CN104068404B - A kind of health product with chloasma-dispelling function - Google Patents
A kind of health product with chloasma-dispelling function Download PDFInfo
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- CN104068404B CN104068404B CN201410337719.4A CN201410337719A CN104068404B CN 104068404 B CN104068404 B CN 104068404B CN 201410337719 A CN201410337719 A CN 201410337719A CN 104068404 B CN104068404 B CN 104068404B
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- radix angelicae
- chloasma
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- folium ginkgo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of health product with chloasma-dispelling function, it is made up of Radix Angelicae Sinensis 30 ~ 90 parts, the Radix Angelicae Dahuricae 90 ~ 270 parts, Folium Ginkgo extract 1 ~ 3 part, vitamin E 1 ~ 3 part, Margarita powder 5 ~ 15 parts, safflower oil 33 ~ 99 parts.The present invention is under the guidance of Chinese medical theory, use determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, pathogeny and disease symptom in conjunction with chloasma, screening raw material, whole raw material composition and ratio is scientific and reasonable, test result indicate that, the health product that the present invention provides can be effectively increased tryrosinase content in liver, skin, effectively reduce mda content, and the target area of melanocyte in skin, average diameter and accumulation optical density can be reduced substantially reduce；And superoxide dismutase content in mouse skin is increased significantly in effect, and experimentation finds no untoward reaction, toxic and side effects is low, and safety is good.
Description
Technical field
The present invention relates to a kind of health product, be specifically related to a kind of with Chinese herbal medicine as raw material, there are the health product of chloasma-dispelling function.
Background technology
The chloasma traditional Chinese medical science is referred to as " chloasma hepaticum ", " chloasma ", is the discosmetic dermatosis of a kind of facial pigmentation dysbolismus, not only shadow
Ring face appearance, and bring all many worries and the miseries such as physiology, psychology, spirit to patient with chloasma.It is apt to occur in
Face, is shaped as irregular filbert or yellowish-brown patch, is often symmetrically distributed in eye socket, two cheeks, forehead, bicker etc.,
Border is relatively clear, divides on skin, and that comforts is not in the way, and is similar to butterfly, and the course of disease is touching, easily examines refractory, is that beauty treatment section is common
Difficult disease.Chinese and western medicine the most all there is no definite Therapeutic Method.Therefore, find one safely, effectively, easy prevention
The method that combines with treatment is the most urgently expected.
The pathogeny of chloasma is sufficiently complex, and possible correlative factor is the most more, but researcher is more generally approved up to now
Saying be: the factors such as human endocrine is disorderly, ultraviolet irradiates, heredity are the principal elements causing chloasma to generate；In and
Doctor then thinks that human body is an organic whole, although chloasma is a kind of generation disease at face, but many by visceral dysfunction,
QI and blood is not sought, poor vein, the stasis of blood and spotting is main, dirty with liver,spleen,kidney three more close, especially the tightest with liver relation
Close, and blood stasis is carried throughout.Though ancient Chinese medicine doctor has difference to the treatment of this disease, but all follows the principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
Summary of the invention
Goal of the invention: it is an object of the invention to overcome the deficiencies in the prior art, it is provided that a kind of raw material using integration of edible and medicinal herbs, proportioning
Scientific and reasonable, use that safety, determined curative effect, medicine source is wide, low cost, there are the health product of good chloasma-dispelling function.
Technical scheme: in order to realize object above, the technical scheme that the present invention takes is:
A kind of health product with chloasma-dispelling function, it is made up of the raw material of following portions by weight:
Radix Angelicae Sinensis 30～90 parts, the Radix Angelicae Dahuricae 90～270 parts, Folium Ginkgo extract 1～3 parts, vitamin e1～3 parts, Margarita powder 5～15
Part, safflower oil 33～99 parts.
Preferably, the above-described health product with chloasma-dispelling function, it is by the raw material system of following portions by weight
Become:
Radix Angelicae Sinensis 30～60 parts, the Radix Angelicae Dahuricae 90～180 parts, Folium Ginkgo extract 1～2 parts, vitamin e1～2 parts, Margarita powder 5～10
Part, safflower oil 33～66 parts.
Preferably, the above-described health product with chloasma-dispelling function, it is by the raw material system of following portions by weight
Become:
Radix Angelicae Sinensis 30 parts, the Radix Angelicae Dahuricae 90 parts, Folium Ginkgo extract 1 part, vitamin e1 part, Margarita powder 5 parts, safflower oil
33 parts.
The health product with chloasma-dispelling function of the present invention, described Folium Ginkgo extract is prepared by following method:
Take Folium Ginkgo suitably to pulverize, addition 8 to 12 times amount volumetric concentration 70% alcohol reflux 1～3 times, each 1～2h, close
And extracting solution, filter, decompression recycling ethanol, add suitable quantity of water and leach, stand, filter, upper AB-8 or D-101 resin column
Absorption, after washing clarification, with dense 95% ethanol elution of volume, collects eluent, concentrating under reduced pressure, upper polyamide column, first uses water
Wash, then by volumetric concentration 70% methanol-eluted fractions, collect 70% meoh eluate, concentrating under reduced pressure, drying under reduced pressure and get final product.
The preparation method of the health product with chloasma-dispelling function of the present invention, it comprises the following steps:
(1) take the Radix Angelicae Dahuricae by weight and Radix Angelicae Sinensis be separately added into 10 times, 10 times, 8 times amount volumetric concentration 70% alcohol refluxs carry
Take 3 times, each 1～2h, united extraction liquid, concentrate final vacuum and be dried, cross 100 mesh sieves, obtain the Radix Angelicae Dahuricae and Radix Angelicae Sinensis extract；
(2) take by weight Folium Ginkgo extract, vitamin E, Margarita powder Flos Carthami seed oil prepare with step (1)
The Radix Angelicae Dahuricae and Radix Angelicae Sinensis extract mix homogeneously, and food or medicine on acceptable carrier prepare health product.
The preparation method of the health product with chloasma-dispelling function of the present invention, preparing health product is oral liquid, capsule
Agent, tablet or granule.
The present invention is under the guidance of Chinese medical theory, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, in conjunction with pathogeny and the disease symptom of chloasma, screening group
Side.
In the present invention, pharmacological action is as follows: Radix Angelicae Sinensis: sweet in the mouth, pungent, warm in nature.Return liver, the heart, spleen channel.There are replenishing and activating blood, regulating menstruation
Pain relieving, effect of relaxing bowel.For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatism numbness
Bitterly, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis is by directly eliminating free radical, and inhibited oxidation reaction and free radical are anti-
The infringement of antagonism radical pair tissue should be waited.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature.Return stomach, large intestine, lung meridian.Having relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, declare clearing the nasal passage, dampness is only
Band, detumescence and apocenosis effect.For headache due to common cold, supraorbital bone pain, watery nasal discharge of having a stuffy nose, nasal sinusitis, toothache, leukorrhagia, skin infection swells and ache.
Modern study, the Radix Angelicae Dahuricae has suppression and pigment production, has white-skinned face function.
Folium Ginkgo extract: sweet in the mouth, hardship, puckery is flat.GUIXIN, lung meridian.There is blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, astringe the lung and relieving asthma,
Change turbid blood fat reducing.
Margarita: its nature and flavor are sweet, salty, cold in nature.GUIXIN, Liver Channel.There is arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation, skin moistening
Speckle dispelling.For insomnia of palpitating with fear, infantile convulsion epilepsy, cataract, skin infection do not holds back, skin splash.
The vitamin E one Natural antioxidant, has stronger anti-radical action, and has the important function of slow down aging.
Linoleic acid, content of vitamin E in safflower oil are high, and crucial problem is that the vitamin E in safflower oil not only contains
Amount height, its extremely strong permeability also makes the vitamin E in safflower oil easily be absorbed by the body.
After the most each raw material is prepared by method for optimizing, mix by preferred proportion, prepare and there is good functions of removing chloasma effect
Health product.
Beneficial effect: compared to the prior art the Traditional Chinese medicine compound composition that the present invention provides has the advantage that
The present invention, under the guidance of Chinese medical theory, uses determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, in conjunction with pathogeny and the disease symptom of chloasma, sieve
Selecting raw material, whole raw material composition and ratio is scientific and reasonable, test result indicate that, the present invention provide health product can be effectively increased liver,
Tryrosinase content in skin, effectively reduces mda content, and can reduce the target area of melanocyte in skin, average
Diameter and accumulation optical density substantially reduce；And superoxide dismutase content in mouse skin is increased significantly effect, and real
Finding no untoward reaction during testing, toxic and side effects is low, and safety is good.
Detailed description of the invention
According to following embodiment, the present invention be may be better understood.But, as it will be easily appreciated by one skilled in the art that embodiment
Described concrete material proportion, process conditions and result thereof are merely to illustrate the present invention, and should be also without limitation on right
The present invention described in detail in claim.
Embodiment 1
1, a kind of health product with chloasma-dispelling function, it is made up of the raw material of following portions by weight:
Radix Angelicae Sinensis 30 parts, the Radix Angelicae Dahuricae 90 parts, Folium Ginkgo extract 1 part, vitamin e1 part, Margarita powder 5 parts, safflower oil
33 parts.
2, the preparation method of the health product with chloasma-dispelling function of the present invention, it comprises the following steps:
(1) take Radix Angelicae Sinensis 30 parts, the Radix Angelicae Dahuricae 90 parts mixing by weight, be separately added into total medical material 10 times, 10 times, 8 times amount
Volumetric concentration 70% alcohol reflux 3 times, each 2h, united extraction liquid, concentrate final vacuum and be dried, cross 100 mesh sieves,
Obtain the Radix Angelicae Dahuricae and Radix Angelicae Sinensis extract；
(2) Folium Ginkgo extract is prepared by following method: takes Folium Ginkgo and suitably pulverizes, and adds 12 times amount volumetric concentrations 70%
Alcohol reflux 3 times, each 2h, united extraction liquid, filter, decompression recycling ethanol, add suitable quantity of water and leach, stand,
Filtering, upper D-101 resin column adsorbs, and after washing clarification, with volumetric concentration 95% ethanol elution, collects eluent, decompression
Concentrate, upper polyamide column, first wash with water, then by volumetric concentration 70% methanol-eluted fractions, collect 70% meoh eluate, decompression
Concentrate, drying under reduced pressure and get final product.
(3) take vitamin e1 part by weight, 5 parts of Flos Carthami seed oil of Margarita powder 33 parts prepare with step (2)
Folium Ginkgo extract 1 part Radix Angelicae Dahuricae and the Radix Angelicae Sinensis extract that prepare with step (1) mix homogeneously, and on food or medicine
Acceptable carrier prepares oral liquid.
Embodiment 2
1, a kind of health product with chloasma-dispelling function, it is made up of the raw material of following portions by weight:
Radix Angelicae Sinensis 90 parts, the Radix Angelicae Dahuricae 270 parts, Folium Ginkgo extract 3 parts, vitamin E 3 parts, Margarita powder 15 parts, Semen Flos Carthami
Oil 99 parts.
2, the preparation method of the health product with chloasma-dispelling function of the present invention, it comprises the following steps:
(1) take Radix Angelicae Sinensis 90 parts, the Radix Angelicae Dahuricae 270 parts mixing by weight, be separately added into total medical material 10 times, 10 times, 8 times
Amount volumetric concentration 70% alcohol reflux 3 times, each 2h, united extraction liquid, concentrate final vacuum and be dried, cross 100 mesh sieves,
Obtain the Radix Angelicae Dahuricae and Radix Angelicae Sinensis extract；
(2) Folium Ginkgo extract is prepared by following method: takes Folium Ginkgo and suitably pulverizes, and adds 10 times amount volumetric concentrations 70%
Alcohol reflux 2 times, each 3h, united extraction liquid, filter, decompression recycling ethanol, add suitable quantity of water and leach, stand,
Filtering, upper AB-8 macroporous resin column is adsorbed, and after washing clarification, with volumetric concentration 95% ethanol elution, collects eluent, subtracts
Pressure concentrates, and upper polyamide column first washes with water, then by volumetric concentration 70% methanol-eluted fractions, collects 70% meoh eluate, subtract
Pressure concentrates, drying under reduced pressure and get final product.
(3) take vitamin E 3 parts by weight, 15 parts of Flos Carthami seed oil of Margarita powder 99 parts prepare with step (2)
Folium Ginkgo extract 3 parts Radix Angelicae Dahuricae and the Radix Angelicae Sinensis extract that prepare with step (1) mix homogeneously, and on food or medicine
Acceptable carrier prepares capsule.
Embodiment 3
1, a kind of health product with chloasma-dispelling function, it is made up of the raw material of following portions by weight:
Radix Angelicae Sinensis 60 parts, the Radix Angelicae Dahuricae 180 parts, Folium Ginkgo extract 2 parts, vitamin E2 part, Margarita powder 10 parts, Semen Flos Carthami
Oil 66 parts.
2, the preparation method of the health product with chloasma-dispelling function of the present invention, it comprises the following steps:
(1) take Radix Angelicae Sinensis 60 parts, the Radix Angelicae Dahuricae 180 parts mixing by weight, be separately added into total medical material 10 times, 10 times, 8 times
Amount volumetric concentration 70% alcohol reflux 3 times, each 2h, united extraction liquid, concentrate final vacuum and be dried, cross 100 mesh sieves,
Obtain the Radix Angelicae Dahuricae and Radix Angelicae Sinensis extract；
(2) Folium Ginkgo extract is prepared by following method: takes Folium Ginkgo and suitably pulverizes, and adds 10 times amount volumetric concentrations 70%
Alcohol reflux 2 times, each 3h, united extraction liquid, filter, decompression recycling ethanol, add suitable quantity of water and leach, stand,
Filtering, upper AB-8 macroporous resin column is adsorbed, and after washing clarification, with volumetric concentration 95% ethanol elution, collects eluent,
Concentrating under reduced pressure, upper polyamide column, first wash with water, then by volumetric concentration 70% methanol-eluted fractions, collect 70% meoh eluate,
Concentrating under reduced pressure, drying under reduced pressure and get final product.
(3) take vitamin E2 part by weight, 10 parts of Flos Carthami seed oil of Margarita powder 66 parts prepare with step (2)
Folium Ginkgo extract 2 parts Radix Angelicae Dahuricae and the Radix Angelicae Sinensis extract that prepare with step (1) mix homogeneously, and on food or medicine
Acceptable carrier prepares tablet.
Embodiment 4
Pharmacological evaluation
1. laboratory animal
Take 60 SPF level Female ICR mice, Shanghai Jie Sijie Experimental Animal Center provide.
2. experiment packet
It is randomly divided into 6 groups by body weight, often group 10, is respectively blank group, model group, positive group (vitamin C, 0.1g kg-1)、
Embodiment 1 low dose group (0.87g kg-1), dosage group (6.1g kg in embodiment 1-1) and embodiment 1 high dose group (12.2
g·kg-1)。
3. experimental technique
In addition to blank group, remaining group adds intramuscular injection Progesterone by ultraviolet irradiation and sets up chloasma mouse model.Modeling
Start simultaneously at and gavage these health product, continuous 31 days.
Judging index:
Measure the tryrosinase content in each group of mouse liver, skin, superoxide dismutase activity, mda content, simultaneously
Immunohistochemical Method is used to observe these health product to the impact of melanocyte in mouse skin.
4, experimental result:
4.1 blank groups: nearly no melanocyte in epidermis, are shown in a small amount of melanin, born of the same parents in hair follicle, sebaceous gland basal cell
Slurry coloring sepia.With Anti-MelanA as positive control, melanocyte proper alignment is even in basal layer, prickle cell layer
See positive cell.
4.2 model group: melanin is mainly expressed at dermal layer of the skin, is more common in sweat gland, hair follicle, sebaceous gland, anti-in strong positive
Should, companion cell core increases and moves on core, endochylema coloring dark brown.
It is that the health product with chloasma-dispelling function can be effectively increased tryrosinase content in liver, skin that 4.3 present invention provide,
Effectively reduce mda content, and it is obvious to reduce the target area of melanocyte in skin, average diameter and accumulation optical density
Reduce；And superoxide dismutase content in mouse skin is increased significantly effect, specific experiment result is as shown in table 1 to table 5.
Table 1 health product of the present invention on the impact of chloasma mouse model liver and skin tryrosinase (N=9)
Note: compare with blank group:#P<0.05；Compare with model group: * P < 0.05, * * P < 0.01.
Each group of table 2 is on the impact (± s, n=9) of superoxide dismutase in chloasma mouse model liver and skin
Note: compare with blank group:#P < 0.05,##P<0.01；Compare with model group:*P<0.05。
Each group of table 3 on in chloasma mouse model liver and skin malonaldehyde impact (N=9)
Note: compare with blank group:#P < 0.05,##P<0.01；Compare with model group:*P < 0.05,**P<0.01。
Each group of average optical on chloasma mouse model skin of table 4, accumulation optical density impact (N=9)
| Group | Average optical | Accumulation optical density |
| Blank group | 0.33±0.02 | 214071.27±57278.41 |
| Model group | 0.31±0.01# | 586841.07±140105.49## |
| VITAMIN C TABLET group | 0.32±0.01 | 229249.60±46009.62** |
| Embodiment 1 low dose group | 0.32±0.01 | 251537.66±120435.56** |
| Dosage group in embodiment 1 | 0.35±0.02** | 317253.63±93511.03** |
| Embodiment 1 high dose group | 0.32±0.01 | 297895.01±111816.21** |
Note: compare with blank group:#P < 0.05,##P<0.01；Compare with model group:**P<0.01。
Each group of target area on chloasma mouse model skin of table 5, average diameter impact (N=9)
Note: compare with blank group:##P<0.01；Compare with model group:**P<0.01。
More than test result indicate that, liver that the health product basic, normal, high dosage group that the present invention provides can increase, cheese ammonia in skin
Acid enzyme content and superoxide dismutase content, and can effectively reduce mda content, reduce the target of melanocyte in skin
Area, average diameter, accumulation optical density, have good therapeutical effect to chloasma.And experimentation find no bright
Aobvious untoward reaction, application security is good.
Embodiment of above only for technology design and the feature of the present invention are described, its object is to allow person skilled in the art understand this
Bright content is also carried out, and can not limit the scope of the invention with this, all equivalences done according to spirit of the invention
Change or modification, all should contain within the scope of the present invention.
Claims (3)
1. health product with chloasma-dispelling function, it is characterised in that it is by following portions by weight
Raw material is made:
Radix Angelicae Sinensis 30 parts, the Radix Angelicae Dahuricae 90 parts, Folium Ginkgo extract 1 part, vitamin E 1 part, Margarita powder 5 parts,
Safflower oil 33 parts；
Described Folium Ginkgo extract is prepared by following method: takes Folium Ginkgo and suitably pulverizes, add 8 to
12 times amount volumetric concentration 70% alcohol reflux 1～3 times, each 1～2h, united extraction liquid, filter,
Decompression recycling ethanol, adds suitable quantity of water and leaches, stand, filter, and upper AB-8 or D-101 macroporous resin column is inhaled
Attached, after washing clarification, with volumetric concentration 95% ethanol elution, collect eluent, concentrating under reduced pressure, upper polyamides
Amine post, first washes with water, then by volumetric concentration 70% methanol-eluted fractions, collects 70% meoh eluate, decompression
Concentrate, drying under reduced pressure and get final product.
2. the preparation method of the health product with chloasma-dispelling function described in claim 1, it is characterised in that
Comprise the following steps:
(1) parts by weight as described in claim 1 take the Radix Angelicae Dahuricae and Radix Angelicae Sinensis, be separately added into 10 times, 10 times,
8 times amount volumetric concentration 70% alcohol reflux 3 times, each 1～2h, united extraction liquid, concentrate final vacuum
It is dried, crosses 100 mesh sieves, obtain the Radix Angelicae Dahuricae and Radix Angelicae Sinensis extract；
(2) parts by weight as described in claim 1 take Folium Ginkgo extract, vitamin E, Margarita powder and
The Radix Angelicae Dahuricae and Radix Angelicae Sinensis extract that safflower oil prepares with step (1) are mixed homogeneously, and on food or medicine
Acceptable carrier prepares health product.
The preparation method of the health product with chloasma-dispelling function the most according to claim 2, its feature
Being, preparing health product is oral liquid, capsule, tablet or granule.
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| CN106309627A (en) * | 2016-11-25 | 2017-01-11 | 南京中医药大学 | Gel for removing Chloasma, preparing method and application thereof |
| CN107224572A (en) * | 2017-06-14 | 2017-10-03 | 湖南恒伟药业股份有限公司 | A kind of functions of removing chloasma capsule and preparation method thereof |
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| CN101822704A (en) * | 2010-05-21 | 2010-09-08 | 贵州益佰制药股份有限公司 | Drug combination for removing freckles and preparation method thereof |
| CN102091007A (en) * | 2009-12-10 | 2011-06-15 | 蒋健 | Traditional Chinese medicine face applying mud |
| CN103006920A (en) * | 2011-12-14 | 2013-04-03 | 西安泰科迈医药科技有限公司 | Chloasma-removing pure traditional Chinese medicine composition and preparation method thereof |
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| CN102091007A (en) * | 2009-12-10 | 2011-06-15 | 蒋健 | Traditional Chinese medicine face applying mud |
| CN101822704A (en) * | 2010-05-21 | 2010-09-08 | 贵州益佰制药股份有限公司 | Drug combination for removing freckles and preparation method thereof |
| CN103006920A (en) * | 2011-12-14 | 2013-04-03 | 西安泰科迈医药科技有限公司 | Chloasma-removing pure traditional Chinese medicine composition and preparation method thereof |
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