CN103990414A - Oxygen humidifying solution with bacteriostasis function and preparation method thereof - Google Patents
Oxygen humidifying solution with bacteriostasis function and preparation method thereof Download PDFInfo
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- CN103990414A CN103990414A CN201410225924.1A CN201410225924A CN103990414A CN 103990414 A CN103990414 A CN 103990414A CN 201410225924 A CN201410225924 A CN 201410225924A CN 103990414 A CN103990414 A CN 103990414A
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- sodium dehydroacetate
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Abstract
The invention discloses an oxygen humidifying solution with a bacteriostasis function and a preparation method thereof. The oxygen humidifying solution is composed of the following raw materials in parts by weight: 0.01-5 parts of sodium dehydroacetate and purified water added until the total weight is 1000 parts. The preparation method comprises the following steps: taking purified water, adding sodium dehydroacetate, heating to ensure that sodium dehydroacetate is dissolved, replenishing purified water until reaching a full dose, sterilizing and filtering, canning, sealing, and storing for later use after detecting the product is qualified. The sodium dehydroacetate is added in the purified water to prepare a humidifying solution, the humidifying solution can be effectively protected from being polluted by bacteria in a clinical use process; meanwhile, the oxygen humidifying solution has the advantages of high safety, no toxic and side effect after entering a human body, and the like; the preparation method is simple, the cost is low, and clinical value and social meaning of popularization and usage are good.
Description
[technical field]
The invention belongs to a kind of oxygen humidifying liquid with bacteria resistance function and preparation method thereof.
[background technology]
Oxygen inhalation therapy is the most frequently used a kind of nursing technique of hospital and rescue means, and CICU (ICU) the patient state of an illness is critical, and great majority need frequent or long-time oxygen uptake.Because the humidity of oxygen own is very low, long-time oxygen uptake meeting causes that patients with respiratory tract is dry, dry and cracked hemorrhage, the sputum of schneiderian membrane is difficult for the adverse consequences such as expectoration, therefore, in process of oxygen therapy, need oxygen humidifying liquid to carry out humidifying to oxygen, to avoid dry oxygen that respiratory mucosa is produced and stimulated, and then improve patient comfort, improve oxygen therapy effect.
Oxygen humidifying liquid refers to the liquid for oxygen humidification in clinical care.The humidification fluid General Requirements that clinical care is used is aqua sterilisa or distilled water, and because itself does not have bacteria resistance function, in long-time clinical care process, humidification fluid is very easily contaminated by bacterial, and brings nosocomial infection risk to patient.It is reported: in China's nosocomial infection case, respiratory tract infection accounts for first place, wherein because of various operation of diagnosis and treatment, the therapeutic device such as medical equipment infects and the pulmonary complication that causes is very important factor.External ventilation infection rate 21%～77%, fatal rate 20.0%～61.7%.In domestic lot of documents report oxygen uptake process, humidification fluid is easily contaminated by bacterial, thereby causes nosocomial infection." microbial population of patients with pulmonary infection induced by pollution of oxygen humidification fluids investigation " (nursing research that such as Liu Jin hides etc., the 21st interim ten days of volume the 7th of July in 2007 version), " Pollution Analysis of oxygen humidifying liquid and countermeasure " (nursing research of Shi Lanping etc., the 5th the 19th the 5th phase of volume of phase in 2005), " monitoring of Daliang City's oxygen humidifying liquid germ contamination degree " (Chinese infection control magazine of Xu Dan etc., the 3rd the 2nd phase of volume of April in 2004) and the Bacteria Culture of the oxygen humidifying liquid " investigation " (Chinese hospital infection magazine of virgin Jian Hua, the 16th the 7th phase of volume in 2006) etc. the bacterium that all existing oxygen humidifying liquid caused of tens sections of articles infect with nosocomial infection problem and carried out the discussion of system.
[summary of the invention]
The problems referred to above that exist for overcoming prior art, the present invention proposes a kind of oxygen humidifying liquid with bacteria resistance function and preparation method thereof, the maximum feature of this humidification fluid be under acid, neutrality and alkali condition, all have good effect and also light and heat little on its impact, even if boil heating in water, also have be not destroyed, never degenerate, nonvolatile advantage.
For achieving the above object, the present invention has adopted following technical scheme: this oxygen humidifying liquid with bacteria resistance function is made up of the material composition of following weight portion:
0.01～5 part of dehydro sodium acetate;
1000 parts of purified water.
Prepare a method for the oxygen humidifying liquid with bacteria resistance function as above, its step is as follows:
The preparation of oxygen humidifying liquid: get purified water, add dehydro sodium acetate, heating makes to dissolve, and adds purified water to full dose, and aseptic filtration is filling, sealing, detect deposit after qualified for subsequent use.
Beneficial effect: compared with existing humidification fluid, dehydro sodium acetate is added into humidification fluid by inventor, not only can effectively ensure that in clinical use procedure, humidification fluid is not subject to germ contamination, have simultaneously safe, enter the advantage such as have no side effect after human body.Preparation technology of the present invention is simple, with low cost, the social effect that has good clinical value and promote the use of.
Dehydro sodium acetate (has another name called sodium dehydroacetate, molecular formula: C
8h
7naO
4h
2o, molecular weight: 208.15), chemical name: 3-(1-hydroxy methylene)-6-methyl isophthalic acid, 2-pyrans-2,4(3H)-diketone sodium, for white or near-white crystalline powder, odorless, easy molten what water, glycerine, propane diols, be slightly soluble in ethanol and acetone, be that a kind of safety food of using of FAO (Food and Agriculture Organization of the United Nation) and World Health Organization approval is anticorrosion, mildew-resistant, antistaling disinfectant, applied for many years in states such as America and Europes.China is in the existing research eighties in last century, and be just widely applied in food industry recent years.This product is decomposed into gradually acetic acid in metabolic processes, nontoxic to human body, this be other mould inhibitor can not and.The maximum feature of this product is all effective under acidity or alkali condition, all more stable to light and heat, though in water, boil heating time be not also destroyed, never degenerate, non-volatile.
Sodium dehydroacetate belongs to broad-spectrum preservative, and saccharomycete, mould and Bacterial Development are had to very strong inhibitory action, especially Chang Yi is caused to food spoilage is the strongest with the inhibitory action of the saccharomycete going mouldy, mould.Its antimicrobial spectrum is as shown in table 1.
The antimicrobial spectrum of table 1 sodium dehydroacetate
Sodium dehydroacetate all has desirable bacteriostasis under acidity, neutrality and alkaline environment, and by sodium dehydroacetate after heat treatment, the inhibitory action of microbial growth laundering period is not changed, Li Wanyuan etc. have studied the antagonistic property of sodium dehydroacetate under different pH environment, and heat treatment is on pressing down the impact of mattress effect, result is as following table:
The bacteriostatic test of sodium dehydroacetate when table 2 acidity (pH5.4)
Note :+indicate bacteria growing ,-asepsis growth represented.Lower same.
The bacteriostatic test of sodium dehydroacetate when table 3 neutrality (pH7.0)
The bacteriostatic test of sodium dehydroacetate when table 4 alkalescence (pH7.5)
The growth adaptation phase of Mixed Microbes after table 5 heat treatment
From table 2, table 3, table 4, can find out, be that sodium dehydroacetate all has very strong bacteriostasis under acid, neutral, alkaline environmental condition.
Common Preservatives potassium sorbate is after high-temperature process as can be seen from Table 5, the growth adaptation phase of Mixed Microbes obviously reduces, sodium dehydroacetate has no change, illustrate by sodium dehydroacetate after heat treatment the inhibitory action of microbial growth laundering period is not changed, show that sodium dehydroacetate does not need to consider temperature factor in use procedure, the scope of application is wide.
At present, there is no the oxygen humidifying liquid listing of similar formula and the report using.
Oxygen humidification when oxygen humidifying liquid of the present invention is not limited to oxygen uptake, also can be used for lung ventilator oxygen humidification, Neonate warm box moisturizing, tracheae (artificial airway) humidification etc.
Oxygen humidifying liquid of the present invention can adopt its aqueous solution directly in clinical care, to use, also can use the hydrophilic substances such as the absorbent material such as sponge, nonwoven or gelatin as the storage carrier of this humidification fluid for clinical care.
Below by embodiment, the invention will be further described.
[detailed description of the invention]
Embodiment 1:
Dehydro sodium acetate 0.02g
Purified water adds water to 1000ml
Step is as follows:
The preparation of oxygen humidifying liquid: get purified water, add dehydro sodium acetate, heating makes to dissolve, and adds purified water to full dose, and 115 DEG C of high temperature wet heating sterilizing 30 minutes is cooling, filling, sealing, detect deposit after qualified for subsequent use.
Embodiment 2:
Dehydro sodium acetate 0.3g
Purified water adds water to 1000ml
Step is as follows:
The preparation of oxygen humidifying liquid: get purified water, add dehydro sodium acetate, heating makes to dissolve, and adds purified water to full dose, and aseptic filtration is filling, sealing, detect deposit after qualified for subsequent use.
Embodiment 3:
Dehydro sodium acetate 4.5g
Purified water adds water to 1000ml
Step is as follows:
The preparation of oxygen humidifying liquid: get purified water, add dehydro sodium acetate, heating makes to dissolve, and adds purified water to full dose, and 115 DEG C of high temperature wet heating sterilizing 30 minutes is cooling, filling, sealing, detect deposit after qualified for subsequent use.
The invention is not restricted to above specific implementation method.
Claims (2)
1. an oxygen humidifying liquid with bacteria resistance function, is characterized in that: the material composition by following weight portion forms:
0.01～5 part of dehydro sodium acetate;
1000 parts of purified water.
2. the preparation method of a kind of oxygen humidifying liquid with bacteria resistance function as claimed in claim 1, is characterized in that comprising the following steps: get purified water, add dehydro sodium acetate, heating makes to dissolve, and adds purified water to full dose, aseptic filtration, filling, sealing, detect deposit after qualified for subsequent use.
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| CN201410225924.1A CN103990414A (en) | 2014-05-27 | 2014-05-27 | Oxygen humidifying solution with bacteriostasis function and preparation method thereof |
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| CN201410225924.1A CN103990414A (en) | 2014-05-27 | 2014-05-27 | Oxygen humidifying solution with bacteriostasis function and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104472541A (en) * | 2014-12-10 | 2015-04-01 | 杭州美泰医疗器械有限公司 | Oxygen humidifying fluid bacteriostatic agent |
| CN105145597A (en) * | 2015-08-26 | 2015-12-16 | 浙江康德药业集团股份有限公司 | Efficient and antibacterial oxygen humidification fluid and method for preparing same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102389743A (en) * | 2011-06-14 | 2012-03-28 | 陈旭良 | Formula of medical bacteriostatic humidifying solution |
| CN102941034A (en) * | 2011-11-18 | 2013-02-27 | 曹青春 | Medical humidification liquid having bacteriostasis function |
| CN203235114U (en) * | 2013-04-25 | 2013-10-16 | 北京东方潮汐科技发展有限公司 | Gas surface humidifying device, gas humidifying device thereof and gas compressing device thereof |
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2014
- 2014-05-27 CN CN201410225924.1A patent/CN103990414A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389743A (en) * | 2011-06-14 | 2012-03-28 | 陈旭良 | Formula of medical bacteriostatic humidifying solution |
| CN102941034A (en) * | 2011-11-18 | 2013-02-27 | 曹青春 | Medical humidification liquid having bacteriostasis function |
| CN203235114U (en) * | 2013-04-25 | 2013-10-16 | 北京东方潮汐科技发展有限公司 | Gas surface humidifying device, gas humidifying device thereof and gas compressing device thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张晓东等: "两种氧疗湿化方式对污染微生物及防腐剂传输规律的研究", 《中华医院感染学杂志》, vol. 21, no. 12, 20 June 2011 (2011-06-20) * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104472541A (en) * | 2014-12-10 | 2015-04-01 | 杭州美泰医疗器械有限公司 | Oxygen humidifying fluid bacteriostatic agent |
| CN105145597A (en) * | 2015-08-26 | 2015-12-16 | 浙江康德药业集团股份有限公司 | Efficient and antibacterial oxygen humidification fluid and method for preparing same |
| CN105145597B (en) * | 2015-08-26 | 2017-06-30 | 浙江康德药业集团股份有限公司 | A kind of oxygen humidifying liquid of Efficient antibacterial and preparation method thereof |
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Address after: 324000 No. 889 Century Avenue, Quzhou Economic Development Zone, Zhejiang, China Applicant after: ZHEJIANG KANGDE PHARMACEUTICAL CO., LTD. Address before: 324000 No. 889 Century Avenue, Quzhou Economic Development Zone, Zhejiang, China Applicant before: Zhejiang Kangde Pharmacy Group Co., Ltd. |
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