CN110215443A - A kind of anti-aging, the preparation method for improving sleep soft capsule - Google Patents
A kind of anti-aging, the preparation method for improving sleep soft capsule Download PDFInfo
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- CN110215443A CN110215443A CN201910608918.7A CN201910608918A CN110215443A CN 110215443 A CN110215443 A CN 110215443A CN 201910608918 A CN201910608918 A CN 201910608918A CN 110215443 A CN110215443 A CN 110215443A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a kind of anti-agings, the preparation method of improvement sleep soft capsule.The soft capsule is made of feed liquid in capsule shells and capsule, wherein feed liquid is made of cannabidiol, astaxanthin, vegetable oil according to the mixing of 1:0.2~5:2~5 in every part of capsule, by weight；Every part of capsule shells are made of gelatin, purified water, glycerol according to 1:0.5~2:0.2~1, by weight；Soft capsule is made by dissolution, degassing, pelleting, sizing, cleaning, drying；The present invention combines cannabidiol protection nerve and antianxiety effect, the anti-oxidation efficacy of astaxanthin；The two is applied in combination, to reach good anti-insomnia effect and scavenger-cell free radical, delays senescence.
Description
Technical field
The invention belongs to field of pharmaceutical technology, and in particular to a kind of anti-aging, the preparation method for improving sleep soft capsule.
Background technique
With the development that society is at full speed, the operating pressure and life stress of people is increasing, causes many people's spirit tight
, it is palpitaition, absent-minded, uncomfortable.Insomnia, easy aging are the states that nowadays social most people is universal, according to related data
Statistics, there are about 50% people insomnia problem occurs in the whole world.Wherein, there are about 20-30% be since different sleep disturbance causes, and
Developed country, city ratio may be higher.Insomnia can cause the feeling of fatigue, uneasiness, general malaise, listless, reaction of people
Slow, headache, attention cannot be concentrated, and more seriously will lead to schizophrenia and depression, anxiety disorder, and vegetative nerve function is disorderly
The functional diseases such as random.
Although the medicament categories with syngignoscism are various, wherein the main application of most drugs is not that treatment is lost
It sleeps.The drug of clinical treatment insomnia at present mainly includes Benzodiazepines receptor stimulating agent, melatonin receptors agonist and has
The antidepressant of hypnotic effect.Antihistamine drug, e.g., diphenhydramine, epiphysin and Valerian root P.E, although having hypnosis
Effect, but existing Clinical Evidence is limited, it should not be as insomnia routine administration.General treatment is recommended: Ai Sizuo
Clone, zolpidem, zolpidem controlled release agent, zopiclone.The drug for treating insomnia is complicated and various, including estazolam, fluorine
West dissolves, Quazepam, Temazepam, triazolam, alprazolam, chlordiazepoxide, western companion, Laura west companion, Dormicum, zolpidem,
Zolpidem controlled release agent, zopiclone, eszopiclone and Zaleplon, Ramelteon, Te Simeiertong, agomelatine, three
Ring class antidepressant, selectivity 5- reuptake inhibitors, serotonin and norepinephrine reuptake inhibition, small dose
Measure Mirtazapine, small-dose trazodone etc..Since some drugs have a possibility that dependence, so, do not advocate generally to take for a long time.
In the market antiaging agent some have the function of really certain adjustment, can be improved vitality, extend existence when
Between, but long-term use can all have some side effects.Microelement is component part important in Kangshuaining mixture, but long-term clothes
With a large amount of various Rare Elements Preparations, no sexual desire state, out of strength, gastrointestinal dysfunction, neuroticism, mental depression may occur in which
Deng；Although vitamin E has anti-aging effects, but daily oral more than 100 milligrams, and continuous application 6 months or more persons may occur in which
Functional disturbances of gastrointestinal tract, angular stomatitis, myasthenia, cheilitis, and hypoglycemia, thrombophlebitis, blood lipid and gallbladder may be caused solid
Alcohol raising etc..It is most also easy to produce diarrhea after largely taking vitamin C, or generates and precipitates with urethra oxalates, and the middle-aged and the old is to upper
It states symptom to tend not to draw attention again, occur dysuric also commonplace；Although ginseng is good tonic, but every
It takes 3 grams of ginseng or more, can cause " Opthalmic Artery Doppler Flowvelocity Study In Diabetic ", be mainly shown as hypertension with neuroticism, unstability,
Insomnia, excitement or amentia and uncomfortable in chest, abdominal distension etc.；Taking the fleece-flower root for a long time may occur in which soft stools, a few patients with
Slight abdominal pain and Nausea and vomiting, individuals patients have extremity numbness sense, fash etc. after taking.
Cannabidiol (CBD) is the main active of the cannboid extracted from industrial hemp, has patron saint
The effect of warp, it is no additive and have anti-spasm, antirheumatic arthritis and effect antianxity, cause extensively in fields such as medicine and pharmacology
General concern and become research hotspot in recent years.Currently, multinomial research can adequately show to us in the world: cannboid is big
Insomnia can be effectively relieved in numb diphenol (CBD).One of SaoPaulo State,Brazil in 1981 is studies have shown that CBD may be due to it
Angst resistance effect, to prevent the duration REM sleep induced by anxiety.One of National Institutes of Health in 2004
Research shows that: using the patient of higher dosage CBD, sleeping time be increased significantly, and bad dream is effectively relieved, and not occur any pair
Effect.The research report being published in for 2013 on U.S.'s psychopharmacology magazine is shown: the CBD of low dosage, is usually had to rat
There is activation, on the contrary, the CBD of higher dosage often promotes the sleep of rat.In a research of Brazil, wherein 15
Insomniac takes 40 milligrams to 160 milligrams of CBD, placebo or nitrazepam.The result shows that the maximum dose level of CBD increases
Sleep.Further investigations have shown that CBD is the effective ways for adjusting REM sleep and changing.
Astaxanthin (astaxanthin) also known as astaxanthin, Astaxanthin are a Carotenoids and class Hu trailing plants
The highest level product of Bu Su synthesis, is in rediance, and chemical structure is similar to beta carotene.And β-carrotene, leaf
Flavine, canthaxanthin, lycopene etc. are all the intermediate products of carotenogenesis, therefore in nature, astaxanthin has most
Strong inoxidizability.It is higher to be widely present in content in the feather of living nature, especially shrimp, crab, fish, frond, yeast and birds,
It is one of main carotenoid in marine organisms body.
Natural astaxanthin (natural astacin) one of strongest natural in the world, the oxygen in effective scavenger-cell
Free radical, enhance cytothesis ability, maintain organism balance and reduce senile cell accumulation, from inside to outside protect cell and
DNA health promotes hair growth to protect skin health, and anti-aging alleviates sports fatigue, invigorates.From 2008 with
Come, domestic and international numerous studies confirm that astaxanthin has stronger antioxidant activity, are improving immunity, pre- preventing tumor, angiocarpy
The occurrence and development of the chronic diseases such as disease, diabetes, delay senescence etc. have positive facilitation.
Natural astaxanthin antioxidant activity is more than existing antioxidant.Its ability for removing free radical is: astaxanthin is
6000 times of ascorbic effect；It is 1000 times of vitamin E；It is 800 times of Co-Q10；It is nitric oxide production 1800 times；
It is 3100 times of natto；It is 700 times of anthocyanidin；It is 100 times of beta carotene effect；It is lycopene(lycopene) function
10 times of effect；It is carotol(lutein) 200 times of effect；It is teapolyphenols(tea polyphenols) 320 times of effect.
Summary of the invention
For anti-insomnia in the market and the apparent side effect of anti-aging drug, it is an object of the invention to prepare a nothing
Side effect and the superior soft capsule of curative effect.Nerve and antianxiety are protected using cannabidiol (CBD), is resisted using astaxanthin is powerful
Oxidability；The two is applied in combination, and soft capsule particle is made, to reach good anti-insomnia effect, scavenger-cell is free
Base delays senescence.
The specific steps of the present invention are as follows:
(1) preparation of interior feed liquid
Cannabidiol, astaxanthin, vegetable oil are uniformly mixed according to a certain percentage, filtered to get feed liquid in soft capsule, it is spare.
(2) preparation of gelatin solution
Gelatin, purified water, glycerol are added sequentially in flask by formula, heating stirring dissolution；Dissolved gelatin is mixed
Liquid filtering, vacuum outgas；Slow breaking vacuum after degassing filters glue again；After glue is kept the temperature it is spare.
(3) pelleting
Rubber is made in glue after the heat preservation, feed liquid in soft capsule, compacting are filled under conditions of certain temperature and humidity
At soft capsule.
(4) dryness finalization
By the just soft capsule processed soft capsule sizing drying machine dryness finalization；After being formed, capsule is cleaned with ethyl alcohol, it is dry,
Soft capsule is made.
Step (1) cannabidiol, astaxanthin, vegetable oil ratio be 1:0.2~5:2~5, filtering using 50~
200 mesh filter clothes.
Step (2) heating temperature is 60~90 DEG C, vacuum outgas -0.08~-0.1MPa of vacuum degree, temperature 60 C；
12~36h is kept the temperature at 30~70 DEG C.
The step (3) carries out in soft capsule pellet press, and glue and content are placed in pellet press, controls content
Loading amount is 0.3~0.5g/, and at 18~30 DEG C, relative humidity is 25~40% for room temperature control.
Step (4) setting temperature is 18~30 DEG C, and relative humidity is 25~40%, 3~6h of setting time；Ethyl alcohol is dense
Degree 70~98%, at 25~40 DEG C, under conditions of relative humidity is 25~40%, dry 12~48h.
The advantages of the method for the present invention and technical effect.
Soft capsule is made in cannabidiol and astaxanthin, effectively prevents being chronically exposed to the problems such as perishable in air,
Extend the quality guarantee period of medicament phase.Meanwhile oral soft capsule can promote effective absorption of medicinal ingredient, improve bioavailability.
The present invention oxidation resistance group that the outstanding protection nerve of cannabidiol and antianxiety effect and astaxanthin is powerful
It closes and uses, reach good anti-insomnia effect, scavenger-cell free radical delays senescence；The composition is without any side effects, for a long time
Taking will not cause to damage to body.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.
Embodiment 1
1) preparation of feed liquid in
100g cannabidiol, 100g astaxanthin, 200g fire sesame oil are mixed evenly to get feed liquid in soft capsule, it is spare.
2) preparation of gelatin solution
450g gelatin, 425g purified water, 150g glycerol are added sequentially in flask, be heated to 75 DEG C and are stirred continuously to complete
Dissolution, is made gelatin mixed liquor；By 100 mesh filter-cloth filtering of gelatin mixed liquor, filtrate is in vacuum degree -0.08MPa, and 60.0 DEG C of temperature
Under the conditions of, stirring to solution bubble-free is released；Slow breaking vacuum, gained gelatin solution carry out 100 mesh filter-cloth filterings again；Filtrate
14 hours are kept the temperature under the conditions of being placed in 60 DEG C, it is spare.
3) pelleting
Interior feed liquid and gelatin solution made from step 1) and step 2 are placed in soft capsule pellet press, discharging speed, control are adjusted
Interior feed liquid loading amount is 0.4g/, and at 22 DEG C, relative humidity is controlled 35% for room temperature control.
4) dryness finalization
By step 3), just soft capsule processed is fixed under conditions of temperature is 22 DEG C, relative humidity is 35% with soft capsule sizing drying machine
Type 3.5 hours, soft capsule surface was cleaned with the ethanol solution of mass fraction 95%；At 26 DEG C, condition that relative humidity is 25%
Under, dry 30h.Soft capsule is made.
Embodiment 2
1) preparation of feed liquid in
100g cannabidiol, 100g astaxanthin, 200g peanut oil are mixed evenly to get feed liquid in soft capsule, it is spare.
2) preparation of gelatin solution
450g gelatin, 425g purified water, 150g glycerol are added sequentially in flask, be heated to 75 DEG C and are stirred continuously to complete
Dissolution, is made gelatin mixed liquor；By 100 mesh filter-cloth filtering of gelatin mixed liquor, filtrate is in vacuum degree -0.08MPa, and 60.0 DEG C of temperature
Under the conditions of, stirring to solution bubble-free is released；Slow breaking vacuum, gained gelatin solution carry out 100 mesh filter-cloth filterings again；Filtrate
14 hours are kept the temperature under the conditions of being placed in 60 DEG C, it is spare.
3) pelleting
Interior feed liquid and gelatin solution made from step 1) and step 2 are placed in soft capsule pellet press, discharging speed, control are adjusted
Interior feed liquid loading amount is 0.4g/, and at 22 DEG C, relative humidity is controlled 35% for room temperature control.
4) dryness finalization
By step 3), just soft capsule processed is fixed under conditions of temperature is 22 DEG C, relative humidity is 35% with soft capsule sizing drying machine
Type 3.5 hours, soft capsule surface was cleaned with the ethanol solution of mass fraction 95%；At 26 DEG C, condition that relative humidity is 25%
Under, dry 30h.Soft capsule is made.
Embodiment 3
1) preparation of feed liquid in
100g cannabidiol, 200g astaxanthin, 300g castor oil are mixed evenly to get feed liquid in soft capsule, it is spare.
2) preparation of gelatin solution
450g gelatin, 425g purified water, 150g glycerol are added sequentially in flask, be heated to 75 DEG C and are stirred continuously to complete
Dissolution, is made gelatin mixed liquor；By 100 mesh filter-cloth filtering of gelatin mixed liquor, filtrate is in vacuum degree -0.08MPa, and 60.0 DEG C of temperature
Under the conditions of, stirring to solution bubble-free is released；Slow breaking vacuum, gained gelatin solution carry out 100 mesh filter-cloth filterings again；Filtrate
14 hours are kept the temperature under the conditions of being placed in 60 DEG C, it is spare.
3) pelleting
Interior feed liquid and gelatin solution made from step 1) and step 2 are placed in soft capsule pellet press, discharging speed, control are adjusted
Interior feed liquid loading amount is 0.4g/, and at 22 DEG C, relative humidity is controlled 35% for room temperature control.
4) dryness finalization
By step 3), just soft capsule processed is fixed under conditions of temperature is 22 DEG C, relative humidity is 35% with soft capsule sizing drying machine
Type 3.5 hours, soft capsule surface was cleaned with the ethanol solution of mass fraction 95%；At 26 DEG C, condition that relative humidity is 25%
Under, dry 30h.Soft capsule is made.
Above embodiments are only the explanations that makes an explanation to the present invention, do not carry out any limit to protection scope of the present invention
System.To those skilled in the art, all to exist without departing from same embodiment or change made by the technology of the present invention spirit
Within protection scope of the present invention.
Claims (5)
1. a kind of anti-aging, the preparation method for improving sleep soft capsule, which comprises the steps of:
Step 1, the preparation of interior feed liquid
Cannabidiol, astaxanthin, vegetable oil are uniformly mixed according to a certain percentage, filtered to get feed liquid in soft capsule, it is spare；
Step 2, the preparation of gelatin solution
Gelatin, purified water, glycerol are added sequentially in flask by formula, heating stirring dissolution；Dissolved gelatin is mixed
Liquid filtering, vacuum outgas；Slow breaking vacuum after degassing filters glue again；After glue is kept the temperature it is spare；
Step 3, pelleting
Rubber is made in glue after the heat preservation, feed liquid in soft capsule, compacting are filled under conditions of certain temperature and humidity
At soft capsule；
Step 4, dryness finalization
By the just soft capsule processed soft capsule sizing drying machine dryness finalization；After being formed, capsule is cleaned with ethyl alcohol, it is dry,
Soft capsule is made.
2. a kind of anti-aging according to claim 1, the preparation method for improving sleep soft capsule, which is characterized in that
(1) in the step 1, cannabidiol, astaxanthin, vegetable oil ratio be 1:0.2~5:2~5；
(2) in the step 1, vegetable oil includes peanut oil, soya-bean oil, linseed oil, castor oil, sunflower oil, tea-seed oil, sesame
Oil, olive oil, camellia oil, palm oil, corn oil；
(3) in the step 1, cannabidiol includes the work of cannabidiol crystal of the content greater than 99%, different cannabidiol contents
The multispectral oil of sparetime university fiber crops and the industrial hemp of different cannabidiol contents compose oil entirely；
(4) in the step 1, filtering uses 50~200 mesh filter clothes.
3. a kind of anti-aging according to claim 1, the composition of medicine preparation method for improving sleep, which is characterized in that
(1) in the step 2, gelatin, purified water, the ratio of glycerol are 1:0.5~2:0.2~1；
(2) in the step 2, heating temperature is 60~90 DEG C, 100~500r/min of speed of agitator；
(3) in the step 2, vacuum outgas -0.08~-0.1MPa of vacuum degree, temperature 60 C；
(4) in the step 2,12~36h is kept the temperature at 30~70 DEG C of glue.
4. a kind of anti-aging according to claim 1, the preparation method for improving sleep soft capsule, which is characterized in that
(1) in the step 3, pelleting carries out in soft capsule pellet press；
(2) in the step 3, feed liquid loadings are 0.3~0.5g/ in capsule；
(3) in the step 3, environmental condition is that room temperature is controlled at 18~30 DEG C, and relative humidity is 25~40%.
5. a kind of anti-aging according to claim 1, the preparation method for improving sleep soft capsule, which is characterized in that
(1) in the step 4, setting temperature is 18~30 DEG C, and relative humidity is 25~40%, 3~6h of setting time；
(2) in the step 4, capsule concentration of alcohol 70~98% is cleaned；
(3) in the step 4, drying condition be at 25~40 DEG C, under conditions of relative humidity is 25~40%, dry 12~
48h。
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111956535A (en) * | 2019-12-30 | 2020-11-20 | 云南汉盟制药有限公司 | Conditioner composition and preparation method and application thereof |
| CN112167636A (en) * | 2020-06-29 | 2021-01-05 | 武汉林宝莱生物科技有限公司 | Cannabidiol and astaxanthin soft capsule and preparation method thereof |
| CN112516120A (en) * | 2021-02-05 | 2021-03-19 | 云南维他源生物科技有限公司 | ASBD composition with anti-aging and anti-inflammatory effects and application thereof |
| CN112603913A (en) * | 2021-02-05 | 2021-04-06 | 云南维他源生物科技有限公司 | ASBD composition for improving sleep disorder and preparation and application thereof |
| CN112618523A (en) * | 2021-02-05 | 2021-04-09 | 云南维他源生物科技有限公司 | Anti-depression ACDV pharmaceutical composition, preparation and application thereof |
| CN112618522A (en) * | 2021-02-05 | 2021-04-09 | 云南维他源生物科技有限公司 | Anti-depression ACD (acute coronary syndrome) pharmaceutical composition as well as preparation and application thereof |
| CN112618524A (en) * | 2021-02-05 | 2021-04-09 | 云南维他源生物科技有限公司 | ASBDV composition for improving sleep disorder and preparation and application thereof |
| CN112690453A (en) * | 2020-12-30 | 2021-04-23 | 北京常春藤经贸有限责任公司 | Composition, compound oil and application thereof |
| WO2021123804A1 (en) * | 2019-12-19 | 2021-06-24 | GW Research Limited | Oral cannabinoid formulations |
| WO2022085622A1 (en) * | 2020-10-23 | 2022-04-28 | 富士カプセル株式会社 | Cannabidiol-containing seamless soft capsule |
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2019
- 2019-07-08 CN CN201910608918.7A patent/CN110215443A/en not_active Withdrawn
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021123804A1 (en) * | 2019-12-19 | 2021-06-24 | GW Research Limited | Oral cannabinoid formulations |
| CN111956535A (en) * | 2019-12-30 | 2020-11-20 | 云南汉盟制药有限公司 | Conditioner composition and preparation method and application thereof |
| CN112167636A (en) * | 2020-06-29 | 2021-01-05 | 武汉林宝莱生物科技有限公司 | Cannabidiol and astaxanthin soft capsule and preparation method thereof |
| WO2022085622A1 (en) * | 2020-10-23 | 2022-04-28 | 富士カプセル株式会社 | Cannabidiol-containing seamless soft capsule |
| CN112690453A (en) * | 2020-12-30 | 2021-04-23 | 北京常春藤经贸有限责任公司 | Composition, compound oil and application thereof |
| CN112516120A (en) * | 2021-02-05 | 2021-03-19 | 云南维他源生物科技有限公司 | ASBD composition with anti-aging and anti-inflammatory effects and application thereof |
| CN112603913A (en) * | 2021-02-05 | 2021-04-06 | 云南维他源生物科技有限公司 | ASBD composition for improving sleep disorder and preparation and application thereof |
| CN112618523A (en) * | 2021-02-05 | 2021-04-09 | 云南维他源生物科技有限公司 | Anti-depression ACDV pharmaceutical composition, preparation and application thereof |
| CN112618522A (en) * | 2021-02-05 | 2021-04-09 | 云南维他源生物科技有限公司 | Anti-depression ACD (acute coronary syndrome) pharmaceutical composition as well as preparation and application thereof |
| CN112618524A (en) * | 2021-02-05 | 2021-04-09 | 云南维他源生物科技有限公司 | ASBDV composition for improving sleep disorder and preparation and application thereof |
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