CN106309627A - Gel for removing Chloasma, preparing method and application thereof - Google Patents
Gel for removing Chloasma, preparing method and application thereof Download PDFInfo
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- CN106309627A CN106309627A CN201611055753.8A CN201611055753A CN106309627A CN 106309627 A CN106309627 A CN 106309627A CN 201611055753 A CN201611055753 A CN 201611055753A CN 106309627 A CN106309627 A CN 106309627A
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention provides gel for removing chloasma gel, prepared from, by weight, 30-40 parts of Cynoglossum roots, 10-20 parts of Viburnum cylindricum, 20-30 parts of angelica sinensis, 20-40 parts of rhizoma chuanxiong, 10-20 parts of peach kernel, 1-3 parts of 940 Carbomer, 10-30 parts of propylene glycol, 10-20 parts of azone, 5-10 parts of sodium hyaluronate and a proper amount of triethanolamine. The gel for removing chloasma can promote blood circulation to remove blood stasis, and remove beverage. The invention also discloses a preparing method and application of the gel for removing chloasma.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of for functions of removing chloasma gel and preparation method and application.
Background technology
The chloasma cause of disease is unclear, is more common in women, and in blood, estrogen level height is main cause.Its morbidity is with pregnant
Be pregnent, Long-term Oral contraceptive, menoxenia relevant.Also some female reproductive system illness, tuberculosis, cancer, chronic ethanol are seen
The patients such as poisoning, hepatopathy.Daylight can promote morbidity.Male patient accounts for 10%, and having research to think, that male falls ill is relevant with heredity.
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide a kind of for functions of removing chloasma gel and
Preparation method and application.
A kind of functions of removing chloasma gel, it is made up of the supplementary material of following parts by weight: Radix cynoglossi divaricati 30-40 part, Folium Viburni Cylindrici
10-20 part, Radix Angelicae Sinensis 20-30 part, Rhizoma Chuanxiong 20-40 part, Semen Persicae 10-20 part, model are 940 carbomer 1-3 parts, propylene glycol 10-30
Part, azone 10-20 part, hyaluronate sodium 5-10 part, triethanolamine are appropriate.
Described functions of removing chloasma gel, it is made up of the supplementary material of following parts by weight: Radix cynoglossi divaricati 35 parts, Folium Viburni Cylindrici 15
Part, Radix Angelicae Sinensis 25 parts, Rhizoma Chuanxiong 30 parts, 15 parts of Semen Persicae, model are 940 carbomer 1.5 parts, propylene glycol 25 parts, azone 14 parts, hyalomitome
7 parts of sodium of acid, triethanolamine are appropriate.
Described functions of removing chloasma gel, preparation method comprises the steps: to take Radix cynoglossi divaricati, Folium Viburni Cylindrici, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Persicae
Core medical material merges, and pulverizes, puts into Chinese medicine pre-treatment machine processing, and medical material boiling twice after process, amount of water is medical material weight
10 times amount of amount, decoct 2h, and collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adds ethanol and makes the volume hundred of alcohol content
Proportion by subtraction reaches 65%, and stirring, standing, filtration, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, will concentrate
Liquid puts into extractum drying machine drying, and adding model is 940 carbomers, propylene glycol, azone, hyaluronate sodium, triethanolamine, 75 DEG C
Left and right melting, to obtain final product.
Described functions of removing chloasma gel, in preparation method, Chinese medicine pre-treatment machine includes device case, at described device case
End face have feed hopper, the sidewall bottom at described device case have Chinese medicine derive passage, be provided with in described device case and incline
Tiltedly stock guide, the top of described inclination stock guide is connected on the inwall of device case by rotary shaft and is just in feed hopper
Lower section, the bottom of described inclination stock guide is derived passage with Chinese medicine and is connected, it is characterised in that: at the diapire of described device case
On be fixed with vibrating seat, described vibrating seat is fixed with electric rotating machine, the main shaft of described electric rotating machine is provided with wheel disc,
Being provided with vibrating arm between card and the bottom tilting stock guide of described wheel disc, the bottom of described vibrating arm is connected to by bearing pin
In the card of wheel disc and the top of described vibrating arm is fixed on the bottom surface, bottom of stock guide, at the sidewall of described device case
Top is provided with strip through-hole, and described strip through-hole and Chinese medicine are derived passage and is arranged on same side, at described device case
U-shaped impurity fixing on outer wall collects body, is provided with central shaft, has with described on described device case in described strip through-hole
The driving motor that central shaft is connected by belt transmission, is additionally provided with magnetic annulus, and the inwall of described magnetic annulus is solid by muscle bar
Determining on center shaft, the edge of described magnetic annulus is connected on stock guide and the outer ledge of magnetic annulus is miscellaneous with U-shaped
Matter is collected the side top of body and is compressed contact.
Described functions of removing chloasma gel, in preparation method, the top of the collection of U-shaped impurity described in Chinese medicine pre-treatment machine body sets
Inclination scraper plate, described inclination scraper plate is had to be connected to the surface of magnetic annulus.
Described functions of removing chloasma gel, tilting stock guide in preparation method described in Chinese medicine pre-treatment machine is sheet of plastic material
Body, the width of described inclination scraper plate is identical with the width of magnetic annulus.
Described functions of removing chloasma gel, in preparation method, extractum dehydrator includes casing, is arranged on the carrying in described casing
Web plate, is provided with hot wind inlet on the diapire of described casing, has chamber door at the top of described casing, it is characterised in that: described
There is vertical guide chute on the inwall of casing, described casing upper side wall is provided with slotted eye, the inner chamber of described slotted eye connection casing
With outside, the middle part of described carrying web plate is connected in casing by rotary shaft, described slotted eye and described vertical guide chute with
It is symmetrical arranged centered by rotary shaft, is fixed with lifting slider in one end of described carrying web plate, at another of described carrying web plate
End is fixed with and compresses pole, in described lifting slider is arranged on vertical guide chute and described in compress pole and stretch through described slotted eye
Go out casing, between the diapire of described lifting slider and described vertical guide chute, be provided with stress extension spring, described stress extension spring
Bottom is fixed on the diapire of vertical guide chute and the top of stress extension spring is fixed on lifting slider, outside described casing
It is fixed with driving motor on wall, the main shaft of described driving motor is fixed with eccentric, on the protruding wheel limit of described eccentric
On be fixed with and compress projection, described eccentric rotates under the drive driving motor and makes compress bump contact and be connected to compress
On pole.
Described functions of removing chloasma gel, the edge carrying web plate in preparation method described in extractum dehydrator is provided with vertical gear
Net, the base of described vertical backstop is weldingly fixed on the edge of carrying web plate.
Described functions of removing chloasma gel, compressing projection in preparation method described in extractum dehydrator is arc block, and described
The surface compressing projection is provided with anti-skidding burr, and described anti-skidding burr is arranged on and compresses on the contact surface of pole, described anti-skidding convex
The height of stricture of vagina is 5-10mm.
The application in preparing functions of removing chloasma gel of the described functions of removing chloasma gel.
Radix cynoglossi divaricati is the root of comfrey exhibition branch Herba Carpesii Cernui.Heat-clearing and toxic substances removing.Treating tonsillitis, furuncle carbuncle.
Folium Viburni Cylindrici is leaf or root, the flower of Radix Ophiopogonis Piao's vegetation water redwood.Clearing away heat and cooling blood, removing dampness dredging collateral.Control cough caused by dryness, dysentery, wind
Wet pain, traumatic injury, skin infection scabies.Remaining is standards of pharmacopoeia.
Beneficial effect:
The present invention is on the basis of clinical proved recipe, theoretical for instructing with Chinese medicine beautifying, chooses heat and toxic materials clearing away medicine Radix cynoglossi divaricati, hangs
Bai Yewei monarch drug, drug for invigorating blood circulation and eliminating stasis Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae are ministerial drug, have effect of dispelling spots, and Formulation of the present invention is reasonable, joins
5 is rigorous, through long-term clinical verification, determined curative effect.Consist of Chinese crude drug, have no side effect, low price.
The novel in structural design of Chinese medicine pre-treatment machine of the present invention, it coordinates vibrating arm to make to be in inclination by electric rotating machine
Chinese medicine on stock guide slowly moves down, and is simultaneously provided with magnetic annulus, owing to the surface of magnetic annulus can be connected to incline when rotated
Tiltedly on stock guide, such that it is able to the metal impurities in Chinese medicine are absorbed, when magnetic annulus rotates, can be collected by U-shaped impurity
The vertical edge end face of body scrapes, thus the metal impurities of absorption are struck off and collected, and thereby may be ensured that the energy of adsorption of magnetic annulus
Power, solves and removes the inefficient technical deficiency of metal impurities in Chinese medicine in conventional art, and stability in use is good and is greatly improved
Remove the efficiency of metal impurities.
The structure of this extractum dehydrator arranges rationally, its simple operation, can effectively and quickly realize entering drug extract
Row agitation, thus beneficially drug extract is uniformly dried, and is greatly improved the drying efficiency of drug extract to a certain extent, solves
The technical deficiency that in conventional art, drying efficiency is relatively low, the suitability is strong and practicality good.
Accompanying drawing explanation
In order to make present disclosure be more likely to be clearly understood, below according to specific embodiment and combine accompanying drawing, right
The present invention is described in further detail, wherein:
Fig. 1 is the Chinese medicine pre-treatment machine structural representation of the present invention；
Fig. 2 is the drug extract drying unit structural representation of the present invention.
Detailed description of the invention
Form by the following examples, is described in further detail the foregoing of the present invention again, but should be by this
Being interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below, all technology realized based on foregoing of the present invention are equal
Belong to the scope of the present invention.
Embodiment 1: take Radix cynoglossi divaricati 30 parts, Folium Viburni Cylindrici 20 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Chuanxiong 40 parts, 10 parts of Semen Persicae, model are
940 carbomers 3 parts, propylene glycol 10 parts, azone 20 parts, hyaluronate sodium 5 parts, appropriate 2 parts of triethanolamine, wherein take Fructus Lithospermi Zollingeri
Root, Folium Viburni Cylindrici, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae medical material merge, and pulverize, put into Chinese medicine pre-treatment machine processing, and after process, medical material adds decocting
Boiling twice, amount of water is 10 times amount of medical material weight, decocts 2h, and collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adds
Ethanol makes the percent by volume of alcohol content reach 65%, and stirring, standing, filtration, during filtrate reduced in volume to 65 DEG C, relative density is
1.20 and reclaim ethanol, concentrated solution is put into extractum drying machine drying, adding model is 940 carbomers, propylene glycol, azone, thoroughly
Bright matter acid sodium, triethanolamine, about 75 DEG C meltings, to obtain final product.
Fig. 1 is shown in by above-mentioned Chinese medicine pre-treatment machine, and including device case 1, the end face at described device case 1 has feed hopper 2,
Sidewall bottom at described device case 1 has Chinese medicine to derive passage 3, is provided with inclination stock guide 4, institute in described device case 1
The top stating stock guide 4 is connected on the inwall of device case 1 and is in the underface of feed hopper 2, institute by rotary shaft 5
The bottom stating stock guide 4 is connected with Chinese medicine derivation passage 3, is fixed with vibrating seat on the diapire of described device case 1
6, described vibrating seat 6 is fixed with electric rotating machine 7, the main shaft of described electric rotating machine 7 is provided with wheel disc 8, at described wheel disc 8
Card and tilt stock guide 4 bottom between be provided with vibrating arm 9, the bottom of described vibrating arm 9 by bearing pin 10 be connected to wheel
In the card of the dish 8 and top of described vibrating arm 9 is fixed on the bottom surface, bottom of stock guide 4, in the side of described device case 1
Wall top is provided with strip through-hole 11, and described strip through-hole 11 and Chinese medicine are derived passage 3 and is arranged on same side, at described device
U-shaped impurity fixing on the outer wall of housing 1 collects body 12, is provided with central shaft 13, at described device in described strip through-hole 11
Having the driving motor 14 being connected by belt transmission with described central shaft 13 on housing 1, belt is connected to the side of central shaft i.e.
Can, it being additionally provided with magnetic annulus 15, the inwall of described magnetic annulus 15 is fixed on central shaft 13 by muscle bar 16, described magnetic circle
The edge of ring 15 is connected on stock guide 4 and outer ledge and the U-shaped impurity of magnetic annulus 15 collects the side top of body 12
End compresses contact.In the present embodiment, electric rotating machine and driving motor are on market the motor of routine, and it has only to according to correspondence
Explanation be attached using.
The top collecting body at described U-shaped impurity is provided with inclination scraper plate 16, and described inclination scraper plate is connected to magnetic annulus
Surface.
Described inclination stock guide is plastic material plate body.
The width of described inclination scraper plate is identical with the width of magnetic annulus.
Fig. 2 is shown in by described drug extract drying unit, including casing 1, is arranged on the carrying web plate 2 in described casing 1, in institute
The diapire stating casing 1 is provided with hot wind inlet 3, has chamber door 4 at the top of described casing 1, has perpendicular on the inwall of described casing 1
To guide chute 5, being provided with slotted eye 6 on described casing 1 upper side wall, described slotted eye 6 connects inner chamber and the outside of casing 1, described
The middle part of carrying web plate 2 is connected in casing 1 by rotary shaft 7, and described slotted eye 6 and described vertical guide chute 5 are with rotary shaft 7
Centered by be symmetrical arranged, be fixed with lifting slider 8 in one end of described carrying web plate 2, solid at the other end of described carrying web plate 2
Surely compress pole 9, in described lifting slider 8 is arranged on vertical guide chute 5 and described in compress pole 9 through described slotted eye 6
Stretch out casing 1, between the diapire of described lifting slider 8 and described vertical guide chute 5, be provided with stress extension spring 10, described stress
The bottom of extension spring is fixed on the diapire of vertical guide chute and the top of stress extension spring is fixed on lifting slider, at described case
It is fixed with driving motor 11 on the outer wall of body 1, the main shaft of described driving motor 11 is fixed with eccentric 12, in described bias
Being fixed with on the protruding wheel limit of wheel 12 and compress projection 13, described eccentric 12 rotates under the drive driving motor 11 and makes to compress
Bump contact also is connected to compress on pole.In the present embodiment, driving motor is motor conventional on market, its have only to according to
Corresponding connection description is attached using.
Be provided with vertical backstop 14 at the edge of described carrying web plate, the base of described vertical backstop is weldingly fixed on bearer network
On the edge of plate.It is possible to prevent drug extract to drop off carrying web plate.
The described projection that compresses is arc block, and is provided with anti-skidding burr 15 on the described surface compressing projection, described anti-skidding convex
Stricture of vagina is arranged on and compresses on the contact surface of pole.The frictional force compressing projection and compressing between pole can be increased.
The height of described anti-skidding burr is 5-10mm.
Its operation principle is summarized as follows: be deposited in by drug extract in use on carrying web plate, according to need in being dried
Driving motor to be started, now drives motor to rotate by band movable eccentric wheel, when eccentric rotates, compresses projection and can contact and compress
Pole drive compress pole and move down, and now carrying web plate can make lifting slider rise centered by rotary shaft, thus will
Stress extension spring stretching storage power, and drug extract can be to a side shifting, when eccentric continues to rotate, compressing projection can progressively disengage
Compressing pole, compressing the moment that pole departs from, lifting slider makes carrying web plate under the reset pulling force effect of stress extension spring
Other end momentary reset thus throw drug extract and drop to carry on web plate, thus realize the agitation to drug extract,
Be conducive to making drug extract uniformly dry.
Embodiment 2: take Radix cynoglossi divaricati 40 parts, Folium Viburni Cylindrici 10 parts, Radix Angelicae Sinensis 30 parts, Rhizoma Chuanxiong 20 parts, 20 parts of Semen Persicae, model are
940 carbomers 1 part, propylene glycol 30 parts, azone 10 parts, hyaluronate sodium 10 parts, triethanolamine 2 parts, wherein take Radix cynoglossi divaricati, hang
Bai Ye, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae medical material merge, and pulverize, put into Chinese medicine pre-treatment machine processing, medical material boiling two after process
Secondary, amount of water is 10 times amount of medical material weight, decocts 2h, and collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adds ethanol
The percent by volume making alcohol content reaches 65%, and stirring, standing, filtration, during filtrate reduced in volume to 65 DEG C, relative density is 1.20
And reclaim ethanol, and concentrated solution is put into extractum drying machine drying, adding model is 940 carbomers, propylene glycol, azone, hyalomitome
Acid sodium, triethanolamine, about 75 DEG C meltings, to obtain final product.
Chinese medicine pre-treatment machine, extractum dehydrator are with embodiment 1.
Embodiment 3: take Radix cynoglossi divaricati 35 parts, Folium Viburni Cylindrici 15 parts, Radix Angelicae Sinensis 25 parts, Rhizoma Chuanxiong 30 parts, 15 parts of Semen Persicae, model are
940 carbomers 2 parts, propylene glycol 20 parts, azone 15 parts, hyaluronate sodium 7 parts, triethanolamine 2 parts, wherein take Radix cynoglossi divaricati, hang
Bai Ye, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae medical material merge, and pulverize, put into Chinese medicine pre-treatment machine processing, medical material boiling two after process
Secondary, amount of water is 10 times amount of medical material weight, decocts 2h, and collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adds ethanol
The percent by volume making alcohol content reaches 65%, and stirring, standing, filtration, during filtrate reduced in volume to 65 DEG C, relative density is 1.20
And reclaim ethanol, and concentrated solution is put into extractum drying machine drying, adding model is 940 carbomers, propylene glycol, azone, hyalomitome
Acid sodium, triethanolamine, about 75 DEG C meltings, to obtain final product.
Chinese medicine pre-treatment machine, extractum dehydrator are with embodiment 1.
Embodiment 4: the clinical trial data of speckle dispelling of the present invention
1. prepared by sample: prepare clinical trial sample by above-described embodiment 1.
2. physical data: 50 example patients are in May, 2012～outpatient service in November, 2013 outpatients.With reference to " Chinese medicine is new
Medicine guideline of clinical investigations ", inclusive criteria: the age between 17 years old-43 years old, women.Without infecting, to this medicine not allergy, nothing
Psychological problem person.Meet diagnostic criteria (Dermatology Professional Committee of the CAIM (Chinese Association Of Integrative Medicine) pigment disease of chloasma
The clinical diagnosis of group chloasma and criterion of therapeutical effect (revised draft in 2003)).Get rid of other dermatosiss and anaphylactic disease: to this medicine
Non-stimulated, not allergy sufferers.Unused similar drug person excessively before treatment, and without carrying out other similar drugs experimenter.Meet Huang
The diagnostic criteria of brown patch and the volunteer patients in the know of inclusive criteria；Complete informed consent and relevant announcer.
Exclusion standard: 1. do not meet diagnosis and the inclusive criteria of chloasma；Do not meet the inclusive criteria of chloasma；2. there is conjunction
And infect, to this medicine allergy, psychological problem.3. judge have and reduce into group probability or make to complicate into group according to researcher
Other medical histories, as working environment often changes, easily cause situation lost to follow-up；Or participating in other drug clinical research
Experimenter.
3. Therapeutic Method
The treatment of patient with chloasma: face aseptic cotton carrier dips emollient cream external application of the present invention, every day 2 times, each 30
Minute, disable during treatment other with special efficacy skin care item and medicine, within one month, be a course for the treatment of.
4. observation of curative effect criterion of therapeutical effect is with reference to " new Chinese medicine guideline of clinical investigations ".Basic healing: 1. naked eyes regard color
Speckle area disappears more than 90%, and color disappears substantially, and 1 meter apart from invisible obvious speckle.2. point system calculates treatment
Rear decline index >=0.8.Effective: 1. naked eyes disappear more than 60% depending on mottle area, and color is the most thin out.2. point system calculates and controls
Index >=0.5 is declined after treatment.Take a turn for the better: 1. naked eyes disappear more than 30% depending on mottle area, and color is thin out.2. point system calculates treatment
Rear decline index >=0.3.Invalid: 1. naked eyes disappear less than 30% depending on mottle area, color change is inconspicuous.2. point system calculates
Index >=0 is declined after treatment.
Computing formula (nimodipine method): [integration before (integration after integration-treatment before treatment)/treatment] × 100%.
5. therapeutic outcome:
50 examples are all checked after terminating 1 course for the treatment of immediately.Result: basic 8 examples of curing, effective 25 examples, effective 13 examples,
Invalid 4 examples, total effective rate 92%.
Embodiment 5: effective ingredient ferulaic acid content determination experiment research data in the present invention
1. Experimental agents: the present invention is prepared by embodiment 1-3 method.Matched group does not use at Chinese medicine pre-treatment machine
Reason, and use ordinary extract dehydrator to prepare.
2. instrument: high performance liquid chromatograph system includes high performance liquid chromatograph (Waters 515)；P200 high-pressure pump；
Waters 2487 UV-detector and GJ605 type high pressure six-way injection valve；Chromatographic column is Hypersil ODSC18 post (4.6mm
×250mm,5μm)；Data acquisition and process use HS Data Processing in Chromatography Workstation V4.0+ (Hangzhou English spectrum science and technology)
3. condition determination: use high performance liquid chromatography, by version official method in 2015, with octadecylsilane bonded silica
Glue is filler；Column temperature: 25 DEG C；Flowing is methanol-water (80:20) mutually, and flow velocity is 1.0mL/min, and detection wavelength is 270nm；
Flow velocity: 1ml/min.Number of theoretical plate is calculated by ferulic acid peak all should be not less than 2000.
4. experimental result
Ferulaic acid content measurement result in each embodiment
| Sample source | Ferulaic acid content (mg/100g) |
| Embodiment 1 | 3.90 |
| Embodiment 2 | 4.24 |
| Embodiment 3 | 3.76 |
| Matched group | 1.03 |
According to the result of the test of upper table, in the present invention prepared by embodiment of the present invention 1-3, active constituent content is obvious
Higher than matched group.
Embodiment 6: content of beary metal determination experiment research data in the present invention
1. Experimental agents: the present invention is prepared by embodiment 1-3 method.Matched group does not use at Chinese medicine pre-treatment machine
Reason, and use ordinary extract dehydrator to prepare.
2. method: use atom the spectrophotometry lead of said medicine, cadmium and mercury content.Result shows,
| Sample source | Lead (mg/kg) | Cadmium (mg/kg) | Hydrargyrum (mg/kg) |
| Embodiment 1 | 0.02 | 0.29 | 0.34 |
| Embodiment 2 | 0.03 | 0.29 | 0.44 |
| Embodiment 3 | 0.03 | 0.22 | 0.39 |
| Matched group | 0.39 | 0.72 | 2.75 |
According to result of the test, in the present invention prepared by embodiment of the present invention 1-3, content of beary metal is significantly lower than comparison
Group.
Claims (10)
1. a functions of removing chloasma gel, it is characterised in that it is made up of the supplementary material of following parts by weight: Radix cynoglossi divaricati 30-40
Part, Folium Viburni Cylindrici 10-20 part, Radix Angelicae Sinensis 20-30 part, Rhizoma Chuanxiong 20-40 part, Semen Persicae 10-20 part, model be 940 carbomer 1-3 parts, third
Glycol 10-30 part, azone 10-20 part, hyaluronate sodium 5-10 part, triethanolamine are appropriate.
2. functions of removing chloasma gel as claimed in claim 1, it is characterised in that it is made up of the supplementary material of following parts by weight: coloured glaze
Glass grass roots 35 parts, Folium Viburni Cylindrici 15 parts, Radix Angelicae Sinensis 25 parts, Rhizoma Chuanxiong 30 parts, 15 parts of Semen Persicae, model are 940 carbomer 1.5 parts, propylene glycol
25 parts, azone 14 parts, hyaluronate sodium 7 parts, triethanolamine appropriate.
3. as claimed in claim 1 functions of removing chloasma gel, it is characterised in that preparation method comprise the steps: to take Radix cynoglossi divaricati,
Folium Viburni Cylindrici, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae medical material merge, and pulverize, put into Chinese medicine pre-treatment machine processing, medical material boiling after process
Twice, amount of water is 10 times amount of medical material weight, decocts 2h, and collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adds second
Alcohol makes the percent by volume of alcohol content reach 65%, and stirring, standing, filtration, during filtrate reduced in volume to 65 DEG C, relative density is
1.20 and reclaim ethanol, concentrated solution is put into extractum drying machine drying, adding model is 940 carbomers, propylene glycol, azone, thoroughly
Bright matter acid sodium, triethanolamine, about 75 DEG C meltings, to obtain final product.
4. functions of removing chloasma gel as claimed in claim 3, it is characterised in that in preparation method, Chinese medicine pre-treatment machine includes device
Housing, the end face at described device case has feed hopper, and the sidewall bottom at described device case has Chinese medicine to derive passage, in institute
Being provided with inclination stock guide in stating device case, the top of described inclination stock guide is connected to the inwall of device case by rotary shaft
Going up and be in the underface of feed hopper, the bottom of described inclination stock guide is derived passage with Chinese medicine and is connected, it is characterised in that:
It is fixed with vibrating seat on the diapire of described device case, described vibrating seat is fixed with electric rotating machine, at described electric rotating machine
Main shaft be provided with wheel disc, described wheel disc card and tilt stock guide bottom between be provided with vibrating arm, described vibrating arm
Bottom be connected in the card of wheel disc by bearing pin and the top of described vibrating arm is fixed on the bottom surface, bottom of stock guide,
Top side wall at described device case is provided with strip through-hole, and described strip through-hole and Chinese medicine are derived passage and is arranged on same side
On, U-shaped impurity fixing on the outer wall of described device case collects body, is provided with central shaft, in institute in described strip through-hole
State and on device case, have the driving motor being connected by belt transmission with described central shaft, be additionally provided with magnetic annulus, described magnetic
The inwall of annulus is fixing on center shaft by muscle bar, and the edge of described magnetic annulus is connected on stock guide and magnetic circle
The outer ledge of ring compresses with the side top of U-shaped impurity collection body and contacts.
5. functions of removing chloasma gel as claimed in claim 4, it is characterised in that U described in Chinese medicine pre-treatment machine in preparation method
Type impurity is collected the top of body and is provided with inclination scraper plate, and described inclination scraper plate is connected to the surface of magnetic annulus.
6. functions of removing chloasma gel as claimed in claim 4, it is characterised in that incline described in Chinese medicine pre-treatment machine in preparation method
Tiltedly stock guide is plastic material plate body, and the width of described inclination scraper plate is identical with the width of magnetic annulus.
7. functions of removing chloasma gel as claimed in claim 3, it is characterised in that in preparation method, extractum dehydrator includes casing, if
Put the carrying web plate in described casing, the diapire of described casing is provided with hot wind inlet, have case at the top of described casing
Door, it is characterised in that: on the inwall of described casing, there is vertical guide chute, described casing upper side wall is provided with slotted eye, institute
Stating inner chamber and the outside of slotted eye connection casing, the middle part of described carrying web plate is connected in casing by rotary shaft, described slotted eye
It is symmetrical arranged centered by rotary shaft with described vertical guide chute, is fixed with lifting slider in one end of described carrying web plate,
The other end at described carrying web plate is fixed with and compresses pole, and described lifting slider is arranged in vertical guide chute and described supports
Pressure pole stretches out casing through described slotted eye, is provided with stress between the diapire of described lifting slider and described vertical guide chute
Extension spring, the bottom of described stress extension spring is fixed on the diapire of vertical guide chute and the top of stress extension spring is fixed on lifting cunning
On block, the outer wall of described casing is fixed with driving motor, the main shaft of described driving motor is fixed with eccentric, in institute
Stating to be fixed with on the protruding wheel limit of eccentric and compress projection, described eccentric rotates under the drive driving motor and makes to compress convex
Block contacts and is connected to compress on pole.
8. functions of removing chloasma gel as claimed in claim 7, it is characterised in that bearer network described in extractum dehydrator in preparation method
The edge of plate is provided with vertical backstop, and the base of described vertical backstop is weldingly fixed on the edge of carrying web plate.
9. functions of removing chloasma gel as claimed in claim 7, it is characterised in that compress convex in preparation method described in extractum dehydrator
Block is arc block, and is provided with anti-skidding burr on the described surface compressing projection, and described anti-skidding burr is arranged on and compresses pole
On contact surface, the height of described anti-skidding burr is 5-10mm.
10. functions of removing chloasma gel application in preparing functions of removing chloasma gel described in claim 1.
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| CN201611055753.8A CN106309627A (en) | 2016-11-25 | 2016-11-25 | Gel for removing Chloasma, preparing method and application thereof |
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Application publication date: 20170111 |