CN111494520A - Medicine for treating rhinitis and preparation method and application thereof - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a medicine for treating rhinitis and a preparation method and application thereof. The medicine is prepared from magnolia flower, grassleaf sweelflag rhizome, asarum, siberian cocklebur fruit, dahurian angelica root and centipeda minima serving as raw materials by a specific method. Compared with the existing medicines, the medicine has the advantages of definite curative effect, convenience in administration, safety in use, slight adverse reaction and the like, can remarkably relieve various clinical symptoms of rhinitis, and can effectively prevent repeated attack of the rhinitis, so that the medicine is popular with a large number of rhinitis patients.

Description

Medicine for treating rhinitis and preparation method and application thereof

Technical Field

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a medicine for treating rhinitis and a preparation method and application thereof.

Background

Rhinitis, an inflammatory disease of the nasal cavity, is an inflammation of the mucous membrane of the nasal cavity caused by viruses, bacteria, allergens (such as pollen, dust mites, etc.), various physicochemical factors (such as irritant gases), and certain systemic diseases. Rhinitis is of various types, most commonly allergic rhinitis.

The pathological changes of rhinitis include nasal mucosa congestion, swelling, exudation, hyperplasia, atrophy or necrosis, and the clinical symptoms mainly include nasal obstruction, nasal discharge, hyposmia, headache, dizziness, easy fatigue, hypomnesis, insomnia and the like, and the normal work and life of a patient are seriously influenced.

Because the cause of rhinitis is complex, the rhinitis not only comprises rhinovirus, parainfluenza virus, adenovirus, coronavirus, coxsackie virus, mucus, paramyxovirus and other types of virus infection, but also can be influenced by factors such as family inheritance, individual nasal mucosa susceptibility of patients, drug allergy history and the like, and can be caused by allergen substances such as pollen, fungi, dust mites, animal dander, dust, fish and shrimp, meat and eggs, milk, fruits and the like, thereby causing great difficulty for the treatment of the rhinitis.

At present, except for the treatment of the factors, more clinical treatment methods aiming at the rhinitis adopt local drug therapy, and mainly use glucocorticoids, antihistamines, anticholinergics, decongestants such as oxymetazoline hydrochloride, ephedrine, and collunarium, etc. to remove inflammation in nasal cavities, relieve congestion of mucous membranes and relieve clinical symptoms. However, the frequent use of the above drugs can cause a plurality of serious adverse reactions, such as damage to nasal mucociliary structures, drug-induced rhinitis, pharyngitis and bronchial asthma, drug resistance or drug dependence, and the like, and the main efficacy of the existing drugs is to relieve the clinical symptoms of rhinitis and have no obvious curative effect on repeated attack of rhinitis. Therefore, a new medicament which is safe, effective, has slight adverse reaction and can effectively prevent repeated rhinitis attack is urgently needed in clinical practice.

Disclosure of Invention

In order to overcome the defects in the application process of the existing rhinitis treatment medicine, the invention provides a novel rhinitis treatment medicine.

The 'Su Wen' is recorded as follows: the mouth and nose are also the portals of qi. And (2) the following: the lung opens into the nose and stores essence in the lung. Therefore, nasal obstruction, mucus obstruction of turbid nose and other nasal inflammation problems, and chest distress, short breath, dizziness, and brain distention caused by the inflammation problems are all caused by turbid qi rising to flush and repel the head and brain. The inventor develops a novel rhinitis treatment traditional Chinese medicine by adopting a treatment idea of strengthening the clear and discharging the turbid and performing a large number of screening and trying on the basis of years of clinical practice according to the traditional Chinese medicine theory and referring to a large number of ancient prescriptions. The medicine aims at clearing and removing stasis and turbidity, so that clear qi ascends, the head is clear, and the medicine can nourish the strong and natural vital qi to enter the nose, ascend in the clear and descend in the turbid, thereby obtaining the treatment effects of smooth nose ventilation and clear head.

The invention relates to a medicine for treating rhinitis, which is prepared from the following raw materials in parts by weight:

10-15 parts of biond magnolia flower, 10-15 parts of grassleaf sweelflag rhizome,

10-15 parts of asarum, 10-15 parts of cocklebur fruit,

10-15 parts of angelica dahurica and 10-15 parts of centipeda minima.

Wherein:

and (3) magnolia flower: expelling wind and cold, promoting the flow of qi and blood circulation, and promoting the restoration of consciousness;

grassleaf sweelflag rhizome: resolving phlegm for resuscitation, eliminating dampness and promoting qi circulation;

asarum: expelling pathogenic wind, dispelling cold, promoting diuresis, and inducing resuscitation;

fructus xanthil: dispelling cold, relieving pain, and eliminating dampness;

radix angelicae: relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, stopping leukorrhagia, relieving swelling, and expelling pus;

centipeda minima: dispelling pathogenic wind and cold, relieving nasal obstruction, relieving cough, and removing toxic substance.

Preferably, the medicine is prepared from the following raw materials in parts by weight:

15 parts of biond magnolia flower, 15 parts of grassleaf sweelflag rhizome,

12 parts of asarum, 12 parts of cocklebur fruit,

15 parts of angelica dahurica and 12 parts of centipeda minima.

Preferably, the medicine is prepared from the following raw materials in parts by weight:

13 parts of biond magnolia flower, 12 parts of grassleaf sweelflag rhizome,

10 parts of asarum, 10 parts of cocklebur fruit,

13 parts of angelica dahurica and 10 parts of centipeda minima.

Further, the medicine is prepared by the following method:

(1) respectively rinsing flos Magnoliae, rhizoma Acori Graminei, herba asari, fructus Xanthii, radix Angelicae Dahuricae, and herba Centipedae with clear water, drying in the shade, mixing, pulverizing, and sieving with 100 mesh sieve to obtain mixed medicinal powder;

(2) adding 3-5 times of sesame oil into the mixed medicinal powder, soaking at room temperature for 15 days, decocting with slow fire until the medicinal liquid becomes golden yellow, and cooling to obtain the medicine.

In addition, the medicine is a nasal cavity external medicine. The medication method comprises the following steps: dipping a medicine with the length of 1 cm by a cotton swab, putting the medicine into a nasal cavity until the medicine can not enter the nasal cavity, then facing the patient to lie face down, and exhaling outwards continuously by a nose, wherein foreign matters flow out of nostrils, and symptoms such as sneezing, rhinorrhea or burning eyes can be accompanied in the process, when the foreign matters do not flow out any more in the nasal cavity, the cotton swab can be pulled out, and the nasal cavity is used once a day for 7-15 days.

Furthermore, the invention also relates to application of the medicine in preparing a medicine for treating rhinitis.

Compared with the existing rhinitis medicine, the medicine of the invention has the following advantages:

(1) the pure traditional Chinese medicine preparation has slight adverse reaction;

(2) the external medicine is convenient to administer and safe to use;

(3) the curative effect is exact, and various clinical symptoms of rhinitis can be remarkably relieved;

(4) can effectively prevent repeated rhinitis attacks.

Detailed Description

The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention.

Before the present embodiments are further described, it is to be understood that the scope of the invention is not limited to the particular embodiments described below; it is also to be understood that the terminology used in the examples is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In addition to the specific methods, devices, and materials used in the examples, any methods, devices, and materials similar or equivalent to those described in the examples may be used in the practice of the invention in addition to the specific methods, devices, and materials used in the examples, in keeping with the knowledge of one skilled in the art and with the description of the invention.

In the present invention, all reagents and raw materials are commercially available or commonly used in the art, unless otherwise specified. The methods in the following examples are conventional in the art unless otherwise specified.

Example 1

A medicine for treating rhinitis is prepared from the following raw materials in parts by weight:

15 parts of biond magnolia flower, 15 parts of grassleaf sweelflag rhizome,

12 parts of asarum, 12 parts of cocklebur fruit,

15 parts of angelica dahurica and 12 parts of centipeda minima.

The preparation method comprises the following steps:

(1) respectively rinsing flos Magnoliae, rhizoma Acori Graminei, herba asari, fructus Xanthii, radix Angelicae Dahuricae, and herba Centipedae with clear water, drying in the shade, mixing, pulverizing, and sieving with 100 mesh sieve to obtain mixed medicinal powder;

(2) adding sesame oil with the volume of 5 times of the obtained mixed medicinal powder, soaking at room temperature for 15 days, then decocting with slow fire until the medicinal liquid becomes golden yellow liquid, and cooling to obtain the medicament.

Example 2

A medicine for treating rhinitis is prepared from the following raw materials in parts by weight:

13 parts of biond magnolia flower, 12 parts of grassleaf sweelflag rhizome,

10 parts of asarum, 10 parts of cocklebur fruit,

13 parts of angelica dahurica and 10 parts of centipeda minima.

The preparation method comprises the following steps:

(1) respectively rinsing flos Magnoliae, rhizoma Acori Graminei, herba asari, fructus Xanthii, radix Angelicae Dahuricae, and herba Centipedae with clear water, drying in the shade, mixing, pulverizing, and sieving with 100 mesh sieve to obtain mixed medicinal powder;

(2) adding 3 times of sesame oil into the mixed medicinal powder, soaking at room temperature for 15 days, decocting with slow fire until the medicinal liquid becomes golden yellow, and cooling to obtain the medicine.

The treatment effect of the cases is as follows:

(1) patient name: liu (Liu xi);

identification card number: 42010619790219;

and (4) contacting the telephone: 1379703;

the medical history: in 2009, the patient got up, got in and out of air-conditioned rooms or heating rooms every day sneezes and gets nasal mucus, and the patient does not feel well asleep when the nose is blocked, and the nasal mucus does not flow off daily, and is more serious when the season changes. The Wuhan collaborates with rhinitis experts for a plurality of times, the Renokott, the budesonide nasal spray, the nasal Shu cold compress condensation and other medicaments are used, the symptoms are not changed, the rhinitis operation is carried out in 2016 under the advice of the experts, the symptoms such as sneezing and nasal discharge after operation are not changed, and the paper towel is still full of a paper basket to wipe the nasal discharge every day when the people go to work.

Treatment of the condition: after the rhinitis medicine is used, the nose, the throat and the eyes are spicy, sneezing and nasal discharge are continuous, the nasal discharge is slow and gentle after half an hour, a lot of sticky nasal discharge flows out, and the nose is ventilated when people sleep at night. The nasal mucus is continuously reused later, the reaction is not so strong for the first use, the nasal mucus flowing out is gradually reduced, and after the nasal mucus is continuously used for 5 days, the nose feels smooth, the nasal mucus does not flow much, and the sneeze does not feel too much.

The curative effect is as follows: after the nasal mask is used, the nose is ventilated, the nose is not blocked, sneezing is avoided, nasal discharge is avoided, the sleep is obviously good, and the rhinitis does not relapse.

(2) Patient name: standing;

identification card number: 12022219861212;

and (4) contacting the telephone: 1382016;

the medical history: in 2016, the nose will sneeze and get nasal mucus in spring and autumn, and the nose will be headache, stuffy nose and sleepless at night. After taking Biyankang, Biyan comfort tablet, chlorphenamine maleate and other anti-inflammatory drugs, the medicine has no obvious effect.

Treatment of the condition: in the beginning of this year, the rhinitis medicine of the invention is used for the first time, and the rhinitis medicine is continuously sneezed and rhinorrhea till night and sweats all over the body. The patient feels sneezing and has a much better nasal discharge when taking the medicine for the second time, but the head is still slightly uncomfortable, the nose is still slightly blocked, and after taking the medicine every day, the patient continuously takes the medicine for 7 days, the symptoms of sneezing and nasal discharge completely disappear, and the patient breathes very smoothly.

The curative effect is as follows: after the medicine is used, the nose is ventilated, the user can sleep at night, the feeling is very comfortable, and the rhinitis does not relapse after stopping the medicine.

(3) Patient name: wangmei;

identification card number: 12010620110416;

and (4) contacting the telephone: 1320765;

the medical history: rhinitis, from three years old to six or seven years old, sneezes and rubs the nose every morning for a long time.

Treatment of the condition: the first time, the child sneezes and flows the nasal mucus ceaselessly after putting the medicine into the nose, the sneezing and the nasal mucus stops gradually after five minutes, the medicine is taken out after ten minutes, the symptoms of kneading the nose and sneezing in the morning of the child every day after 3 days of continuous use are reduced greatly, and the child basically has no symptoms of sneezing and running the nasal mucus after insisting on the medicine for 7 days.

(4) Patient name: cao;

identification card number: 1102231978100;

and (4) contacting the telephone: 1361116;

the medical history: after the baby grows in 2013, the dry nose itching appears and is sensitive to hair, and the nasal discharge starts to flow as soon as the baby is cold and hot. The use of the ointment for treating the chronic gastritis and the chronic gastritis has no any effect.

Treatment of the condition: the medicine is used for the first time at the beginning of 4 months in 2020, the using effect is obvious, the nasal discharge and the tears flow together, the nose flows smoothly after the nasal discharge is finished, the second time of use is better than the first time, the tears do not flow, the nasal discharge is as much as the number of the nasal discharge, the nasal discharge hardly exists after the seventh time of use, and the breath is very smooth.

The curative effect is as follows: the phenomenon of dry nose and itching nose does not exist until the use, no nasal discharge occurs after the cold and the hot, and the breathing is always very smooth.

(5) Patient name: wangyongxi;

identification card number: 12011420030918;

and (4) contacting the telephone: 1500226;

the medical history: in 2015, sneezing is continuous every day, the nose is blocked and dizzy, normal breathing cannot be realized, particularly, the alternating cold and warm is serious, and a plurality of western medicines and sprays are used in the process, and medicines such as Miao Fang Shutan in Qiyuan Tang and the like are used, so that the effect is not achieved.

Treatment of the condition: after the rhinitis medicament is used, eyes are lacrimated a little, sneezes and nasal mucus are discharged a lot, and the eyes are good a little after more than twenty minutes, so that the rhinitis medicament is continuously used for 13 times, and the nose is not problematic in the daytime or at night and is smooth.

The curative effect is as follows: after the pillow is used up, the effect is very good, sneezing and rhinorrhea are avoided, and the pillow is very good in sleep. The rhinitis does not recur until the medicine is stopped.

(6) Patient name: high;

identification card number: 13102319870906;

and (4) contacting the telephone: 1852278;

the medical history: from the beginning of 2013, the patient sneezes a lot from the beginning of cold sneezing to the later of waking in the morning or in the middle of the night, the nasal obstruction is serious and the patient cannot sleep in the night, particularly in winter or air-conditioned rooms, the nasal mucosa is damaged due to sneezing in the long year, and the patient always bleeds! In the six and seven years, a plurality of western medicines are used, and the traditional Chinese medicine conditioning is drunk, so that the effect is not great basically.

Treatment of the condition: after the rhinitis medicine is used, eyes can tear, a plurality of toxins are discharged after sneezing, and after the rhinitis medicine is used for 10 days, the nose is very smooth and does not sneeze any more!

The curative effect is as follows: after the medicine is taken, the effect is remarkable, sneezing is not caused any more in the daytime or at night, the nose is very smooth, and the nasal cavity bleeding symptom completely disappears! Moreover, the symptoms are not relapsed after the withdrawal of the medicine.

(7) Patient name: plum blossom;

identification card number: 12022219650521;

and (4) contacting the telephone: 1392079;

the medical history: allergic rhinitis began to develop in early 2020, and sneezing and nasal obstruction continued. In the meantime, western medicines and spray are used, which are not good, and in severe cases, the patient feels dizzy and bloated, cannot work normally, and can only rest at home.

Treatment of the condition: after the rhinitis medicine is used, the effect is remarkable, sneezing and nasal obstruction symptoms completely disappear after the medicine is continuously used for 12 days, and the symptoms do not relapse after the medicine is stopped.

While the preferred embodiments and examples of the present invention have been described in detail, the present invention is not limited to the embodiments and examples, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.

Claims (6)

1. The medicine for treating rhinitis is characterized by being prepared from the following raw materials in parts by weight:

10-15 parts of biond magnolia flower, 10-15 parts of grassleaf sweelflag rhizome,

10-15 parts of asarum, 10-15 parts of cocklebur fruit,

10-15 parts of angelica dahurica and 10-15 parts of centipeda minima.

2. The medicament of claim 1, wherein the medicament is prepared from the following raw materials in parts by weight:

15 parts of biond magnolia flower, 15 parts of grassleaf sweelflag rhizome,

12 parts of asarum, 12 parts of cocklebur fruit,

15 parts of angelica dahurica and 12 parts of centipeda minima.

3. The medicament of claim 1, wherein the medicament is prepared from the following raw materials in parts by weight:

13 parts of biond magnolia flower, 12 parts of grassleaf sweelflag rhizome,

10 parts of asarum, 10 parts of cocklebur fruit,

13 parts of angelica dahurica and 10 parts of centipeda minima.

4. The medicament of claim 1, wherein the medicament is prepared by a method comprising:

(1) respectively rinsing flos Magnoliae, rhizoma Acori Graminei, herba asari, fructus Xanthii, radix Angelicae Dahuricae, and herba Centipedae with clear water, drying in the shade, mixing, pulverizing, and sieving with 100 mesh sieve to obtain mixed medicinal powder;

(2) adding 3-5 times of sesame oil into the mixed medicinal powder, soaking at room temperature for 15 days, decocting with slow fire until the medicinal liquid becomes golden yellow, and cooling to obtain the medicine.

5. A medicament as claimed in any one of claims 1 to 4, wherein said medicament is a medicament for nasal administration.

6. Use of a medicament as claimed in any one of claims 1 to 4 in the manufacture of a medicament for the treatment of rhinitis.