CN1813702A - Ketoprofen cataplasm and its preparing method - Google Patents
Ketoprofen cataplasm and its preparing method Download PDFInfo
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- CN1813702A CN1813702A CN 200510110907 CN200510110907A CN1813702A CN 1813702 A CN1813702 A CN 1813702A CN 200510110907 CN200510110907 CN 200510110907 CN 200510110907 A CN200510110907 A CN 200510110907A CN 1813702 A CN1813702 A CN 1813702A
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- ketoprofen
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Abstract
The present invention belongs to the field of medicine technology, in particular, it relates to a ketoprofen cataplasma preparation and its preparation method. The experiments of initial adhesion, paste content, excipient property, external release and external percutaneous test show that the invented ketoprofen cataplasma preparation can meet the requirements related to pharmacopeia.
Description
Technical field
The present invention relates to medical technical field, is a kind of ketoprofen cataplasm and preparation method thereof.
Background technology
Ketoprofen (Ketoprofen) is a kind of non-steroidal antipyretic-antalgic anti-inflammatory agent thing (NSAID), has antiinflammatory, analgesia, refrigeration function, the clinical treatment of diseases such as rheumatic, rheumatoid arthritis that are widely used in.Similar to the untoward reaction of other non-steroidal antipyretic-antalgic anti-inflammatory agent thing, ketoprofen is oral also more easily to cause digestive tract reaction such as stomach pain, feel sick, ulcer, hemorrhage etc.The ketoprofen percutaneous preparation can improve the local drug concentration of ketoprofen at painful area, strengthen antiinflammatory action, the gastrointestinal side effect of avoiding oral administration to cause, and can be by the adjustment control dosage of administration area, also interruption of the administration at any time, easy to use, improve the compliance of patient's medication.Launch such as now existing ketoprofen gel agent, liniment, liniment, patch, patch and cataplasma belong to the matrix type percutaneous preparation, and patch is used pressure-sensitive film substrate always, and cataplasma then adopts water-soluble high-molecular material to make medicine carrying substrate.Compare with traditional emplastrum cataplasma have contain that dose is big, transdermal absorption factor is higher, (can paste repeatedly) easy to use, little, the no sensitization composition of zest, advantage such as pollution-free, but do not see that so far ketoprofen cataplasm and relevant report thereof are arranged.
Summary of the invention
The invention provides a kind of easy to use, effect is obvious, side reaction is little ketoprofen cataplasm, compare with other transdermal patch, it is big that cataplasma has a drug loading, water conservation, preserve moisture, the advantage of good permeability, do not contain gasoline class organic solvent, no sensitization, zest is little.
Ketoprofen of the present invention comprises backing layer, drug-reservoir and protective layer, it is characterized in that drug-reservoir is made up of ketoprofen Emulsion or ketoprofen solution, hydrophilic catablasm base material, penetration enhancer and additives, and proportioning is as follows: (%W/W)
Ketoprofen 0.5-15
Emulsifying agent 0-20
Oil phase 0-30
Hydrophilic catablasm base material 35-90
Penetration enhancer 1-35
Additives 0.4-6
Their composition is respectively:
1. hydrophilic catablasm base material is made up of hydrophilic cohesiveness substrate, cross-linking agent, wetting agent, filler, water, wherein:
(1) hydrophilic cohesiveness substrate: be selected from sodium carboxymethyl cellulose, carboxymethyl starch, tragakanta, polyvinylpyrrolidone, sodium polyacrylate, Polyethylene Glycol, arabic gum, sodium hydroxyethyl cellulose, hydroxypropyl cellulose, agar, gelatin, corn starch etc.
(2) cross-linking agent: be selected from aluminum salt, calcium salt and magnesium salt,, can select wherein one or both polyvalent metal hydrochlorates simultaneously for use as calcium hydroxide, magnesium aluminate, aluminium hydroxide, aluminum chloride, aluminium potassium sulfate, aluminum nitrate, calcium chloride, lime nitrate etc.
(3) wetting agent is selected from glycerol, mannitol, propylene glycol, sorbitol, lanoline etc.
(4) filler: be selected from kaolin, zinc oxide, kieselguhr, Pulvis Talci etc.
2. ketoprofen, can be ketoprofen Emulsion or ketoprofen solution form, wherein Emulsion is made up of water, oil phase and emulsifying agent, and emulsifying agent is selected from tween, span, sodium lauryl sulphate or sodium stearate, potassium or ammonium monovalent salt, and hydrophile-lipophile balance value (HLB) is more than 10.Oil phase or solution solvent are selected from ethanol, propylene glycol, liquid paraffin, silicone, isopropyl myristate, can select wherein 1～2 kind simultaneously for use.
3. penetration enhancer: be selected from (1) organic solvent: as ethanol, propylene glycol, ethyl acetate; (2) organic acid, aliphatic alcohol: as oleic acid, isopropyl myristate, lauryl alcohol; (3) surfactant: as sodium lauryl sulphate, Tween 80; (4) azone and homologue thereof; (5) terpenes: as menthol, Camphora, limonene and eucalyptole; (6) cutin is preserved moisture and softening agent: as carbamide, salicylic acid and pyrrolidinone compounds.Can select wherein 1～3 kind simultaneously for use.
4. additives: comprise various antioxidant commonly used, as vitamin C, vitamin E, Potassium acid sulfite, sodium sulfite etc.; Antiseptic is as benzoic acid, sorbic acid, parabens; Also comprise pigment, spice etc.
The preparation method of ketoprofen cataplasm of the present invention is as follows:
1. prepare (I) phase solution: it is ketoprofen solution or ketoprofen Emulsion
(1) preparation ketoprofen solution:
With stirring in the ketoprofen powder adding solvent, put the heating in water bath dissolving by proportioning; Again additives are added in the ketoprofen solution and stir, put the heating in water bath dissolving, get ketoprofen solution;
(2) preparation ketoprofen Emulsion:
The ketoprofen powder is added oil phase, put the heating in water bath dissolving; Emulsifying agent is added to the water the heating in water bath dissolving; Water slowly poured in the oil phase mixes, ketoprofen Emulsion;
2. prepare (II) phase solution:
Filler is crossed 100 mesh sieves, and adds entry after cross-linking agent mixes, stir (II) phase solution.
3. prepare (III) phase solution:
Hydrophilic cohesiveness substrate, wetting agent, (I) phase solution are added water dissolution, stir, get (III) phase solution.
4. preparation ketoprofen cataplasm
(II) phase solution is joined (III) phase solution, and vacuum stirring is even, evenly is applied to backing layer, protective mulch.50 ℃ of about 3h of baking, cutting packs as required, is ketoprofen cataplasm of the present invention.
Above-mentioned backing layer material can be selected cotton, non-woven fabrics, aluminium foil, polyethylene, paper and polyester etc. for use.Protective layer material is selected from polyethylene, polypropylene etc.
Ketoprofen cataplasm of the present invention has been carried out relevant release, transdermal, viscosity, paste containing amount and plastic property experiment:
1. extracorporeal releasing experiment
Method sees two appendix XD of 2005 editions Chinese Pharmacopoeias drug release determination method three therapeutic methods of traditional Chinese medicine for details.Adopt the drug release determination device of pharmacopeia regulation to carry out ketoprofen release in vitro degree mensuration.Because ketoprofen is slightly soluble in water, thus be release medium with the freshly prepared PBS buffer 900ml of ultrasonic degas, pre-warm (32 ± 0.5) ℃.Get the ketoprofen cataplasm 4cm * 4cm of baking different time, take off, be fixed in the central authorities of two-layer video disc from protective layer, emission surface upwards, again with the net dish as for the stripping rotor bottom, and parallel with the surfaces of revolution at the bottom of the oar, both are at a distance of (25 ± 2) mm.Rotating speed is 100rpm/min, respectively at 10,20,40,60,90,150,240, the 360min sampling, each 5ml, and in time additional isopyknic fresh PBS buffer, 0.45 μ m microporous filter membrane filters, and carries out high performance liquid chromatography (HPLC) working sample concentration behind the centrifugal 10min of reuse 3000rpm/min.Experimental result: with unit are cumulative release amount Q time t is returned:
R=0.9976, Td=19.21 illustrates that release in vitro meets the Weibull function.
2. transdermal test in vitro experiment
Method sees the percutaneous dosing novel form among the Lu Bin chief editor " novel pharmaceutical formulation and new technique " for details.Adopt improvement Franz diffusion cell, BLAB/c Corium Mus skin is fixed on the diffusion cell, corium is towards receiving chamber, and stratum corneum side is to supply chamber.Cataplasma sticks on stratum corneum side, adds quantitative PH7.4 phosphate buffer (PBS liquid) in the receiving chamber.32 ℃ of water bath with thermostatic control circulations and magnetic stirring apparatus (300 rev/mins), sampling in 1,2,3,4,6,8,10,12,18,24 hour, each PBS liquid that takes out all receiving chamber, and replenish 37 ℃ of PBS solution of equal-volume, high performance liquid chromatography (HPLC) working sample concentration immediately.Experimental result: with unit are accumulation transit dose Q time t is returned: Q=10.196t-7.9547, r=0.9977, drug transdermal speed is 10.196ug/cm
2H illustrates that cataplasma transdermal of the present invention is functional.
3. the first viscous force experiment of ketoprofen cataplasm
According to the regulation of two appendix XJ of 2005 editions Chinese Pharmacopoeias, get three of ketoprofen cataplasms, all can cling No. 12 steel balls (8.731mm), first viscous force experiment is qualified.
4. the paste containing amount of ketoprofen cataplasm experiment
According to the predetermined operation of two appendix II of 2000 editions Chinese Pharmacopoeias, paste containing amount is 6.29g/100cm
2, RSD% is 2.46%, the paste containing amount experiment is qualified.
5. the plastic property of ketoprofen cataplasm experiment
According to the predetermined operation of two appendix II of 2000 editions Chinese Pharmacopoeias, the cream face does not have the trickling phenomenon, and the plastic property experiment is qualified.
The specific embodiment
Now in conjunction with the embodiments, ketoprofen cataplasm of the present invention and preparation method thereof is described in detail.
Embodiment 1: preparation ketoprofen cataplasm, ketoprofen 0.5mg/cm
2
Component and proportioning:
Ketoprofen 4g sodium carboxymethyl cellulose 20g
Propylene glycol 100g polyvinylpyrrolidone (PVP-K90) 30g
Kaolin 20g sodium polyacrylate (NP-700) 10g
Gelatin 10g sorbitol 200g
Ethyl hydroxybenzoate 1g ethanol 25g
Ca (OH)
22g glycerol 50g
Distilled water 340g
Preparation method:
1. prepare (I) phase solution:
By said ratio ketoprofen is joined in the ethanol, stirring and dissolving, adding ethyl hydroxybenzoate again, to continue stirring and dissolving complete, (I) phase solution.
2. prepare (II) phase solution:
Get kaolin, the Ca (OH) that crosses 100 mesh sieves by said ratio
2Mix the back and add 150g water, stir into (II) phase solution of mix homogeneously.
3. prepare (III) phase solution:
Getting sodium carboxymethyl cellulose, sodium polyacrylate, polyvinylpyrrolidone by said ratio joins in propylene glycol, the glycerol and mixes into pasty state, after adding (I) phase solution and sorbitol mixing, be added in the jelly of the abundant swelling of gelatin in 150g water in 60 ℃ of water-baths again, fully stir, mixing gets (III) phase solution.
4. preparation ketoprofen cataplasm:
(II) phase solution is joined (III) phase solution, and vacuum stirring is even, gets mastic.Evenly be applied on the non-woven fabrics, cover polyethylene film, 50 ℃ of baking 3～4h cut into 60cm
2/ open, pack.
Embodiment 2: preparation ketoprofen cataplasm, ketoprofen 1mg/cm
2
Component and proportioning:
Ketoprofen 9g sodium hydroxyethlcellulose 25g
Paraffin oil 100g polyvinylpyrrolidone (PVP-K90) 30g
Kaolin 20g sodium polyacrylate (NP-700) 10g
Gelatin 10g sorbitol 200g
Ethyl hydroxybenzoate 1g azone 8g
Aluminium potassium sulfate 1g ethanol 25g
Glycerol 50g isopropyl myristate 15g
Tween 80 10g distilled water 380g
Preparation method:
1. prepare (I) phase Emulsion:
By said ratio ketoprofen is joined in the isopropyl myristate, 50 ℃ of heating for dissolving add the 15g paraffin oil, and the room temperature cooling is oil phase.The 10g tween 80 is dissolved in the 60g distilled water, pours above-mentioned oil phase again into, be mixed into breast, get (I) phase Emulsion.
2. prepare (II) phase solution:
Get kaolin, the aluminium potassium sulfate of crossing 100 mesh sieves by said ratio and mix back adding 150g water, stir into (II) phase solution of mix homogeneously.
3. prepare (III) phase solution:
Getting sodium hydroxyethlcellulose, sodium polyacrylate, polyvinylpyrrolidone by said ratio joins in 85g paraffin oil, the 50g glycerol and is mixed into pasty state, after adding (I) phase Emulsion and sorbitol mixing, be added in the jelly of the abundant swelling of gelatin in 150g water in 60 ℃ of water-baths again, fully stir, mixing gets (III) phase solution.
4. preparation ketoprofen cataplasm:
(II) phase solution is joined (III) phase solution, add ethyl hydroxybenzoate and azone again, vacuum stirring is even, gets mastic.Evenly be applied on the non-woven fabrics, cover polyethylene film, 50 ℃ of baking 3h cut into 60cm
2/ open, pack.
Embodiment 3: preparation ketoprofen cataplasm, ketoprofen 1.2mg/cm
2
Component and proportioning:
Ketoprofen 10g carboxymethyl starch 25g
Propylene glycol 100g polyvinylpyrrolidone (PVP-K90) 30g
Kaolin 20g sodium polyacrylate (NP-700) 10g
Gelatin 20g sorbitol 200g
Propyl hydroxybenzoate 1g isopropyl myristate 8g
Aluminium hydroxide 2g N-Methyl pyrrolidone 5g
Glycerol 50g distilled water 380g
Preparation method:
1. prepare (I) phase solution:
By said ratio ketoprofen is joined in the 30g propylene glycol, fully stirring and dissolving adds propyl hydroxybenzoate, N-Methyl pyrrolidone and isopropyl myristate again and continues stirring and dissolving, gets (I) phase solution.
2. prepare (II) phase solution:
Get kaolin, the aluminium hydroxide of crossing 100 mesh sieves by said ratio and mix back adding 150g water, stir into (II) phase solution of mix homogeneously.
3. prepare (III) phase solution:
Getting carboxymethyl starch, sodium polyacrylate, polyvinylpyrrolidone by said ratio joins in 70g propylene glycol, the 50g glycerol and is mixed into pasty state, after adding ketoprofen solution and sorbitol mixing, be added in the jelly of the abundant swelling of gelatin in 150g water in 60 ℃ of water-baths again, fully stir, mixing gets (III) phase solution.
4. preparation ketoprofen cataplasm:
(II) phase solution is joined (III) phase solution, and vacuum stirring is even, gets mastic.Evenly be applied on the non-woven fabrics, cover polyethylene film, 50 ℃ of baking 3h cut into 40cm
2/ open, pack.
Embodiment 4: preparation ketoprofen cataplasm, ketoprofen 1.2mg/cm
2
Prescription and proportioning:
Ketoprofen 11g tragakanta 22g
Propylene glycol 100g polyvinylpyrrolidone (PVP-K90) 30g
Kaolin 20g sodium polyacrylate (NP-700) 10g
Gelatin 20g sorbitol 200g
EDTA-Na1g azone 8g
Ca (OH)
22g N-Methyl pyrrolidone 5g
Paraffin oil 50g distilled water 380g
Preparation method:
1. prepare (I) phase solution:
By said ratio ketoprofen is joined in the 30g propylene glycol, fully stirring and dissolving adds N-Methyl pyrrolidone and azone again and continues stirring and dissolving, gets (I) phase solution.
2. prepare (II) phase solution:
Get kaolin, the Ca (OH) that crosses 100 mesh sieves by said ratio
2, EDTA-Na mixes the back and adds 160g water, stirs into (II) phase solution of mix homogeneously.
3. prepare (III) phase solution
Getting tragakanta, sodium polyacrylate, polyvinylpyrrolidone by said ratio joins in 70g propylene glycol, the 50g paraffin oil and is mixed into pasty state, after adding (I) phase solution and sorbitol mixing, be added in the jelly of the abundant swelling of gelatin in 160g water in 60 ℃ of water-baths again, fully stir, mixing gets (III) phase solution.
4. preparation ketoprofen cataplasm
(II) phase solution is joined (III) phase solution, and vacuum stirring is even, gets mastic.Evenly be applied on the non-woven fabrics, cover polyethylene film, 50 ℃ of baking 3～4h cut into 40cm
2/ open, pack.
Embodiment 5: preparation ketoprofen cataplasm, ketoprofen 0.8mg/cm
2
Component and proportioning:
Ketoprofen 8g corn starch 23g
Propylene glycol 100g polyvinylpyrrolidone (PVP-K90) 30g
Kaolin 10g sodium polyacrylate (NP-700) 10g
Gelatin 20g sorbitol 200g
Ethyl hydroxybenzoate 1g isopropyl myristate 8g
Ca (OH)
21g glycerol 50g
ZnO1g Pulvis Talci 10g
Distilled water 350g
Preparation method:
1. prepare (I) phase solution:
By said ratio ketoprofen is joined in the 30g propylene glycol, fully stirring and dissolving adds ethyl hydroxybenzoate and isopropyl myristate again and continues stirring and dissolving, gets (I) phase solution.
2. prepare (II) phase solution:
Get kaolin, Pulvis Talci, the Ca (OH) that crosses 200 mesh sieves by said ratio
2, ZnO mixes the back and adds 150g water, stirs into (II) phase solution of mix homogeneously.
3. prepare (III) phase solution:
Join in 70g propylene glycol and the 50g glycerol by said ratio extracting corn starch, sodium polyacrylate, polyvinylpyrrolidone and to be mixed into pasty state, after adding (I) phase solution and sorbitol mixing, be added in the jelly of the abundant swelling of gelatin in 150g water in 60 ℃ of water-baths again, fully stir, mixing gets (III) phase solution.
4. preparation ketoprofen cataplasm:
(II) phase solution is joined (III) phase solution, and vacuum stirring is even, gets mastic.Evenly be applied on the non-woven fabrics, cover polypropylene film, 50 ℃ of baking 3～4h cut into 40cm
2/ open, pack.
Claims (1)
1. a ketoprofen cataplasm comprises backing layer, drug-reservoir and protective layer, it is characterized in that drug-reservoir is made up of ketoprofen Emulsion or ketoprofen solution, hydrophilic catablasm base material, penetration enhancer and additives;
Said ketoprofen Emulsion is made up of ketoprofen, water, oil phase and emulsifying agent, and emulsifying agent wherein is selected from tween, span, sodium lauryl sulphate, stearic sodium, potassium or ammonium monovalent salt; Ketoprofen solution is made up of ketoprofen and organic solvent, and the oil phase of ketoprofen Emulsion and the organic solvent of ketoprofen solution are selected from ethanol, propylene glycol, liquid paraffin, silicone, isopropyl myristate, can select 1～2 kind in the solvent simultaneously for use;
Said hydrophilic catablasm base material is made up of hydrophilic cohesiveness substrate, wetting agent, filler, cross-linking agent and water, and wherein hydrophilic cohesiveness substrate is selected from sodium carboxymethyl cellulose, carboxymethyl starch, tragakanta, polyvinylpyrrolidone, sodium polyacrylate, Polyethylene Glycol, arabic gum, sodium hydroxyethyl cellulose, hydroxypropyl cellulose, agar, gelatin, corn starch;
Said cross-linking agent is selected from calcium hydroxide, magnesium aluminate, aluminium hydroxide, aluminum chloride, aluminium potassium sulfate, aluminum nitrate, calcium chloride, lime nitrate etc., can select wherein 1～2 kind simultaneously for use;
Said wetting agent is selected from glycerol, mannitol, propylene glycol, sorbitol, lanoline, can select wherein 1～2 kind simultaneously for use;
Said filler is selected from kaolin, zinc oxide, kieselguhr, Pulvis Talci;
Said penetration enhancer is selected from ethanol, propylene glycol, ethyl acetate, oleic acid, isopropyl myristate, lauryl alcohol, sodium lauryl sulphate, Tween 80, azone, menthol, Camphora, limonene, eucalyptole, carbamide, salicylic acid, pyrrolidinone compounds, can select 1～4 kind simultaneously for use;
Said additives are antioxidant, antiseptic, pigment, spice;
Component and proportioning are respectively:
(1)
Ketoprofen 4g sodium carboxymethyl cellulose 20g
Propylene glycol 100g polyvinylpyrrolidone (PVP-K90) 30g
Kaolin 20g sodium polyacrylate (NP-700) 10g
Gelatin 10g sorbitol 200g
Ethyl hydroxybenzoate 1g ethanol 25g
Ca (OH)
22g glycerol 50g
Distilled water 340g
(2)
Ketoprofen 9g sodium hydroxyethlcellulose 25g
Paraffin oil 100g polyvinylpyrrolidone (PVP-K90) 30g
Kaolin 20g sodium polyacrylate (NP-700) 10g
Gelatin 10g sorbitol 200g
Ethyl hydroxybenzoate 1g azone 8g
Aluminium potassium sulfate 1g ethanol 25g
Glycerol 50g isopropyl myristate 15g
Tween 80 10g distilled water 380g
(3)
Ketoprofen 10g carboxymethyl starch 25g
Propylene glycol 100g polyvinylpyrrolidone (PVP-Kg0) 30g
Kaolin 20g sodium polyacrylate (NP-700) 10g
Gelatin 20g sorbitol 200g
Propyl hydroxybenzoate 1g isopropyl myristate 8g
Aluminium hydroxide 2g N-Methyl pyrrolidone 5g
Glycerol 50g distilled water 380g
(4)
Ketoprofen 11g tragakanta 22g
Propylene glycol 100g polyvinylpyrrolidone (PVP-K90) 30g
Kaolin 20g sodium polyacrylate (NP-700) 10g
Gelatin 20g sorbitol 200g
EDTA-Na1g azone 8g
Ca (OH)
22g N-Methyl pyrrolidone 5g
Paraffin oil 50g distilled water 380g
(5)
Ketoprofen 8g corn starch 23g
Propylene glycol 100g polyvinylpyrrolidone (PVP-K90) 30g
Kaolin 10g sodium polyacrylate (NP-700) 10g
Gelatin 20g sorbitol 200g
Ethyl hydroxybenzoate 1g isopropyl myristate 8g
Ca (OH)
21g glycerol 50g
ZnO1g Pulvis Talci 10g
Distilled water 350g.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101109074A CN100477989C (en) | 2005-11-29 | 2005-11-29 | Ketoprofen cataplasm and its preparing method |
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|---|---|---|---|
| CNB2005101109074A CN100477989C (en) | 2005-11-29 | 2005-11-29 | Ketoprofen cataplasm and its preparing method |
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| CN100477989C CN100477989C (en) | 2009-04-15 |
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|---|---|---|---|
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1973836B (en) * | 2006-12-01 | 2010-05-12 | 中国人民解放军第二军医大学 | Hydrophilic plaster for treating dysmenorrhea |
| CN101518520B (en) * | 2009-04-09 | 2011-07-27 | 浙江省医学科学院 | Framework-type transdermal patch with dextro ketoprofen accumulated in subcutaneous deep tissues |
| CN102379862A (en) * | 2011-11-03 | 2012-03-21 | 北京泰德制药股份有限公司 | Spirosal-containing hydrophilic cataplasm |
| CN103893775A (en) * | 2012-12-26 | 2014-07-02 | 江苏康倍得药业有限公司 | Hydrophilic composition and cataplasm containing hydrophilic composition |
| CN104415024A (en) * | 2013-08-22 | 2015-03-18 | 和心医药科技（上海）有限公司 | Diclofenac-containing cataplasm, and composition and preparation method thereof |
| CN105287361A (en) * | 2015-11-13 | 2016-02-03 | 北京泰德制药股份有限公司 | External preparation containing non-steroid anti-inflammatory drug microemulsion and used for skin |
| CN107007574A (en) * | 2017-05-16 | 2017-08-04 | 蔡志浩 | A kind of Ketoprofen Babu cream |
| CN111789832A (en) * | 2019-08-19 | 2020-10-20 | 湖南九典制药股份有限公司 | Deketoprofen trometamol gel plaster and preparation method thereof |
| CN113546064A (en) * | 2021-04-27 | 2021-10-26 | 北京鑫开元医药科技有限公司 | Ketoprofen transdermal patch and preparation method thereof |
| US11903915B2 (en) | 2019-02-14 | 2024-02-20 | Hisamitsu Pharmaceutical Co., Inc. | Poultice |
-
2005
- 2005-11-29 CN CNB2005101109074A patent/CN100477989C/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1973836B (en) * | 2006-12-01 | 2010-05-12 | 中国人民解放军第二军医大学 | Hydrophilic plaster for treating dysmenorrhea |
| CN101518520B (en) * | 2009-04-09 | 2011-07-27 | 浙江省医学科学院 | Framework-type transdermal patch with dextro ketoprofen accumulated in subcutaneous deep tissues |
| CN102379862A (en) * | 2011-11-03 | 2012-03-21 | 北京泰德制药股份有限公司 | Spirosal-containing hydrophilic cataplasm |
| CN103893775A (en) * | 2012-12-26 | 2014-07-02 | 江苏康倍得药业有限公司 | Hydrophilic composition and cataplasm containing hydrophilic composition |
| CN104415024A (en) * | 2013-08-22 | 2015-03-18 | 和心医药科技（上海）有限公司 | Diclofenac-containing cataplasm, and composition and preparation method thereof |
| CN104415024B (en) * | 2013-08-22 | 2018-05-11 | 和心医药科技（上海）有限公司 | Cataplasm containing Diclofenac, and combinations thereof and preparation method |
| CN105287361A (en) * | 2015-11-13 | 2016-02-03 | 北京泰德制药股份有限公司 | External preparation containing non-steroid anti-inflammatory drug microemulsion and used for skin |
| CN107007574A (en) * | 2017-05-16 | 2017-08-04 | 蔡志浩 | A kind of Ketoprofen Babu cream |
| US11903915B2 (en) | 2019-02-14 | 2024-02-20 | Hisamitsu Pharmaceutical Co., Inc. | Poultice |
| CN111789832A (en) * | 2019-08-19 | 2020-10-20 | 湖南九典制药股份有限公司 | Deketoprofen trometamol gel plaster and preparation method thereof |
| CN113546064A (en) * | 2021-04-27 | 2021-10-26 | 北京鑫开元医药科技有限公司 | Ketoprofen transdermal patch and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100477989C (en) | 2009-04-15 |
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