CN109908131A - Pharmaceutical composition of nasal irrigation and its preparation method and application - Google Patents
Pharmaceutical composition of nasal irrigation and its preparation method and application Download PDFInfo
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- CN109908131A CN109908131A CN201910350298.1A CN201910350298A CN109908131A CN 109908131 A CN109908131 A CN 109908131A CN 201910350298 A CN201910350298 A CN 201910350298A CN 109908131 A CN109908131 A CN 109908131A
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Abstract
The invention belongs to medicine, health care, nursing fields, and in particular to pharmaceutical composition of nasal irrigation and its preparation method and application.Technical problem to be solved by the invention is to provide a kind of pharmaceutical compositions of nasal irrigation.The raw material weight proportioning of soup processed of pharmaceutical composition of the present invention is as follows: 45~180 parts of sodium chloride, EGCG1~20 part.The pharmaceutical composition can dilute, clean the hazardous air pollutants of nasal cavity inflammation secretion, the absorption of nasal cavity mucus, clean various bacterial viruses, antibacterial anti-inflammatory, resist air pollution damage, repair mucous membrane health, treat nasal obstruction caused by nasal cavity and various upper respiratory tract acute and chronic infections, have a running nose, nasal mucus band blood, nasal mucus refluences, nasal mucus peculiar smell, nose is bleeding, sneezing, nasal cavity are formed a scab, nasal cavity it is dry itch, foreign body sensation in the throat, abundant expectoration, expectoration, phlegm peculiar smell, blood-stained sputum, laryngopharyngitis etc..Have many advantages, such as curative effect it is stable, it is controllable, be not easy to cause allergy.
Description
Technical field
The invention belongs to medicine, health care, nursing fields, and in particular to pharmaceutical composition of nasal irrigation and preparation method thereof
And purposes.
Background technique
It is fallen for nasal obstruction caused by the nasal cavities acute and chronic infection such as flu, rhinitis, nasosinusitis, rhinorrhea, nasal mucus band blood, nasal mucus
Stream, nasal mucus peculiar smell, nose is bleeding, sneezing, nasal cavity incrustation, nasal cavity be dry to itch, foreign body sensation in the throat, abundant expectoration, expectoration, phlegm peculiar smell, in phlegm
The band nasal cavities such as blood, laryngopharyngitis and the infection of the upper respiratory tract, existing treatment means are that customary physiological salt washes nose, lysozyme soln
Wash nose, oral and intravenous antibiotics, using glucocorticoid, atomization anti-inflammatory treatment etc..
Nose is washed using physiology salt, this method is through Long-term clinical and practical application, poor, remission that there are cleaning effects
Slow disadvantage.Physiological saline is as just the effect of statocyte osmotic pressure, main being soaked and rinse and clean by clear water
Purulent secretion in nasal cavity and other be deposited with harmful object, in nasal cavity germ, virus without killing effect, to inflammation mucous membrane without
Repair.Cause the inflammation duration long, remission is slow.
Nose is washed using lysozyme soln, this method exists through long-term clinical trials and practical application and is easy to induce allergy, right
The invalid disadvantage of allergic rhinitis (also known as allergic rhinitis), and lysozyme itself is easy inactivation, affects the treatment, is unfavorable for promoting
Using.
It researches and develops a kind of for nasal obstruction, rhinorrhea, nasal mucus band blood, nasal mucus refluence, nasal mucus peculiar smell, nose is bleeding, sneezing, nasal cavity
Incrustation, nasal cavity be dry to itch, foreign body sensation in the throat, abundant expectoration, expectoration, phlegm peculiar smell, blood-stained sputum, therapeutic effects are good, are not easy for laryngopharyngitis etc.
It induces allergy and there is the drug of good result to be highly desirable for allergic rhinitis.
Summary of the invention
It is fallen technical problem to be solved by the invention is to provide a kind of for nasal obstruction, rhinorrhea, nasal mucus band blood, nasal mucus
Stream, nasal mucus peculiar smell, nose is bleeding, sneezing, nasal cavity incrustation, nasal cavity be dry to itch, foreign body sensation in the throat, abundant expectoration, expectoration, phlegm peculiar smell, in phlegm
The medicine of nasal irrigation that is good with therapeutic effects such as blood, laryngopharyngitis, being not easy to induce allergy and have good result to allergic rhinitis
Compositions.
The pharmaceutical composition of nasal irrigation of the present invention is external curing common cold, stream using EGCG as main active
The various infection of the upper respiratory tracts such as row flu, rhinitis, nasosinusitis, pharyngitis, nasopharyngitis, laryngitis, tonsillitis.
The hazardous air pollutants of nasal cavity inflammation secretion, the absorption of nasal cavity mucus, cleaning can be diluted, cleaned using EGCG
Various bacterial viruses, antibacterial anti-inflammatory resist air pollution damage, repair mucous membrane health, treat nasal cavity and the various upper respiratory tracts are anxious
Nasal obstruction caused by chronic infection, have a running nose, nasal mucus band blood, nasal mucus refluences, nasal mucus peculiar smell, nose is bleeding, sneezing, nasal cavity are formed a scab,
Nasal cavity is dry to itch, foreign body sensation in the throat, abundant expectoration, expectoration, phlegm peculiar smell, blood-stained sputum, laryngopharyngitis etc..Physiology of the nose ring can faster be improved
Border, accelerates the recovery of nasal cavity own health, to achieve the purpose that the various nasal cavities for the treatment of and the infection of the upper respiratory tract.
In order to preferably realize above-mentioned therapeutic effect, the present invention is and to be aided with sodium chloride using EGCG as main active
The pharmaceutical composition of external application cleaning nasal cavity.
In the pharmaceutical composition of nasal irrigation of the present invention, sodium chloride, EGCG are matched according to following weight and are mixed: sodium chloride 45
~180 parts, EGCG1~20 part.
Further preferably, sodium chloride, EGCG are matched according to following weight and are mixed: 45~90 parts of sodium chloride, EGCG1~4 part.
Or still more preferably, sodium chloride, EGCG are matched according to following weight and are mixed: 60~90 parts of sodium chloride, EGCG1~
4 parts.
It is summarized by long-term experiment application, pharmaceutical composition sodium chloride of the present invention, EGCG are matched according to following weight and mixed:
90 parts of sodium chloride, EGCG2.7 parts.The pharmaceutical composition curative effect of its consumption proportion relationship composition is more stable, controllable.
For the ease of application, pharmaceutically acceptable auxiliary material can be added and be made outside common on the basis of sodium chloride, EGCG
Use preparation.Such as: pulvis, lotion, concentrate, spray, drops, solution, gelling agent, emulsion agent or cream.
For the application characteristic of drug of the present invention, the preparation method of aforementioned pharmaceutical compositions is additionally provided, using such as lower section
Method preparation:
Method one: sodium chloride, EGCG are mixed according to the weight ratio to get pulvis.
Method two: sodium chloride, EGCG are mixed according to the weight ratio, and adding water to be configured to sodium chloride concentration is 0.5%~3%
Solution to get lotion.
Method three: sodium chloride, EGCG are mixed according to the weight ratio, add water be configured to sodium chloride concentration be 3.1%~
90% solution is to get concentrate.
Method four: sodium chloride, EGCG are mixed according to the weight ratio, and adding water to be configured to sodium chloride concentration is 0.5%~3%
Spray solution.
Method five: sodium chloride, EGCG are mixed according to the weight ratio, and adding water to be configured to sodium chloride concentration is 0.5%~3%
Drops, solution.
Method six: sodium chloride, EGCG are mixed according to the weight ratio, and semisolid is made in the auxiliary material that addition is capable of forming gel
Gel preparation.
Method seven: sodium chloride, EGCG are mixed according to the weight ratio, and latex is made in the auxiliary material that addition can form emulsion type
Agent.
Method eight: sodium chloride, EGCG are mixed according to the weight ratio, and the matrix pharmaceutically received is added, is uniformly mixed into
Semi-solid cream agent.
The present invention also provides the pharmaceutical compositions of above-mentioned nasal irrigation in the drug of the preparation treatment infection of the upper respiratory tract
Purposes.
Further, the infection of the upper respiratory tract includes common cold, influenza, rhinitis, nasosinusitis, pharyngitis, nasopharynx
Inflammation, laryngitis, tonsillitis.
Further, the upper respiratory tract infection symptoms are different including nasal obstruction, rhinorrhea, nasal mucus band blood, nasal mucus refluence, nasal mucus
Taste, nose is bleeding, sneezing, nasal cavity incrustation, nasal cavity it is dry itch, foreign body sensation in the throat, abundant expectoration, expectoration, phlegm peculiar smell, blood-stained sputum, throat
Inflammation.
To sum up, various upper respiratory tract senses can be treated or improved for nasal irrigation using pharmaceutical composition provided by the invention
Dye, the nasal obstruction as caused by common cold, influenza, rhinitis, nasosinusitis, pharyngitis, nasopharyngitis, laryngitis, tonsillitis etc. flow nose
Tears, nasal mucus band blood, nasal mucus refluences, nasal mucus peculiar smell, nose is bleeding, sneezing, nasal cavity form a scab, nasal cavity it is dry itch, foreign body sensation in the throat, phlegm
More, expectoration, phlegm peculiar smell, blood-stained sputum, laryngopharyngitis etc..It can be diluted using pharmaceutical composition nasal irrigation of the present invention, clean nose
The hazardous air pollutants that chamber inflammation secretion, nasal cavity mucus adsorb, clean various bacterial viruses, antibacterial anti-inflammatory resists air
Pollution damage repairs mucous membrane health, improves physiology of the nose environment, accelerates nasal cavity self-recovery health.Nasal irrigation of the present invention
Pharmaceutical composition has a preferable therapeutic effect to allergic rhinitis, and long-time service is not likely to produce drug resistance, and without sensitization at
Point, be not easy to cause allergy, it is nonirritant, have clear effect, curative effect stablize, it is controllable the advantages that.
Specific embodiment
In the prior art, that there are cleaning effects is poor, remission is slow, easily induces allergy etc. lacks for the drug of nasal irrigation
It falls into.Inventor has found by Long-term clinical and practical application, using EGCG as main active, and is aided with sodium chloride external application cleaning
Nasal cavity can play the role of anti-inflammatory, antibacterial, reparation mucous membrane, can treat nasal cavity and various upper respiratory tract acute and chronic infections, such as feel
It emits, nasal obstruction caused by rhinitis, nasosinusitis, pharyngitis etc., rhinorrhea, nose is bleeding, nasal mucus band blood, nasal mucus are flow backwards, sneezing, nasal cavity knot
Scab, nasal cavity be dry to itch, foreign body sensation in the throat, abundant expectoration, expectoration, blood-stained sputum, abscess of throat etc., and is not easy to cause allergy, and curative effect is stablized.
It is currently, there are the oral drugs of the rhinitis of component for treating containing EGCG.It is most of but since EGCG molecular weight is big
EGCG, which is digested, to be decomposed, and the EGCG a part absorbed by oral administration is absorbed in enteron aisle, enters liver by vein, most
In intestinal mucosa or liver conjugation reaction occurs for EGCG, while also some is further methylated in liver.Existing literature report
Road[1]Only 0.1%~0.26% EGCG is absorbed into blood, and bioavailability is low.If EGCG in blood is enable to reach
Active drug concentration, it is necessary to increasing oral dose can just make EGCG play a role, still, while increasing oral EGCG dosage,
EGCG oral dose can be made considerably beyond safe dose, toxicity is brought to liver.If 50kg adult health volunteer oral 2~
Behind 5gEGCG1~2 hour, with 0.26% bioavailability calculate blood plasma in sequestered EGCG concentration for 1.3ug~
3.25ug/mL.Dong Xinling[2]It is disclosed in Shaanxi Tech Univ's journal when EGCG concentration is 50ug/mL, free radical is clear
Removing solid capacity is 40% or so, and when EGCG concentration is 200ug/ml, free radical scavenging ability is in 80% or so, therefore, very moment
When taking 2~5gEGCG, only extremely faint oxidation resistance is poor to the therapeutic effect of rhinitis.Existing literature discloses[3]It is small
Mouse oral dose is 500~1500mg/kg, and when the oral dose for being scaled adult is 30~90mg/kg, there are hepatotoxicity wind agitation, and
Toxicity increases with the raising of dosage.2~5gEGCG is taken orally once a day when adult, is calculated, is taken orally according to adult weight 50kg
Dosage is 40~100mg/kg, has had reached and has caused hepatotoxic concentration range.So the drug of the ingredient containing EGCG is not suitable for
Oral medication rhinitis.
Preparing nasal wash with EGCG ingredient and drug matching, there is not been reported, but with the direct nasal irrigation meeting of the drug
Lead to patient's spinosity excitation in use, and Chinese medicine taste is big, strong sense of discomfort is had during medication.
Inventor screens adjustment drug dose and administration mode in view of the foregoing drawbacks, by a large number of experiments, and chlorine is prepared
Change 45~180 parts of sodium, the pharmaceutical composition of the nasal irrigation of EGCG1~20 part, in the raw material range, inventor was being tested
It is found in journey, nasal membrane is very faint to the metabolism of EGCG, so the bioavailability to EGCG is high, using nasal-cavity administration side
Formula makes the effective component of drug directly act on therapeutic effect of the lesions position performance to nasal cavity inflammation, while avoiding oral
Bring hepatotoxic influence.And using comfortable, nonirritant.
In the pharmaceutical composition of nasal irrigation of the present invention, sodium chloride, EGCG are matched according to following weight and are mixed: sodium chloride 45
~180 parts, EGCG1~20 part.Preferably, 45~90 parts of sodium chloride, EGCG1~4 part.It is highly preferred that 60~90 parts of sodium chloride,
EGCG1~4 part.Most preferably, 90 parts of sodium chloride, EGCG2.7 parts.
Inventor adjusts the dosage of bulk pharmaceutical chemicals in clinical application in 1 year within the scope of above-mentioned weight proportion, can be clear
Wash nasal cavity inflammation secretion, nasal cavity mucus absorption hazardous air pollutants and cleaning bacterium, virus, treatment nasal obstruction, have a running nose,
Nasal mucus flows backwards, nasal mucus band blood, sneezing, nasal cavity incrustation, the dry various nasal cavities such as itch of nasal cavity are uncomfortable；And pass through nasal mucosal surface
Part washing lotion is transported to throat by fibre swing, is exhaled on treatment foreign body sensation in the throat, abundant expectoration, expectoration, blood-stained sputum, laryngopharyngitis etc.
Inhale road infection；Inflammation is mitigated to the damage of mucosa cells by antibacterial anti-inflammatory simultaneously and newborn mucosa cells is helped to keep strong
Health plays reparation mucous membrane, accelerates nasal cavity self-recovery health, alleviates because of the various acute and chronics such as flu, rhinitis, nasosinusitis, pharyngitis
Nasal obstruction caused by the infection of the upper respiratory tract is had a running nose, nasal mucus band blood, nasal mucus refluence, nasal mucus peculiar smell, nose is bleeding, sneezing, nasal cavity knot
Scab, nasal cavity be dry to itch, foreign body sensation in the throat, abundant expectoration, expectoration, phlegm peculiar smell, blood-stained sputum, laryngopharyngitis etc. and shortens disease time.
For the ease of application, external preparation can conventionally be made on the basis of sodium chloride, EGCG；Or it is added
Common external preparation is made in pharmaceutically acceptable auxiliary material.Such as: pulvis, concentrate, spray, drops, solution, coagulates at lotion
Jelly, emulsion agent or cream.
The present invention also provides the preparation methods of the pharmaceutical composition of above-mentioned nasal irrigation, prepare with the following method:
Method one: sodium chloride, EGCG are mixed according to the weight ratio to get pulvis.When clinical use, according to regulation dosage
Solubilizer is configured to nasal wash.
Method two: sodium chloride, EGCG are mixed according to the weight ratio, and adding water to be configured to sodium chloride concentration is 0.5%~3%
Solution to get lotion.When clinical use, it is directly used in nasal douche.
Method three: sodium chloride, EGCG are mixed according to the weight ratio, add water be configured to sodium chloride concentration be 3.1%~
90% solution is to get concentrate.When clinical use, being configured to sodium chloride concentration according to regulation concentration solubilization liquid is 0.5~3%
Nasal wash.
Method four: sodium chloride, EGCG are mixed according to the weight ratio, and adding water to be configured to sodium chloride concentration is 0.5%~3%
Spray solution.When clinical use, by the pressure of manual pump, high pressure gas, ultrasonic vibration or other methods by solution with
Sprayable sprays into nasal cavity.
Method five: sodium chloride, EGCG are mixed according to the weight ratio, and adding water to be configured to sodium chloride concentration is 0.5%~3%
Drops, solution.When clinical use, solution is instilled nasal cavity or nasal irrigation by cooperation dropper, drop bottle or other devices.
Method six: sodium chloride, EGCG are mixed according to the weight ratio, and semisolid is made in the auxiliary material that addition is capable of forming gel
Gel preparation.It is directly spread in nasal cavity when clinical use.
Method seven: sodium chloride, EGCG are mixed according to the weight ratio, and latex is made in the auxiliary material that addition can form emulsion type
Agent.It is directly spread in nasal cavity when clinical use.
Method eight: sodium chloride, EGCG are mixed according to the weight ratio, and the matrix pharmaceutically received is added, is uniformly mixed into
Semi-solid cream agent.It is directly spread in nasal cavity when clinical use.
Treatment nasal cavity may be implemented in the above-mentioned dosage form being prepared using above-mentioned preparation method and the various upper respiratory tracts are anxious
Nasal obstruction caused by chronic infection, have a running nose, nasal mucus band blood, nasal mucus refluences, nasal mucus peculiar smell, nose is bleeding, sneezing, nasal cavity are formed a scab,
Nasal cavity is dry to itch, foreign body sensation in the throat, abundant expectoration, expectoration, phlegm peculiar smell, blood-stained sputum, laryngopharyngitis etc..For the convenience of practical application
With the simplicity of preparation, pulvis mostly is made in pharmaceutical composition of the present invention and is used.
The present invention also provides the pharmaceutical compositions of the nasal irrigation in the drug of the preparation treatment infection of the upper respiratory tract
Purposes.
Further, the infection of the upper respiratory tract includes common cold, influenza, rhinitis, nasosinusitis, pharyngitis, nasopharynx
Inflammation, laryngitis, tonsillitis.
Further, the upper respiratory tract infection symptoms are different including nasal obstruction, rhinorrhea, nasal mucus band blood, nasal mucus refluence, nasal mucus
Taste, nose is bleeding, sneezing, nasal cavity incrustation, nasal cavity it is dry itch, foreign body sensation in the throat, abundant expectoration, expectoration, phlegm peculiar smell, blood-stained sputum, throat
Inflammation.
In the compositions of the present invention, raw material EGCG and NaCl proportion relation are calculated with EGCG and NaCl purity with 100%
It obtains, when EGCG or/and NaCl purity used is not 100%, is then added after being scaled 100%, so to original
Expect the no requirement (NR) of EGCG, NaCl purity, if purity met for 100%EGCG and NaCl it is above-mentioned to proportionate relationship.
The pharmacological effect of nasal cavity irrigants of the present invention is tested
Nasal douche or spraying, collunarium, the topical application of drug etc. are carried out after pharmaceutical composition preparation of the present invention, by 45 parts of sodium chloride,
EGCG20 parts, NaCl is that the solution bronchia mucosal of 3% concentration absorbs 5mL calculating, every time using highest bronchia mucosal to EGCG's
Uptake is no more than 66.67mg.Wherein the dosages such as drops, spray, topical application of drug are no more than 3mL, and uptake is no more than 40mg.Adult,
Children are used with same dosage, are once in the morning and once at night used, daily uptake not more than 133.34mg, at
People, children have the advantages that have no toxic side effect, without allergic reaction.
(1) sodium chloride: the clinical research of EGCG nasal cavity irrigants
In following experiment, nasal cavity irrigants of the present invention be according to the weight ratio 90 parts of sodium chloride, EGCG2.7 parts be configured to
The nasal cavity irrigants of normal concentration use, and dosage is that the EGCG0.0862g that sodium chloride 2.815g adds mass fraction to be 98% converts 300
Milliliter water, uses after shaking up.
Curative effect comparision is carried out with normal saline flushing nasal cavity, lysozyme irrigation nasal irrigation, clinical study results summarize
It is shown in Table 1.
1 sodium chloride of table: EGCG nasal cavity irrigants and physiological saline and lysozyme nasal cavity irrigants nasal irrigation effect
As shown in Table 1, in common nasal cavity and upper respiratory tract infection symptoms, normal saline flushing nasal cavity and sodium chloride:
Lysozyme washing lotion nasal irrigation, sodium chloride: the total effective rate of EGCG washing lotion nasal irrigation is above 95%.But in observing time
Interior, use sodium chloride: EGCG washing lotion corresponds to the ratio highest of symptom disappearance, in symptom mitigation crowd, sodium chloride: EGCG washing lotion
To remission degree and speed also highest.Wherein, sodium chloride: right there are 3 in the clinical trial of lysozyme nasal cavity irrigants
Lysozyme allergy.Sodium chloride: without allergy case in the clinical trial of EGCG nasal cavity irrigants and normal saline flushing.
Above-mentioned experiment symptom without in improvement crowd, have a stuffy nose class crowd, using normal saline flushing symptom without improvement 8
In people, 3 people are that concha is loose, and 1 people is deviation of nasal septum, and 2 people are nasal polyp, and 2 people have long term vascular shrinkage drug medication history,
There are Drug nasal obstructions；Using sodium chloride: in 3 people of the lysozyme nasal cavity irrigants symptom without improvement, 1 people is allergia nose
Inflammation, 1 people have long term vascular shrinkage drug medication history, and there are Drug nasal obstruction, 1 people is lysozyme allergy, stop experiment；It uses
Sodium chloride: 1 people of the EGCG nasal cavity irrigants symptom without improvement is three-level nasal polyp, and nasal polyp has extended to above concha nasalis inferior, breath
Meat blocks nasal meatus, needs operative treatment.
In sneezing class crowd, using normal saline flushing symptom without in 3 improved people, 2 people are allergic rhinitis, 1
Artificial nasal polyp；Using lysozyme nasal cavity irrigants symptom without in 2 improved people, 1 people is allergic rhinitis, and 1 people is lysozyme
Allergy stops experiment；Use sodium chloride: EGCG nasal cavity irrigants symptom of sneezing in experiment periods disappears substantially, and only 1 people is because of dirt
Mite allergy causes to sneeze, and is still relieved to sneezing symptom, and the frequency and number sneezed after contact allergy is former are equal
There is decline.
In expectoration class crowd, using normal saline flushing symptom without in 2 improved people, 1 people is both sides severe nasal blockage, punching
It washes and makes slow progress, 1 people is that cough and asthma band caused by bronchial infection is spat；Using lysozyme nasal cavity irrigants symptom without improvement 1
Artificial lysozyme allergy, stops experiment；Use sodium chloride: EGCG nasal cavity irrigants in experiment periods 66.25% patient symptom
It disappears, 33.75% patient symptom is substantially reduced.
Conclusion: that there are remissions when using normal saline flushing nasal cavity therapy is slow, nasal obstruction when using it is difficult the problems such as；
Using sodium chloride: when lysozyme nasal cavity irrigants are treated, remission is very fast, nasal obstruction when it is lower using difficulty, but exist
Patient of hypersensitivity and to the allergic rhinitis such as dust mite allergy without alleviate the problem of；Using sodium chloride: EGCG nasal cavity irrigants are controlled
When treatment, no allergy case, nasal obstruction is easy to wash logical and different to nasal obstruction, rhinorrhea, nasal mucus refluence, sneezing, nasal cavity incrustation, throat
The remissions such as object sense, expectoration faster, therapeutic effect it is more preferable.
(2) curative effect of EGCG nasal cavity irrigants and recurrence summary
Inventor is applied to clinical treatment nasal obstruction, rhinorrhea, nasal mucus band blood, nasal mucus using pharmaceutical composition of the present invention and falls
Stream, nasal mucus peculiar smell, nose is bleeding, sneezing, nasal cavity incrustation, nasal cavity be dry to itch, foreign body sensation in the throat, abundant expectoration, expectoration, phlegm peculiar smell, in phlegm
The various nasal cavities of band blood, laryngopharyngitis etc. and the infection of the upper respiratory tract, treat more than 670 people in 1 year.This pharmaceutical composition and bacteriolyze
Enzyme nasal cavity irrigants, normal saline flushing nasal cavity are compared, have work faster, alleviate that degree is higher, therapeutic effect is preferably excellent
Point.By clinical observation, this medicament works and healing time is different according to the weight and medication history of symptom.
Wherein for nasal obstruction symptom, alternately nasal obstruction had clear improvement at 3 days or so, and 5 days or so nasal obstructions are basic to disappear；Both sides
It has a stuffy nose and had clear improvement with thick secretions at 7 days or so, nasal obstruction disappears within 15 days or so；Due to decongestant is used for a long time
Caused rhinitis medicamentosa both sides nasal obstruction had clear improvement at 10 days or so, and 15 days or so daytimes are substantially without nasal obstruction.Nasal obstruction is cured
Afterwards, it is discontinued and has no rebound.If but because of acute upper respiratory infections such as flu, influenzas nasal obstruction can be caused again, but relative to application
Symptoms are mild, is easier to treat before the treatment of EGCG nasal cavity irrigants.
For symptom snotty, if nasal mucus is thick, and without nasal obstruction symptom, then nose can be observed on the day of use
Tears significantly reduce, and 3~5 days yellow-white nasal mucus switch to the gluey nasal mucus of a small amount of light color；If nasal mucus is green viscous shape, amount is more and causes
Nasal obstruction, nasal mucus significantly reduces within 3 days or so, switchs within 10 days or so the gluey nasal mucus of a small amount of light color.Most of patients was tied in 15 day observation period
Shu Qianyi no longer has a running nose, and wettability is moderate in nasal cavity, and there is no the discomforts such as dry, pain.If because of the acute upper breathing such as flu, influenza
Road infection can induce rhinorrhea symptom again, but before the opposite treatment using EGCG nasal cavity irrigants, rhinorrhea amount is reduced, nasal mucus is viscous
Consistency reduces, and treatment difficulty accordingly reduces.
For the symptom that nasal mucus is flow backwards, foreign body sensation in the throat caused by slight nasal mucus is flow backwards is applying EGCG nasal cavity irrigants 1
Amount reduction snotty is obvious in it, and symptom was completely disappeared at 5 days or so；Flowing backwards nasal mucus is yellow or yellow green, green
It when thick secretions, significantly reduces in 3 days or so refluence nasal mucus, viscosity reduces, lighter；7 days or so the nasal mucus flow backwards
Compared with reducing 70% or so before treatment, and switch to light gluey secretion, the symptoms such as have sore throat, do disappear substantially；Most of patients
It is flow backwards without nasal mucus before 10 day observation period terminated.After the symptom that nasal mucus is flow backwards is cured, without the acute upper breathing such as flu, influenza
Road infection influences to recur, and the nasal mucus after the acute upper respiratory infections such as flu, influenza is flow backwards to be rushed compared to using EGCG nasal cavity
The nasal mucus amount flow backwards before lotion for treatment is few and dilute, and treatment difficulty is low.
For the symptom of sneezing, sneezes and controlled with a small amount of gluey nasal mucus patient using EGCG nasal cavity irrigants sooner or later
After treatment, the visible alleviation of sneeze in 1 day, 3 days or so sneezes and nasal mucus disappear substantially, no relapse after deactivating；Sneezing is with yellow
After application EGCG nasal cavity irrigants treatment in 3 days, sneeze is significantly reduced by color, yellow green, green viscous shape nasal mucus patient, and 10 days
Frequently sneezing is reduced to one or two of sneeze once in a while to left and right sneeze from script morning, when blowing a cold wind over, sucking secondhand smoke.It was seen at 15 days
After examining the phase, most of patient's sneezing symptom disappears.Only 1 dust mite allergy patient due to still contact allergy it is former, observing
There are still sneezing symptoms at the end of phase, but compared with using before the treatment of EGCG nasal cavity irrigants, and sneezing frequency continuously plays spray
Number is sneezed to be substantially reduced.EGCG nasal cavity irrigants are apparently higher than sneezing alleviation degree caused by dust mite allergy rhinitis
Alleviation degree of the lysozyme nasal cavity irrigants to dust mite allergy rhinitis.It is treated through EGCG nasal cavity irrigants and sneezes and cure
Afterwards, in the case where not occurring the acute upper respiratory infections such as flu, influenza, air pollutants inducing, sneezing symptom is had no
Recurrence.
It is less when forming a scab for the symptom of nasal cavity incrustation, and when adjoint gluey transparent secretion, using EGCG nasal douche
Agent is treated to form a scab in 1 day and be significantly reduced, and without incrustation in 3 days or so nasal cavities, only a small amount of secretion, 5 days or so nasal cavities are formed a scab and divided
Secretion disappears.When incrustation is thicker and with yellow, yellow green or grass green thick secretions, controlled using EGCG nasal cavity irrigants
It treats incrustation in 3 days or so to significantly reduce, be significantly reduced with secretion, viscosity reduces.Most of patients terminated in 7 day observation period
When without nasal cavity form a scab.The nasal cavity incrustation patient cured in experiment periods, lures without acute upper respiratory infections such as flu, influenzas
Hair, drug withdrawal have no rebound, and mucous membrane secretion is normal in nasal cavity, and wettability is moderate, disappear simultaneously with the dry sensation that nasal cavity incrustation occurs
It loses.
It is answered for the symptom of foreign body sensation in the throat when foreign body sensation in the throat is with gluey or white, light yellow gum secretion
It is significantly reduced with 1 day endocrine of EGCG nasal cavity irrigants；Foreign body sensation disappears within 3 days or so, and foreign body sensation is brighter when only get up in the morning
It is aobvious；Foreign body sensation completely disappears within 5 days or so.When foreign body sensation in the throat is with yellow, yellow green, grass green are sticky or glutinous purulence secretion
When, it is significantly reduced using EGCG nasal cavity irrigants 3 days or so foreign body sensations, 5 days or so throat secretion is further reduced and bright
It is aobvious to weaken.To 7 day observation period, most of patients foreign body sensation in the throat disappeared, partially with the foreign body sensation of glutinous purulence secretion
Patient symptom mitigates significantly, and foreign body sensation time of occurrence postpones after rinsing using EGCG nasal cavity irrigants, and throat comfort level increases.It is real
The foreign body sensation in the throat patient cured in the phase is tested, in the case where inducing without the upper respiratory tracts acute infection such as flu, influenza, has no multiple
Hair.The patient recurred after acute infection induces, symptom is lighter before applying EGCG nasal cavity irrigants to treat relatively, is easier to treat.
It is rushed when phlegm is clear gum, white foam or thick white shape using EGCG nasal cavity for the symptom of expectoration
Visible amount of expectoration, number of spitting significantly reduce in lotion 1 day, cough frequency reduces；Throat phlegm disappears within 5 days or so, cough symptom
It disappears.When phlegm is yellow, yellow green, grass green are thick, significantly reduced using EGCG nasal cavity irrigants 3 days or so phlegm, cough
Frequency of coughing reduces；5 days or so phlegm colors obviously shoal, viscosity reduces, and amount of expectoration is further reduced, and cough symptom further subtracts
Gently；70% or so are reduced before amount of expectoration is relatively treated within 7 days or so, and switchs to light jelly, cough symptom is substantially reduced, throat is swollen
Bitterly, the uncomfortable basic disappearance such as dry.Amount of expectoration is further reduced within 10~15 days, and viscosity further decreases, color switch to it is translucent or
Clear gum object, accidental cough.To 15 days experiment periods, completely disappeared more than half expectoration patient symptom.In experiment periods
The expectoration patient of healing, no relapse in the case where being induced without the upper respiratory tracts acute infection such as flu, influenza.It is multiple after inducing
The patient of hair, symptom is opposite to apply EGCG nasal cavity irrigants to treat preceding cough frequency, frequency of spitting reduction, and amount of expectoration is reduced, phlegm is viscous
Consistency reduces, and is easier to treat.
(3) typical case analysis
In following case, in nasal cavity irrigants of the present invention, the weight proportion of bulk pharmaceutical chemicals are as follows: sodium chloride 2.815g,
EGCG0.085g is configured to the solution of 300mL.
Case 1: patient Chen, female, 42 years old.There is yellow, viscous nasal mucus for a long time, flows backwards symptom with apparent nasal mucus, hand over
For nasal obstruction, cough frequently, spits yellow, viscous phlegm for a long time, nasal mucus when get up in the morning, cough, situation of spitting is particularly acute.For a long time
Take rhinitis tablet, antibiotic treatment.
Using sodium chloride: treatment condition and analysis after EGCG nasal cavity irrigants
Observation duration: 15 days
Treatment condition:
Patient applies sodium chloride: EGCG nasal cavity irrigants were treated in 1 day, and yellow, viscous nasal mucus starts to reduce, refluence
Nasal mucus and the amount of expectoration to spue through throat, number of spitting are reduced therewith；Having a stuffy nose, it is logical to wash, and ten minutes left sides are able to maintain after washing
It is right unobstructed.
Applying sodium chloride: after EGCG nasal cavity irrigants 3 days, nasal mucus, the nasal mucus of refluence, amount of expectoration are further reduced, and see
The color for observing secretion starts to shoal, and viscosity starts to reduce；It washes logical rear nose and is able to maintain 4 hours or so unobstructed, cough frequencies
Rate reduces.
Applying sodium chloride: after EGCG nasal cavity irrigants 5 days, nasal mucus, the nasal mucus of refluence, phlegm are further reduced, viscosity
It further decreases, nasal mucus color is opposite to switch to light yellow gum, and the nasal mucus of refluence, phlegm color are relatively slightly deep, between yellow and shallowly
Between yellow, cough frequency and severity further mitigate；Nasal obstruction washes logical rear daytime substantially without nasal obstruction, and side is slept during sleep at night
Lower section nasal obstruction.
Applying sodium chloride: after EGCG nasal cavity irrigants 7 days, nasal mucus switchs to light yellow gum, phlegm switchs to light yellow gum,
Nasal mucus and amount of expectoration greatly reduce, and cough and further mitigate, nasal obstruction wash it is logical after daytime substantially without nasal obstruction, degree of nasal congestion during sleep at night
Mitigate.
Applying sodium chloride: EGCG nasal cavity irrigants 15 days, nasal mucus disappeared, and nasal mucus flows backwards sense and disappears, and phlegm switchs to minute quantity
Clear gum secretion, throat remain a small amount of foreign body sensation, can be alleviated by clearing one's throat；Cough symptom disappears, and sleeps at night daytime
Without nasal obstruction.
Treatment condition analysis:
The patient is that common rhinitis chronic causes rhinorrhea, nasal mucus to flow backwards, refluence nasal mucus stimulation throat causes cough,
Rhinorrhea forms the case where phlegm.Nasal mucus, the nasal mucus of refluence and phlegm are that the rheuminess object of chronic inflammation mucous membrane in nasal cavity closes
And bacterium, virus, fungi, particulate in air, part aqueous chemicals and formed into.The mixture causes through nostril discharge
Symptom snotty；The swing of part mixing secretion via intranasal application mucous membrane surface cilium is transported to throat, due to the mixture
More sticky and amount is more, and transport process is perceived and forms nasal mucus refluence；Flow backward to the mixing secretion stimulation throat of throat
Mucous membrane causes to cough, and is coughed mixing secretion discharge then forming phlegm.Since secretion stops nasal meatus, nose more during sleep at night
At sinus, nasopharynx, when get up in the morning, the mixing secretion by an evening deposition concentrates discharge through nasal meatus, throat, stream when causing from morning
Nasal mucus, cough, symptom of spitting it is relatively serious.
Through applying sodium chloride: the solution of EGCG nasal cavity irrigants exchange is diluted, clearly the mixing secretion in nasal cavity
It washes, Rapid Cleaning, which is fallen, mixes secretion and inflammatory mediator therein, various bacterial viruses, particulate pollutant and part water in nasal cavity
Insoluble chemical pollutant reduces nasal cavity flora total amount and improves physiology of the nose environment；And it is mentioned using nasal cavity irrigants of the present invention
High mucous membrane restores efficiency, directly from affected part play the role of it is antibacterial, anti-inflammatory, repair mucous membrane, to directly reduce nose from affected part
The secretion of chamber inflammation secretion.Nasal mucus, nasal mucus refluence, phlegm etc. are reduced, thinning, nasal cavity and laryngopharyngitis with the rehabilitation of mucous membrane
Mitigate therewith and fades away.
After 15 days experiment periods, patient treats preceding yellow, viscous nasal mucus, nasal mucus flows backwards, alternately has a stuffy nose, cough, glues
The symptoms such as thick phlegm disappear, only in the remaining a small amount of foreign body sensation of throat, it is contemplated that 3~5 days foreign body sensation symptoms of re-treatment can disappear.
Case 2: patient Liu, male, 33 years old.Two sides nasal obstruction is with the sticky nasal mucus of yellow green, and nasal mucus band blood, nasal mucus is flow backwards and band
Blood, abscess of throat, cough frequently, the sticky phlegm of a large amount of yellow greens, blood-stained sputum, with paroxysmal headaches.It is diagnosed as on inspection chronic
Rhinitis organizes nasosinusitis entirely, and medical history nearly 20 years.Various antibiotic are largely taken, there is long term vascular contracting agent medication history.
Using sodium chloride: treatment condition and analysis after EGCG nasal cavity irrigants
Observation duration: 15 days
Treatment condition:
Patient apply sodium chloride: EGCG nasal cavity irrigants treat 3 days after, nasal cavity Neihuang County green viscous nasal mucus, refluence nose
Tears, phlegm, which are observed, to be significantly reduced, and the trace of blood starts to reduce in nasal mucus, phlegm.It coughs, frequency of spitting reduction, headache starts to alleviate.
Through applying sodium chloride: after EGCG nasal cavity irrigants 5 days, nasal mucus, phlegm switch to yellow colloidal, and the nasal mucus of refluence is further
It reduces, abscess of throat is substantially reduced, and the trace of blood significantly reduces in nasal mucus, phlegm, coughs, frequency of spitting further decreases, amount of expectoration is into one
Step is reduced, and headache relief is obvious, and nasal obstruction starts to mitigate.
Through applying sodium chloride: after EGCG nasal cavity irrigants 7 days, the nasal mucus of refluence relatively reduces 70% or so using preceding, nasal mucus
It flows backwards sense almost to disappear, phlegm switchs to light yellow gum, has a running nose and relatively reduces 90% or so using preceding.The trace of blood disappears in nasal mucus, phlegm,
Cough, frequency of spitting further decreases, amount of expectoration and viscosity further decrease, headache disappear, have a stuffy nose further mitigate.
Through applying sodium chloride: after EGCG nasal cavity irrigants 10 days, nasal mucus switchs to a small amount of light yellow gum nasal mucus, and nasal mucus is flow backwards
Sense disappears, but still has a small amount of light yellow gum secretion to be transported to throat by cilium and form phlegm, and disappearance of having sore throat from morning and is eaten
It coughs several times when meal, the cough of remaining time disappears.It is substantially unobstructed that nasal obstruction switchs to daytime both sides respiratory nasal, at night side during sleep
Nasal obstruction.
Applied sodium chloride: EGCG nasal cavity irrigants 15 days, rhinorrhea symptom disappeared, and daytime, the sense of throat phlegm disappeared substantially
It loses, only with a small amount of pharynx nasalis clear gum secretion when from morning.Cough symptom disappears substantially, at night two sides nose during sleep
Breathe substantially unobstructed, closing on morning side occurs and slightly have a stuffy nose.
Treatment condition analysis:
The patient is common rhinitis chronic with full group nasosinusitis, simultaneously because prolonged application vasoconstrictor and occur
The rhinitis medicamentosa symptom of multi-purpose reduction.The sticky nasal mucus of yellow green, the nasal mucus of refluence, phlegm are chronic inflammation mucous membrane in nasal cavity
Rheuminess object merges equal, virus, fungi, particulate pollutant and part aqueous chemical pollutant and is formed.Mixture warp
The glutinous purulence nasal mucus of formation is blown out in nostril, and the swing that part mixes secretion via intranasal application mucous membrane surface cilium is transported to throat and is formed
Phlegm；Since the mixing secretion is sticky and amount is more, transport process is perceived and forms nasal mucus refluence；Flow backward to the mixing of throat
Secretion stimulation throat mucous membrane causes abscess of throat, cough；It is coughed and mixing secretion discharge is then formed into phlegm；Simultaneously because long
The extensive inflammation of phase, causes bronchia mucosal blood vessel to be chronically at swelling state, and blood vessel easily rupturable bleeding in part forms nasal mucus band
Blood flows backwards nasal mucus band blood, blood-stained sputum；Nasal cavity and rhinosinusitis condition stimulation nerve cause to have a headache, headache suffer from cold, strenuous exercise,
Aggravate when overheat.Lead to the opposite exacerbation of symptom of having a stuffy nose since vasoconstrictor is used for a long time in patient.
Through applying sodium chloride: the solution of EGCG nasal cavity irrigants exchange is diluted, clearly the mixing secretion in nasal cavity
It washes, Rapid Cleaning, which is fallen, mixes secretion and inflammatory mediator therein, various bacterial viruses, particulate pollutant and part water in nasal cavity
Insoluble chemical pollutant reduces nasal cavity flora total amount and improves physiology of the nose environment；And it is mentioned using nasal cavity irrigants of the present invention
High mucous membrane restores efficiency, directly from affected part play the role of it is antibacterial, anti-inflammatory, repair mucous membrane.To directly reduce nose from affected part
The secretion of chamber inflammation secretion, nasal mucus, nasal mucus flow backwards it is thinning with the rehabilitation of mucous membrane, reduce to disappear, phlegm with mucous membrane health
It is multiple and thinning, reduce to basic and disappear, laryngopharyngitis mitigates and fades away therewith, mucosa hemorrhage with the mitigation of mucosal inflammation and
It disappears, gradually mitigates and disappear substantially because vasoconstrictor bring Drug is used for a long time and has a stuffy nose.
After 15 days experiment periods, the two sides nasal obstruction before patient's treatment is with the sticky nasal mucus of yellow green, nasal mucus refluence and band
Blood, the symptoms such as abscess of throat, cough, headache disappear, only with a small amount of pharynx nasalis clear gum secretion and from morning when from morning
Slight nasal obstruction.Foreign body sensation and nasal obstruction symptom can disappear from intended treatment 5 days or so mornings.
Case 3: patient paints certain, male, and 12 years old.It is on inspection the allergic rhinitis of dust mite allergy.Winter is almost asymptomatic, the summer
Season breaks out for a long time.It has a stuffy nose when breaking-out with more than a succession of ten a sneezes, a large amount of clear water sample nasal mucus, two sides.Long-term nose during breaking-out
Portion applies hormone spray, and oral antihistamines object alleviates symptom.Certain drug resistance is generated to common medicine.
Using sodium chloride: treatment condition and analysis after EGCG nasal cavity irrigants
Observation duration: 15 days
Treatment condition:
Patient applies sodium chloride: EGCG nasal cavity irrigants were treated in 1 day, and sneezing, rhinorrhea symptom, which are shown in, to be relieved,
Nasal obstruction symptom is shown in mitigation.
Patient applies sodium chloride: after EGCG nasal cavity irrigants are treated 3 days, sneezing, rhinorrhea symptom are further alleviated, nose
Plug symptom further mitigates.
Patient applies sodium chloride: after EGCG nasal cavity irrigants are treated 7 days, symptom of sneezing daytime reduces 70% before relatively treating
Left and right, sneezing symptom is still more concentrated when from morning.Clear water sample nasal mucus reduces 70% or so before relatively treating.It is daytime that nasal obstruction, which mitigates,
Two sides be able to maintain substantially it is unobstructed, the dusk time-division start occur alternately have a stuffy nose.
Patient applies sodium chloride: when EGCG nasal cavity irrigants are treated 15 days, sneezing to have reduced to accidental symptom daytime and beat
Sneeze, number of sneezing from morning are reduced within ten times, and clear water sample nasal mucus is further reduced.Daytime, nasal obstruction symptom completely disappeared,
There is alternately obstruction sense, no nasal obstruction in night respiratory nasal.
Since patient is still in the environment of Long Term Contact anaphylactogen, a small amount of sneezing, stream are expected after the observation period
The symptoms such as clear water sample nasal mucus, respiratory nasal obstruction will continue.But before treatment, remission degree is high, and patient is anti-
It presents.
Treatment condition analysis:
The patient is typical allergic rhinitis, and anaphylactogen is dust mite.Patient is after sucking anaphylactogen, due to immune system
Targets identification mistake and immune attack is started to the dust mite clast and dust mite excreta that enter respiratory tract with air and leads to nose
Inflammation breaking-out.Since patient lives Heilungkiang, spring autumn and winter room air is dry, is not suitable for the growth of dust mite, therefore spring autumn and winter three
Season, rhinitis hardly broke out.Summer air humidity, which increases, is suitble to dust mite growth, dust mite clast, dust mite excreta when temperature increases
It is easier to get into the air and be inhaled by a patient.Therefore patient's summer is in long-term paresthesia epilepsy.
Applied sodium chloride: EGCG nasal cavity irrigants carry out nasal douche according to the solution of regulation ratio exchange, in addition to right
Enter dust mite clast and dust mite excreta in nasal cavity with breathing to be rinsed, Rapid Cleaning is fallen to come into the allergy in nasal cavity
Original is alleviated except sneezing, also washes inflammation secretion and a large amount of inflammatory mediators therein and the secretion for reducing inflammatory mediator,
Directly anti-inflammatory, the reparation mucous membrane from affected part, alleviates the symptoms such as have a running nose, have a stuffy nose.Although patient is still in high concentration anaphylactogen environment
In, due to anaphylactogen and inflammatory mediator concentration in sustainable reduction nasal cavity during use, the higher general level of the health of mucous membrane is kept, from
And keep patient symptom substantially reduced, improve the quality of life of patient.
In comparative experiments, using sodium chloride: the patient of EGCG nasal cavity irrigants treatment nasal obstruction, alternately nasal obstruction is usually 3
~5 days or so nasal obstructions are basic to disappear, and clear yellow viscous nasal mucus usually switched to a small amount of clear gum nasal mucus at 5~7 days or so, and yellow is viscous
Thick phlegm usually switched to a small amount of clear gum phlegm at 5~7 days or so, and mucosa hemorrhage usually disappeared at 3~7 days.And it compares and uses chlorine
Change sodium: usually alternately nasal obstruction disappeared lysozyme nasal cavity irrigants patient substantially in 10~15 days or so nasal obstructions, clear yellow viscous nasal mucus
Usually switching to a small amount of clear gum nasal mucus at 7~12 days, clear yellow viscous phlegm usually switched to a small amount of clear gum phlegm at 7~12 days,
Mucosa hemorrhage usually disappeared at 3~15 days；Control uses the patient of normal saline flushing nasal cavity, and alternately nasal obstruction is usually 10~15
It is substantially reduced, and clear yellow viscous nasal mucus usually switched to light yellow gum at 15 days or so, and clear yellow viscous phlegm is usually at 15 days or so
Switch to light yellow gum, mucosa hemorrhage usually mitigates in 15 days or so symptoms, no healing.
To sum up, pharmaceutical composition of the present invention is observed through abundant clinical statistics, and what determination obtained after screening prescription has good
The nasal cavity irrigants of good effect.The acute and chronics infection of the upper respiratory tract effects such as its treatment rhinitis, nasosinusitis, flu, influenza are best, are
The acute and chronics infection of the upper respiratory tract such as clinical treatment rhinitis, nasosinusitis, pharyngitis, flu, influenza provides a kind of completely new selection.
Bibliography
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Akiko Takagaki；Fumio Nanjo；Akira Minami；Yoriyuki Nakamura.Blood–Brain Barrier
Permeability of Green Tea Catechin Metabolites and their Neuritogenic
Activity in Human Neuroblastoma SH-SY5Y Cells[J].Molecular Nutrition & Food
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[2] Dong Xinling .EGCG antioxidation in vitro performance and its Shaanxi influence [J] science and technology to casein emulsifiability are big
It learns journal .2018.36 (5): 58-62.
[3]Joshua D.Lambert；Mary J.Kennett；Shengmin Sang；Kenneth R.Reuhl；
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Epigallocatechin-3-Gallate in Mice[J].Food and Chemical
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Claims (10)
1. the pharmaceutical composition of nasal irrigation, it is characterised in that: sodium chloride, EGCG are matched according to following weight and mixed: sodium chloride
45~180 parts, EGCG1~20 part.
2. the pharmaceutical composition of nasal irrigation according to claim 1, it is characterised in that: sodium chloride, EGCG are according to following
Weight proportion mixing: 45~90 parts of sodium chloride, EGCG1~4 part.
3. the pharmaceutical composition of nasal irrigation according to claim 2, it is characterised in that: sodium chloride, EGCG are according to following
Weight proportion mixing: 60~90 parts of sodium chloride, EGCG1~4 part.
4. the pharmaceutical composition of nasal irrigation according to claim 3, it is characterised in that: sodium chloride, EGCG are according to following
Weight proportion mixing: 90 parts of sodium chloride, EGCG2.7 parts.
5. the pharmaceutical composition of nasal irrigation according to any one of claims 1 to 4, it is characterised in that: sodium chloride,
On the basis of EGCG, pharmaceutically acceptable auxiliary material is added, common external preparation is made.
6. the pharmaceutical composition of nasal irrigation according to claim 5, it is characterised in that: the common external preparation is powder
Agent, lotion, concentrate, spray, drops, solution, gelling agent, emulsion agent or cream.
7. the preparation method of the pharmaceutical composition of the described in any item nasal irrigations of claim 1~6, it is characterised in that: use
Following method preparation:
Method one: sodium chloride, EGCG are mixed according to the weight ratio to get pulvis；
Method two: sodium chloride, EGCG are mixed according to the weight ratio, add water be configured to sodium chloride concentration be 0.5%~3% it is molten
Liquid is to get lotion；
Method three: sodium chloride, EGCG are mixed according to the weight ratio, and adding water to be configured to sodium chloride concentration is 3.1%~90%
Solution is to get concentrate；
Method four: sodium chloride, EGCG are mixed according to the weight ratio, and water is added to be configured to the spray that sodium chloride concentration is 0.5%~3%
Mist agent solution；
Method five: sodium chloride, EGCG are mixed according to the weight ratio, and water is added to be configured to the drop that sodium chloride concentration is 0.5%~3%
Agent, solution；
Method six: sodium chloride, EGCG are mixed according to the weight ratio, and semi-solid gel is made in the auxiliary material that addition is capable of forming gel
Preparation；
Method seven: sodium chloride, EGCG are mixed according to the weight ratio, and emulsion agent is made in the auxiliary material that addition can form emulsion type；
Method eight: sodium chloride, EGCG are mixed according to the weight ratio, and the matrix pharmaceutically received is added, and it is solid to be uniformly mixed into half
Body cream.
8. the pharmaceutical composition of the described in any item nasal irrigations of claim 1~6 is in the medicine of the preparation treatment infection of the upper respiratory tract
Purposes in object.
9. purposes according to claim 8, it is characterised in that: the infection of the upper respiratory tract includes common cold, popular sense
It emits, rhinitis, nasosinusitis, pharyngitis, nasopharyngitis, laryngitis, tonsillitis.
10. purposes according to claim 8 or claim 9, it is characterised in that: the infection of the upper respiratory tract is nasal obstruction, has a running nose, nose
Tears band blood, nasal mucus refluences, nasal mucus peculiar smell, nose is bleeding, sneezing, nasal cavity form a scab, nasal cavity it is dry itch, foreign body sensation in the throat, abundant expectoration, cough
Phlegm, phlegm peculiar smell, blood-stained sputum, laryngopharyngitis.
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