JP6031662B2 - Cognitive decline improvement composition - Google Patents

Description

  The present invention relates to a composition for preventing or improving cognitive decline. More specifically, cognitive functions, including extracts from a mixture of safflower, strawberry, sash, lion, sarcophagus, masochito, ginseng, ginseng, ginseng, ninfuto, daiso, licorice, sensu and lotus wick The present invention relates to a composition for preventing or improving a decrease.

  Although dementia has a juvenile type that develops in the 40s to 50s, it frequently develops in the elderly after the 60s. The proportion of the so-called silver generation in their 60s and over has reached 30.5% (Statistics Bureau of the Ministry of Internal Affairs and Communications “Population Monthly Report”). They are people. As a therapeutic agent for dementia, only one kind is currently approved in Japan, it is a component called donepezil hydrochloride, and the trade name is called Aricept. This drug is positioned as a symptomatic treatment for dementia such as Alzheimer, and is used to suppress the progression of dementia symptoms in Alzheimer type dementia. Although it causes temporary improvement of cognitive function when used early in Alzheimer's dementia, it is not a drug that treats the pathology of Alzheimer's dementia or ultimately prevents the dementia from getting worse.

  As a herbal medicine to relieve the accompanying symptoms of dementia, yokukansan prevents neuronal cell death due to endoplasmic reticulum stress, so it effectively prevents and treats neuronal cell death related diseases such as Alzheimer's disease. Has been reported to be possible (Patent Document 1). In addition, Japanese cypress, carrots, carrots (white carp), bakuryu (white birch), bukkuri (clams), Onji (distant), taisou (daegu), touki (toki), licorice (licorice) ), Ginger, mokko, sansounin (acido-jin), and longannik (longan meat) return neurites to normal in cultured neurons and improve memory impairment From the above, it is reported that it is useful as a preventive / ameliorating agent for Alzheimer-type memory impairment (Patent Document 2). Furthermore, it has been reported that Tokiyakuyakusan, including Toki, glaze, samurai, acupuncture, acupuncture and senkyu, has an inhibitory effect on apoptosis and can be used for senile neurosis including Alzheimer's disease (Patent Document 3). ). In addition, plants and herbal medicines such as Yamabushitake and Ginkgo biloba are also known (for example, Patent Documents 4 and 5).

  Safflower has long been widely known as a red dye and cooking oil. Its roots are frequently used as blood purification drugs, especially as women's drugs, and are effective in, for example, irregular menstruation, coldness, climacteric disorder, etc., and also in improving blood due to blood circulation disorders. The dried flowers are called safflowers and are listed in the Japanese Pharmacopoeia as herbal medicines that have blood circulation promoting effects and are used in various Chinese medicine prescriptions. In recent years, there is also a report that reduction of cognitive / memory function is reduced (for example, Patent Document 6).

  Gajutsu is a herbal medicine with an aromatic healthy stomach action that is recorded in the Japanese Pharmacopoeia. In addition, it is known that a component extracted from gadget has a nerve growth factor production enhancing action (Patent Document 7).

  Yuzu is a herb medicine, a herbal medicine listed in the Japanese Pharmacopoeia, anti-fatigue anti-aging effect, immunostimulatory effect, hepatocyte protection effect, anti-fatty liver effect, blood fat lowering effect, hypoglycemic effect, The blood pressure lowering action is known. In addition, the effect of preventing or improving cerebral nerve cell death has been reported (Patent Document 8).

  In the Chinese medicine, sarcophagus has been recognized for its effects of fragrance opening and Ningxin Anjin, and is used in combination with other Anjin herbs and is also used for treatment of frenzy, dementia, amnesia, tinnitus, deafness, etc. ing.

Masuthijin is a herbal medicine listed in the Japanese Pharmacopoeia, and is known to have a healthy stomach, antidiuretic, and salivary secretion inhibiting action.

Turmeric is a perennial plant belonging to the ginger family and is used as a flavoring, coloring, and herbal medicine. It is well known for its English name, turmeric, and is also used as a material for curry in Indian cuisine. As a medicinal effect as a crude drug, the promotion of bile secretion and the action of a healthy stomach are known.

  Sensen has been used as a herbal medicine because it has the effect of “Warm kidney soyo, de-humidification”. It has also been applied to night urine in elderly people and various symptoms caused by menopause in women. In addition, immune activation and excitability are also known.

  Carrots are herbal medicines listed in the Japanese Pharmacopoeia and are blended into various Kampo prescriptions. Its effects include anti-diabetic action, anti-cancer action, heart strengthening and blood pressure adjustment, liver function strengthening, gastrointestinal function strengthening, stress relieving and tonic effect, physical strength (strength) enhancement, brain function strengthening, aging suppression, radiation irradiation protection action In addition, an anemia recovery effect and a hematopoietic effect, an immune function enhancement, an anti-inflammatory effect and a weak constitution improving effect are known.

  Tanana ginseng is a medicinal plant belonging to the family Araceae, native to southern China and cultivated in the highlands of Yunnan Province and Guangxi Zhuang Autonomous Region. As an effect of the ginseng, it is known to have both hemostatic action and active blood (improvement of blood circulation). Further, antiviral action, anticholesterol action, antitumor action and the like are also known.

  Shinobu is a non-toxic herbal medicine that has been widely used and is listed in the Japanese Pharmacopoeia. Traditionally, Kampo has been used for the treatment of arthritis and bronchitis as it is effective for hemorrhoids (internal and external inflammation). It is also known to be effective for epidemic colds, various purulent infections, redness of joints due to wet heat, swelling, protection against hepatotoxicity and reduction of cellular immunity.

  Daegu is a jujube fruit of the aceae family that contains sugar, mucus, malic acid, tartaric acid, etc. and is known for its tonic and sedative effects. In addition, it has sweetness and is blended in various Chinese medicines for the purpose of alleviating side effects.

  Licorice is a herbal medicine listed in the Japanese Pharmacopoeia and contains glycyrrhizin and glycosides, and is known to have analgesic, anti-inflammatory, gastric pain, antitussive expectorant, detoxification, and duodenal ulcer.

Renkoko is usually drunk as tea, and is said to be effective for the heart and liver and also for mental stability. The present inventors have recognized and reported a clear psychotropic effect on the germ component of this lotus at the level of animal experiments (Non-Patent Documents 1 and 2).
However, the effects of human medicine and herbal medicines that are said to prevent or ameliorate cognitive decline such as Alzheimer's disease are not clear in humans.

JP2011-037722 JP2007-230938 JP 09-087187 JP 2003-212790 A Special table 2011-506512 JP2010-126529 JP2009-269927A Table 2005/018656

Phytomedicine, Vol. 15, 1117, 2008 European J. Pharmacology, 634, 62, 2010

  An object of the present invention is to provide a composition for improving cognitive function lowering that exhibits an excellent inhibitory effect on the decline of cognitive function in humans and is highly safe.

  In view of such circumstances, the present inventors have conducted extensive research from a medicinal point of view in order to solve the above-mentioned problems, and as a result, improved the qualitative state of blood and blood such as tissue congestion and blood circulation disorders. A variety of extracts that combine herbal medicines with vitality to improve blood flow, herbal medicines that strengthen kidneys, improve water metabolism and suppress aging, and herbal medicines with awakening brain action that clarify awareness As a result, it was found that an extract of a mixture obtained by combining specific herbal medicines has an effect of improving the cognitive function, and further research was conducted to complete the present invention.

That is, the present invention
[1] A mixture of safflower, persimmon, coconut, sarcophagus, Masutoshi Jin, ginseng, carrot, ginseng, ginseng, ninfuto, daegu, licorice, sensu and lotus wick is acceptable for pharmaceutical or food hygiene A composition for preventing and / or improving cognitive decline, characterized by containing an extract obtained by extraction with a polar solvent,
[2] The mixture contains safflower 30 mg to 9 g parts by weight, cocoon 30 mg to 9 g parts by weight, eggplant 30 mg to 18 g parts by weight, sarcophagus 10 mg to 9 g parts by weight, Masutoshi Jin 30 mg to 9 g parts by weight, plating 30 mg to 9 g. Parts by weight, 10 mg to 9 g parts by weight of ginseng, 10 mg to 6 g parts by weight of ginseng, 60 mg to 15 g parts by weight of Shinobifu, 30 mg to 9 g parts by weight of licorice, 30 mg to 6 g parts of licorice, 30 mg to 9 g parts by weight of ginger The composition according to the above [1], wherein the composition is mixed at a ratio of 10 mg to 6 g by weight of a lotus core.
[3] The extract is a polar solvent for a mixture of safflower, persimmon, eggplant, sarcophagus, Masutoshi Jin, Jinjin, ginseng, nanana ginseng, Shinobifuto, Oiso, licorice, Sengan and lotus wick. The composition according to the above [1] or [2], which is extracted in an amount of 10 to 100 times.
[4] The composition according to any one of [1] to [3], wherein the polar solvent is water, ethanol, acetic acid, or a mixture thereof.
[5] The composition according to any one of [1] to [4], wherein the extraction temperature is in a range from room temperature to normal pressure or a boiling point of the solvent under pressure.
[6] The composition according to any one of [1] to [5] above, wherein the composition is in the form of a powder formulation, granule, tablet, pill, capsule, or liquid formulation,
About.

  The composition of the present invention can effectively prevent, suppress, or improve the decline of cognitive function.

It is a figure which shows the result of the revised Hasegawa type | formula simple intelligence evaluation scale before administration of the composition of this invention, and 1 month after administration (Example 2).

  Hereinafter, the present invention will be described in detail. The composition of the present invention is a herbal medicine that improves the blood state and has a vitalizing action that improves blood flow such as tissue congestion and blood circulation disorder; strengthens the kidneys, improves water metabolism, and suppresses aging It is characterized by the fact that it contains licorice that harmonizes the pharmacological properties of some herbal medicines; Examples of herbal medicines that have a vigorous action include safflower, cocoon, rice bran and ginseng. Herbal medicines with a prorenal action include citron and sasen. Herbal medicines that have an awakening brain action include sarcophagus, Masutoshi Jin, Sakin, Ginseng, Daegu, Renkoko, and Shinobifuto. In this specification, the Japanese Pharmacopoeia refers to the 16th revised Japanese Pharmacopoeia.

  The safflower is a perennial or perennial safflower (Carthamas tinctorius L), and its leaves, stems, flowers, roots, etc. and the whole plant are used as they are or as dried. However, it is preferable to use a flower or the whole plant on the ground, and it is more preferable to use a safflower as described in the Japanese Pharmacopoeia as it is or without removing most of the yellow pigment. As for safflower, what was sometimes pressed and made into a plate shape can also be preferably used.

  Persimmons (Curcuma zedoaria), one of the ginger family turmeric genus (Curcuma zedoaria), can be preferably used as it is or dried, and moreover, as described in the Japanese Pharmacopoeia. preferable.

Lycium is a deciduous shrub of the solanaceae native to China.
chinense Miller or Lyciumbarbatum L.) can be preferably used as it is or dried, and the eggplant described in the Japanese Pharmacopoeia is more preferred.

  As the sarcophagus, the roots, stems, and leaves of taros (Acorus gramineus) naturally grown in clear streams in various parts of Japan can be preferably used as they are or as dried.

  As for Masuthijin (yakutinin), it is possible to preferably use the fruits of Yakuchi (Alpinia oxyphylla Miquel) belonging to the ginger family as it is or dried, and Masuthi (nin) described in the Japanese Pharmacopoeia is more preferred. .

As the plating, a ginseng perennial turmeric root or stem dried as it is can be preferably used. In addition, there are spring turmeric (scientific name: Curcuma aromtica S) that attaches red flowers in spring and autumn turmeric (scientific name: Curcuma longa L) that attaches white flowers in autumn, and curcumin, the main medicinal ingredient, is added. Autumn turmeric containing a large amount is more preferable.

Sengan is a genus of the family Amaryllidaceae (Curculigo)
orchioides GAERIN.) can be preferably used as they are or as dried.

  As the carrot, roots excluding fine roots of the perennial perennial ginseng (Panax ginseng C.A. Meyer) or lightly boiled can be used, and the carrot described in the Japanese Pharmacopoeia is more preferable. Red ginseng that has been peeled off ginseng and dried naturally or by hot-air drying at 60 ° C. or less to a moisture content of 15% or less, or dried steamed steamed ginseng can be preferably used.

  Ginseng (Ginseng) is also called Ginseng (Ginseng), and the roots or stems of Panax notoginseng can be preferably used as they are or dried.

  Nintofu is simply referred to as Shinobu, and the leaves and stems of honeysuckle (Loniceraj aponica Thunberg (Caprifoliaceae)) can be preferably used as they are or dried, and the Nintofu described in the Japanese Pharmacopoeia is more preferable.

  For example, as for the Japanese oak (Thizou), it is preferable to use a jujube millet var. Is more preferable.

  Licorice is a product obtained by removing the roots and strons of leguminous larvae (Glycyrrhiza uralensis Fisch) or licorice (Glycyrrhiza glabra Linne (Leguminosae)), or their perical skin (peeled licorice) as is or dried. Licorice as described in Japanese Pharmacopoeia is more preferable.

  As the lotus core, it is possible to preferably use a mature seed portion of a lotus (Nelumbo nucifera), which is a water lily family, as it is or after it has been dried.

  “Cognition” in the present invention includes memory, learning, attention, concentration, thought (eg, problem solving ability), language (eg, understanding, word search) or visuospatial cognition, and “cognitive decline” This refers to a decrease in function, but includes a decrease in intelligence caused by acquired brain dysfunction. Intellectual decline includes, for example, a decline in the ability to solve by its own judgment based on memory of innate ability (instinct) and experience learned after birth, such as memory impairment (memory Reduced function), judgment, cognitive impairment and behavioral disorder. Cognitive decline includes brain dysfunction such as brain aging and Alzheimer's disease, as well as impaired ability to remember new experiences. Further, in the cognitive function decline in the present invention, the cognitive function exceeds the normal range and the memory ability is reduced, but the cognitive function disorder has not yet appeared, and the daily life is not disturbed. Also includes mild cognitive impairment (MCI).

  Any evaluation method of dementia can be preferably used for the evaluation of cognitive decline. As a specific evaluation method, for example, Hasegawa's simple method can be used to evaluate short-term memory, orientation (feeling of time, place, time, etc.), writing ability, etc. relatively easily by using verbal questions to subjects. An intelligence scale (HDS-R), MMSE (Mini-Mental State Examination), etc. are mentioned preferably.

The extract used in the present invention is the above-described crude drug (preferably, dried crude drug) as it is or after being cut, chopped, crushed (preferably cut, chopped, crushed around several mm to 1 cm), or crushed. Or it can obtain by extracting the mixture which mixed what was made into powder with an extraction solvent.

  The blended amount of each herbal medicine in the mixture is 30 mg to 9 g parts by weight of safflower, 30 mg to 9 g parts by weight, 30 mg to 18 g parts by weight, 10 mg to 9 g parts by weight of sarcophagus, 30 mg to 9 g parts by weight. Parts, 30 mg to 9 g parts by weight, 10 mg to 9 g parts by weight of ginseng, 10 mg to 6 g parts by weight of ginseng, 60 mg to 15 g parts by weight of Shinobifu, 30 mg to 9 g parts by weight, 30 mg to 6 g parts by weight of licorice, Sen 30 mg to 9 g parts by weight and 10 mg to 6 g parts by weight of lotus core are preferred; 1 g to 5 g parts by weight of safflower (1, 2, 3, 4, 5 g parts by weight), 2 g to 6 g parts by weight (2, 3, 4, 5, 6 g parts by weight), 8 g to 12 g parts by weight (8, 9, 10, 11, 12 g parts by weight), 2 g to 6 g parts by weight (2, 3, 4, 5, 6 g parts by weight), profit Tomojin 1g-5g parts by weight (1, 3, 4, 5 g parts by weight), plating 2 g to 6 g parts by weight (2, 3, 4, 5, 6 g parts by weight), carrot 1 g to 5 g parts by weight (1, 2, 3, 4, 5 g parts by weight) 1 g-5 g parts by weight of ginseng (1, 2, 3, 4, 5 g parts by weight), 6 g-10 g parts by weight of Shinobifu (6, 7, 8, 9, 10 g parts by weight), 1 g-5 g parts by weight Parts (1, 2, 3, 4, 5 g parts by weight), licorice 1 g to 5 g parts by weight (1, 2, 3, 4, 5 g parts by weight), ginseng 2 g to 6 g parts by weight (2, 3, 4, 5 parts) 6 g parts by weight) and 1 g to 5 g parts by weight of a lotus core (1, 2, 3, 4, 5 g parts by weight) are more preferable.

  The extraction solvent is preferably a polar solvent that is pharmaceutically or food hygiene acceptable. Examples of the polar solvent include water (for example, purified water, distilled water, tap water, etc.); ethanol or a mixed solvent of water and ethanol (hydrous ethanol); or a mixed solvent of acetic acid or acetic acid and water, or Examples thereof include a mixed solvent of water, ethanol and acetic acid. Water or water-containing ethanol is preferred. The water content in hydrous ethanol is 1 to 99% by volume. An acid may be added to water or hydrous ethanol. Preferred examples of the acid include inorganic acids such as hydrochloric acid; organic acids such as malic acid and citric acid.

  The extraction method is not particularly limited, and an immersion method or a countercurrent extraction method can be employed. Moreover, it can extract by heating in the range to the boiling point of a solvent under normal temperature extraction or a normal pressure, and you may extract under pressure reduction or pressurization as needed. The pressurization may be a pressure exceeding 1 atm, and preferably about 2 to 3 atm. For example, an extraction solvent (polar solvent) is used as a herbal medicine in a mixture of safflower, cocoon, coconut, sarcophagus, masochito, jinkin, carrot, ginseng, ginseng, ninfuto, daegu, licorice, sensu and lotus wick. 10 to 100 times, preferably 10 to 40 times the amount of the above mixture, and usually 30 minutes to 5 hours, preferably 1 to 3 hours in the range from room temperature to the boiling point of the solvent under normal pressure or pressure. The extract can be obtained by dipping for 1, 2, 3 hours) and filtering by a known method. The extract can be used as an extract as it is. Moreover, what concentrated the said extract, what was concentrated and dried or freeze-dried can also be used as an extract.

  The composition of the present invention is a preparation or food that can be taken orally by mixing the extract with a pharmaceutically or food hygienically acceptable carrier that is optionally blended by a known method. Can be easily prepared. The food includes health foods, functional foods, and supplements.

  Examples of the preparation of the composition of the present invention include a solid preparation or a liquid preparation. Examples of solid preparations include powder preparations, granules, tablets, pills or capsules. Granules and tablets may be coated with a sugar coating or a film coating agent. The liquid preparation is not limited as long as it is a liquid internal preparation, and includes, for example, emulsion, syrup, suspension, shaking mixture, limonase, elixir and the like.

  As the pharmaceutically or food hygiene acceptable carrier in the present invention, various organic or inorganic carrier substances commonly used as pharmaceutical materials are used, and excipients, lubricants, binders, disintegrants in solid preparations; liquid preparations Solvents, solubilizers, suspending agents (emulsifiers, thickeners) and the like. If necessary, preparation additives such as preservatives, antioxidants, coloring agents, sweetening agents, and fragrances can be used.

Suitable examples of excipients include sugars or sugar alcohols such as lactose, corn starch, maltose, mannitol; starch or starch derivatives such as corn starch, dextrin, pregelatinized starch; celluloses such as crystalline cellulose and hydroxypropyl cellulose And cellulose derivatives; light anhydrous silicic acid and the like.
Preferable examples of the lubricant include magnesium stearate, calcium stearate, talc, colloidal silica and the like.

Preferable examples of the binder include crystalline cellulose, sucrose, mannitol, dextrin, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone and the like.
Preferable examples of the disintegrant include starch, carboxymethyl cellulose, carboxymethyl cellulose calcium, croscarmellose sodium, carboxymethyl starch sodium and the like.

Preferable examples of the solvent include water (tap water, purified water, distilled water, etc.), alcohol, propylene glycol, macrogol, sesame oil, corn oil and the like.
Preferable examples of the solubilizer include polyethylene glycol, propylene glycol, D-mannitol, benzyl benzoate, ethanol, trisaminomethane, cholesterol, triethanolamine, sodium carbonate, sodium citrate and the like.

  Preferable examples of the suspending agent include surfactants such as stearyltriethanolamine, sodium lauryl sulfate, laurylaminopropionic acid, lecithin, benzalkonium chloride, benzethonium chloride, glyceryl monostearate, and sucrose fatty acid ester. A hydrophilic polymer such as polyvinyl alcohol, polyvinyl pyrrolidone, sodium carboxymethyl cellulose, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose; xanthan gum, soybean saponin, dextran, pectin and the like.

  Preferable examples of preservatives include, for example, paraoxybenzoates (eg, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, methyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, etc.), Examples include sodium hydrogen sulfite, dehydroacetic acid, sorbic acid, potassium metabisulfite, and sodium metabisulfite.

  Preferable examples of the antioxidant include, for example, sulfites (for example, sodium sulfite and sodium hydrogen sulfite), ascorbic acid, sodium ascorbate, erythorbic acid, sodium erythorbate, citric acid, enzyme-treated rutin, sodium hyposulfite , Potassium metabisulfite, sodium metabisulfite and the like.

Preferable examples of the colorant include blue No. 1, red No. 2, red No. 40, red No. 102, red cabbage, anthocyanin, caramel dye, gardenia dye and the like.
Preferable examples of the sweetening agent include sucrose, licorice extract, xylitol, saccharin, stevia and the like.
Preferable examples of the flavor include cinnamic acid, methyl salicylate, menthol and the like.

  When the composition of the present invention is prepared as a food, it can be prepared in the same manner as in the above-described preparation.

  The content of the extract in the composition or food of the present invention is, for example, a solid preparation, usually about 1 to 99% by weight, preferably about 5 to 90% by weight of the preparation as an extract dry product, More preferably, it is about 10 to 80% by weight. In the case of a liquid preparation, it is about 0.0001 to 80% by weight, preferably about 10 to 50% by weight, and more preferably about 20 to 35% by weight of the usual preparation as a dry extract. Moreover, the liquid formulation can also use the concentrate which concentrated the extract of the crude drug as it is. Preferably, the extraction rate (extract yield) when extracted with 1 to 3 hours (1, 2, 3 hours) using a polar solvent (preferably water) 10 to 40 times the mixture of herbal medicines An extract liquid of 25% to 33% can be used as a liquid preparation as it is.

  The method of taking the composition or food of the present invention is preferably taken orally. The composition of the present invention is more preferably taken after a meal, before a meal, or between meals. The dose and the number of doses of the composition of the present invention vary depending on age, body weight, dosage form, etc., but are usually about 1 mg to 500 mg, preferably about 5 mg to 300 mg per kg body weight as a dry extract per adult day. Can be taken. It is preferable to take this amount in 1 to several times, preferably 1 to 3 times. In the case of a liquid preparation, for example, safflower 30 mg to 9 g (preferably 1 g to 5 g), cocoon 30 mg to 9 g (preferably 2 g to 6 g), eggplant 30 mg to 18 g (preferably 8 g to 12 g), sarcophagus 10 mg ~ 9g (preferably 2g ~ 6g), Masuthijin 30mg ~ 9g (preferably 1g ~ 5g), plating 30mg ~ 9g (preferably 2g ~ 6g), ginseng 10mg ~ 9g (preferably 1g ~ 5 g), ginseng 10 mg to 6 g (preferably 1 g to 5 g), Shinobifu 60 mg to 15 g (preferably 6 g to 10 g), Oiso 30 mg to 9 g (preferably 1 g to 5 g), licorice 30 mg to 6 g (Preferably 1 g to 5 g), a mixture of Senpaku 30 mg to 9 g (preferably 2 g to 6 g) and lotus core 10 mg to 6 g (preferably 1 g to 5 g) Preferably, the extract obtained by extraction with water) is preferably taken as a daily dose, and this extract is usually taken 1 to several times, preferably 1 to 3 times. preferable.

  Since the composition of the present invention can prevent or improve a decline in cognitive function, it can prevent or improve brain aging, Alzheimer's disease, mild cognitive impairment (MCI) and the like. Therefore, symptoms that interfere with daily life that appear with the aging or disability, such as memory impairment, memory impairment (deterioration of memory function), judgment failure, cognitive impairment and behavioral disorder, are prevented, and symptoms thereof Can be effectively improved, or the progression of symptoms can be effectively prevented. Furthermore, the composition of the present invention can be effectively taken to improve the health and memory of examinees and general normal people. Even if the dose in this case is a small amount of about 30 to 70% compared to the subject whose cognitive function is reduced, the effect of taking can be expected.

  The subject of administration (or ingestion) of the composition of the present invention is preferably human, but may be administered (or ingestion) to mammals such as mice, rats, rabbits, dogs, cats, cows, monkeys, and pigs.

  Hereinafter, the present invention will be described in more detail through examples. However, the scope of the present invention is not limited to these examples.

(Preparation of composition)
3g safflower, 4g cocoon, 10g eggplant, 4g stone, 3g machin, 2g carrot, 2g ginseng, 2g ginseng, 8g Shinobifu, 2g daikon, 2g licorice, 4g sengo and 2g 1600 cc of water was added to the mixture (corresponding to the total amount of 48 g / 4 days), and the mixture was subjected to boiling extraction at 2-3 atm for 2 hours with a pressure extractor, followed by filtration. The obtained filtrate (composition; 1000-1200 mL) was divided into 8 and packaged in aluminum packs.
Each herbal medicine used was obtained by cutting dry herbal medicine into several millimeters to about 1 cm.

(Cognitive function improvement effect)
1. Test substance The composition packaged in the aluminum pack obtained in Example 1 was used as a test substance.
2. Subjects Widely used in medical and welfare settings as a recognition method for 51 healthy people (age: 48-89 years old, 15 men, 36 women) who wanted to participate as volunteers as volunteers at their own will The revised Hasegawa-type simplified intelligence evaluation scale (HDS-R; Table 1). The total score of HDS-R was 20 points or less out of 30 points. Suspected dementia, 21 to 25 points were MCI, 26 to 28 points, or MCI reserve. As a result of HDS-R, 24 volunteers (age: 62-85 years old, 5 males, 19 females) who had a total score of 14-28 were used as volunteers.

3. Test Method The subject volunteers were allowed to take the test substance twice a day [before morning and evening (125-150 mL / 1 pack / once)] for one month. One month after the administration, HDS-R was performed again. At the same time, we also conducted a questionnaire survey on subjective symptoms as to whether or not “forgetfulness has become better”.

4). Results FIG. 1 and Table 2 show the total HDS-R score of each subject volunteer before administration of the test substance and 1 month after administration. Improvement of HDS-R value was observed in 17 out of 24 subjects by administration of the test substance. Among the subjects who showed improvement, 10 out of 24 subjects improved the HDS-R value by 3 points or more. Four subjects showed no change in the HDS-R value. Of those, 2 subjects out of 4 responded that they had forgotten things in the subjective symptom questionnaire, and 1 subject replied that they thought they had become forgetful. It was. Although there were three subjects whose HDS-R values decreased, subjects (W17) whose HDS-R values decreased (-1) immediately noticed even if they were forgotten. Admitted. From this result, it was revealed that the composition of the present application is useful for improving cognitive function deterioration.

  The composition of the present invention can be advantageously used as a composition for preventing or improving cognitive decline, particularly as a health food, functional food or supplement in the field of pharmaceuticals and foods that can prevent or improve the decline of cognitive function.

Claims (6)

A mixture of safflower, persimmon, eggplant, stone wall, Masutoshihito, jinkin, carrot, ginseng, carrot, ginseng, licorice, licorice, and lotus wick, with a pharmaceutical or food hygiene acceptable polarity Extracted with a solvent to obtain an extract ,
A method for producing a composition containing the extract for preventing and / or improving cognitive decline . 30 mg to 9 g parts by weight of safflower, 30 mg to 9 g parts by weight of eggplant, 30 mg to 18 g parts by weight of coconut, 10 mg to 9 g parts by weight of sarcophagus, 30 mg to 9 g parts by weight of Jinji, 30 mg to 9 g parts by weight of plating, Carrots 10 mg-9 g parts by weight, Nanae ginseng 10 mg-6 g parts by weight, Shinobu Futo 60 mg-15 g parts by weight, Oiso 30 mg-9 g parts by weight, Licorice 30 mg-6 g parts by weight, Sengan 30 mg-9 g parts by weight and Lotus root 10 mg The method for producing a composition according to claim 1, wherein the composition is mixed at a ratio of ˜6 g parts by weight. The extract is a polar solvent 10-100 for a mixture of safflower, persimmon, eggplant, sarcophagus, Masutoshi Jin, ginseng, ginseng, ginseng, ninfutoto, daiso, licorice, senso and lotus wick. The method for producing a composition according to claim 1 or 2, wherein the composition is extracted in a double amount. The method for producing a composition according to any one of claims 1 to 3, wherein the polar solvent is water, ethanol, acetic acid or a mixture thereof. The method for producing a composition according to any one of claims 1 to 4, wherein the extraction temperature is in a range from normal temperature to normal pressure or a boiling point of the solvent under pressure . The method for producing a composition according to any one of claims 1 to 5, wherein the composition is in the form of a powder formulation, a granule, a tablet, a pill, a capsule, or a liquid formulation.

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