CN1814296A - Cataplasm substrate and its preparing method - Google Patents
Cataplasm substrate and its preparing method Download PDFInfo
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- CN1814296A CN1814296A CN 200510095682 CN200510095682A CN1814296A CN 1814296 A CN1814296 A CN 1814296A CN 200510095682 CN200510095682 CN 200510095682 CN 200510095682 A CN200510095682 A CN 200510095682A CN 1814296 A CN1814296 A CN 1814296A
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Abstract
This invention discloses a babu agent ground substance and its preparation method. Water soluble high molecular polymer gelatin, carboxymethylcellulose sodium, polyvinyl pyrrolidon, poly-sodium acrylate, polyvinyl alcohol, white bole, calcium carbonate, zinc oxide, glycerol are used as weight rate to make the ground substance. First, gelatin is watered and heated to dissolve and expand. Then carboxymethylcellulose sodium is watered and heated to dissolve and expand, and then polyvinyl pyrrolidon and polyvinyl alcohol are added. They are equally agitated and be added into gelatin liquor to get I phase liquor. Secondly, poly-sodium acrylate, white bole or calcium carbonate or zinc oxide are dispersed into glycerol, then II phase liquor is got after agitation. Finally, II phase liquor is added into I phase liquor, the babu agent is got after heated and agitated. Its medicine carry is large, medicine compatibility is good, ground material's character is stable, and it doesn't react with main medicine. There is also no stimulus to skin, no anaphylactic response, gas permeation ability is good and preparation technique is simple.
Description
One, technical field
The present invention relates to medical technical field, relate to substrate of a kind of cataplasma and preparation method thereof specifically
Two, background technology
Cataplasma is coated the external preparation of making on the non-woven fabrics after being meant medicine and suitable hydrophilic matrix mixing.The drug loading of the more common plaster of cataplasma is big, and good permeability is good to the tackness of skin.
Because of the matrix components complexity of cataplasma, difficult imitated, so high-quality catablasm base material prescription is generally externally not open, the composition of multiple catablasm base material and the method for preparation also just have nothing in common with each other.
The ordinary rubber unguentum is applied to and mounts by on the material after adding prescription medicament, and its coating is very thin, and the contained pharmaceutical quantities of the substrate of this kind plaster is very low, and permeability is relatively poor, easily produces anaphylaxis.
Three, summary of the invention
The object of the present invention is to provide a kind of drug loading big, non-stimulated to skin, do not have irritated reaction, a catablasm base material ventilative, the host material stable performance of preserving moisture; Another object of the present invention is to provide a kind of preparation method simply, not need high temperature, does not destroy the method for preparing catablasm base material of pharmaceutical compositions.
Catablasm base material is mainly selected multiple water-soluble high-molecular compound for use, reasonably combined and make as gelatin, sodium carboxymethyl cellulose, polyvinylpyrrolidone, sodium polyacrylate, polyvinyl alcohol and kaolin, calcium carbonate, zinc oxide, glycerol etc., catablasm base material of the present invention is made by the base stock collocation of following weight portion proportioning:
3～12 parts of 5～20 parts of sodium carboxymethyl cellulose of sodium polyacrylate
10～35 parts in 10～45 parts of gelatin of polyvinylpyrrolidone
30～80 parts of 3～15 parts of glycerol of kaolin
40～110 parts in water.
Perhaps:
3～12 parts of 5～20 parts of sodium carboxymethyl cellulose of sodium polyacrylate
10～35 parts in 10～45 parts of gelatin of polyvinylpyrrolidone
30～80 parts of 3～15 parts of glycerol of calcium carbonate
40～110 parts in water.
Or:
3～12 parts of 5～20 parts of sodium carboxymethyl cellulose of sodium polyacrylate
10～35 parts in 10～30 parts of gelatin of polyvinyl alcohol
30～80 parts of 3～15 parts of glycerol of zinc oxide
40～110 parts in water.
The preparation method of catablasm base material of the present invention, concrete preparation process is as follows:
1, preparation I phase solution: gelatin is added 10～45 parts in water, fully swelling is standby under 40～80 ℃ of water-baths, in addition sodium carboxymethyl cellulose is added 20～80 parts in water, add polyvinylpyrrolidone or polyvinyl alcohol in the back fully in 50～80 ℃ of water-bath swellings, in the gelatin solution that the back adding that stirs stirs, stir and promptly get I phase solution;
2, preparation II phase solution: sodium polyacrylate, kaolin or calcium carbonate or zinc oxide are scattered in the glycerol, stir and promptly get II phase solution;
3, preparation catablasm base material: II phase solution is added in the I phase solution, obtain all after stirring at 50～80 ℃
Even thickness mastic promptly gets catablasm base material.
Pastille substrate was not observed 24,48,72 hours rabbit intact skin and the effect of destruction local skin, and show speckle and edema occur, and illustrated that this substrate is to intact skin and the equal nonirritant of destruction skin.Abnormal response does not appear in anaphylaxis laboratory animal skin.
The result shows that this catablasm base material does not have sensitization to skin.
Catablasm base material of the present invention has the following advantages:
1, non-stimulated to skin, there is not irritated phenomenon, it is ventilative to preserve moisture, and is pasting comfortable convenience;
2, pollution clothes not can also paste when needing to take off during sticking again;
3, drug loading is big, medicine in the ratio of substrate can reach 1: 4～10, thereby the suitable Chinese medical concrete that adds makes Chinese medicine patcher, and good to drug compatibility;
4, host material stable in properties does not react with principal agent, and with low cost;
5, preparation method is simple, and matrix formulations and preparation technology do not need high temperature, does not destroy ingredient.
6, peel strength and to hold viscous force all more satisfactory.
Four, the specific embodiment:
Embodiment 1: the basic proportioning of catablasm base material prescription
4 parts of 8 parts of sodium carboxymethyl cellulose of sodium polyacrylate
15 parts in 15 parts of gelatin of polyvinylpyrrolidone
40 parts of 5 parts of glycerol of kaolin
55 parts in water
Preparation method
1, preparation I phase solution: gelatin is added 25 parts in water, abundant swelling under 60 ℃ of water-baths, simultaneously sodium carboxymethyl cellulose is added water and add polyvinylpyrrolidone for 30 parts after 80 ℃ of water-bath swellings are complete, the back that stirs adds in the gelatin solution that stirs, and stirs and promptly gets I phase solution;
2, preparation II phase solution: sodium polyacrylate, kaolin are scattered in the glycerol, stir and promptly get II phase solution;
3, preparation catablasm base material: II phase solution is added in the I phase solution, and 60 ℃ obtain even thickness mastic after stirring, promptly get catablasm base material.
Embodiment 2: the basic proportioning of catablasm base material prescription
4 parts of 8 parts of sodium carboxymethyl cellulose of sodium polyacrylate
15 parts in 15 parts of gelatin of polyvinylpyrrolidone
40 parts of 6 parts of glycerol of calcium carbonate
55 parts in water
Preparation method
1, preparation I phase solution: gelatin is added 25 parts in water, abundant swelling under 60 ℃ of water-baths, simultaneously sodium carboxymethyl cellulose is added water and add polyvinylpyrrolidone for 30 parts after 80 ℃ of water-bath swellings are complete, the back that stirs adds in the gelatin solution that stirs, and stirs and promptly gets I phase solution;
2, preparation II phase solution: sodium polyacrylate, calcium carbonate are disperseed in glycerol, stir and promptly get II phase solution;
3, preparation catablasm base material: II phase solution is added in the I phase solution, and 60 ℃ obtain even thickness mastic after stirring, promptly get catablasm base material.
Embodiment 3: the basic proportioning of catablasm base material prescription
4 parts of 8 parts of sodium carboxymethyl cellulose of sodium polyacrylate
15 parts in 12 parts of gelatin of polyvinyl alcohol
40 parts of 4 parts of glycerol of zinc oxide
55 parts in water
Preparation method
1, preparation I phase solution: gelatin is added 25 parts in water, abundant swelling under 60 ℃ of water-baths, simultaneously sodium carboxymethyl cellulose is added water and add polyvinyl alcohol for 30 parts after 80 ℃ of water-bath swellings are complete, the back that stirs adds in the gelatin solution that stirs, and stirs and promptly gets I phase solution;
2, preparation II phase solution: sodium polyacrylate, zinc oxide are scattered in the glycerol, stir and promptly get II phase solution;
3, preparation catablasm base material: II phase solution is added in the I phase solution, and 60 ℃ obtain even thickness mastic after stirring, promptly get catablasm base material.
Embodiment 4: the basic proportioning of catablasm base material prescription
6 parts of 12 parts of sodium carboxymethyl cellulose of sodium polyacrylate
23 parts in 23 parts of gelatin of polyvinylpyrrolidone
60 parts of 8 parts of glycerol of kaolin
80 parts in water
Preparation method
1, preparation I phase solution: gelatin is added 35 parts in water, abundant swelling under 60 ℃ of water-baths, simultaneously sodium carboxymethyl cellulose is added water and add polyvinylpyrrolidone for 45 parts after 80 ℃ of water-bath swellings are complete, the back that stirs adds in the gelatin solution that stirs, and stirs and promptly gets I phase solution;
2, preparation II phase solution: sodium polyacrylate, kaolin are scattered in the glycerol, stir and promptly get II phase solution;
3, preparation catablasm base material: II phase solution is added in the I phase solution, and 60 ℃ obtain even thickness mastic after stirring, promptly get catablasm base material.
Embodiment 5: the basic proportioning of catablasm base material prescription
8 parts of 16 parts of sodium carboxymethyl cellulose of sodium polyacrylate
30 parts in 30 parts of gelatin of polyvinylpyrrolidone
80 parts of 10 parts of glycerol of calcium carbonate
110 parts in water
Preparation method
1, preparation I phase solution: gelatin is added 25 parts in water, abundant swelling under 60 ℃ of water-baths, simultaneously sodium carboxymethyl cellulose is added water and add polyvinylpyrrolidone for 30 parts after 80 ℃ of water-bath swellings are complete, the back that stirs adds in the gelatin solution that stirs, and stirs and promptly gets I phase solution;
2, preparation II phase solution: sodium polyacrylate, calcium carbonate are disperseed in glycerol, stir and promptly get II phase solution;
3, preparation catablasm base material: II phase solution is added in the I phase solution, and 60 ℃ obtain even thickness mastic after stirring, promptly get catablasm base material.
Embodiment 6: the basic proportioning of catablasm base material prescription
6 parts of 12 parts of sodium carboxymethyl cellulose of sodium polyacrylate
23 parts in 18 parts of gelatin of polyvinyl alcohol
60 parts of 6 parts of glycerol of zinc oxide
85 parts in water
Preparation method
1, preparation I phase solution: gelatin is added 35 parts in water, abundant swelling under 60 ℃ of water-baths, simultaneously sodium carboxymethyl cellulose is added water and add polyvinyl alcohol for 50 parts after 80 ℃ of water-bath swellings are complete, the back that stirs adds in the gelatin solution that stirs, and stirs and promptly gets I phase solution;
2, preparation II phase solution: sodium polyacrylate, zinc oxide are scattered in the glycerol, stir and promptly get II phase solution;
3, preparation catablasm base material: II phase solution is added in the I phase solution, and 60 ℃ obtain even thickness mastic after stirring, promptly get catablasm base material.
Claims (6)
1, a kind of substrate of cataplasma is characterized in that the basic recipe of this substrate has following soluble high-molecular chemical compound to be mixed and made into by weight ratio:
3～12 parts of 5～20 parts of sodium carboxymethyl cellulose of sodium polyacrylate
10～35 parts in 10～45 parts of gelatin of polyvinylpyrrolidone
30～80 parts of 3～15 parts of glycerol of kaolin
40～110 parts in water.
2, a kind of substrate of cataplasma is characterized in that the basic recipe of this substrate has following soluble high-molecular chemical compound to be mixed and made into by weight ratio:
3～12 parts of 5～20 parts of sodium carboxymethyl cellulose of sodium polyacrylate
10～35 parts in 10～45 parts of gelatin of polyvinylpyrrolidone
30～80 parts of 3～15 parts of glycerol of calcium carbonate
40～110 parts in water.
3, a kind of substrate of cataplasma is characterised in that the basic recipe of this substrate has following soluble high-molecular chemical compound to be mixed and made into by weight ratio:
3～12 parts of 5～20 parts of sodium carboxymethyl cellulose of sodium polyacrylate
10～35 parts in 10～30 parts of gelatin of polyvinyl alcohol
30～80 parts of 3～15 parts of glycerol of zinc oxide
40～110 parts in water.
4, according to the preparation method of claim 1,2 or 3 described catablasm base materials, its preparation process is as follows:
(1) preparation I phase solution: gelatin is added water, and abundant swelling is standby under the water-bath of heating; In addition sodium carboxymethyl cellulose is added water, swelling adds polyvinylpyrrolidone or polyvinyl alcohol in the back fully in the water-bath of heating, and the back that stirs adds in the gelatin solution that stirs, and stirs and promptly gets I phase solution;
(2) preparation II phase solution: sodium polyacrylate, kaolin or zinc oxide or calcium carbonate are disperseed in glycerol, stir and promptly get II phase solution;
(3) preparation catablasm base material: II phase solution is added in the I phase solution, heat and stir after obtain even thickness mastic, promptly get catablasm base material.
5, according to the preparation method of the described Chinese medicine patcher substrate of claim 5, it is characterized in that in step (1) gelatin added 10～45 parts in water, heating-up temperature is 40～80 ℃, and sodium carboxymethyl cellulose is added 20～80 parts in water, is heated to 50～80 ℃ water-bath swelling.
6,, it is characterized in that in step (3), heating-up temperature is 50～80 ℃ according to the preparation method of the described Chinese medicine patcher substrate of claim 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510095682 CN1814296A (en) | 2005-11-28 | 2005-11-28 | Cataplasm substrate and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510095682 CN1814296A (en) | 2005-11-28 | 2005-11-28 | Cataplasm substrate and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1814296A true CN1814296A (en) | 2006-08-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510095682 Pending CN1814296A (en) | 2005-11-28 | 2005-11-28 | Cataplasm substrate and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105078645A (en) * | 2014-05-12 | 2015-11-25 | 天津卓普医疗器械有限公司 | Cold-compression patch with hydrogel as substrate and method for manufacturing cold-compression patch |
| CN106309627A (en) * | 2016-11-25 | 2017-01-11 | 南京中医药大学 | Gel for removing Chloasma, preparing method and application thereof |
-
2005
- 2005-11-28 CN CN 200510095682 patent/CN1814296A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105078645A (en) * | 2014-05-12 | 2015-11-25 | 天津卓普医疗器械有限公司 | Cold-compression patch with hydrogel as substrate and method for manufacturing cold-compression patch |
| CN106309627A (en) * | 2016-11-25 | 2017-01-11 | 南京中医药大学 | Gel for removing Chloasma, preparing method and application thereof |
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