CN110193010A - A kind of preparation and preparation method thereof for alleviating schneiderian membrane symptom - Google Patents
A kind of preparation and preparation method thereof for alleviating schneiderian membrane symptom Download PDFInfo
- Publication number
- CN110193010A CN110193010A CN201910532144.4A CN201910532144A CN110193010A CN 110193010 A CN110193010 A CN 110193010A CN 201910532144 A CN201910532144 A CN 201910532144A CN 110193010 A CN110193010 A CN 110193010A
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- CN
- China
- Prior art keywords
- preparation
- glycyrrhizin
- alleviating
- schneiderian membrane
- symptom
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
Abstract
A kind of preparation and preparation method thereof for alleviating schneiderian membrane symptom, the component including mass percent: pure water 10%~99%, glycerol 0.1%~20%, glycyrrhizin salt 0.1%~10%, Beta glucan 0.1%~5%, sodium chloride 0.1%~5%.The invention has the advantages that the 1, present invention can make schneiderian membrane keep wet, alleviates the schneiderian membrane swelling of lesser degree or mitigate stimulated schneiderian membrane swelling.Using nasal spray according to the present invention, there is the dry sensation occurred when using the nasal spray containing hormone, antihistamine drug, leukotriene antagonist etc. in smaller probability；2, because preparation provided by the invention does not contain any forbidden amphetamine, so having no toxic side effect, being safe and reliable；3, preparation provided by the present invention can be used in conjunction with the nasal spray containing hormone, antihistamine drug, leukotriene antagonist etc..In order to reduce using the nasal spray bring side effect containing hormone, antihistamine drug, leukotriene antagonist etc., their dosage can be reduced more than half.
Description
Technical field
The invention belongs to preparation for treating rhinitis field, specifically a kind of preparation for alleviating schneiderian membrane symptom and its preparation side
Method.
Background technique
In common cold, allergen allergic rhinitis or other rhinitis (rhinitides), schneiderian membrane is subjected to swelling.So far
Until the present, local use hormone (for example, glucocorticoid etc.), antihistamine drug usually in the form of nasal drop or nasal spray
(for example, Loratadine, Desloratadine etc.), leukotriene antagonist etc. are treated, to realize the mitigation of mucous membrane swelling.So
And the above drug has many undesirable side effects because of absorption and may cause palpitaition and respiratory disorder.In addition, they
Schneiderian membrane is set to dry out, and when chronic administration, in fact it could happen that the permanent damage of nasal epithelial.This pharmacological dependence is led
The rhinitis of cause is referred to as rhinitis medicamentosa.In recent years, occur hormone-free, anti-based on sea salt and/or common saline solution
The nasal spray of histamine drug, leukotriene antagonist.They do not have acute pharmacological action to schneiderian membrane, but by keeping mucous membrane wet clear
It is clean that mucous membrane can be alleviated and thus alleviate symptom (especially after applying for several times).But due to the residence time of solution compared with
It is short, solution must be fairly frequently applied, and alleviation degree is often insufficient when disease is serious.
Summary of the invention
For existing nasal spray there are a variety of shortcomings, the present invention provides a kind of preparation for alleviating schneiderian membrane symptom, this hair
Bright purpose, which is to provide, has relaxation effect to schneiderian membrane compared with known product, but it not will lead to use and contains hormone (example
Such as, glucocorticoid etc.), antihistamine drug (for example, Loratadine, Desloratadine etc.), leukotriene antagonist etc. product
When the dependence and side effect that will appear, to solve defect in the prior art.
The present invention is achieved by the following technical programs:
A kind of preparation for alleviating schneiderian membrane symptom, the component including mass percent: pure water 10%~99%, glycerol
0.1%~20%, glycyrrhizin salt 0.1%~10%, Beta glucan 0.1%~5%, sodium chloride 0.1%~5%.
A kind of preparation for alleviating schneiderian membrane symptom as described above, the component including mass percent: pure water 90%~
98%, glycerol 0.5%~5%, glycyrrhizin salt 0.5%~5%, Beta glucan 0.1%~2%, sodium chloride 0.5%~
2%.
A kind of preparation for alleviating schneiderian membrane symptom as described above, the glycyrrhizin salt is glycyrrhizin disodium, sweet
It is one sodium of oxalic acid glycosides, glycyrrhizin monoamine, glycyrrhizin diamines, one potassium of glycyrrhizin, glycyrrhizin dipotassium, glycyrrhizin salt, sweet
Oxalic acid glycosides trisodium, glycyrrhizin tripotassium, any one or any two or more of glycyrrhizin triamine are mixed with arbitrary proportion.
A kind of preparation for alleviating schneiderian membrane symptom as described above, the present invention, can be by medicine of the present invention by pH controlling agent
The pH value of product is adjusted to the pH of pharmaceutical formulation.
A kind of preparation for alleviating schneiderian membrane symptom as described above, the pH controlling agent are sodium hydroxide, sodium phosphate, lemon
Any of them of lemon acid sodium, phosphate, citrate buffer agent.
A kind of preparation for alleviating schneiderian membrane symptom as described above, osmotic pressure of the invention is towards slight hyperosmosis tune
Section.
A kind of preparation for alleviating schneiderian membrane symptom as described above, osmotic pressure of the invention are 400mosmol.
A kind of preparation for alleviating schneiderian membrane symptom as described above, osmotic pressure adjusting group of the invention are divided into glucose, mountain
Pears alcohol, mannitol, xylitol any of them any two or more are mixed with arbitrary proportion.
A kind of preparation method of preparation that alleviating schneiderian membrane symptom, characterized by the following steps:
Step 1: glycerol, sodium chloride is added into pure water under stirring, is stirred until homogeneous dispersed；
Step 2: step 1 acquired solution is stirred, addition licorice, beta glucan into it, homogeneous stirring,
Discharging sterilizes to get the preparation of the alleviation schneiderian membrane symptom.
A kind of preparation method of preparation for alleviating schneiderian membrane symptom as described above, the present invention can be made into drops, spray,
Any one dosage form of irrigation.
The invention has the advantages that
1, preparation provided by the present invention " can alleviate schneiderian membrane symptom ", in particular, being that schneiderian membrane is instigated to keep wet
Profit alleviates the schneiderian membrane swelling of lesser degree or mitigates stimulated schneiderian membrane swelling.Using nasal spray according to the present invention,
Smaller probability occur using containing hormone (for example, glucocorticoid etc.), antihistamine drug (for example, Loratadine, chlorine thunder he
It is fixed etc.), the nasal spray of leukotriene antagonist etc. when the dry sensation that occurs.
2, because preparation provided by the invention does not contain any forbidden amphetamine (such as heavy metal, hormone, toxin, non-permitted chemistry
Substance etc.), so having no toxic side effect, being safe and reliable.
3, preparation provided by the present invention can with contain hormone (such as glucocorticoid etc.), antihistamine drug (example
Such as, Loratadine, Desloratadine etc.), the nasal spray of leukotriene antagonist etc. is used in conjunction with.Contain hormone to reduce use
The spray of (for example, glucocorticoid etc.), antihistamine drug (for example, Loratadine, Desloratadine etc.), leukotriene antagonist etc.
Their dosage can be reduced more than half by nose agent bring side effect.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention,
Technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is the present invention one
Divide embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not making
Every other embodiment obtained, shall fall within the protection scope of the present invention under the premise of creative work.
Embodiment 1
A kind of preparation for alleviating schneiderian membrane symptom, said preparation includes the component of following mass percent: glycerol 1%, Radix Glycyrrhizae
Sour glycosides salt 2%, Beta glucan 1%, sodium chloride 0.9%, remaining ingredient are pure water.
Follow the steps below operation:
Step 1: being added glycerol, sodium chloride into pure water under stirring, be stirred until homogeneous dispersed, spare；
Step 2: glycyrrhizin salt, beta glucan, constant temperature is added in step 1 acquired solution under stirring into it
Homogeneous stirring, it is spare；
Step 3: step 2 acquired solution is sterilized；
Step 4: step 3 acquired solution is bottled.
Embodiment 2
A kind of preparation for alleviating schneiderian membrane symptom, said preparation includes the component of following mass percent: glycerol 2%, Radix Glycyrrhizae
Sour glycosides salt 2%, Beta glucan 1%, sodium chloride 0.9%, remaining ingredient are pure water.
Follow the steps below operation:
Step 1: being added glycerol, sodium chloride into pure water under stirring, be stirred until homogeneous dispersed, spare；
Step 2: glycyrrhizin salt, beta glucan, constant temperature is added in step 1 acquired solution under stirring into it
Homogeneous stirring, it is spare；
Step 3: step 2 acquired solution is sterilized；
Step 4: step 3 acquired solution is bottled.
The preparation of the present invention for alleviating schneiderian membrane symptom is transparent or close to transparent liquid, there is faint special gas
Taste, pH
Value is 5.5~7.4, which should be sealed in a cool and dry place, can be stablized storage 1 year or more.This goes wrinkle tight
Also dried frozen aquatic products further can be made by means such as freeze-dryings in skin liquid, and are restored to liquid condition by being dissolved in aqueous solution and make
With.It may be made as the products such as drops, spray and/or irrigation.
Confirmatory experiment 1
Experimental subjects: the age 20-70 years old crowd, the male and female for selecting schneiderian membrane to have different stimulated symptom have 17 altogether
Example.
Experimental method: for the drop of preparation provided by daily Example 1 in nasal membrane position 3~5 times, 5 days are a treatment
Journey.
Criterion of therapeutical effect: 1, cure: nasal membrane irritation completely disappears；2, effective: nasal membrane irritation is obvious
Alleviate；3, effectively: alleviating nasal membrane irritation part；3, invalid: unchanged before and after use.
Using effect is as follows:
Confirmatory experiment 2:
Experimental subjects: the age 20-70 years old crowd, the male and female for selecting schneiderian membrane to have different stimulated symptom have 24 altogether
Example.
Experimental method: for the drop of preparation provided by daily Example 2 in nasal membrane position 3~5 times, 5 days are a treatment
Journey.
Criterion of therapeutical effect: 1, cure: nasal membrane irritation completely disappears；2, effective: nasal membrane irritation is obvious
Alleviate；3, effectively: alleviating nasal membrane irritation part；3, invalid: unchanged before and after use.
Using effect is as follows:
According to verifying
Finally it should be noted that: the above embodiments are merely illustrative of the technical scheme of the present invention and are not intended to be limiting thereof, to the greatest extent
Invention is explained in detail referring to above-described embodiment for pipe, it should be understood by those ordinary skilled in the art that: still
It can be with modifications or equivalent substitutions are made to specific embodiments of the invention, and without departing from any of spirit and scope of the invention
Modification or equivalent replacement, are intended to be within the scope of the claims of the invention.
The preparation of the present invention for alleviating schneiderian membrane symptom is transparent or close to transparent liquid, there is faint special gas
Taste, pH value are 5.5~7.4, which should be sealed in a cool and dry place, can be stablized storage 1 year or more.This removes wrinkle Firm liquid
Also dried frozen aquatic products further can be made by means such as freeze-dryings, and be restored to liquid condition use by being dissolved in aqueous solution.?
It can be made into the products such as drops, spray and/or irrigation.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: it still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features；
And these are modified or replaceed, technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution spirit and
Range.
Claims (10)
1. a kind of preparation for alleviating schneiderian membrane symptom, it is characterised in that: the component including mass percent:: pure water 10%~
99%, glycerol 0.1%~20%, glycyrrhizin salt 0.1%~10%, Beta glucan 0.1%~5%, sodium chloride 0.1%~
5%.
2. a kind of preparation for alleviating schneiderian membrane symptom according to claim 1, it is characterised in that: including mass percent
Component: pure water 90%~98%, glycerol 0.5%~5%, glycyrrhizin salt 0.5%~5%, Beta glucan 0.1%~
2%, sodium chloride 0.5%~2%.
3. a kind of preparation for alleviating schneiderian membrane symptom according to claim 1, it is characterised in that: the glycyrrhizin salt
For glycyrrhizin disodium, one sodium of glycyrrhizin, glycyrrhizin monoamine, glycyrrhizin diamines, one potassium of glycyrrhizin, glycyrrhizin two
Potassium, glycyrrhizin salt, glycyrrhizin trisodium, glycyrrhizin tripotassium, glycyrrhizin triamine it is any one or any two or more
It is mixed with arbitrary proportion.
4. a kind of preparation for alleviating schneiderian membrane symptom according to claim 1, it is characterised in that: the present invention is controlled by pH
The pH value of drug of the present invention can be adjusted to the pH of pharmaceutical formulation by agent.
5. a kind of preparation for alleviating schneiderian membrane symptom according to claim 4, it is characterised in that: the pH controlling agent is
Any of them of sodium hydroxide, sodium phosphate, sodium citrate, phosphate, citrate buffer agent.
6. a kind of preparation for alleviating schneiderian membrane symptom according to claim 1, it is characterised in that: osmotic pressure court of the invention
It is adjusted to slight hyperosmosis.
7. a kind of preparation for alleviating schneiderian membrane symptom according to claim 6, it is characterised in that: osmotic pressure of the invention is
400mosmol。
8. a kind of preparation for alleviating schneiderian membrane symptom according to claim 1, it is characterised in that: osmotic pressure tune of the invention
Section group is divided into glucose, sorbierite, mannitol, xylitol any of them or any two or more is mixed with arbitrary proportion.
9. a kind of preparation method for the preparation for alleviating schneiderian membrane symptom, characterized by the following steps:
Step 1: glycerol, sodium chloride is added into pure water under stirring, is stirred until homogeneous dispersed；
Step 2: step 1 acquired solution is stirred, addition licorice, beta glucan into it, homogeneous stirring, out
Material sterilizes to get the preparation of the alleviation schneiderian membrane symptom.
10. a kind of preparation method of preparation for alleviating schneiderian membrane symptom according to claim 9, it is characterised in that: this hair
It is bright to can be made into any one dosage form of drops, spray, irrigation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910532144.4A CN110193010A (en) | 2019-06-19 | 2019-06-19 | A kind of preparation and preparation method thereof for alleviating schneiderian membrane symptom |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910532144.4A CN110193010A (en) | 2019-06-19 | 2019-06-19 | A kind of preparation and preparation method thereof for alleviating schneiderian membrane symptom |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110193010A true CN110193010A (en) | 2019-09-03 |
Family
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| CN201910532144.4A Pending CN110193010A (en) | 2019-06-19 | 2019-06-19 | A kind of preparation and preparation method thereof for alleviating schneiderian membrane symptom |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836176A (en) * | 2012-09-20 | 2012-12-26 | 滨海金桥医药科技（北京）有限公司 | Drug combination for treating allergic rhinitis or asthma as well as preparation method and application of same |
| EP2857068A1 (en) * | 2013-10-04 | 2015-04-08 | Aboca S.p.A. Societa' Agricola | Fractions of liquorice extracts depleted of glycyrrhizic acid and uses thereof |
| CN105902555A (en) * | 2016-06-22 | 2016-08-31 | 张波 | Novel nasal irrigation composition and preparation method thereof |
| CN106166273A (en) * | 2016-08-30 | 2016-11-30 | 王晓琴 | A kind of otorhinolaryngology nursing medicine for external use and preparation method thereof |
| CN106902075A (en) * | 2017-02-23 | 2017-06-30 | 任君刚 | A kind of water sensitive adhesiveness ointment based on non-aqueous techniques and preparation method thereof |
| CN110279695A (en) * | 2019-08-07 | 2019-09-27 | 北京博达绿洲医药科技研究有限公司 | It is a kind of to treat pharmaceutical compositions of cold symptoms such as runny nose, nasal obstruction and its preparation method and application |
-
2019
- 2019-06-19 CN CN201910532144.4A patent/CN110193010A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836176A (en) * | 2012-09-20 | 2012-12-26 | 滨海金桥医药科技（北京）有限公司 | Drug combination for treating allergic rhinitis or asthma as well as preparation method and application of same |
| EP2857068A1 (en) * | 2013-10-04 | 2015-04-08 | Aboca S.p.A. Societa' Agricola | Fractions of liquorice extracts depleted of glycyrrhizic acid and uses thereof |
| CN105902555A (en) * | 2016-06-22 | 2016-08-31 | 张波 | Novel nasal irrigation composition and preparation method thereof |
| CN106166273A (en) * | 2016-08-30 | 2016-11-30 | 王晓琴 | A kind of otorhinolaryngology nursing medicine for external use and preparation method thereof |
| CN106902075A (en) * | 2017-02-23 | 2017-06-30 | 任君刚 | A kind of water sensitive adhesiveness ointment based on non-aqueous techniques and preparation method thereof |
| CN110279695A (en) * | 2019-08-07 | 2019-09-27 | 北京博达绿洲医药科技研究有限公司 | It is a kind of to treat pharmaceutical compositions of cold symptoms such as runny nose, nasal obstruction and its preparation method and application |
Non-Patent Citations (1)
| Title |
|---|
| XIAO-LAN LI: "Antioxidant Status and Immune Activity of Glycyrrhizin in Allergic Rhinitis Mice", 《INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: No. 1148, Longteng Road, Beihu science and Technology Development Zone, Changchun City, Jilin Province 130000 Applicant after: JILIN HUAEN BIOLOGICAL TECHNOLOGY Co.,Ltd. Address before: Room 402, 4th floor, C2-1 Beihu Science Park, 3333 Shengbei Street, Beihu Science and Technology Development Zone, Changchun High-tech Development Zone, Jilin Province Applicant before: JILIN HUAEN BIOLOGICAL TECHNOLOGY Co.,Ltd. |
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190903 |