CN105920094A - Nasal cavity nursing composition, application thereof and obtained nasal cavity nursing product - Google Patents
Nasal cavity nursing composition, application thereof and obtained nasal cavity nursing product Download PDFInfo
- Publication number
- CN105920094A CN105920094A CN201610531875.3A CN201610531875A CN105920094A CN 105920094 A CN105920094 A CN 105920094A CN 201610531875 A CN201610531875 A CN 201610531875A CN 105920094 A CN105920094 A CN 105920094A
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- CN
- China
- Prior art keywords
- nasal
- nasal cavity
- essential oil
- product
- peppermint essential
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
- A61K35/08—Mineral waters; Sea water
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention provides a nasal cavity nursing composition. The nasal cavity nursing composition is formed by peppermint essential oil and seawater. The invention also provides an application of the composition to preparation of a product used for moisturizing and ventilating nasal cavities and a nasal cavity nursing product. The nursing composition has the beneficial effects that the nursing composition can give full play to the moisturizing function of the peppermint essential oil and can also promote cilium beat while keeping the ambient humidity in the nasal cavities appropriate, thus being beneficial to nasal cavity ventilation; meanwhile, seawater can be used for effectively cleaning the nasal cavities; after the peppermint essential oil and the seawater are combined, the nursing composition can achieve moisturizing and ventilation for a long time on the basis of nasal cavity cleaning, has good moisturizing and ventilating effects and can maintain cleanliness of the nasal cavities; through mutual promotion of the two functions, nasal cavity health can be maintained and various problems of the nasal cavities can be improved; and the nasal cavity nursing composition can be derived from natural resources, is scientific in prescription formula, has high safety and does not have risks after being used for a long term.
Description
Technical field
The present invention relates to field of medical technology, be specifically related to a kind of nasal cavity nursing combination thing and application thereof, with
And it is a kind of by the nasal nursing product of described nasal cavity nursing combination thing gained.
Background technology
It is known that nasal cavity be breathe main thoroughfare, carry olfactory sensation, remove exotic disease pathogenic microorganism,
Dust and the physiological function of heating and moistening.And owing to natural environment being flooded with the disease such as dust mite, bacterial virus
The paathogenic factors such as pathogenic microorganism and haze, vegetalitas and chemical industry dust so that suffer from the trouble of nose diseases
Person increases day by day, has had a strong impact on routine work and the life of people.In daily life, except noting
The ventilation of local environment, often local environment is carried out sterilizing, and regulate and control the wet of local environment in good time
Outside the plan of the passive reply such as degree, also should be for the method self working out positive reply, that is, nose
Chamber is nursed.
The function majority of presently commercially available nasal nursing series products is suppression nasal cavity bacterial growth and suppression inflammation
Sex factor is secreted, and regulates and controls nasal cavity environment (humidity), promotes that nasal airflow aspect is almost without any
Effect.
Peppermint essential oil is a kind of common plant extract product, and its effect includes: antiinflammatory, antioxidation, press down
Bacterium, resisting fatigue, enhancing Transdermal absorption, parasite killing etc..Peppermint essential oil is also commonly used in nasal formulations product,
But it is all to be used in mixed way with other multiple quintessence oils, plays moisture-keeping efficacy by other derived essential oils.
Summary of the invention
For overcoming existing nasal nursing series products deficiency in terms of promoting nasal cavity moisturizing, ventilation, this
One of bright purpose is to provide a kind of nasal cavity nursing combination thing.
The nasal cavity nursing combination thing that the present invention provides is made up of with sea water Peppermint essential oil.
In described compositions, the mass percent of Peppermint essential oil can be 0.001%～4%, can basis
It is actually needed the consumption that Peppermint essential oil is increased or decreased.
In described compositions, sea water can be physiology sea water, it is also possible to ooze sea water for height, it is also possible to
Concentration is mediate, and wherein the mass percent of sodium chloride can be 0.9%～3%.
Present invention also offers described compositions preparation for nasal cavity moisturizing, ventilation product in
Purposes.
Present invention also offers a kind of nasal nursing product, it comprises above any one of technical scheme institute
The nasal cavity nursing combination thing stated.
The nasal nursing product of the present invention becomes as activity except the nasal cavity nursing combination thing using the present invention
Exceptionally, other auxiliary elements can be added according to the purposes difference of product, make pharmaceutical preparation, medical treatment
Polytype products such as apparatus, health product, cosmetics.Preferably, described nasal nursing product
Including pH value regulator, it is 6.0～8.0 in order to regulate the pH value of described nasal nursing product, with
The pH value making product is maintained at the acid-base value scope that human body nasal cavity accommodates most.
The pH value regulator that can be used for nasal nursing product of the present invention can be selected for arbitrary pharmaceutic adjuvant,
Include but not limited to use appropriateness proportioning (such as 1:100～100:1) citric acid-sodium citrate buffering
Liquid.
It was found by the inventors of the present invention that (include that natural and chemistry closes compared to conventional moisturizer
The product become), extract from the Peppermint essential oil of plant and there is good moisture absorption, moisture-keeping functions, for nasal cavity
Time can effectively facilitate nasal airflow.The care composition of the present invention can give full play to the moisturizing of Peppermint essential oil
Function, moreover it is possible to while keeping nasal cavity ambient humidity suitable, promote fibre swing, beneficially nasal cavity
Ventilation；Meanwhile, sea water can effectively be removed the pollutant of nasal cavity accumulation, alien bacteria virus, be planted
The deleterious particle things such as anaphylactogen and haze such as physical property and chemical industry dust, after the two combines, can be at nasal cavity
Long-time moisturizing ventilation on the basis of cleaning, and good moisturizing, ventilatory effect can persistently maintain nasal cavity
Cleaning, two kinds of functions promote mutually, Z can be continuously maintained nasal cavity healthy, and can improve multiple nasal cavity problem,
Therefore, the care composition of the present invention can be effectively used for nasal nursing, in particular for nasal cavity moisturizing, logical
The product of gas.Additionally, the nasal cavity nursing combination thing of the present invention may originate from natural, prescription proportioning science, peace
Quan Xinggao, there is not risk in life-time service.
Detailed description of the invention
Following case study on implementation is used for explaining the present invention, but is not limited thereto.Peppermint essence used in it
Oil, wash smelling salt, buffer etc. as being commercially available prod without clearly stating.
Embodiment 1
The components such as Peppermint essential oil and sea water (washing smelling salt configuration) are mixed homogeneously and get final product by according to the form below, pH
Value is about 7.0.
| Peppermint essential oil | 20μl |
| Wash smelling salt | 9.0g |
| Citric acid | 0.02g |
| Sodium citrate | 1.44g |
| Purified water | To 1000ml |
Embodiment 2
The components such as Peppermint essential oil and sea water (washing smelling salt configuration) are mixed homogeneously and get final product by according to the form below, pH
Value is about 7.0.
| Peppermint essential oil | 100μl |
| Wash smelling salt | 9.0g |
| Citric acid | 0.02g |
| Sodium citrate | 1.44g |
| Purified water | To 1000ml |
Embodiment 3
The components such as Peppermint essential oil and sea water (washing smelling salt configuration) are mixed homogeneously and get final product by according to the form below, pH
Value is about 7.0.
| Peppermint essential oil | 40ml |
| Wash smelling salt | 9.0g |
| Citric acid | 0.02g |
| Sodium citrate | 1.44g |
| Purified water | To 1000ml |
Embodiment 4
The components such as Peppermint essential oil and sea water (washing smelling salt configuration) are mixed homogeneously and get final product by according to the form below, pH
Value is about 7.0.
| Peppermint essential oil | 40μl |
| Wash smelling salt | 9.0g |
| Citric acid | 0.03g |
| Sodium citrate | 2.16g |
| Purified water | To 1000ml |
Embodiment 5
The components such as Peppermint essential oil and sea water (washing smelling salt configuration) are mixed homogeneously and get final product by according to the form below, pH
Value is about 7.0.
| Peppermint essential oil | 40μl |
| Australia sea salt | 23.0g |
| Citric acid | 0.02g |
| Sodium citrate | 1.44g |
| Purified water | To 1000ml |
Embodiment 6
The components such as Peppermint essential oil and sea water (washing smelling salt configuration) are mixed homogeneously and get final product by according to the form below, pH
Value is about 7.0.
| Peppermint essential oil | 1ml |
| Australia sea salt | 30.0g |
| Citric acid | 0.02g |
| Sodium citrate | 1.44g |
| Purified water | To 1000ml |
Pharmacodynamics test
Test one: the moisture-keeping efficacy of Peppermint essential oil
1, fuchsin(e)test
Bottom exsiccator, add 100mL distilled water carry out fuchsin(e)test.Precision weighs about 1g
Sample put in the crystallizing dish of a diameter of 25mm, every 24h crystallizing dish taken out and weighs, logical
Cross measure before and after sample weight difference calculate hydroscopicity:
Hydroscopicity (%)=100 × (Mn-M0)/M0
In formula, M0Weight before placing for sample, MnFor weight (n=2) after placing n days.
2, moisturizing test
Bottom exsiccator, put into the variable color silica gel of 170g drying, put into the sample of fuchsin(e)test
Product carry out moisturizing test.Every 24h, crystallizing dish taking-up is weighed, by the weight of sample before and after measuring
Amount difference calculating moisturizing rate:
Moisturizing rate (%)=100 × Hn/H0
In formula, H0For sample wet weight, HnFor sample wet weight (n=2) after placing n days.
3, conclusion
The performance test of 1 four kinds of samples of table
Glycerol as the wetting agent of chemosynthesis, Aloe as natural wetting agent, its moisture-keeping efficacy
It is widely recognized；In plants essential oil series products, the moisturizing effect of sweet orange oil is to have been reported that
's.Compare so choosing above-mentioned three kinds of products.Table 1 result shows, the moisture absorption of Peppermint essential oil and
Performance of keeping humidity is superior to above-mentioned three kinds of products, and there is not yet about before the moisture-keeping efficacy of Peppermint essential oil
Report.
Test two: nasal airflow effect of Peppermint essential oil physiology sea water
1, subject enrollment condition
1. to increase caused nasal airflow poor for nasal secretion；2. nasal cavity checks bilateral concha nasalis inferior swelling,
Smooth surface, sensitive to ephedrine；3. nasal sinuses CT examination and nasal endoscopy get rid of deviation of nasal septum,
Chronic sinusitis.
2, case packet
198 examples are divided into two groups.Matched group 45 example, male 24 example, women 21 example；Age 17～
45 years old.Treatment group 1:55 example, male 30 example, women 25 example；Treatment group 2:50 example, man
Property 26 examples, women 24 example；Treatment group 3:48 example, male 25 example, women 23 example；Age
15～40 years old.
3, Therapeutic Method
All tested patients disable other treatment medicine more than 7 days.Matched group: give budesonide
Nasal spray 64 μ g, 3 times/d.Treatment group 1: after giving budesonide, then give Peppermint essential oil
Physiology seawater flushing nasal cavity, 3 times/d；Treatment group 2: after giving budesonide, then give physiology
Seawater flushing nasal cavity, 3 times/d；Treatment group 3: after giving budesonide, then give height and ooze sea water
Nasal irrigation, 3 times/d.Using the course for the treatment of is 7 days.
4, efficacy assessment standard
Nasal obstruction efficacy assessment standard:
Cure: nasal obstruction transference cure, concha nasalis inferior is without swelling；Effective: nasal obstruction symptom alleviates, lower nose
First mild swelling；Invalid: nasal obstruction symptom is without alleviation, concha nasalis inferior swelling.
Secretions efficacy assessment standard:
Cure: secretions increase transference cure, nasal meatus is without secretions；Effective: secretions increase disease
Shape alleviates, a small amount of secretions of nasal meatus；Invalid: secretions increase symptom is without alleviating, and nasal meatus divides in a large number
Secretion.
5, result
Four groups of patient's nasal obstructions, secretions increase symptoms improve situation, are shown in Table 2.
As can be seen from Table 2, the therapeutic effect for the treatment of group 1 is substantially better than other 3 groups.Four groups of trouble
All there are not nasal mucosa atrophy, perforation of nasal septum, epistaxis etc. in person, illustrates of the present invention thin
Lotus quintessence oil physiology seawater compositions has good nasal cavity moisturizing, ventilation effect.
2 four groups of patient's nasal obstructions of table are improved situation with watery nasal discharge symptom and are compared (example, %)
Unless limited otherwise, what term used herein was that those skilled in the art are generally understood that contains
Justice.
Embodiment described in the invention is merely for exemplary purpose, and is not used to limit the present invention
Protection domain, those skilled in the art can be made within the scope of the invention various other replace,
Changes and improvements, thus, the invention is not restricted to above-mentioned embodiment, and be only defined by the claims.
Claims (7)
1. a nasal cavity nursing combination thing, it is characterised in that be made up of with sea water Peppermint essential oil.
Compositions the most according to claim 1, it is characterised in that in described compositions, described
The mass percent of Peppermint essential oil is 0.001%～4%.
Compositions the most according to claim 1, it is characterised in that sodium chloride in described sea water
Mass percent is 0.9%～3%.
4. compositions described in any one of claim 1-3 is used for nasal cavity moisturizing, the product of ventilation in preparation
In purposes.
5. a nasal nursing product, it is characterised in that comprise described in any one of claim 1-3
Compositions.
Nasal nursing product the most according to claim 5, it is characterised in that described nasal nursing
Product also includes pH value regulator, is 6.0～8.0 in order to regulate the pH value of described nasal nursing product.
Nasal nursing product the most according to claim 6, it is characterised in that described pH value is adjusted
Joint agent is selected from citric acid-sodium citrate buffer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610531875.3A CN105920094A (en) | 2016-07-07 | 2016-07-07 | Nasal cavity nursing composition, application thereof and obtained nasal cavity nursing product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610531875.3A CN105920094A (en) | 2016-07-07 | 2016-07-07 | Nasal cavity nursing composition, application thereof and obtained nasal cavity nursing product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105920094A true CN105920094A (en) | 2016-09-07 |
Family
ID=56827653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610531875.3A Pending CN105920094A (en) | 2016-07-07 | 2016-07-07 | Nasal cavity nursing composition, application thereof and obtained nasal cavity nursing product |
Country Status (1)
| Country | Link |
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| CN (1) | CN105920094A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581148A (en) * | 2017-02-28 | 2017-04-26 | 四川艾医生医疗科技有限公司 | Nasal irrigation care solution |
| CN115590899A (en) * | 2022-09-19 | 2023-01-13 | 自然资源部天津海水淡化与综合利用研究所（Cn） | Preparation method of compound deep-sea nasal wash salt |
| CN117100699A (en) * | 2023-10-10 | 2023-11-24 | 江苏泰德医药有限公司 | Nose washing agent and preparation method thereof |
-
2016
- 2016-07-07 CN CN201610531875.3A patent/CN105920094A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 吴晴伟 等: "生理海水辅助鼻用激素治疗常年性变应性鼻炎的疗效观察", 《中国中西医结合耳鼻咽喉科杂志》 * |
| 国家药品监督管理局: "鼻腔护理液（商品名：鼻康）", 《国产器械》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581148A (en) * | 2017-02-28 | 2017-04-26 | 四川艾医生医疗科技有限公司 | Nasal irrigation care solution |
| CN115590899A (en) * | 2022-09-19 | 2023-01-13 | 自然资源部天津海水淡化与综合利用研究所（Cn） | Preparation method of compound deep-sea nasal wash salt |
| CN117100699A (en) * | 2023-10-10 | 2023-11-24 | 江苏泰德医药有限公司 | Nose washing agent and preparation method thereof |
| CN117100699B (en) * | 2023-10-10 | 2024-01-23 | 江苏泰德医药有限公司 | Nose washing agent and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Liang Xiao Inventor after: Liu Xuan Inventor after: Xin Yan Inventor after: Liu Weiwei Inventor before: Liu Xuan Inventor before: Xin Yan Inventor before: Liu Weiwei |
|
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160907 |