CN110248671A - 包含溶瘤痘病毒和nk细胞的治疗剂及其在治疗肿瘤和/或癌症的药物中的应用 - Google Patents

包含溶瘤痘病毒和nk细胞的治疗剂及其在治疗肿瘤和/或癌症的药物中的应用 Download PDF

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CN110248671A
CN110248671A CN201880004934.9A CN201880004934A CN110248671A CN 110248671 A CN110248671 A CN 110248671A CN 201880004934 A CN201880004934 A CN 201880004934A CN 110248671 A CN110248671 A CN 110248671A
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胡放
陈霖
赵荣华
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Hangzhou Converd Co Ltd
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Abstract

提供了包含溶瘤痘病毒和NK细胞的治疗剂及其在制备治疗肿瘤和/或癌症的药物中的应用。所述治疗剂的活性成分包括溶瘤痘病毒和NK细胞,所述溶瘤痘病毒能够选择性地在肿瘤细胞中复制。

Description

PCT国内申请,说明书已公开。

Claims (37)

  1. PCT国内申请,权利要求书已公开。
CN201880004934.9A 2017-01-04 2018-01-03 包含溶瘤痘病毒和nk细胞的治疗剂及其在治疗肿瘤和/或癌症的药物中的应用 Active CN110248671B (zh)

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CN2017100039541 2017-01-04
CN201710003954.1A CN108261426B (zh) 2017-01-04 2017-01-04 药物组合物及其在治疗肿瘤和/或癌症的药物中的应用
PCT/CN2018/070172 WO2018127053A1 (zh) 2017-01-04 2018-01-03 包含溶瘤痘病毒和nk细胞的治疗剂及其在治疗肿瘤和/或癌症的药物中的应用

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CN201880004934.9A Active CN110248671B (zh) 2017-01-04 2018-01-03 包含溶瘤痘病毒和nk细胞的治疗剂及其在治疗肿瘤和/或癌症的药物中的应用
CN201880004947.6A Active CN110325200B (zh) 2017-01-04 2018-01-03 治疗剂及其在治疗肿瘤和/或癌症的药物中的应用

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110325200A (zh) * 2017-01-04 2019-10-11 杭州康万达医药科技有限公司 治疗剂及其在治疗肿瘤和/或癌症的药物中的应用
CN114569708A (zh) * 2020-12-02 2022-06-03 四川大学华西医院 Nkg2d car-免疫细胞在抗衰老中应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109022374B (zh) * 2018-08-16 2021-05-14 华中农业大学 一种塞内卡谷病毒重组质粒、重组病毒及构建方法
CN110856751A (zh) 2018-08-24 2020-03-03 合成免疫股份有限公司 包含核酸及tcr修饰的免疫细胞的治疗剂及其应用
CN111110706A (zh) * 2018-10-30 2020-05-08 中国科学院武汉病毒研究所 肠道病毒71型在制备溶瘤药物中的应用
WO2020230785A1 (ja) * 2019-05-14 2020-11-19 国立大学法人鳥取大学 細胞融合を誘導するワクシニアウイルス及びその利用

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070077231A1 (en) * 2005-09-30 2007-04-05 Contag Christopher H Immune effector cells pre-infected with oncolytic virus
CN105307671A (zh) * 2013-04-18 2016-02-03 蒂尔坦生物制药有限公司 增强过继细胞疗法
CN108261426A (zh) * 2017-01-04 2018-07-10 杭州康万达医药科技有限公司 药物组合物及其在治疗肿瘤和/或癌症的药物中的应用
CN108338994A (zh) * 2017-01-25 2018-07-31 杭州康万达医药科技有限公司 溶瘤病毒作为用于治疗肿瘤和/或癌症的免疫刺激剂的应用
CN109554353A (zh) * 2017-09-26 2019-04-02 杭州康万达医药科技有限公司 分离的重组溶瘤痘病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途
WO2019062250A1 (zh) * 2017-09-28 2019-04-04 杭州康万达医药科技有限公司 包含分离的重组溶瘤腺病毒和nk细胞的治疗剂及应用、药盒、治疗肿瘤和/或癌症的方法
WO2019133847A1 (en) * 2017-12-29 2019-07-04 Oncorus, Inc. Oncolytic viral delivery of therapeutic polypeptides
CN111743923A (zh) * 2019-03-27 2020-10-09 北京康万达医药科技有限公司 包含分离的重组溶瘤腺病毒和免疫细胞的治疗剂及其应用
WO2021159035A1 (en) * 2020-02-07 2021-08-12 City Of Hope Oncolytic virus compositions and methods for the treatment of cancer
CN113583977A (zh) * 2020-04-30 2021-11-02 杭州康万达医药科技有限公司 可受微小rna调控的分离的重组溶瘤痘病毒及其应用
CN114072416A (zh) * 2019-02-18 2022-02-18 克里尔治疗股份有限公司 使用正痘病毒主要组织相容性复合物(mhc)i类样蛋白(omcp)和肿瘤特异性结合伴侣的双特异性融合蛋白

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009332883B2 (en) * 2008-12-22 2015-05-21 Oncos Therapeutics Oy Oncolytic adenoviral vectors and methods and uses related thereto
FI20090030A0 (fi) * 2009-02-02 2009-02-02 Akseli Eetu Hemminki Onkolyyttiset virukset
KR101942237B1 (ko) 2011-01-04 2019-01-25 신라젠(주) 종양 항원에 대한 항체의 생산 및 종양용해 우두 바이러스의 투여에 의한 종양 특이적 보체 의존적 세포독성의 생산
US10238700B2 (en) * 2014-01-02 2019-03-26 Genelux Corporation Oncolytic virus adjunct therapy with agents that increase virus infectivity
US10555981B2 (en) 2014-07-16 2020-02-11 Transgene S.A. Oncolytic virus for expression of immune checkpoint modulators
EP3169340B1 (en) 2014-07-16 2020-09-02 Institut Gustave Roussy Combination of oncolytic virus with immune checkpoint modulators
US11485791B2 (en) * 2015-03-17 2022-11-01 Tilt Biotherapeutics Oy Oncolytic adenoviruses coding for bi-specific antibodies
CN108367057B (zh) * 2015-04-06 2022-11-22 赛通免疫股份有限公司 用于胶质母细胞瘤的egfr导向的car疗法
CA3010987A1 (en) * 2016-01-08 2017-07-13 Replimune Limited Oncolytic herpes simplex virus type 1 strain
CN108606982B (zh) 2016-08-18 2020-02-04 广州威溶特医药科技有限公司 Vcp抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用
US10301451B2 (en) 2016-10-11 2019-05-28 Novartis Ag Chain-extended polydimethylsiloxane vinylic crosslinkers and uses thereof
JP7173495B2 (ja) * 2016-11-04 2022-11-16 セントロ デ インベスティガシオン ビオメディカ エン レッド 敗血症又は敗血症性ショック(ss)患者に由来する血漿中の循環ヒストンh3及びh2bを検出する質量分析ベースの方法
EP3916098A1 (en) * 2020-05-25 2021-12-01 Medizinische Hochschule Hannover Adenovirus for anti-tumour therapy
CN114657150A (zh) * 2020-12-23 2022-06-24 北京康万达医药科技有限公司 用于改善免疫疗法的重组溶瘤腺病毒及其应用

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070077231A1 (en) * 2005-09-30 2007-04-05 Contag Christopher H Immune effector cells pre-infected with oncolytic virus
CN105307671A (zh) * 2013-04-18 2016-02-03 蒂尔坦生物制药有限公司 增强过继细胞疗法
CN110325200A (zh) * 2017-01-04 2019-10-11 杭州康万达医药科技有限公司 治疗剂及其在治疗肿瘤和/或癌症的药物中的应用
CN108261426A (zh) * 2017-01-04 2018-07-10 杭州康万达医药科技有限公司 药物组合物及其在治疗肿瘤和/或癌症的药物中的应用
JP2020503344A (ja) * 2017-01-04 2020-01-30 ハンジョウ・コンバード・カンパニー, リミテッドHangzhou Converd Co., Ltd 腫瘍溶解性ワクシニアウイルスおよびnk細胞を含む治療剤、ならびに腫瘍および/またはがんの治療のための薬物のためのその使用
EP3566709A1 (en) * 2017-01-04 2019-11-13 Hangzhou Converd Co., Ltd. Therapeutic agent comprising oncolytic viruses and nk cells and application thereof in drugs for treating tumors and/or cancer
US20190336549A1 (en) * 2017-01-04 2019-11-07 Hangzhou Converd Co., Ltd. Therapeutic agents and uses thereof for drugs for treatment of tumors and/or cancers
CN108338994A (zh) * 2017-01-25 2018-07-31 杭州康万达医药科技有限公司 溶瘤病毒作为用于治疗肿瘤和/或癌症的免疫刺激剂的应用
CN109554353A (zh) * 2017-09-26 2019-04-02 杭州康万达医药科技有限公司 分离的重组溶瘤痘病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途
WO2019062233A1 (zh) * 2017-09-26 2019-04-04 杭州康万达医药科技有限公司 包含分离的重组溶瘤痘病毒和nk细胞的治疗剂及应用、药盒、治疗肿瘤和/或癌症的方法
WO2019062250A1 (zh) * 2017-09-28 2019-04-04 杭州康万达医药科技有限公司 包含分离的重组溶瘤腺病毒和nk细胞的治疗剂及应用、药盒、治疗肿瘤和/或癌症的方法
CN111344398A (zh) * 2017-09-28 2020-06-26 杭州康万达医药科技有限公司 分离的重组溶瘤腺病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途
WO2019133847A1 (en) * 2017-12-29 2019-07-04 Oncorus, Inc. Oncolytic viral delivery of therapeutic polypeptides
CN114072416A (zh) * 2019-02-18 2022-02-18 克里尔治疗股份有限公司 使用正痘病毒主要组织相容性复合物(mhc)i类样蛋白(omcp)和肿瘤特异性结合伴侣的双特异性融合蛋白
CN111743923A (zh) * 2019-03-27 2020-10-09 北京康万达医药科技有限公司 包含分离的重组溶瘤腺病毒和免疫细胞的治疗剂及其应用
WO2021159035A1 (en) * 2020-02-07 2021-08-12 City Of Hope Oncolytic virus compositions and methods for the treatment of cancer
CN113583977A (zh) * 2020-04-30 2021-11-02 杭州康万达医药科技有限公司 可受微小rna调控的分离的重组溶瘤痘病毒及其应用
WO2021218802A1 (zh) * 2020-04-30 2021-11-04 杭州康万达医药科技有限公司 可受微小rna调控的分离的重组溶瘤痘病毒及其应用

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ANGELICA P. ASPIRIN等: "Polytherapeutic strategies with oncolytic virus–bortezomib and adjuvant NK cells in cancer treatment", 《J. R. SOC. INTERFACE》 *
ANGELICA P. ASPIRIN等: "Polytherapeutic strategies with oncolytic virus–bortezomib and adjuvant NK cells in cancer treatment", 《J. R. SOC. INTERFACE》, vol. 18, 6 January 2021 (2021-01-06), pages 1 - 13 *
ELAINE Y. L. LEUNG等: "Strategies to Optimise Oncolytic Viral Therapies: The Role of Natural Killer Cells", 《VIRUS》 *
ELAINE Y. L. LEUNG等: "Strategies to Optimise Oncolytic Viral Therapies: The Role of Natural Killer Cells", 《VIRUS》, vol. 13, no. 1450, 26 July 2021 (2021-07-26), pages 1 - 12 *
刘耕陶主编: "《当代药理学》", 31 May 2008, 中国协和医科大学出版社, pages: 274 - 276 *
喻启桂;: "肿瘤治疗的新突破:溶瘤病毒治疗", 安徽医药, no. 01, pages 1 - 7 *
崔姣艳等: "溶瘤病毒联合其他药物用于肿瘤治疗的研究进展", 《中国新药杂志》 *
崔姣艳等: "溶瘤病毒联合其他药物用于肿瘤治疗的研究进展", 《中国新药杂志》, vol. 30, no. 3, 15 March 2021 (2021-03-15), pages 246 - 253 *
张思汗等: "肿瘤免疫治疗药物的开发现状及展望", 《临床与病理杂志》 *
张思汗等: "肿瘤免疫治疗药物的开发现状及展望", 《临床与病理杂志》, vol. 41, no. 10, 28 October 2021 (2021-10-28), pages 2447 - 2460 *
贾晓渊;郭彦孜;: "溶瘤痘苗病毒对肿瘤细胞作用机制的研究进展", 中国科学:生命科学, no. 04, pages 414 - 422 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110325200A (zh) * 2017-01-04 2019-10-11 杭州康万达医药科技有限公司 治疗剂及其在治疗肿瘤和/或癌症的药物中的应用
CN114569708A (zh) * 2020-12-02 2022-06-03 四川大学华西医院 Nkg2d car-免疫细胞在抗衰老中应用

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