CN103006920A - Chloasma-removing pure traditional Chinese medicine composition and preparation method thereof - Google Patents
Chloasma-removing pure traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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- CN103006920A CN103006920A CN2011104175798A CN201110417579A CN103006920A CN 103006920 A CN103006920 A CN 103006920A CN 2011104175798 A CN2011104175798 A CN 2011104175798A CN 201110417579 A CN201110417579 A CN 201110417579A CN 103006920 A CN103006920 A CN 103006920A
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- 208000003351 Melanosis Diseases 0.000 title claims abstract description 23
- 206010008570 Chloasma Diseases 0.000 title claims abstract description 22
- 239000003814 drug Substances 0.000 title claims abstract description 18
- 239000000203 mixture Substances 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 20
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 18
- 239000002775 capsule Substances 0.000 claims abstract description 14
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 9
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 9
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 9
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 9
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- 239000008187 granular material Substances 0.000 claims description 15
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 12
- 244000293323 Cosmos caudatus Species 0.000 claims description 12
- 241000628997 Flos Species 0.000 claims description 12
- 235000009392 Vitis Nutrition 0.000 claims description 12
- 241000219095 Vitis Species 0.000 claims description 12
- 210000000582 semen Anatomy 0.000 claims description 12
- 241000545442 Radix Species 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 3
- 230000006837 decompression Effects 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000007689 inspection Methods 0.000 claims description 3
- 239000012567 medical material Substances 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 238000004064 recycling Methods 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 241000125175 Angelica Species 0.000 abstract 2
- 241000213006 Angelica dahurica Species 0.000 abstract 2
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 2
- 235000009754 Vitis X bourquina Nutrition 0.000 abstract 2
- 235000012333 Vitis X labruscana Nutrition 0.000 abstract 2
- 240000006365 Vitis vinifera Species 0.000 abstract 2
- 235000014787 Vitis vinifera Nutrition 0.000 abstract 2
- 230000003631 expected effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- 150000003254 radicals Chemical class 0.000 description 5
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000002503 metabolic effect Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 description 2
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 description 2
- MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
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- 229940079593 drug Drugs 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 description 2
- 229920002414 procyanidin Polymers 0.000 description 2
- 206010010144 Completed suicide Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000201295 Euphrasia Species 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
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- 235000006694 eating habits Nutrition 0.000 description 1
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- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
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- 235000013402 health food Nutrition 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
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- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- 230000002936 tranquilizing effect Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention discloses a chloasma-removing pure traditional Chinese medicine composition and a preparation method thereof. The chloasma-removing pure traditional Chinese medicine composition comprises the following material components in parts by weight: 27 parts of Chinese angelica, 20 parts of angelica root, 32.6 parts of red flower, 10 parts of pearl powder, 10.7 parts of grape seeds, 50 parts of microcrystalline cellulose and 0.5 part of magnesium stearate. The traditional Chinese medicine capsule disclosed by the invention can be prepared according to the conventional health-care formula theory, so that an expected effect of removing the chloasma is reached. The chloasma-removing pure traditional Chinese medicine composition adopts the Chinese angelica, the angelica root, the red flower, the pearl powder and the grape seeds as the main materials, and is processed by adopting a scientific and reasonable production process. The chloasma-removing pure traditional Chinese medicine composition has a definite product function and controllable quality, is safe to take and simple in preparation process, and can be prepared by conventional equipment.
Description
Technical field
The invention belongs to the health care medicine technical field, particularly pure Chinese medicine combination of a kind of functions of removing chloasma and preparation method thereof.
Background technology
Chloasma is a kind of of facial melanosis, is the pigmentation spots that occurs in face; It is a kind of external dominant performance in endocrine disturbance, the metabolic waste alluvial body.Existing effect of drugs is bad, and side effect is large.
Summary of the invention
Purpose of the present invention aims to provide pure Chinese medicine combination of a kind of functions of removing chloasma and preparation method thereof, and the functional component that it extracts Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Flos Carthami, Margarita powder, Semen Vitis viniferae is as the main matter of functions of removing chloasma, and Multiple components is collaborative to play a role.
Technical scheme of the present invention is: design pure Chinese medicine combination of a kind of functions of removing chloasma and preparation method thereof, it is characterized in that material composition and weight proportion thereof that it contains are: 27 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Angelicae Dahuricae, 32.3 parts on Flos Carthami, 10 parts of Margarita powder, 10.7 parts of Semen Vitis viniferae, 50 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate.
The pure Chinese medicine combination its preparation method of above-mentioned a kind of functions of removing chloasma is that it may further comprise the steps:
1) takes by weighing raw material by following weight ratio: 27 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Angelicae Dahuricae, 32.3 parts on Flos Carthami, 10 parts of Margarita powder, 10.7 parts of Semen Vitis viniferae, 50 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate;
2) above medical material is got 27 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Angelicae Dahuricae, 32.3 parts on Flos Carthami, 10 parts of Margarita powder, 10.7 parts of Semen Vitis viniferae, with twice of 70% alcohol reflux, add 8 times of amount 70% ethanol, filtered in each 2 hours, decompression recycling ethanol also continues to be concentrated into relative density 1.28～1.30(80 ℃), drying is pulverized, cross 80 mesh sieves, powder gets dry extract;
3) with above-mentioned dried cream powder, with 50 parts of microcrystalline Cellulose mix homogeneously, add 85% ethanol and granulate, in 55-60 ℃ of baking oven, dry 18 mesh sieve granulate;
4) with whole good granule and 0.5 part of magnesium stearate, insert mix homogeneously in the mixer, get always mixed granule;
5) capsule filling machine on above-mentioned total mixed granule is carried out No. 0 capsule of filling;
6) inner packing;
7) outer package, product inspection, warehouse-in.
Radix Angelicae Sinensis among the present invention has the removing free radical, and restraint of tyrosinase is active, prevents that the tyrosine oxidation from forming the effect of pigment; The main mechanism that Flos Carthami can improve hemorheological property is to have improved erythrocytic function, by reducing erythrocytic gathering row, improve erythrocyte deformability and antioxidation, immune adherence ability, reduced the erythrocytic damage of radical pair, prolonged its life-span, keep the normal of blood viscosity, thereby reached blood circulation promoting and blood stasis dispelling, the good result of promoting blood circulation; The Radix Angelicae Dahuricae can stop the generation of tryrosinase; The contained effective ingredient procyanidin (procyanidin) of Semen Vitis viniferae has antioxidation, removes the effects such as free radical, blood fat reducing, antitumor; Margarita powder has tranquilizing mind, and yin nourishing relieves dizziness, high fever, infantile convulsions, epilepsy, etc., heat clearing away pendant expectorant, and removing nebula makes eye bright, the effects such as removing toxic substances and promoting granulation skin moistening.Each material combination together, take Traditional health care prescription theory as the basis, reach and eliminate alluvial in the body, discharge metabolic waste, it is refreshing to make light of one's life by commiting suicide, the effect of skin moistening skin care, by for oral administration, engulf alluvial melanin simultaneously, promote human body cell SOD synthetic, remove " free radical ", from inside of human body root dispelling stain.
Advantage of the present invention is: the present invention is extracted and is processed by Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Flos Carthami, Margarita powder, Semen Vitis viniferae Chinese crude drug, uses the Traditional health care theory, special treatment for chloasma.Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Flos Carthami, Margarita powder, five kinds of composition synergism of Semen Vitis viniferae are adjusted endocrine, remove alluvial in the body, discharge metabolic waste, engulf alluvial melanin, promote human body cell SOD synthetic, remove " free radical ", from inside of human body root dispelling stain, thereby reach treatment to the chloasma disease.Effect is lasting, has no side effect no dependence.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, but not as limitation of the present invention.The part that is not described in detail in the present embodiment is to adopt prior art, and industry standard or known approaches.
Embodiment
Pure Chinese medicine combination of a kind of functions of removing chloasma and preparation method thereof, adopt following steps to make:
1) takes by weighing raw material by following weight ratio: 27 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Angelicae Dahuricae, 32.3 parts on Flos Carthami, 10 parts of Margarita powder, 10.7 parts of Semen Vitis viniferae, 50 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate;
2) above medical material is got 27 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Angelicae Dahuricae, 32.3 parts on Flos Carthami, 10 parts of Margarita powder, 10.7 parts of Semen Vitis viniferae, with twice of 70% alcohol reflux, add 8 times of amount 70% ethanol, filtered in each 2 hours, decompression recycling ethanol also continues to be concentrated into relative density 1.28～1.30(80 ℃), drying is pulverized, cross 80 mesh sieves, powder gets dry extract;
3) with above-mentioned dried cream powder, with 50 parts of microcrystalline Cellulose mix homogeneously, add 85% ethanol and granulate, in 55-60 ℃ of baking oven, dry 18 mesh sieve granulate;
4) with whole good granule and 0.5 part of magnesium stearate, insert mix homogeneously in the mixer, get always mixed granule;
5) capsule filling machine on above-mentioned total mixed granule is carried out No. 0 capsule of filling;
6) inner packing;
7) outer package, product inspection, warehouse-in.
The below is capsule (hereinafter to be referred as the sample capsules of the present invention) clinical testing data of the pure Chinese medicine combination preparation of this functions of removing chloasma of the embodiment of the invention:
The inventor selects patient with chloasma 450 examples for object of study, 450 experimenters is divided into sample sets 228 examples, matched group 222 examples, sample sets oral sample capsules of the present invention every day, each two, one day three times.The oral VC of matched group, edible time is 2 months, guarantees that the experimenter does not change dietary habit during edible.After 2 months, learn by statistics and process, the result shows, 74 examples are recovery from illness among the 228 routine sample sets patients, and 86 examples are produce effects, and 65 examples effectively, 3 examples are invalid, and total effective rate is that the 98.68%(matched group is 60.55%), show that this invention sample capsules has good therapeutical effect to the chloasma crowd.These invention sample capsules 2 all rear experimenter's indices are all normal cutting out, and illustrate that this invention sample capsules does not have dependency.According to the criterion of " health food check and assessment technique standard ", think that this invention sample capsules has the effect of functions of removing chloasma, and respond well.
Claims (2)
1. pure Chinese medicine combination of functions of removing chloasma and preparation method thereof, it is characterized in that material composition and weight proportion thereof that it contains are: 27 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Angelicae Dahuricae, 32.3 parts on Flos Carthami, 10 parts of Margarita powder, 10.7 parts of Semen Vitis viniferae, 50 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate.
2. the pure Chinese medicine combination its preparation method of above-mentioned a kind of functions of removing chloasma is that it may further comprise the steps:
1) takes by weighing raw material by following weight ratio: 27 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Angelicae Dahuricae, 32.3 parts on Flos Carthami, 10 parts of Margarita powder, 10.7 parts of Semen Vitis viniferae, 50 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate;
2) above medical material is got 27 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Angelicae Dahuricae, 32.3 parts on Flos Carthami, 10 parts of Margarita powder, 10.7 parts of Semen Vitis viniferae, with twice of 70% alcohol reflux, add 8 times of amount 70% ethanol, filtered in each 2 hours, decompression recycling ethanol also continues to be concentrated into relative density 1.28～1.30(80 ℃), drying is pulverized, cross 80 mesh sieves, powder gets dry extract;
3) with above-mentioned dried cream powder, with 50 parts of microcrystalline Cellulose mix homogeneously, add 85% ethanol and granulate, in 55-60 ℃ of baking oven, dry 18 mesh sieve granulate;
4) with whole good granule and 0.5 part of magnesium stearate, insert mix homogeneously in the mixer, get always mixed granule;
5) capsule filling machine on above-mentioned total mixed granule is carried out No. 0 capsule of filling;
6) inner packing;
7) outer package, product inspection, warehouse-in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201110417579.8A CN103006920B (en) | 2011-12-14 | 2011-12-14 | Chloasma-removing pure traditional Chinese medicine composition and preparation method thereof |
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| CN201110417579.8A CN103006920B (en) | 2011-12-14 | 2011-12-14 | Chloasma-removing pure traditional Chinese medicine composition and preparation method thereof |
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| CN103006920A true CN103006920A (en) | 2013-04-03 |
| CN103006920B CN103006920B (en) | 2015-05-06 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103300369A (en) * | 2013-06-19 | 2013-09-18 | 江西安正利康生命科技有限公司 | Method for preparing anti-oxidation chloasma-removing capsule by using nelumbo nucifera gaertn as base raw material |
| CN104068404A (en) * | 2014-07-15 | 2014-10-01 | 南京中医药大学 | Health product with function of chloasma removal |
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| CN103006920B (en) | 2015-05-06 |
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