stated according to claim 1-3 and preparation method thereof,
It is characterized in that: a kind of Novel washing nose combination agent preparation method:
1), after taking glycyrrhizic acid dipotassium and the dissolving of puerarin purified water of formula ratio respectively, use
Spray drying method is uniformly sprayed on NAC1, adds the sodium citrate stirring of formula ratio all
Even.
2) stirring after gained wash nose combination agent thing sterilized after preserve at normal temperatures.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610460061.5A CN105902555A (en) | 2016-06-22 | 2016-06-22 | Novel nasal irrigation composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610460061.5A CN105902555A (en) | 2016-06-22 | 2016-06-22 | Novel nasal irrigation composition and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105902555A true CN105902555A (en) | 2016-08-31 |
Family
ID=56758459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610460061.5A Pending CN105902555A (en) | 2016-06-22 | 2016-06-22 | Novel nasal irrigation composition and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105902555A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109999048A (en) * | 2019-04-17 | 2019-07-12 | 成都市汉家林生物技术有限公司 | One kind washing nose combination agent and preparation method thereof |
| CN110193010A (en) * | 2019-06-19 | 2019-09-03 | 吉林省华恩生物科技有限公司 | A kind of preparation and preparation method thereof for alleviating schneiderian membrane symptom |
| CN110279656A (en) * | 2019-07-11 | 2019-09-27 | 温州医科大学 | A kind of composition for alleviating mycteroxerosis and preparation method thereof and application method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583172A (en) * | 2004-05-31 | 2005-02-23 | 刘近周 | Multifunctional liquid for clean therapy of nasal cavity and sinuses |
| CN102204926A (en) * | 2011-05-31 | 2011-10-05 | 江苏富林医疗设备有限公司 | Nasal cavity cleaning agent |
| CN103083356A (en) * | 2013-02-20 | 2013-05-08 | 中国医科大学附属第一医院 | Anti-allergic and anti-inflammation water |
-
2016
- 2016-06-22 CN CN201610460061.5A patent/CN105902555A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583172A (en) * | 2004-05-31 | 2005-02-23 | 刘近周 | Multifunctional liquid for clean therapy of nasal cavity and sinuses |
| CN102204926A (en) * | 2011-05-31 | 2011-10-05 | 江苏富林医疗设备有限公司 | Nasal cavity cleaning agent |
| CN103083356A (en) * | 2013-02-20 | 2013-05-08 | 中国医科大学附属第一医院 | Anti-allergic and anti-inflammation water |
Non-Patent Citations (1)
| Title |
|---|
| 黄雄峰 等: "葛根素的神经保护作用机制研究进展", 《中国实验方剂学杂志》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109999048A (en) * | 2019-04-17 | 2019-07-12 | 成都市汉家林生物技术有限公司 | One kind washing nose combination agent and preparation method thereof |
| CN110193010A (en) * | 2019-06-19 | 2019-09-03 | 吉林省华恩生物科技有限公司 | A kind of preparation and preparation method thereof for alleviating schneiderian membrane symptom |
| CN110279656A (en) * | 2019-07-11 | 2019-09-27 | 温州医科大学 | A kind of composition for alleviating mycteroxerosis and preparation method thereof and application method |
| CN110279656B (en) * | 2019-07-11 | 2021-11-09 | 温州医科大学 | Composition for relieving nasal dryness and preparation method and using method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106581148A (en) | Nasal irrigation care solution | |
| NO20063047L (en) | Aqueous ciclesonide suspensions for nebulization | |
| CN103120703A (en) | Care solution for cleaning nasal cavity and related composition | |
| CN102204926A (en) | Nasal cavity cleaning agent | |
| CN105902555A (en) | Novel nasal irrigation composition and preparation method thereof | |
| CN108743776A (en) | A kind of flushing powder for nasal disease prevention | |
| CN107899006A (en) | Pharmaceutical composition of nasal irrigation and preparation method thereof | |
| WO2015082965A2 (en) | Novel chitosan nasal wash | |
| CN104940994B (en) | A kind of artificial schneiderian membrane and application thereof | |
| JP5467678B2 (en) | Pollen for masks, glasses and goggles, and anti-virus external preparation | |
| CN104798823A (en) | Bactericide for clinical laboratory | |
| CN105920094A (en) | Nasal cavity nursing composition, application thereof and obtained nasal cavity nursing product | |
| CN107549206A (en) | Expelling parasite, purification air, the composition to refresh the mind and its application and application method | |
| CN111388421A (en) | Oral-nasal-throat bi-component spray with antibacterial and antiviral functions and preparation method thereof | |
| CN109260257A (en) | A kind of medical disinfectant and preparation method thereof | |
| CN104547682A (en) | Composition with effects of clearing away lung heat, relieving sore throat, cooling throat and relieving asthma | |
| CN112516156A (en) | Product for inhibiting virus, preparation method and application | |
| CN103877288A (en) | Biomedical film made of chitosan for nasopharyngitis and preparation method thereof | |
| CN109999048A (en) | One kind washing nose combination agent and preparation method thereof | |
| CN112472669A (en) | Nasal spray based on red pepper extract and heparin for preventing influenza and preparation method thereof | |
| CN103990414A (en) | Oxygen humidifying solution with bacteriostasis function and preparation method thereof | |
| Kacker | Looking after local nasal and sinus mucosa in health, disease and after surgery | |
| CN104127354B (en) | The onion essential oil composition for oral cavity of preventing pharyngitis and periodontitis | |
| WO2021203101A1 (en) | Hypochlorous acid solutions and methods of use | |
| Alshalah | Microsafe (Oral Care) to Control COVID-19 Infection. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20170122 Address after: Wenjiang District 611130 of Sichuan city of Chengdu province Chengdu Strait science and Technology Industry Development Park Tsingtao Road No. 319 building 3, 4 floor 3 Applicant after: Chengdu Han Lin Biotechnology Co., Ltd. Address before: Jinniu District Shu Road Chengdu city Sichuan province 610000 289 No. 38 Building 1 unit 6 Building No. 1 Applicant before: Zhang Bo |
|
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160831 |
|
| RJ01 | Rejection of invention patent application after publication |