CN111569024B - Traditional Chinese medicine composition for treating cough, traditional Chinese medicine preparation and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating cough, traditional Chinese medicine preparation and preparation method thereof Download PDFInfo
- Publication number
- CN111569024B CN111569024B CN202010537189.3A CN202010537189A CN111569024B CN 111569024 B CN111569024 B CN 111569024B CN 202010537189 A CN202010537189 A CN 202010537189A CN 111569024 B CN111569024 B CN 111569024B
- Authority
- CN
- China
- Prior art keywords
- parts
- liquid medicine
- traditional chinese
- chinese medicine
- filtering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 175
- 206010011224 Cough Diseases 0.000 title claims abstract description 71
- 238000002360 preparation method Methods 0.000 title claims abstract description 46
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 241000931705 Cicada Species 0.000 claims abstract description 31
- 235000009008 Eriobotrya japonica Nutrition 0.000 claims abstract description 31
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 18
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 18
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 17
- 235000011477 liquorice Nutrition 0.000 claims abstract description 17
- 241001522129 Pinellia Species 0.000 claims abstract description 15
- 244000274050 Platycodon grandiflorum Species 0.000 claims abstract description 15
- 244000144725 Amygdalus communis Species 0.000 claims abstract description 14
- 235000011437 Amygdalus communis Nutrition 0.000 claims abstract description 14
- 241000218671 Ephedra Species 0.000 claims abstract description 14
- 241000951473 Schizonepeta Species 0.000 claims abstract description 14
- 235000020224 almond Nutrition 0.000 claims abstract description 14
- 241000596154 Belamcanda Species 0.000 claims abstract description 13
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims abstract description 13
- 235000008326 Trichosanthes anguina Nutrition 0.000 claims abstract description 13
- 244000078912 Trichosanthes cucumerina Species 0.000 claims abstract description 13
- 241000490229 Eucephalus Species 0.000 claims abstract description 12
- 239000006187 pill Substances 0.000 claims abstract description 8
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 239000008187 granular material Substances 0.000 claims abstract description 4
- 244000061508 Eriobotrya japonica Species 0.000 claims abstract 4
- 239000007788 liquid Substances 0.000 claims description 111
- 238000001914 filtration Methods 0.000 claims description 53
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 45
- 238000002156 mixing Methods 0.000 claims description 27
- 239000000463 material Substances 0.000 claims description 22
- 238000002791 soaking Methods 0.000 claims description 21
- 239000002671 adjuvant Substances 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 6
- 241000218989 Trichosanthes Species 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 5
- 229940079593 drug Drugs 0.000 abstract description 12
- 230000001717 pathogenic effect Effects 0.000 abstract description 8
- 235000019640 taste Nutrition 0.000 abstract description 4
- 235000019658 bitter taste Nutrition 0.000 abstract description 3
- 235000019633 pungent taste Nutrition 0.000 abstract description 2
- 239000003826 tablet Substances 0.000 abstract description 2
- 241001092070 Eriobotrya Species 0.000 description 27
- 210000004072 lung Anatomy 0.000 description 22
- 206010062717 Increased upper airway secretion Diseases 0.000 description 13
- 208000026435 phlegm Diseases 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 208000015181 infectious disease Diseases 0.000 description 6
- 208000011580 syndromic disease Diseases 0.000 description 6
- 230000006378 damage Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 210000003800 pharynx Anatomy 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 206010036790 Productive cough Diseases 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 241001180876 Saposhnikovia Species 0.000 description 3
- 244000273928 Zingiber officinale Species 0.000 description 3
- 235000006886 Zingiber officinale Nutrition 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 235000008397 ginger Nutrition 0.000 description 3
- 206010063659 Aversion Diseases 0.000 description 2
- 241000675108 Citrus tangerina Species 0.000 description 2
- 206010016326 Feeling cold Diseases 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 235000006751 Platycodon Nutrition 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000002555 auscultation Methods 0.000 description 2
- 208000013116 chronic cough Diseases 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 208000017574 dry cough Diseases 0.000 description 2
- 230000000210 effect on cough Effects 0.000 description 2
- 239000003973 paint Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 229930189914 platycodon Natural products 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 244000276331 Citrus maxima Species 0.000 description 1
- 235000001759 Citrus maxima Nutrition 0.000 description 1
- 101100136092 Drosophila melanogaster peng gene Proteins 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 241000212941 Glehnia Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 241000288140 Gruiformes Species 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- 208000004186 Pulmonary Heart Disease Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 206010040925 Skin striae Diseases 0.000 description 1
- 241001671204 Stemona Species 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003434 antitussive agent Substances 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 201000009267 bronchiectasis Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 239000000850 decongestant Substances 0.000 description 1
- 229940124581 decongestants Drugs 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 210000004224 pleura Anatomy 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 206010037833 rales Diseases 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Insects & Arthropods (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for treating cough, a traditional Chinese medicine preparation and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 20-50 parts of platycodon grandiflorum, 5-15 parts of liquorice, 5-15 parts of aster, 5-15 parts of schizonepeta, 5-20 parts of dried orange peel, 5-20 parts of radix stemonae, 10-30 parts of roasted loquat leaves, 5-15 parts of cicada slough, 10-30 parts of blackberrylily rhizome, 5-15 parts of ephedra, 5-15 parts of almond, 10-20 parts of snakegourd peel, 10-20 parts of pinellia ternate and 5-15 parts of radix glehniae. The traditional Chinese medicine preparation comprises pills, granules, tablets and capsules, and the traditional Chinese medicine composition can effectively solve the problems of bitter taste, cold and stomach-patrinia, yang-impairment, pungent taste, heat and yin-impairment, greasy taste and pathogenic factor astringing of the existing medicines.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating cough, a traditional Chinese medicine preparation and a preparation method thereof.
Background
Cough after infection is caused by inflammation, foreign body, physical or chemical stimulation to trachea, bronchial mucosa or pleura, common respiratory diseases all the year round and is frequently generated in weak elderly and teenagers. A small part of patients with mild cough can heal and relieve themselves without taking antitussives, but frequent and violent cough can influence learning, working or sleeping, aggravate pulmonary heart diseases such as emphysema, bronchiectasis, hypertension and coronary heart disease, even induce hemoptysis, heart failure, cerebral hemorrhage and the like, and can be chronic cough without healing, so that the harm is huge. Western medicines lack specific treatment on cough after infection at present, mainly take anti-infection and symptomatic treatment as main treatment, mainly treat cough-relieving medicines, antihistamine medicines, decongestants and the like, and use central cough-relieving medicines when necessary.
The traditional Chinese medicine considers that the cough belongs to the category of exogenous cough, exogenous pathogenic factors are identified to attack the lung and cause failure of qi and blood circulation to descend, and the common symptoms are cough with little phlegm or dry cough without phlegm, cough with discomfort and itching throat, chilliness or aversion to wind, nasal obstruction, thin and thin nasal discharge, red or reddish tongue, thin and white tongue coating, floating pulse and the like. The traditional Chinese medicine has unique insights on the treatment of exogenous cough, for example, in the Ming Dynasty Zhang Jingyue in Jingyue quan Shu, miscellaneous syndrome deserts and cough: cough due to external infection is always caused by cold in all four seasons. Cold in the cap enters the lung with qi, so it is pungent and warm in property for treating cough, and its pathogens are dispersed. "Qing Dynasty famous physicians Peng in" medical Xin Wu "also says: the lung is covered with metal, and the patient is afraid of fire, and the patient is cough due to overheating; the golden nature is strong and dry, and the cold is averse, and the cough is also caused by excessive cold. Moreover, the lung is delicate and the attacking agent is not attacked, but it is most susceptible to pathogen, and the pathogenic qi stays and is not released without dispersing the exterior. Although the traditional Chinese medicine has long history of cough treatment and obvious curative effect, the medicine for clinically treating cough after infection has the disadvantages of bitter and large cold, stomach and stomach deficiency and yang damage, or large pungent and large heat and yin damage, or greasy and astringing pathogenic factors, and can cause certain damage to the body.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a traditional Chinese medicine composition for treating cough, a traditional Chinese medicine preparation and a preparation method thereof, and the traditional Chinese medicine composition can effectively solve the problems of bitter taste, cold and stomach-fettering, yang-hurting, pungent taste, heat and yin-hurting, greasy taste and pathogenic factor astringing of the existing medicines.
In order to achieve the purpose, the technical scheme adopted by the invention for solving the technical problems is as follows:
a traditional Chinese medicine composition for treating cough comprises the following components in parts by weight: 20-50 parts of platycodon grandiflorum, 5-15 parts of liquorice, 5-15 parts of aster, 5-15 parts of schizonepeta, 5-20 parts of dried orange peel, 5-20 parts of radix stemonae, 10-30 parts of roasted loquat leaves, 5-15 parts of cicada slough, 10-30 parts of blackberrylily rhizome, 5-15 parts of ephedra, 5-15 parts of almond, 10-20 parts of snakegourd peel, 10-20 parts of pinellia ternate and 5-15 parts of radix glehniae.
Further, the paint comprises the following components in parts by weight: 25-35 parts of platycodon grandiflorum, 8-12 parts of liquorice, 8-12 parts of aster, 8-12 parts of schizonepeta, 10-15 parts of dried orange peel, 12-18 parts of radix stemonae, 15-25 parts of roasted loquat leaves, 8-12 parts of cicada slough, 15-25 parts of blackberrylily rhizome, 8-12 parts of ephedra, 8-12 parts of almond, 12-18 parts of trichosanthes peel, 12-18 parts of pinellia ternate and 8-12 parts of radix glehniae.
Further, the paint comprises the following components in parts by weight: 30 parts of platycodon grandiflorum, 10 parts of liquorice, 10 parts of aster, 10 parts of schizonepeta, 12 parts of dried orange peel, 15 parts of radix stemonae, 20 parts of roasted loquat leaves, 10 parts of periostracum cicada, 20 parts of blackberry lily, 10 parts of ephedra, 10 parts of almond, 15 parts of snakegourd peel, 15 parts of pinellia ternate and 10 parts of radix glehniae.
The beneficial effects produced by adopting the scheme are as follows: the platycodon root is bitter in taste and neutral in nature, enters lung meridian, and has the effects of dispersing lung qi and eliminating phlegm, and treating cough with excessive phlegm and chest distress. Schizonepeta, herba Schizonepetae is pungent and warm in property, and can dispel wind and relieve exterior syndrome to expel the remaining pathogenic factors on the exterior; the dried orange peel regulates qi to reduce phlegm, the liquorice coordinates the other drugs, and the drugs and the platycodon root have the effects of benefiting the pharynx and relieving cough;
radix Stemonae and radix Asteris both enter lung meridian, and they are warm in nature but not hot, moist but not greasy, and combined together to improve the action of relieving cough and resolving phlegm. The ephedra herb is bitter in taste and warm in nature, enters lung and bladder channels, is good at opening striae and sweating, dispelling wind-cold on the surface, ventilating the lung and relieving asthma, and opening and closing depressed lung qi; the apricot kernel, semen Armeniacae amarum, when combined with Ma Huang, acts on both the lung and lung to restore the function of dispersing and dispersing lung qi and relieve dyspnea;
radix Adenophorae has effects of nourishing yin, moistening lung, eliminating phlegm, relieving cough, and invigorating qi, and can be used for treating chronic cough due to yin deficiency, and dry cough with little phlegm; pinellia tuber, rhizoma Pinelliae is a key herb for dispelling heat and dryness, entering spleen, stomach and lung channels, clearing damp and resolving phlegm, and treating damp-phlegm and cold-phlegm; the snakegourd peel is sweet, cold and slightly bitter, and has the effects of moistening lung and reducing phlegm; roasted loquat leaves are bitter and slightly cold, enter lung channel and stomach channel, have the functions of clearing lung and relieving cough, and can be used for treating cough caused by lung heat; the cicada slough and the blackberrylily rhizome have the functions of relieving sore throat, and can treat pharynx itch, sore throat and hoarseness, and the combination of the four medicinal materials has good treatment effect on cough and excessive phlegm caused by various reasons. The invention has the advantages of mild warmness, warmness without dryness, moistness without greasiness, cold dispelling without heat assistance, exterior syndrome relieving without damaging the body resistance.
A traditional Chinese medicine preparation for treating cough comprises the traditional Chinese medicine composition.
Further, the Chinese medicinal preparation comprises pills, granules, mixture, oral liquid, tablets and capsules.
The preparation method of the traditional Chinese medicine preparation for treating cough comprises the following steps:
(1) soaking herba Schizonepetae, pericarpium Citri Tangerinae, folium Eriobotryae preparata and periostracum Cicadae in water, decocting, filtering to obtain first residue and first liquid medicine, decocting and extracting the first residue with water, filtering to obtain second residue and second liquid medicine, adding ethanol into the second residue, decocting and extracting, filtering to obtain third liquid medicine, mixing the first liquid medicine, the second liquid medicine and the third liquid medicine, and concentrating to obtain first extract;
(2) soaking the other medicinal materials in water, decocting, filtering to obtain fourth residue and fourth liquid medicine, decocting the fourth residue in water, filtering to obtain fifth residue and fifth liquid medicine, extracting the fifth residue with ethanol, filtering to obtain sixth liquid medicine, mixing the fourth liquid medicine, the fifth liquid medicine and the sixth liquid medicine, and concentrating to obtain a second extract;
(3) mixing the first extract and the second extract, adding adjuvants, and making into corresponding dosage forms.
Further, in the step (1), the soaking time is 30-60min, the first decoction and extraction time is 30-90min, the second decoction time is 30-60min, and the third decoction time is 30-60 min.
Further, in the step (1), the soaking time is 30min, the first decoction extraction time is 60min, the second decoction extraction time is 40min, and the third decoction extraction time is 40 min.
Further, in the step (1), the first water addition is carried out until the medicinal materials reach 3-4 cm, the second water addition is carried out until the first decoction dregs reach 2-3 cm, and the ethanol addition is carried out until the second decoction dregs reach 2-3 cm.
Further, in the step (2), the soaking time is 30-120min, the first decoction time is 60-120min, the second decoction time is 30-90min, and the third decoction time is 30-60 min.
Further, in the step (2), the soaking time is 50min, the first decoction time is 90min, the second decoction time is 60min, and the third decoction time is 40 min.
Further, in the step (2), the first water addition is carried out until the medicinal materials are 4-6 cm, the second water addition is carried out until the fourth decoction dregs are 3-5 cm, and the ethanol addition is carried out until the fifth decoction dregs are 3-5 cm.
Further, the ethanol concentration in the step (1) and the step (2) is 60-90%.
Further, the ethanol concentration in step (1) and step (2) was 75%.
Further, the relative density of the first fluid extract and the second fluid extract in the steps (1) and (2) is 1.1-1.20.
Further, the relative densities of the first fluid extract and the second fluid extract in the steps (1) and (2) at the temperature of 80 ℃ are both 1.1.
The beneficial effects produced by adopting the scheme are as follows: the schizonepeta, the dried orange peel, the loquat leaf and the cicada slough are stem leaves, fruit peels and animal medicinal materials, the medicinal materials are light in weight, the soaking and extraction time is not too long, and otherwise, the effective components are decomposed and damaged; the other medicinal materials are relatively thick and heavy, and the soaking and extracting time is relatively prolonged so as to fully dissolve out the effective components; the decoction time is too long, and the active ingredients are subjected to high temperature for a long time, so that the structure of the active ingredients is unstable and decomposed and damaged, and the treatment effect of the medicine is weakened;
the polarity of water is relatively large, the polarity of ethanol is relatively small, and two solvents with different polarities of water and ethanol are respectively adopted to extract the medicine, so that effective components in the medicine can be fully dissolved out, and the treatment effect of the medicine is further improved.
The beneficial effects brought by the invention are as follows:
the traditional Chinese medicine composition disclosed by the invention is reasonable in formula and moderate in dosage, has the advantages of being mild, warm but not dry, moist but not greasy, capable of dispelling cold without helping heat, relieving exterior syndrome without damaging vital qi, has a good treatment effect on cough after infection, and does not damage the vital qi of a patient after treatment.
Detailed Description
Example 1
A traditional Chinese medicine composition for treating cough comprises the following components in parts by weight: 30 parts of platycodon grandiflorum, 10 parts of liquorice, 10 parts of aster, 10 parts of schizonepeta, 12 parts of dried orange peel, 15 parts of radix stemonae, 20 parts of roasted loquat leaves, 10 parts of periostracum cicada, 20 parts of blackberry lily, 10 parts of ephedra, 10 parts of almond, 15 parts of snakegourd peel, 15 parts of pinellia ternate and 10 parts of radix glehniae.
A preparation method of a traditional Chinese medicine preparation for treating cough comprises the following steps:
(1) adding water into herba schizonepetae, dried orange peel, roasted loquat leaves and cicada slough, immersing the herba schizonepetae, dried orange peel, roasted loquat leaves and cicada slough by 4 centimeters, decocting and extracting for 60 minutes, filtering to obtain first decoction dregs and first liquid medicine, continuously adding water into the first decoction dregs, decocting and extracting for 40 minutes by 3 centimeters, filtering to obtain second decoction dregs and second liquid medicine, adding 75% ethanol by volume concentration into the second decoction dregs, decocting and extracting for 40 minutes, filtering to obtain third liquid medicine, mixing the first liquid medicine, the second liquid medicine and the third liquid medicine, and concentrating at 80 ℃ to obtain a first extract, wherein the relative density of the first extract is 1.10;
(2) adding water into the other medicinal materials to submerge the medicinal materials for 6 cm, soaking for 50min, then decocting and extracting for 90min, filtering to obtain a fourth decoction dregs and a fourth liquid medicine, adding water into the fourth decoction dregs to submerge the fourth decoction dregs for 4 cm, decocting and extracting for 60min, filtering to obtain a fifth decoction dregs and a fifth liquid medicine, adding 75% ethanol into the fifth decoction dregs to submerge the fifth decoction dregs for 4 cm, decocting and extracting for 40min, filtering to obtain a sixth liquid medicine, mixing the fourth liquid medicine, the fifth liquid medicine and the sixth liquid medicine, and concentrating at 80 ℃ to obtain a second extract, wherein the relative density of the second extract is 1.10;
(3) mixing the first extract and the second extract, adding adjuvants, and making into pill.
Example 2
A traditional Chinese medicine composition for treating cough comprises the following components in parts by weight: 35 parts of platycodon grandiflorum, 15 parts of liquorice, 15 parts of aster, 15 parts of schizonepeta, 20 parts of dried orange peel, 20 parts of radix stemonae, 30 parts of roasted loquat leaves, 15 parts of periostracum cicada, 30 parts of blackberry lily, 15 parts of ephedra, 15 parts of almond, 20 parts of snakegourd peel, 20 parts of pinellia ternate and 15 parts of radix glehniae.
A preparation method of a traditional Chinese medicine preparation for treating cough comprises the following steps:
(1) adding water into herba schizonepetae, dried orange peel, roasted loquat leaves and cicada slough, immersing the herba schizonepetae, dried orange peel, roasted loquat leaves and cicada slough for 60min after soaking for 4 cm, decocting and extracting for 90min, filtering to obtain first decoction dregs and first liquid medicine, continuously adding water into the first decoction dregs, decocting and extracting for 60min after immersing the first decoction dregs for 3 cm, filtering to obtain second decoction dregs and second liquid medicine, adding 60% ethanol in volume concentration into the second decoction dregs, immersing the second decoction dregs for 3 cm, decocting and extracting for 60min, filtering to obtain third liquid medicine, mixing the first liquid medicine, the second liquid medicine and the third liquid medicine, and concentrating at 80 ℃ to obtain a first extract, wherein the relative density of the first extract is 1.20;
(2) adding water into the other medicinal materials to submerge the medicinal materials for 6 cm, soaking for 120min, then decocting and extracting for 120min, filtering to obtain a fourth decoction dregs and a fourth liquid medicine, adding water into the fourth decoction dregs to submerge the fourth decoction dregs for 5 cm, decocting and extracting for 90min, filtering to obtain a fifth decoction dregs and a fifth liquid medicine, adding 60% ethanol by volume concentration into the fifth decoction dregs to submerge the fifth decoction dregs for 5 cm, decocting and extracting for 60min, filtering to obtain a sixth liquid medicine, mixing the fourth liquid medicine, the fifth liquid medicine and the sixth liquid medicine, and concentrating at 80 ℃ to obtain a second extract, wherein the relative density of the second extract is 1.20;
(3) mixing the first extract and the second extract, adding adjuvants, and making into capsule.
Example 3
A traditional Chinese medicine composition for treating cough comprises the following components in parts by weight: 25 parts of platycodon grandiflorum, 8 parts of liquorice, 8 parts of aster, 8 parts of schizonepeta, 10 parts of dried orange peel, 12 parts of radix stemonae, 15 parts of roasted loquat leaves, 8 parts of cicada slough, 15 parts of blackberry lily, 8 parts of ephedra, 8 parts of almond, 12 parts of snakegourd peel, 12 parts of pinellia ternate and 8 parts of radix glehniae.
A preparation method of a traditional Chinese medicine preparation for treating cough comprises the following steps:
(1) adding water into herba schizonepetae, dried orange peel, roasted loquat leaves and cicada slough, immersing the herba schizonepetae, dried orange peel, roasted loquat leaves and cicada slough by 3 centimeters, decocting and extracting for 30 minutes, filtering to obtain first decoction dregs and first liquid medicine, continuously adding water into the first decoction dregs, decocting and extracting for 30 minutes by 2 centimeters, filtering to obtain second decoction dregs and second liquid medicine, adding 90% ethanol by volume concentration into the second decoction dregs, decocting and extracting for 30 minutes, filtering to obtain third liquid medicine, mixing the first liquid medicine, the second liquid medicine and the third liquid medicine, and concentrating at 80 ℃ to obtain a first extract, wherein the relative density of the first extract is 1.10;
(2) adding water into the other medicinal materials to submerge the medicinal materials for 4 cm, soaking for 30min, then decocting and extracting for 60min, filtering to obtain a fourth decoction dregs and a fourth liquid medicine, adding water into the fourth decoction dregs to submerge the fourth decoction dregs for 3 cm, decocting and extracting for 40min, filtering to obtain a fifth decoction dregs and a fifth liquid medicine, adding 90% ethanol into the fifth decoction dregs to submerge the fifth decoction dregs for 3 cm, decocting and extracting for 30min, filtering to obtain a sixth liquid medicine, mixing the fourth liquid medicine, the fifth liquid medicine and the sixth liquid medicine, and concentrating at 80 ℃ to obtain a second extract, wherein the relative density of the second extract is 1.10;
(3) mixing the first extract and the second extract, adding adjuvants, and making into granule.
Comparative example 1
A traditional Chinese medicine composition for treating cough comprises the following components in parts by weight: 30 parts of pummelo peel, 10 parts of liquorice, 10 parts of radix asteris, 10 parts of dried ginger, 12 parts of dried orange peel, 15 parts of radix stemonae, 20 parts of roasted loquat leaf, 10 parts of cicada slough, 20 parts of blackberry lily, 10 parts of ephedra, 20 parts of almond, 15 parts of snakegourd peel, 15 parts of pinellia tuber and 10 parts of radix glehniae.
A preparation method of a traditional Chinese medicine preparation for treating cough comprises the following steps:
(1) adding water into dried ginger, dried orange peel, roasted loquat leaf and cicada slough, immersing the dried ginger, dried orange peel, roasted loquat leaf and cicada slough in water for 30min, then decocting and extracting for 60min, filtering to obtain first decoction dregs and first liquid medicine, continuously adding water into the first decoction dregs, decocting and extracting for 40min, filtering to obtain second decoction dregs and second liquid medicine, adding 75% ethanol by volume concentration into the second decoction dregs, immersing the second decoction dregs in 3 cm, decocting and extracting for 40min, filtering to obtain third liquid medicine, mixing the first liquid medicine, the second liquid medicine and the third liquid medicine, and concentrating at 80 ℃ to obtain a first extract, wherein the relative density of the first extract is 1.10;
(2) adding water into the other medicinal materials to submerge the medicinal materials for 6 cm, soaking for 50min, then decocting and extracting for 90min, filtering to obtain a fourth decoction dregs and a fourth liquid medicine, adding water into the fourth decoction dregs to submerge the fourth decoction dregs for 4 cm, decocting and extracting for 60min, filtering to obtain a fifth decoction dregs and a fifth liquid medicine, adding 75% ethanol into the fifth decoction dregs to submerge the fifth decoction dregs for 4 cm, decocting and extracting for 40min, filtering to obtain a sixth liquid medicine, mixing the fourth liquid medicine, the fifth liquid medicine and the sixth liquid medicine, and concentrating at 80 ℃ to obtain a second extract, wherein the relative density of the second extract is 1.10;
(3) mixing the first extract and the second extract, adding adjuvants, and making into pill.
Comparative example 2
A traditional Chinese medicine composition for treating cough comprises the following components in parts by weight: 30 parts of platycodon grandiflorum, 10 parts of liquorice, 10 parts of divaricate saposhnikovia root, 12 parts of dried orange peel, 15 parts of sessile stemona root, 20 parts of roasted loquat leaf, 10 parts of cicada slough, 20 parts of blackberrykiky rhizome, 10 parts of ephedra herb, 10 parts of almond, 15 parts of snakegourd peel, 15 parts of pinellia ternate and 10 parts of coastal glehnia root.
A preparation method of a traditional Chinese medicine preparation for treating cough comprises the following steps:
(1) adding water into divaricate saposhnikovia root, tangerine peel, roasted loquat leaf and cicada slough, immersing the divaricate saposhnikovia root, tangerine peel, roasted loquat leaf and cicada slough in 4 cm of water for 30min, then decocting and extracting for 60min, filtering to obtain first decoction dregs and first liquid medicine, continuously adding water into the first decoction dregs, immersing the first decoction dregs in 3 cm of water, decocting and extracting for 40min, filtering to obtain third liquid medicine, mixing the first liquid medicine, the second liquid medicine and the third liquid medicine, concentrating at 80 ℃ to obtain a first extract, wherein the relative density of the first extract is 1.10;
(2) adding water into the other medicinal materials to submerge the medicinal materials for 6 cm, soaking for 50min, then decocting and extracting for 90min, filtering to obtain a fourth decoction dregs and a fourth liquid medicine, adding water into the fourth decoction dregs to submerge the fourth decoction dregs for 4 cm, decocting and extracting for 60min, filtering to obtain a fifth decoction dregs and a fifth liquid medicine, adding 75% ethanol into the fifth decoction dregs to submerge the fifth decoction dregs for 4 cm, decocting and extracting for 40min, filtering to obtain a sixth liquid medicine, mixing the fourth liquid medicine, the fifth liquid medicine and the sixth liquid medicine, and concentrating at 80 ℃ to obtain a second extract, wherein the relative density of the second extract is 1.10;
(3) mixing the first extract and the second extract, adding adjuvants, and making into pill.
Comparative example 3
A traditional Chinese medicine composition for treating cough comprises the following components in parts by weight: 20 parts of platycodon grandiflorum, 10 parts of liquorice, 5 parts of aster, 10 parts of schizonepeta, 12 parts of dried orange peel, 20 parts of radix stemonae, 20 parts of roasted loquat leaves, 10 parts of periostracum cicada, 20 parts of blackberry lily, 10 parts of ephedra, 5 parts of almond, 15 parts of snakegourd peel, 9 parts of pinellia ternate and 10 parts of radix glehniae.
A preparation method of a traditional Chinese medicine preparation for treating cough comprises the following steps:
(1) adding water into herba schizonepetae, dried orange peel, roasted loquat leaves and cicada slough, immersing the herba schizonepetae, dried orange peel, roasted loquat leaves and cicada slough for 80min after soaking the herba schizonepetae, dried orange peel, roasted loquat leaves and cicada slough for 4 cm, decocting and extracting for 80min, filtering to obtain first decoction dregs and first liquid medicine, continuously adding water into the first decoction dregs, decocting and extracting for 40min after immersing the first decoction dregs for 3 cm, filtering to obtain second decoction dregs and second liquid medicine, adding 40% ethanol by volume concentration into the second decoction dregs, decocting and extracting for 40min, filtering to obtain third liquid medicine, mixing the first liquid medicine, the second liquid medicine and the third liquid medicine, and concentrating at 80 ℃ to obtain first extract, wherein the relative density of the first extract is 1.10;
(2) adding water into the other medicinal materials to submerge the medicinal materials for 6 cm, soaking for 50min, then decocting and extracting for 150min, filtering to obtain a fourth decoction dregs and a fourth liquid medicine, adding water into the fourth decoction dregs to submerge the fourth decoction dregs for 4 cm, decocting and extracting for 60min, filtering to obtain a fifth decoction dregs and a fifth liquid medicine, adding 40% ethanol in volume concentration into the fifth decoction dregs to submerge the fifth decoction dregs for 4 cm, decocting and extracting for 40min, filtering to obtain a sixth liquid medicine, mixing the fourth liquid medicine, the fifth liquid medicine and the sixth liquid medicine, and concentrating at 80 ℃ to obtain a second extract, wherein the relative density of the second extract is 1.10;
(3) mixing the first extract and the second extract, adding adjuvants, and making into pill.
Comparative example 4
A traditional Chinese medicine composition for treating cough comprises the following components in parts by weight: 20 parts of platycodon grandiflorum, 4 parts of liquorice, 20 parts of aster, 15 parts of schizonepeta, 12 parts of dried orange peel, 15 parts of radix stemonae, 20 parts of roasted loquat leaves, 10 parts of periostracum cicada, 20 parts of blackberrykiky rhizome, 10 parts of almond, 15 parts of snakegourd peel, 15 parts of pinellia ternate and 10 parts of radix glehniae.
A preparation method of a traditional Chinese medicine preparation for treating cough comprises the following steps:
(1) adding water into herba schizonepetae, dried orange peel, roasted loquat leaves and cicada slough, immersing the herba schizonepetae, dried orange peel, roasted loquat leaves and cicada slough by 4 centimeters, decocting and extracting for 60 minutes, filtering to obtain first decoction dregs and first liquid medicine, continuously adding water into the first decoction dregs, decocting and extracting for 40 minutes by 3 centimeters, filtering to obtain second decoction dregs and second liquid medicine, adding 75% ethanol by volume concentration into the second decoction dregs, decocting and extracting for 40 minutes, filtering to obtain third liquid medicine, mixing the first liquid medicine, the second liquid medicine and the third liquid medicine, and concentrating at 80 ℃ to obtain a first extract, wherein the relative density of the first extract is 1.10;
(2) adding water into the other medicinal materials to submerge the medicinal materials for 6 cm, soaking for 50min, then decocting and extracting for 90min, filtering to obtain a fourth decoction dregs and a fourth liquid medicine, adding water into the fourth decoction dregs to submerge the fourth decoction dregs for 4 cm, decocting and extracting for 60min, filtering to obtain a fifth decoction dregs and a fifth liquid medicine, adding 75% ethanol into the fifth decoction dregs to submerge the fifth decoction dregs for 4 cm, decocting and extracting for 40min, filtering to obtain a sixth liquid medicine, mixing the fourth liquid medicine, the fifth liquid medicine and the sixth liquid medicine, and concentrating at 80 ℃ to obtain a second extract, wherein the relative density of the second extract is 1.10;
(3) mixing the first extract and the second extract, adding adjuvants, and making into pill.
Test examples
160 cough patients with the age of 18-60 years are searched, 78 men and 82 women are randomly divided into 8 groups, 20 patients in each group have no significant difference and are comparable through statistical calculation, 8 groups of patients take the traditional Chinese medicine preparation and the compound liquorice oral liquid in the examples 1-3 and the comparative examples 1-4 respectively, the traditional Chinese medicine and the preparation are taken 3 times after meals and 6g every time for 6 days, the compound liquorice oral liquid is taken 3 times every day and 10ml every time for 6 days, and the cough conditions of the patients are observed and recorded on the days 2, 4 and 6, and the specific results are shown in tables 1 and 2.
Among them, the cough diagnosis criteria: firstly, coughing up with sound or accompanied with pharynx itch and expectoration; ② cough caused by exogenous pathogenic factor, which is acute in onset and can be accompanied by exterior syndromes such as cold and heat; ③ auscultation of both lungs can be carried out without abnormality, and the auscultation can also hear the thickening of breath sound, or be accompanied with the dry and wet rales sound; x-ray or chest CT examination of the lung mostly shows normal or pulmonary infection.
The diagnosis standard of the lung affected by wind-cold is as follows: cough with loud voice, thin and white sputum, aversion to cold, fever, no sweating, thin and white tongue coating, and superficial and tense pulse.
The evaluation standard of curative effect is as follows: and (3) curing: cough and disappearance of clinical symptoms;
the effect is shown: cough was relieved, sputum volume decreased;
and (4) invalidation: no obvious change of symptoms;
total effective rate (number of cure cases + number of significant cases)/total cases × 100%.
Table 1: statistical table of treatment conditions
| Display effect (human) | Invalid (human) | Cure (human) | Total effective rate (%) | |
| Example 1 | 5 | 0 | 15 | 100 |
| Example 2 | 6 | 2 | 12 | 90 |
| Example 3 | 6 | 3 | 11 | 85 |
| Comparative example 1 | 11 | 6 | 3 | 70 |
| Comparative example 2 | 12 | 5 | 3 | 75 |
| Comparative example 3 | 12 | 6 | 2 | 70 |
| Comparative example 4 | 11 | 5 | 4 | 75 |
| Control group | 5 | 8 | 7 | 60 |
As can be seen from the above table, the traditional Chinese medicine preparations prepared in embodiments 1 to 3 of the present invention have better therapeutic effects on cough, which are superior to the traditional Chinese medicine preparations and the compound licorice oral liquid in comparative examples 1 to 4, especially the traditional Chinese medicine preparation in embodiment 1 has the best therapeutic effect, wherein the number of cured people is up to 15, and the total effective rate is up to 100%.
Table 2: specific treatment condition table for different time periods
As can be seen from the above table, the formulations of examples 1-3 had a superior therapeutic effect on the cough condition of the patients, and the treatment conditions of examples 1-3 were all better than those of comparative examples 1-4.
Comparing comparative examples 1-4 with examples 1-3, it can be seen that the therapeutic effects of the prepared traditional Chinese medicine preparations are poor after the medicines in the formula are replaced by the medicines with the same efficacy, the dosage of the medicines is changed, part of the medicines are deleted, and the preparation method is changed, so that the medicines in the traditional Chinese medicine composition in the application are proved to have mutual synergy and mutual promotion effects, and further the therapeutic effect on cough is improved; moreover, after the traditional Chinese medicine preparation is taken, patients do not feel uncomfortable and do not have the symptoms of mouth feel, bitter taste, dryness-heat, chilliness and the like, and the traditional Chinese medicine composition is mild and mild, can dispel cold without helping heat, and can relieve exterior syndrome without hurting the body.
Claims (10)
1. The traditional Chinese medicine composition for treating cough is characterized by comprising the following components in parts by weight: 20-50 parts of platycodon grandiflorum, 5-15 parts of liquorice, 5-15 parts of aster, 5-15 parts of schizonepeta, 5-20 parts of dried orange peel, 5-20 parts of radix stemonae, 10-30 parts of roasted loquat leaves, 5-15 parts of cicada slough, 10-30 parts of blackberrylily rhizome, 5-15 parts of ephedra, 5-15 parts of almond, 10-20 parts of snakegourd peel, 10-20 parts of pinellia ternate and 5-15 parts of radix glehniae.
2. The traditional Chinese medicine composition for treating cough according to claim 1, which is prepared from the following components in parts by weight: 25-35 parts of platycodon grandiflorum, 8-12 parts of liquorice, 8-12 parts of aster, 8-12 parts of schizonepeta, 10-15 parts of dried orange peel, 12-18 parts of radix stemonae, 15-25 parts of roasted loquat leaves, 8-12 parts of cicada slough, 15-25 parts of blackberrylily rhizome, 8-12 parts of ephedra, 8-12 parts of almond, 12-18 parts of trichosanthes peel, 12-18 parts of pinellia ternate and 8-12 parts of radix glehniae.
3. The traditional Chinese medicine composition for treating cough according to claim 1 or 2, which is prepared from the following components in parts by weight: 30 parts of platycodon grandiflorum, 10 parts of liquorice, 10 parts of aster, 10 parts of schizonepeta, 12 parts of dried orange peel, 15 parts of radix stemonae, 20 parts of roasted loquat leaves, 10 parts of periostracum cicada, 20 parts of blackberry lily, 10 parts of ephedra, 10 parts of almond, 15 parts of snakegourd peel, 15 parts of pinellia ternate and 10 parts of radix glehniae.
4. A Chinese medicinal preparation for treating cough, which is characterized by comprising the Chinese medicinal composition of any one of claims 1 to 3.
5. The traditional Chinese medicine preparation for treating cough as claimed in claim 4, wherein the traditional Chinese medicine preparation comprises pills, granules and capsules.
6. The method for preparing a Chinese medicinal preparation for treating cough as claimed in claim 4 or 5, comprising the steps of:
(1) soaking herba Schizonepetae, pericarpium Citri Tangerinae, folium Eriobotryae preparata and periostracum Cicadae in water, decocting, filtering to obtain first residue and first liquid medicine, decocting and extracting the first residue with water, filtering to obtain second residue and second liquid medicine, adding ethanol into the second residue, decocting and extracting, filtering to obtain third liquid medicine, mixing the first liquid medicine, the second liquid medicine and the third liquid medicine, and concentrating to obtain first extract;
(2) soaking the other medicinal materials in water, decocting, filtering to obtain fourth residue and fourth liquid medicine, decocting the fourth residue in water, filtering to obtain fifth residue and fifth liquid medicine, extracting the fifth residue with ethanol, filtering to obtain sixth liquid medicine, mixing the fourth liquid medicine, the fifth liquid medicine and the sixth liquid medicine, and concentrating to obtain a second extract;
(3) mixing the first extract and the second extract, adding adjuvants, and making into corresponding dosage forms.
7. The method for preparing a Chinese medicinal preparation for treating cough according to claim 6, wherein the soaking time in step (1) is 30-60min, the first decoction extraction time is 30-90min, the second decoction extraction time is 30-60min, and the third decoction extraction time is 30-60 min.
8. The method for preparing a Chinese medicinal preparation for treating cough according to claim 6, wherein the soaking time in step (2) is 30-120min, the first decoction time is 60-120min, the second decoction time is 30-90min, and the third decoction time is 30-60 min.
9. The method for preparing a Chinese medicinal preparation for treating cough as claimed in claim 6, wherein the volume concentration of ethanol in step (1) and step (2) is 60-90%.
10. The method for preparing a Chinese medicinal preparation for treating cough as claimed in claim 6, wherein the relative densities of the first fluid extract and the second fluid extract in step (1) and step (2) are both 1.1-1.20.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010537189.3A CN111569024B (en) | 2020-06-12 | 2020-06-12 | Traditional Chinese medicine composition for treating cough, traditional Chinese medicine preparation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010537189.3A CN111569024B (en) | 2020-06-12 | 2020-06-12 | Traditional Chinese medicine composition for treating cough, traditional Chinese medicine preparation and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111569024A CN111569024A (en) | 2020-08-25 |
| CN111569024B true CN111569024B (en) | 2021-12-21 |
Family
ID=72125864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010537189.3A Active CN111569024B (en) | 2020-06-12 | 2020-06-12 | Traditional Chinese medicine composition for treating cough, traditional Chinese medicine preparation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111569024B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101138591A (en) * | 2007-08-25 | 2008-03-12 | 尹克华 | Traditional Chinese medicine for treating exogenous cough |
| CN102397495A (en) * | 2010-09-19 | 2012-04-04 | 张玉芳 | Medicine for treating infantile allergic cough |
| CN105412742A (en) * | 2015-12-02 | 2016-03-23 | 肖燕萍 | Cough stopping soap for expelling wind and dispelling cold |
| CN109771534A (en) * | 2017-11-15 | 2019-05-21 | 广西西林县农本生物科技有限公司 | It is a kind of treat flu after remaining cough Chinese medicine composition |
| CN109985194A (en) * | 2017-12-29 | 2019-07-09 | 郭广法 | A kind of Chinese medicine preparation of wind cold type cough |
-
2020
- 2020-06-12 CN CN202010537189.3A patent/CN111569024B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101138591A (en) * | 2007-08-25 | 2008-03-12 | 尹克华 | Traditional Chinese medicine for treating exogenous cough |
| CN102397495A (en) * | 2010-09-19 | 2012-04-04 | 张玉芳 | Medicine for treating infantile allergic cough |
| CN105412742A (en) * | 2015-12-02 | 2016-03-23 | 肖燕萍 | Cough stopping soap for expelling wind and dispelling cold |
| CN109771534A (en) * | 2017-11-15 | 2019-05-21 | 广西西林县农本生物科技有限公司 | It is a kind of treat flu after remaining cough Chinese medicine composition |
| CN109985194A (en) * | 2017-12-29 | 2019-07-09 | 郭广法 | A kind of Chinese medicine preparation of wind cold type cough |
Non-Patent Citations (2)
| Title |
|---|
| 咳嗽颗粒加味治疗小儿外感咳嗽72例;陈英妹等;《中外医疗 药物与临床》;20090131(第3期);第103页摘要及正文第6段、第11段 * |
| 枇蝉止嗽散三九配方颗粒治疗外感咳嗽50例;应武江;《浙江中医杂志》;20110516;第46卷(第05期);第331页第1段、第3段、第8-9段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111569024A (en) | 2020-08-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103977314A (en) | Medicinal composition for treating respiratory diseases as well as preparation method and application of medicinal composition | |
| CN104800700B (en) | It is a kind of to treat dermopathic herbal composite | |
| CN111569024B (en) | Traditional Chinese medicine composition for treating cough, traditional Chinese medicine preparation and preparation method thereof | |
| CN106620097A (en) | Cough-relieving plaster prepared from traditional Chinese medicine composition, and preparation method of cough-relieving plaster | |
| CN104306793A (en) | Chinese herba preparation for treating lobar pneumonia | |
| CN110721303A (en) | Traditional Chinese medicine composition for treating allergic rhinitis and application thereof | |
| CN104940764A (en) | Traditional Chinese medicine composition preparation for treating pulmonary tuberculosis | |
| CN104623217A (en) | Traditional Chinese medicine preparation for treating asthma and preparation method thereof | |
| CN104815151A (en) | Traditional Chinese medicine for treating warm-dryness lung injury type cough | |
| CN104258020A (en) | Traditional Chinese medicine composition for treating pneumonia | |
| CN103977313B (en) | Diuresis promoting and itching relieving pills and preparation method thereof | |
| CN111569029B (en) | Traditional Chinese medicine composition for improving respiratory tract mucosa immunologic function and preparation method thereof | |
| CN106692698B (en) | Bletilla striata cough relieving granule and preparation method thereof | |
| CN104758346A (en) | Medicine for treating migraine, as well as preparation method and preparation of medicine | |
| CN113304196A (en) | Traditional Chinese medicine composition for treating lung yin deficiency type chronic pharyngitis and application thereof | |
| CN104940763A (en) | Traditional Chinese medicine preparation for treating primary pulmonary tuberculosis | |
| CN112022936A (en) | Tonsil health-care patch and preparation method thereof | |
| CN105194545B (en) | A kind of Chinese medicine composition for treating asthma | |
| CN105055788A (en) | Pharmaceutical composition for treating anaphylactic rhinitis | |
| CN116832104A (en) | Traditional Chinese medicine for relieving cough and reducing sputum | |
| CN111514215A (en) | Traditional Chinese medicine prescription for treating upper respiratory tract infection and viral pneumonia and application | |
| CN104435636B (en) | A kind of Chinese medicine composition for preventing paracmasis chronic bronchitis to recur | |
| CN111068017A (en) | Traditional Chinese medicine composition for treating cough, preparation method thereof and traditional Chinese medicine preparation | |
| CN104189610A (en) | Traditional Chinese medicine composition for treating bronchitis | |
| CN113730542A (en) | Traditional Chinese medicine formula for treating allergic rhinitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |