CN107899006A - Pharmaceutical composition of nasal irrigation and preparation method thereof - Google Patents
Pharmaceutical composition of nasal irrigation and preparation method thereof Download PDFInfo
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- CN107899006A CN107899006A CN201711213728.2A CN201711213728A CN107899006A CN 107899006 A CN107899006 A CN 107899006A CN 201711213728 A CN201711213728 A CN 201711213728A CN 107899006 A CN107899006 A CN 107899006A
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- lysozyme
- sodium chloride
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- glycine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Abstract
The invention belongs to medicine, health care, nursing field, it is related to pharmaceutical composition of nasal irrigation and preparation method thereof.The pharmaceutical composition can dilute, clean nasal cavity inflammation secretion, the hazardous air pollutants of nasal cavity mucus absorption and dissolving part germ virus, the various bacterial viruses of cleaning, improve physiology of the nose environment, achieve the purpose that treatment nasal obstruction, have a running nose, nasal mucus with blood, nasal mucus flow backwards, sneezing, nasal cavity incrustation, nasal cavity it is dry itch, foreign body sensation in the throat, abundant expectoration, expectoration, blood-stained sputum, various nasal cavities and the infection of the upper respiratory tract such as laryngopharyngitis.Pharmaceutical composition of the present invention is mixed using sodium chloride, lysozyme or sodium chloride, glycine, lysozyme according to weight proportion：35 75 parts of sodium chloride, 14 parts of lysozyme；Or 35 85 parts of sodium chloride, 0.1 0.5 parts of glycine, 14 parts of lysozyme.With physiology of the nose environment is faster improved, accelerate nasal cavity self-recovery health.The advantages that pharmaceutical composition has clear and definite effect, and curative effect is stable, controllable.
Description
Technical field
The invention belongs to medicine, health care, nursing field, it is related to pharmaceutical composition of nasal irrigation and preparation method thereof.Should
Pharmaceutical composition can dilute, clean nasal cavity inflammation secretion, the hazardous air pollutants of nasal cavity mucus absorption and dissolving part
Germ virus, the various bacterial viruses of cleaning, improve physiology of the nose environment, reaches treatment nasal obstruction, has a running nose, nasal mucus band blood, nasal mucus
Flow backwards, sneezing, nasal cavity incrustation, nasal cavity it is dry itch, foreign body sensation in the throat, abundant expectoration, expectoration, blood-stained sputum, the various noses such as laryngopharyngitis
The purpose of chamber and the infection of the upper respiratory tract.
Background technology
Fallen for nasal obstruction, rhinorrhea, nasal mucus band blood, nasal mucus caused by the nasal cavity acute and chronic infection such as flu, rhinitis, nasosinusitis
Stream, sneezing, nasal cavity incrustation, nasal cavity be dry itch and the nasal cavity such as foreign body sensation in the throat, abundant expectoration, expectoration, blood-stained sputum, laryngopharyngitis and on
Respiratory tract infection, existing treatment means wash nose, oral and intravenous antibiotics for customary physiological salt, use sugared cortical hormone
Element, atomization anti-inflammatory treatment etc..
And physiology salt washing nose is used, this method is through Long-term clinical and practical application, and there are cleaning performance is poor, symptom is delayed
Solve the shortcomings that slow.Physiological saline is as just the effect of statocyte osmotic pressure, mainly being soaked and rinsing come clear by clear water
Purulent secretion and other deposition nuisances in clean nasal cavity, to the germ in nasal cavity, virus without killing effect.Inflammation is caused to be held
Continuous time length, remission are slow.
And lysozyme is a kind of alkaline enzyme that can hydrolyze glutinous polysaccharide in pathogenic bacteria, mainly made carefully by dissolution of bacteria cell membrane
Cell wall content escapes and makes bacterolysis.Lysozyme can also with negatively charged virus protein directly in conjunction with, with DNA, RNA,
Apoprotein forms double salt, make it is virally inactivated, so as to possess antibacterial, antiviral, hemostasis, clear swollen, analgesia and accelerate tissue and repair
The function such as multiple.And lysozyme is widely present in human multiple tissue, the egg white of birds and poultry, the tears of mammal,
Also contain this enzyme in the body fluid such as saliva, blood plasma, urine, milk and microorganism, belong to pure natural enzyme, it is safe to the human body, also without resistance to
Pharmacological property.
There is not yet report passes through external application lysozyme nasal irrigation, for diluting, cleaning nasal cavity inflammation secretion, nasal cavity sticks
The hazardous air pollutants of liquid absorption and dissolving part germ virus, the various bacterial viruses of cleaning, improve physiology of the nose environment, reach
To treatment nasal obstruction, have a running nose, nasal mucus band blood, nasal mucus flow backwards, sneezing, nasal cavity incrustation, nasal cavity it is dry itch, foreign body sensation in the throat, abundant expectoration,
The precedent of the various nasal cavities such as expectoration, blood-stained sputum, laryngopharyngitis and the infection of the upper respiratory tract.
The present invention is intended to provide a kind of nasal cavity cleaning medicine using lysozyme as main active.
The content of the invention
First technical problem solved by the invention there is provided the new medical usage of lysozyme, external curing nasal cavity and
The various infection of the upper respiratory tracts, such as nasal obstruction, have a running nose, nasal mucus band blood, nasal mucus are flow backwards, sneezing, nasal cavity incrustation, nasal cavity is dry itches, swallows
Laryngeal foreign body sense, abundant expectoration, expectoration, blood-stained sputum, laryngopharyngitis etc..
Can be diluted using lysozyme, clean nasal cavity inflammation secretion, nasal cavity mucus absorption hazardous air pollutants and
Part bacterial virus, the various bacterial viruses of cleaning are dissolved, alleviation nasal obstruction, rhinorrhea, nasal mucus band blood, nasal mucus flow backwards, sneeze, nose
Chamber incrustation, the dry various discomforts such as itch of nasal cavity；And part washing lotion is transported to by throat, treatment pharynx by bronchia mucosal ciliary movement
The infection of the upper respiratory tracts such as laryngeal foreign body sense, abundant expectoration, expectoration, blood-stained sputum, laryngopharyngitis, faster improve physiology of the nose environment, accelerate
Nasal cavity self-recovery health, so as to reach various nasal cavity and the upper respiratory tract acute and chronics such as treatment flu, rhinitis, nasosinusitis, pharyngitis
The purpose of infection.
In order to preferably realize above-mentioned therapeutic effect, the present invention is using lysozyme as main active, and is aided with chlorination
The pharmaceutical composition of nasal cavity is cleaned in sodium external application.
In pharmaceutical composition of the present invention, sodium chloride, lysozyme are matched according to following weight and mixed：
35-75 parts of sodium chloride, 1-4 parts of lysozyme.
Further preferably, sodium chloride, lysozyme are matched according to following weight and mixed：
35-50 parts of sodium chloride, 1-4 parts of lysozyme.
Or further preferably, sodium chloride, lysozyme are matched according to following weight and mixed：
51-75 parts of sodium chloride, 1-4 parts of lysozyme.
Summarized by Long-term clinical or experimental applications, pharmaceutical composition sodium chloride of the present invention, lysozyme are according to following weight
Proportioning mixing：
55 parts of sodium chloride, 1 part of lysozyme.
The pharmaceutical composition curative effect being made of above-mentioned consumption proportion relation is more stable, controllable.
For the ease of application, can on the basis of sodium chloride, lysozyme, add pharmaceutically acceptable auxiliary material be made it is common
External preparation, such as pulvis, lotion, concentrate, spray, drops, solution, gelling agent, emulsion agent or cream.For this
The application characteristic of invention medicine, additionally provides the common preparation method of the pharmaceutical composition.
Method one：Sodium chloride, lysozyme are mixed according to weight proportion, up to pulvis.During Clinical practice, agent according to the rules
Amount solubilizer is configured to nasal wash use.
Method two：Sodium chloride, lysozyme are configured to the solution of 0.5%-3% according to weight proportion mixing and water adding.It is clinical
In use, it is directly used in nasal douche.
Method three：Sodium chloride, lysozyme are mixed according to weight proportion, add water to be configured to the solution of 3.1-30%.It is clinical
Used in use, adding water to be configured to nasal wash according to regulation concentration.
Method four：Sodium chloride, lysozyme are mixed according to weight proportion, add the spray that water is configured to 0.5%-3% molten
Liquid.Solution is sprayed into Sprayable by the pressure, gases at high pressure, ultrasonic vibration or the other methods that pump manually during Clinical practice
In nasal cavity.
Method five：Sodium chloride, lysozyme are mixed according to weight proportion, add water to be configured to the drops of 0.5%-3%, solution
Agent.Coordinate dropper, drop bottle or other devices that solution is instilled nasal cavity or nasal irrigation during Clinical practice.
Method six：Sodium chloride, lysozyme are mixed according to weight proportion, add the auxiliary material that can form gel to be made semi-solid solidifying
Glue preparation.Directly spread on during Clinical practice in nasal cavity.
Method seven：Sodium chloride, lysozyme are mixed according to weight proportion, add the emulsion agent that can form emulsion type.Face
Bed is directly spread in nasal cavity when using.
Method eight：Sodium chloride, lysozyme are mixed according to weight proportion, add the matrix pharmaceutically received, uniformly mixing
Into the semi-solid cream agent with certain denseness.Directly spread on during Clinical practice in nasal cavity.
Since lysozyme easily inactivates, therefore in order to ensure the therapeutic effect of medicine, second technology that the present invention solves is asked
Topic is to maintain the activity of lysozyme, there is provided one kind is aided with glycine, sodium chloride external application using lysozyme as main active
Clean the pharmaceutical composition of nasal cavity.
In pharmaceutical composition of the present invention, sodium chloride, glycine, lysozyme are matched according to following weight and mixed：
35-85 parts of sodium chloride, 0.1-0.5 parts of glycine, 1-4 parts of lysozyme.
Further preferably, lysozyme, glycine, sodium chloride are matched according to following weight and mixed：
35-60 parts of sodium chloride, 0.1-0.5 parts of glycine, 1-4 parts of lysozyme.
Or further preferably, lysozyme, glycine, sodium chloride are matched according to following weight and mixed：
61-85 parts of sodium chloride, 0.1-0.5 parts of glycine, 1-4 parts of lysozyme.
Summarized by Long-term clinical or experimental applications, pharmaceutical composition lysozyme of the present invention, glycine, sodium chloride are under
State weight proportion mixing：
52 parts of sodium chloride, 0.2 part of glycine, 1 part of lysozyme.
The pharmaceutical composition curative effect of above-mentioned consumption proportion relation composition is more stable, controllable.
For the ease of application, pharmaceutically acceptable auxiliary material can be added on the basis of sodium chloride, glycine, lysozyme
Common external preparation is made, such as pulvis, lotion, concentrate, spray, drops, solution, gelling agent, emulsion agent or cream
Deng.For the application characteristic of medicine of the present invention, the common preparation method of the pharmaceutical composition is additionally provided.
Method one：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, up to pulvis.During Clinical practice, press
Nasal wash is configured to according to prescribed dose solubilizer to use.
Method two：Sodium chloride, glycine, lysozyme are configured to the molten of 0.5%-3% according to weight proportion mixing and water adding
Liquid.During Clinical practice, nasal douche is directly used in.
Method three：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, add water to be configured to the molten of 3.1-30%
Liquid.During Clinical practice, add water to be configured to nasal wash according to regulation concentration and rinse.
Method four：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, add water to be configured to the spray of 0.5%-3%
Mist agent solution.During Clinical practice by pressure, gases at high pressure, ultrasonic vibration or the other methods pumped manually by solution with shape of spraying
Formula is sprayed into nasal cavity.
Method five：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, add water to be configured to the drop of 0.5%-3%
Agent, solution.Coordinate dropper, drop bottle or other devices that solution is instilled nasal cavity or nasal irrigation during Clinical practice.
Method six：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, the auxiliary material that gel can be formed by adding is made
Semi-solid gel preparation.Directly spread on during Clinical practice in nasal cavity.
Method seven：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, add the breast that can form emulsion type
Jelly.Directly spread on during Clinical practice in nasal cavity.
Method eight：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, add the matrix pharmaceutically received,
It is even to be mixed into the semi-solid cream agent with certain denseness.Directly spread on during Clinical practice in nasal cavity.
Treatment nasal cavity and various upper respiratory tract acute and chronic infections, such as flu, nose can be realized using above-mentioned preparation method
Caused by inflammation, nasosinusitis, pharyngitis etc. have a stuffy nose, have a running nose, nasal mucus band blood, nasal mucus flow backwards, sneezing, nasal cavity incrustation, nasal cavity it is dry itch,
The diseases such as foreign body sensation in the throat, abundant expectoration, expectoration, blood-stained sputum, abscess of throat, but convenience and the simplicity of preparation because of application, invention
People is made into pulvis use more.
To sum up, it is used for nasal irrigation using pharmaceutical composition provided by the invention, can treats or improve nasal cavity and various
Upper respiratory tract acute and chronic infection, has a stuffy nose as caused by flu, rhinitis, nasosinusitis, pharyngitis etc., has a running nose, nasal mucus band blood, nasal mucus fall
Stream, sneezing, nasal cavity incrustation, nasal cavity be dry to itch, foreign body sensation in the throat, abundant expectoration, expectoration, blood-stained sputum, abscess of throat etc., can be dilute
Release, clean nasal cavity inflammation secretion, the hazardous air pollutants of nasal cavity mucus absorption and dissolving part germ are viral, it is various to clean
Bacterial virus, treatment nasal obstruction, have a running nose, nasal mucus band blood, nasal mucus are flow backwards, sneezing, nasal cavity incrustation, the dry various nasal cavities such as itch of nasal cavity
Discomfort, and part washing lotion is transported to by throat, treatment foreign body sensation in the throat, abundant expectoration, expectoration, phlegm by bronchia mucosal ciliary movement
The infection of the upper respiratory tracts such as middle band blood, laryngopharyngitis.Physiology of the nose environment is faster improved at the same time, accelerates nasal cavity self-recovery health.
The advantages that pharmaceutical composition has clear and definite effect, and curative effect is stable, controllable.
Embodiment
Illustrate below by way of specific description of embodiments of the present invention but do not limit the present invention.
Inventor adjusts the dosage of bulk pharmaceutical chemicals in clinical practice in 2 years in the range of following weight proportion, can be real
Now treatment nasal obstruction, have a running nose, nasal mucus band blood, nasal mucus flow backwards, sneezing, nasal cavity incrustation, nasal cavity it is dry itch, foreign body sensation in the throat, abundant expectoration,
The various nasal cavities such as expectoration, blood-stained sputum, laryngopharyngitis and the infection of the upper respiratory tract：The weight proportion of bulk pharmaceutical chemicals is sodium chloride 35-75
Part, 1-4 parts of lysozyme or 35-85 parts of sodium chloride, 0.1-0.5 parts of glycine, 1-4 parts of lysozyme.
For the ease of application, it can add pharmaceutically acceptable auxiliary material on the basis of bulk pharmaceutical chemicals and common pulvis be made, washes
The preparations such as agent, concentrate, spray, drops, solution, gelling agent, emulsion agent or cream.
The pharmacological effect experiment of nasal cavity irrigants of the present invention
Lysozyme is a kind of alkaline enzyme that can be hydrolyzed and polysaccharide is sticked in pathogenic bacteria, mainly makes cell by dissolution of bacteria cell membrane
Wall content escapes and makes bacterolysis.Lysozyme can also be with negatively charged virus protein directly in conjunction with DNA, RNA, de-
Apoprotein forms double salt, makes virally inactivated.Therefore lysozyme has the effect such as sterilization, anti-inflammatory, antiviral.And lysozyme is extensive
It is present in the body fluid such as the tears of people, saliva, blood plasma, urine, milk and human multiple tissue, belongs to pure natural enzyme, to people
Body safety, also has no drug resistance.
Glycine is a kind of human body nonessential amino acid, by endogenous antioxidant --- reductive glutathione forms
Amino acid, with lysozyme with the use of can slow down lysozyme inactivation.The result shows that by lysozyme and glycine, lysozyme
Applied to nasal obstruction, have a running nose, nasal mucus band blood, nasal mucus flow backwards, sneezing, nasal cavity incrustation, nasal cavity it is dry itch, foreign body sensation in the throat, abundant expectoration,
Expectoration, blood-stained sputum, laryngopharyngitis when the treatment of various nasal cavities and the infection of the upper respiratory tract, have directly against affected part sterilization,
Anti-inflammatory, antiviral effect, and therapeutic effect is safe efficient.
(1) sodium chloride：The clinical research of lysozyme nasal cavity irrigants
Nasal cavity irrigants are to be configured to normal concentration according to 55 parts of weight proportion sodium chloride, 1 part of lysozyme in testing below
Nasal cavity irrigants use, dosage converts 300 milliliters of water for 2.65g, is used after shaking up.
Curative effect comparision is carried out with normal saline flushing nasal cavity, clinical study results, which collect, is shown in Table 1.Table 1 is with table 2 to according to the facts
Group (i.e. using physiological saline experimental group) is tested as same group.
1 Lvization Na ︰ lysozymes nasal cavity irrigants of table and normal saline flushing nasal cavity effect comparison
(nasal cavity irrigants A is referred to as in Lvization Na ︰ lysozyme nasal cavity irrigants tables)
Table 1 shown in common nasal cavity and upper respiratory tract infection symptoms, normal saline flushing nasal cavity and sodium chloride：It is molten
The total effective rate of bacterium enzyme washing lotion nasal irrigation is above 95%, but within observing time, uses sodium chloride：Lysozyme washing lotion corresponds to
The ratio higher that symptom disappears, in symptom mitigation crowd, sodium chloride：Lysozyme washing lotion to remission degree and speed also more
It is high.Wherein, sodium chloride：There are 3 to lysozyme allergy in the clinical test of lysozyme nasal cavity irrigants.After allergic symptom occurs
Experiment has been interrupted immediately, is included in symptom without in improvement.
Above-mentioned experiment symptom without in improvement crowd, have a stuffy nose class crowd, uses 8 of normal saline flushing symptom without improvement
In people, 3 people are loose for nose clip, and 1 people is deviation of nasal septum, and 2 people are nasal polyp, and 2 people have long term vascular shrinkage drug medication history,
There are Drug nasal obstruction；Using sodium chloride：In 3 people of the lysozyme nasal cavity irrigants symptom without improvement, 1 people is allergy
Rhinitis, 1 people have long term vascular shrinkage drug medication history, and there are Drug nasal obstruction, 1 people is lysozyme allergy, stop experiment.
In the class crowd that sneezes, using in 3 people of the normal saline flushing symptom without improvement, 2 people are allergy nose
Inflammation, 1 people are nasal polyp；Using in 2 people of the lysozyme nasal cavity irrigants symptom without improvement, 1 people is allergic rhinitis, 1 people
For lysozyme allergy, stop experiment.
In expectoration class crowd, using in 2 people of the normal saline flushing symptom without improvement, 1 people is both sides severe nasal blockage, punching
Wash and make slow progress, 1 people spits for cough and asthma band caused by bronchial infection；Use 1 of lysozyme nasal cavity irrigants symptom without improvement
Artificial lysozyme allergy, stops experiment.
Conclusion：Using sodium chloride：In 1390 of lysozyme nasal cavity irrigants treatment, there is about 0.215% allergy,
But this lotion is to having a stuffy nose, having a running nose, nasal mucus band blood, nasal mucus are flow backwards, sneezing, nasal cavity incrustation, nasal cavity it is dry itch, foreign body sensation in the throat,
The various nasal cavities such as abundant expectoration, expectoration, blood-stained sputum, laryngopharyngitis and upper respiratory tract infection symptoms overall treatment effect are compared with physiological saline
Rinse and alleviate faster, treated effect higher.
(2) clinical research of Lvization Na ︰ Gan An Suan ︰ lysozyme nasal cavity irrigants
Nasal cavity irrigants are matched somebody with somebody according to 52 parts of weight proportion sodium chloride, 0.2 part of glycine, 1 part of lysozyme in testing below
The nasal cavity irrigants that normal concentration is made use, and dosage converts 300 milliliters of water for 2.65g, is used after shaking up.With normal saline flushing
Nasal cavity carries out curative effect comparision, and clinical study results, which collect, is shown in Table 2.Table 1 and the control experiment group of table 2 are (real i.e. using physiological saline
Test group) it is same group.
2 Lvization Na ︰ Gan An Suan ︰ lysozymes nasal cavity irrigants of table and normal saline flushing nasal cavity effect comparison
(nasal cavity irrigants B is referred to as in Lvization Na ︰ Gan An Suan ︰ lysozyme nasal cavity irrigants tables)
Table 2 shown in common nasal cavity and upper respiratory tract infection symptoms, normal saline flushing nasal cavity and sodium chloride：It is sweet
Propylhomoserin：The total effective rate of lysozyme washing lotion nasal irrigation is above 95%, but within observing time, is corresponded to using lysozyme washing lotion
The ratio higher that symptom disappears, in symptom mitigation crowd, lysozyme washing lotion is to remission degree and speed also higher.Its
In, there are 2 to lysozyme allergy in the clinical test of lysozyme nasal cavity irrigants, 1 to glycine allergy.Allergic symptom goes out
Experiment has been interrupted after now immediately, has been included in symptom without in improvement.
Above-mentioned experiment symptom without in improvement crowd, have a stuffy nose class crowd, uses 8 of normal saline flushing symptom without improvement
In people, 3 people are loose for nose clip, and 1 people is deviation of nasal septum, and 2 people are nasal polyp, and 2 people have long term vascular shrinkage drug medication history,
There are Drug nasal obstruction；Using in 5 people of the lysozyme nasal cavity irrigants symptom without improvement, 2 people are allergic rhinitis, 1
Artificial deviation of nasal septum, 1 people have long term vascular shrinkage drug medication history, and there are Drug nasal obstruction, 1 people is lysozyme allergy,
Stop experiment.
In nasal mucus flows backwards class crowd, 1 lysozyme nasal cavity irrigants symptom stops examination without glycine allergy is improved as
Test.
In the class crowd that sneezes, using in 3 people of the normal saline flushing symptom without improvement, 2 people are allergy nose
Inflammation, 1 people are nasal polyp；The use of 1 people of the lysozyme nasal cavity irrigants symptom without improvement is lysozyme allergy.
In expectoration class crowd, using in 2 people of the normal saline flushing symptom without improvement, 1 people is both sides severe nasal blockage, punching
Wash and make slow progress, cough and asthma band caused by the infection of 1 human bronchial is spat；Use 1 people of the lysozyme nasal cavity irrigants symptom without improvement
Spit for cough and asthma band caused by bronchial infection.
Conclusion：Although Lvization Na ︰ Gan An Suan ︰ lysozymes nasal cavity irrigants have about 0.203% in 1480 for the treatment of
Lysozyme and glycine allergy, but to having a stuffy nose, having a running nose, nasal mucus band blood, nasal mucus are flow backwards, sneezing, nasal cavity incrustation, nasal cavity are done
Itch, foreign body sensation in the throat, abundant expectoration, expectoration, blood-stained sputum, various nasal cavity and the upper respiratory tract infection symptoms overall therapeutics such as laryngopharyngitis
Effect is alleviated faster compared with normal saline flushing, treated effect higher.
Supplementary notes：Because of the limitation of sample number, the sodium chloride in this statistics：The allergy of lysozyme nasal cavity irrigants
The Allergy rates of a little higher than Lvization Na ︰ Gan An Suan ︰ lysozyme nasal cavity irrigants of ratio.After sample size is sufficiently large, Lvization Na ︰
The Allergy rates of Gan An Suan ︰ lysozyme nasal cavity irrigants can a little higher than Lvization Na ︰ lysozyme nasal cavity irrigants Allergy rates.
(3) experiment that glycine influences lysozyme activity
It is placed on since the nasal cavity irrigants in experiment are that configuration is good in -20 DEG C of freezing environments, when use, further takes out,
The lysozyme activity caused by environmental factor in practical applications can not be embodied to change.Therefore it is directed to sodium chloride：Lysozyme and
Sodium chloride：Glycine：Lysozyme activity contrast is individually tested in lysozyme lotion.Result of the test refers to table 3.
Table 3：The activity test of Lvization Na ︰ lysozymes nasal cavity irrigants and Lvization Na ︰ Gan An Suan ︰ lysozyme nasal cavity irrigants
Conclusion：Although there are the glycine allergy case of few quantity, no matter under refrigeration or room temperature environment, sweet ammonia
Acid is provided with obvious holding to the activity of lysozyme and acts on.
(4) the effect of lysozyme nasal cavity irrigants and recurrence summary
Inventor is applied to clinical treatment nasal obstruction, rhinorrhea, nasal mucus band blood, nasal mucus using pharmaceutical composition of the present invention and falls
Stream, sneezing, nasal cavity incrustation, nasal cavity be dry to itch, foreign body sensation in the throat, abundant expectoration, expectoration, blood-stained sputum, the various nasal cavities such as laryngopharyngitis
And the infection of the upper respiratory tract.More than 2870 people, wherein sodium chloride were treated in 2 years：Lysozyme nasal cavity irrigants treat 1390 people, chlorine
Change sodium：Glycine：Lysozyme nasal cavity irrigants treat 1480 people.Due to sodium chloride：Lysozyme and sodium chloride：Glycine：Bacteriolyze
The therapeutic effect of enzyme is identical, merges description herein, is referred to as lysozyme nasal cavity irrigants.Pass through clinical observation, the action of this medicament
It is different according to the weight of symptom with healing time.
Wherein for the symptom of nasal obstruction, if alternately having a stuffy nose, then it is obviously improved in 5 days or so nasal obstructions.It is usually expressed as, it is long
Phase replaces nasal obstruction person, and after using 5 days, daytime, lower section nasal obstruction was slept in side of sleeping at night substantially without nasal obstruction.Usually in 15 days or so noses
Plug disappears.If both sides nasal obstruction and with sticky secretion, then recovery time about postpone 5 to 15 days.After nasal obstruction is cured, it is discontinued
Have no bounce-back.If but because of acute upper respiratory infections such as flu, influenzas, can be by initiation nasal obstruction, but relative to using bacteriolyze again
Before the treatment of enzyme nasal cavity irrigants, symptoms are mild, is more easy to treat.
For symptom snotty, if nasal mucus is thick, and without nasal obstruction symptom, then usually nasal mucus substantially subtracts after 2 days
It is few and thinning, generally switch to light gluey nasal mucus in the nasal mucus of 5-7 days yellow-whites.If green viscous nasal mucus, and measure cause more
Nasal obstruction, then usually significantly reduce in 7 days or so nasal mucus, thinning, lighter；Switch to light gluey nose in 12 to 15 days nasal mucus
Tears, and measure and reduce, while see that nasal obstruction mitigates or disappears.Usual initial symptoms are the patient of clear gum or shallow white nasal obstruction,
Disappear substantially in 5 to 12 days nasal mucus, visible a small amount of clear gum secretion in nasal cavity, nasal cavity moistening degree is moderate, and there is no nasal cavity
Interior dry and astringent sensation.If because of acute upper respiratory infections such as flu, influenzas, symptom snotty can be induced again, but it is corresponding
Before being treated with lysozyme nasal cavity irrigants, symptoms are mild, and treatment difficulty accordingly reduces.
Situation about being flow backwards for nasal mucus, common nasal mucus flow backwards the symptom for causing foreign body sensation in the throat, are applying lysozyme nose
2 days or so symptoms of chamber irrigation are obviously improved, and are usually wholly absent in 5 to 7 days symptoms.More serious nasal mucus is flow backwards, and is such as flow backwards
Nasal mucus be yellow or the thick secretions of green, then the nasal mucus that can be observed to flow backwards at 7 days or so it is obvious it is thinning, reduce,
Lighter, more than 50% can be reduced in the nasal mucus that 10 days or so flow backwards, and stickiness reduces, it is easy to be ingested or spat
Go out.The patient that the symptom that nasal mucus is flow backwards is cured, will not recur without acute upper respiratory infections such as flu, influenzas, follow-up recurrence
Patient symptom is relatively using gently, treatment difficulty reduces before the treatment of lysozyme nasal cavity irrigants.
For the symptom of sneezing, sneeze sooner or later and applying lysozyme nasal cavity with the patient of a small amount of clear gum nasal mucus
After irrigation, the visible alleviation of sneeze after 1 day, 5 days or so sneezes and nasal mucus disappear substantially, no relapse after deactivation.But suffering from cold
Blow a cold wind over or air in dust it is heavier in the case of can still beat a small number of sneezes, have no and be considered as nose with gluey nasal mucus, this situation
The normal physiological reaction of chamber.When sneezing with white sticky shape nasal mucus after a large amount of clear gums, usual 5 days or so nasal mucus with
Sneeze is relieved, and sneezing symptom disappears substantially within 10-15 days.After the symptom of sneezing disappears, due to still suffering from a small amount of nose
The secretion of tears, deactivation are likely to occur sneezing from slight morning for 3 days or so.Not occurring, the upper respiratory tracts such as flu, influenza are acute
In the case of infection-induced, sneezing has no exacerbation.
It is less when forming a scab for the symptom of nasal cavity incrustation, and during adjoint gluey transparent secretion, rushed using lysozyme nasal cavity
Lotion incrustation in 1 day or so significantly reduces, and incrustation in 5 days or so switchs to a small amount of white scraps of paper shape solids, nasal cavity incrustation in 7 days or so and
Secretion disappears.When incrustation is more and with yellow or green secretion, form a scab within 5-7 days using lysozyme nasal cavity irrigants
Significantly reduce, lighter.The nasal cavity incrustation patient of interior healing during experiment, without the acute upper respiratory tract sense such as flu, influenza
No relapse is contaminated, and wettability is moderate in nasal cavity, the dry sensation occurred with nasal cavity incrustation disappears at the same time.
For the symptom of foreign body sensation in the throat, when adjoint slight foreign body sensation in the throat, there is gluey transparent or shallow white secretion can
When being spued by throat through expectoration, substantially mitigate using 1 day or so foreign body sensation of lysozyme nasal cavity irrigants, 3 days or so daytimes foreign matter
Sense disappears, and only morning and evening foreign body sensation is more apparent, and foreign body sensation is wholly absent within 7 days or so.When the obvious foreign body sensation of adjoint throat, and foreign matter sticks
Denseness is high, it is difficult to or the patient that can not spue, reduced using 2 days or so foreign body sensation stickinesses after lysozyme nasal cavity irrigants, 5 days
Left and right foreign body sensation significantly reduces, and stickiness further reduces, and most of patients can spue through expectoration.Can be observed within 7 days or so through
The throat foreign matter lighter that expectoration spues, starts clear gum material occur, and nose is being rinsed using lysozyme nasal cavity irrigants
After chamber, it was observed that the time delay that foreign body sensation in the throat occurs, the increase of throat comfort.The foreign body sensation in the throat cured in experimental period is suffered from
Person, in the case of being induced without the acute infection of the upper respiratory tract such as flu, influenza, no relapse.The patient recurred after induction, disease
It is lighter before the corresponding treatment with lysozyme nasal cavity irrigants of shape, it is more easy to treat.
For the symptom of expectoration, when the color of phlegm is clear gum, white foam or white sticky shape, using bacteriolyze
2 days or so phlegm stickinesses of enzyme nasal cavity irrigants reduce, number of spitting is reduced, and phlegm significantly reduces within 5-7 days, and color is changed into light glue
Shape, 10-12 days, phlegm was wholly absent, and corresponding throat discomfort sense disappears, it is no longer necessary to clears one's throat.When phlegm is glutinous for yellow or green
During thick shape, the color that phlegm can be observed in 7 days or so using lysozyme nasal cavity irrigants is thinning, reduces, lighter, 10-15 days
Left and right can be observed phlegm and switch to based on glue, a small amount of light yellow or light green color secretion of band, and amount of expectoration reduces 60% or so, daytime from
Frequently spitting to be changed into and spit once in a while before treatment, and the stickiness of phlegm reduces, it is easier to spit clean, the sense of discomfort drop of throat
It is low.The expectoration patient cured in experimental period, in the case of being induced without the acute infection of the upper respiratory tract such as flu, influenza, has no multiple
Hair.The patient recurred after induction, it is lighter before the corresponding treatment with lysozyme nasal cavity irrigants of symptom, it is more easy to treat.
(5) typical case analysis
In following case, in nasal cavity irrigants of the present invention the weight proportion of bulk pharmaceutical chemicals for 55 parts of sodium chloride, 1 part of lysozyme or
52 parts of sodium chloride, 0.2 part of glycine, 1 part of lysozyme.
Using sodium chloride：The typical case analysis of lysozyme：
Case 1：Patient Zhang, man, 26 years old, flows nearly 2 years of white gum nasal mucus time, the symptom flow backwards with nasal mucus.Through
The phlegm that throat spues is white foam to the sticky shape of white, and phlegm is especially more after get up in the morning, and partially sticky.Without nasal obstruction, morning and evening
And blow a cold wind over, hear penetrating odor after easily sneeze.Long-term use of Yanyan slice and cephalo treatment, has a running nose, nasal mucus flows backwards, spits
Situation alleviated, easily recurrence, symptom aggravates year by year.
Use the treatment after Lvization Na ︰ lysozyme nasal cavity irrigants and analysis：
Treatment：
Patient applies sodium chloride：After lysozyme nasal cavity irrigants 1 day, nasal mucus starts to reduce, the nasal mucus of refluence and through pharynx
The phlegm that larynx spues is reduced therewith.Using sodium chloride：After lysozyme nasal cavity irrigants 7 days, nasal mucus is changed by a large amount of white nasal mucus
For a small amount of gluey band White Flocculus nasal mucus.By needing frequently cleaning nasal mucus to be changed into 3 to 5 cleanings in one day before treating daily
Nasal mucus, sooner or later the symptom of sneezing be clearly better, a succession of sneeze when being got up by morning before treating switchs to after getting up once in a while one
Two sneezes.Using sodium chloride：After lysozyme nasal cavity irrigants 15 days, nasal mucus disappears, and nasal mucus flows backwards basic disappearance, only in morning
Morning can feel a small amount of nasal mucus for flowing backward to throat, can be observed through spuing as a small amount of clear gum band white flock secretion.
White foam before treatment to the sticky shape phlegm of white disappears, and sooner or later and blows a cold wind over, hears the symptom such as sneeze after penetrating odor
Disappear.
Treatment is analyzed：
The patient is the situation that common rhinitis chronic causes pharyngitis and spits.The inflammation secretion discharge of rhinitis causes
Long-term rhinorrhea, and the swing of part intranasal cilium more sticky in secretion is transported to throat and forms nasal mucus and flow backwards
And have the symptom of phlegm, simultaneously because the presence of inflammation causes bronchia mucosal to suffering from cold, cold air and penetrating odor it is quick
Sense.Through using sodium chloride：The solution of lysozyme nasal cavity irrigants exchange is harmful to nasal cavity inflammation secretion, nasal cavital mucus absorption
Dilution, the cleaning of air pollutants, the dissolving and cleaning to part germ virus and the cleaning to various bacteriums, virus,
While washing various pungents in nasal cavity, improve physiological environment in nasal cavity, more by lysozyme to part bacterium, disease
The dissolving of poison, killing effect, directly from affected part sterilization, anti-inflammatory, promote bronchia mucosal to get well.So as to directly reduce nasal cavity
The secretion of inflammation secretion, nasal mucus, the nasal mucus flow backwards, phlegm etc. is corresponding to be reduced, and sphagitis symptom mitigates and fades away therewith.
After experiment in 15 days, the symptom of patient can only feel a small amount of nasal mucus for flowing backward to throat in the morning, can spue.
Case 2：In patient's summer, female, 42 years old, alternately has a stuffy nose, has a large amount of yellow nose dung, nasal mucus, more Huang in nasal cavity throughout the year
The sticky shape phlegm of color, pain is done in nasal cavity, with throughout the year dizzy, accidental headache.Autumn and winter in spring easily breaks out.It is rhinitis chronic after diagnosing,
Medical history 15 years or so.Various antibiotic largely were taken, penicillin and rhinitis tablet have produced drug resistance.Once nasal cavity topical application swashed
Element, took orally hormone, is to alleviate, easily rebounds after drug withdrawal.Hormone or so half a year is disabled at present.
Use the treatment after Lvization Na ︰ lysozyme nasal cavity irrigants and analysis：
Treatment：
Patient applies sodium chloride：After lysozyme nasal cavity irrigants 1 day, yellow nose dung is reduced, and alternately nasal obstruction nothing is clearly better,
Yellow nasal mucus and the sticky phlegm of yellow are slightly thinning, and pain is done in nasal cavity and has been alleviated, dizzy improvement unobvious.Using sodium chloride：
After lysozyme nasal cavity irrigants 7 days, alternately nasal obstruction see alleviation, can be kept after flushing 4 to 5 hours without nasal obstruction, nasal mucus and phlegm by
The sticky shape of yellow switchs to the dilute shape of pale yellow colour cast, and the amount of nasal mucus and phlegm is reduced to 70% or so before treatment, and pain is done in nasal cavity and is disappeared, but
Still there is tight dry sensation, dizzy, headache syndromes disappear.Using sodium chloride：After lysozyme nasal cavity irrigants 15 days, alternately have a stuffy nose
Basic to disappear, nasal mucus and phlegm switch to light yellow gum, and amount is reduced to 40% or so before treatment, almost without tight drying in nasal cavity
Sense.
Treatment is analyzed：
The patient cause for more serious rhinitis chronic spit, be dizzy, the symptom such as headache, belong to typical rhinitis chronic disease
Example, and it is more serious, in addition to nasal mucus flows backwards and causes the sticky phlegm of a large amount of yellow, cause giddy, headache is caused when serious.Through
Using sodium chloride：Noxious air of the solution of lysozyme nasal cavity irrigants exchange to nasal cavity inflammation secretion, nasal cavital mucus absorption
Dilution, the cleaning of pollutant, the dissolving and cleaning to part germ virus and the cleaning to various bacteriums, virus, are being removed
While falling various noxious stimulus in nasal cavity, raising physiology of the nose environment, also directly promote nasal cavity from affected part sterilization, anti-inflammatory
Mucous membrane is got well.Gradual with bronchia mucosal recovers, the purulent material for ultimately forming nasal mucus, phlegm of inflammation mucous membrane area secretion
Be able to gradually it is thinning, reduce, the symptom such as dizzy, headache also with inflammation in nasal cavity regression and rehabilitation.
Using the typical case analysis of Lvization Na ︰ Gan An Suan ︰ lysozymes：
Case 1：Chen, man, 51 years old, both sides nasal obstruction, respiratory nasal was difficult, is breathed throughout the year by oral cavity.Have sticky yellowish green
Color nasal mucus and phlegm, nasal mucus and the phlegm median year band trace of blood, the interior incrustation of nasal cavity is serious, the position such as forehead and temple, cheek, bridge of the nose pain
Frequently, sleep quality is low for pain, long-term absent-minded.It is a large amount of to take antibiotic, various rhinitis tablets, capsule for treating rhinitis, rhinitis punching
Agent, once long-time service collunarium the hormone medicine such as lead to.Patient medical history is longer, has the history of rhinitis of nearly 30 years, is fond of smoking, daily about
Smoke 30.
Use the treatment after Lvization Na ︰ Gan An Suan ︰ lysozyme nasal cavity irrigants and analysis：
Treatment：
Patient rinses 2 times on the 1st day using the sweet ammonia acid ︰ lysozymes nasal cavity irrigants of chlorine sodium ︰, flushes out about 200 every time
The glutinous pussy discharge of milliliter.Since patient symptom is serious, after 1 day in addition to nasal cavity incrustation and phlegm are slightly reduced, remaining symptom
Nothing is clearly better.
Using Lvization Na ︰ Gan An Suan ︰ lysozymes nasal cavity irrigants after 7 days, the secretion flushed out is sticked patient by yellow green
Purulence shape is changed into the sticky shape of yellow, and lighter, character is thinning, and the amount of the secretion flushed out every time is reduced to before treating
80% or so, nasal obstruction is alleviated, rinse or so latter hour can by nose breathing, in nasal mucus, phlegm, nasal cavity incrustation significantly reduce,
Nasal mucus and blood-stained sputum are reduced, and the position pain relief such as forehead and temple, cheek, the bridge of the nose, the state of mind improves.
Using Lvization Na ︰ Gan An Suan ︰ lysozymes nasal cavity irrigants after 15 days, the secretion flushed out further becomes patient
It is dilute, switch to the secretion that yellow is partially gluey, flushes out amount be reduced to treatment before 50% or so, have a stuffy nose further alleviate, punching
Can be kept after washing 2 it is small when or so without nasal obstruction, 4 it is small when or so can scrape nose breathing.Incrustation disappears in nasal cavity, nasal mucus, phlegm
Significantly reduce, and it is partially gluey by the sticky shape of yellow to switch to yellow.Mucosa hemorrhage symptom disappears, and there is no the trace of blood in nasal mucus and phlegm.
The position such as forehead and temple, cheek, bridge of the nose pain disappears, and still has slightly dizziness, the state of mind further to improve.
Treatment is analyzed：
The patient is serious rhinitis chronic with full group chronic nasosinusitis, wherein forehead and temple, cheek, the bridge of the nose etc.
Position pain is serious chronic nasosinusitis complication.Through using sodium chloride：Glycine：Lysozyme nasal cavity irrigants exchange it is molten
Liquid is to sticking pussy discharge in nasal cavity, the hazardous air pollutants of nasal cavital mucus absorption are diluted, clean, to part germ,
The dissolving and cleaning of virus and the cleaning to various germs, virus, are disposing various noxious stimulus in nasal cavity, are improving nose
While chamber physiological environment, also directly bronchia mucosal is promoted to get well from affected part sterilization, anti-inflammatory.With mucous membrane in nasal cavity
Rehabilitation, inflammation mucous membrane area secretion ultimately form nasal mucus, the purulent material of phlegm be able to gradually it is thinning, reduce, mucosa hemorrhage symptom
Disappear, the position such as forehead and temple, cheek, bridge of the nose pain disappears with the improvement of rhinosinusitis condition.Since the patient is once big
Amount uses hormone, has caused rhinitis medicamentosa, improvement process is relatively slow, but still obvious therapeutic effect was obtained in 15 days.
The involved sodium chloride of experiment：Lysozyme nasal cavity irrigants and sodium chloride：Glycine：Lysozyme nasal cavity irrigants remove
Dilution, cleaning to the hazardous air pollutants of nasal cavity inflammation secretion, nasal cavital mucus absorption, to the molten of part germ virus
Solution and cleaning and the cleaning to various bacteriums, virus, are disposing various noxious stimulus in nasal cavity, raising physiology of the nose ring
While border, also directly bronchia mucosal is promoted to get well to nasal cavity inflammation secretion, nasal cavital mucus from affected part sterilization, anti-inflammatory
The dilutions of the hazardous air pollutants of absorption, cleaning, dissolving and cleaning to part germ virus and to various bacteriums, virus
Cleaning, disposing various noxious stimulus in nasal cavity, raising physiology of the nose environment, and directly from affected part sterilization, anti-inflammatory,
Outside promotion bronchia mucosal is got well, it may have accelerate the healing of bronchia mucosal blutpunkte, to nasal cavity caused by mucosal inflammation
Interior pain and concurrent dizziness, headache relief faster, have the function of to accelerate mucous membrane tissue reparation.
In contrast test, rushed using Lvization Na ︰ lysozymes nasal cavity irrigants and Lvization Na ︰ Gan An Suan ︰ lysozymes nasal cavity
Pain patients in the nasal cavity of lotion, pain disappears usually in 3-5 days nasal cavities, and headache usually disappeared in headache in 7-15 days,
Bronchia mucosal bleeding or the common 3-15 days mucosa hemorrhages of nose is bleeding patient disappear.And compare using normal saline flushing nasal cavity
Patient, pain usually disappeared at 15 days or so in nasal cavity, and headache and mucosa hemorrhage or nose is bleeding patient are usually at 15 days or so
Symptom mitigates, no healing.
To sum up, pharmaceutical composition of the present invention is observed through clinical statistics for many years, finally determines that lysozyme is after screening prescription
Main active, glycine treat rhinitis, nasosinusitis effect to maintain the nasal cavity irrigants of the auxiliary element of lysozyme activity
Most preferably, a kind of brand-new selection is provided for the upper respiratory tract acute and chronic infection such as clinical treatment rhinitis, nasosinusitis, pharyngitis, flu.
Claims (8)
1. the pharmaceutical composition of nasal irrigation, it is characterised in that：Sodium chloride, lysozyme are matched according to following weight and mixed：Chlorination
35-75 parts of sodium, 1-4 parts of lysozyme.
2. the pharmaceutical composition of nasal irrigation according to claim 1, it is characterised in that：Sodium chloride, lysozyme are under
State weight proportion mixing：35-50 parts of sodium chloride, 1-4 parts of lysozyme；
Mixed alternatively, sodium chloride, lysozyme are matched according to following weight：51-75 parts of sodium chloride, 1-4 parts of lysozyme；
Mixed alternatively, sodium chloride, lysozyme are matched according to following weight：55 parts of sodium chloride, 1 part of lysozyme.
3. the pharmaceutical composition of nasal irrigation according to claim 1 or 2, it is characterised in that：In sodium chloride, lysozyme
On the basis of, add pharmaceutically acceptable auxiliary material and common external preparation is made；
Preferably, the common external preparation is pulvis, lotion, concentrate, spray, drops, solution, gelling agent, latex
Agent or cream.
4. the preparation method of the pharmaceutical composition of the nasal irrigation described in claim 1 or 2, it is characterised in that：Using such as lower section
It is prepared by method：
Method one：Sodium chloride, lysozyme are mixed according to weight proportion, up to pulvis；
Method two：Sodium chloride, lysozyme are mixed according to weight proportion, add water to be configured to the solution of 0.5%-3%；
Method three：Sodium chloride, lysozyme are mixed according to weight proportion, add water to be configured to the solution of 3.1-30%；
Method four：Sodium chloride, lysozyme are mixed according to weight proportion, add water to be configured to the spray solution of 0.5%-3%；
Method five：Sodium chloride, lysozyme are mixed according to weight proportion, add water to be configured to the drops of 0.5%-3%, solution；
Method six：Sodium chloride, lysozyme are mixed according to weight proportion, semi-solid gel system is made in the auxiliary material that gel can be formed by adding
Agent；
Method seven：Sodium chloride, lysozyme are mixed according to weight proportion, add the emulsion agent that can form emulsion type；
Method eight：Sodium chloride, lysozyme are mixed according to weight proportion, the matrix pharmaceutically received is added, is uniformly mixed into tool
There is the semi-solid cream agent of certain denseness.
5. the pharmaceutical composition of nasal irrigation, it is characterised in that：Sodium chloride, glycine, lysozyme match mixed according to following weight
Close：35-85 parts of sodium chloride, 0.1-0.5 parts of glycine, 1-4 parts of lysozyme.
6. the pharmaceutical composition of nasal irrigation according to claim 5, it is characterised in that：Lysozyme, glycine, sodium chloride
Match and mix according to following weight：35-60 parts of sodium chloride, 0.1-0.5 parts of glycine, 1-4 parts of lysozyme；
Mixed alternatively, lysozyme, glycine, sodium chloride are matched according to following weight：61-85 parts of sodium chloride, glycine 0.1-0.5
Part, 1-4 parts of lysozyme；
Mixed alternatively, lysozyme, glycine, sodium chloride are matched according to following weight：52 parts of sodium chloride, 0.2 part of glycine, bacteriolyze
1 part of enzyme.
7. the pharmaceutical composition of the nasal irrigation according to claim 5 or 6, it is characterised in that：Sodium chloride, glycine,
On the basis of lysozyme, add pharmaceutically acceptable auxiliary material and common external preparation is made；
Preferably, the common external preparation is pulvis, lotion, concentrate, spray, drops, solution, gelling agent, latex
Agent or cream.
8. the preparation method of the pharmaceutical composition of the nasal irrigation described in claim 5 or 6, it is characterised in that：Using such as lower section
It is prepared by method：
Method one：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, up to pulvis；
Method two：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, add water to be configured to the solution of 0.5%-3%；
Method three：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, add water to be configured to the solution of 3.1-30%；
Method four：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, add water to be configured to the spray of 0.5%-3%
Solution；
Method five：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, add water be configured to 0.5%-3% drops,
Solution；
Method six：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, add the auxiliary material that can form gel to be made half solid
Body gel preparation；
Method seven：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, add the emulsion agent that can form emulsion type；
Method eight：Sodium chloride, glycine, lysozyme are mixed according to weight proportion, add the matrix pharmaceutically received, it is uniformly mixed
Semi-solid cream agent of the synthesis with certain denseness.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109310087A (en) * | 2016-06-30 | 2019-02-05 | 贴近科学Ip控股私人有限公司 | The method of antimicrobial composition and application the composition |
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| WO2021036572A1 (en) * | 2019-08-29 | 2021-03-04 | 广州新创忆药物临床研究有限公司 | Composition for preventing or treating uric acid-related disease |
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| CN114340658B (en) * | 2019-08-29 | 2023-09-26 | 广州新创忆药物临床研究有限公司 | Composition for preventing or treating uric acid diseases |
| CN112999340A (en) * | 2021-03-04 | 2021-06-22 | 首都医科大学附属北京同仁医院 | Nasal cavity flushing fluid and preparation method thereof |
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Application publication date: 20180413 |