CN107080239A - It is a kind of that there is the black fruit fructus lycii piece and its preparation technology for alleviating visual fatigue - Google Patents
It is a kind of that there is the black fruit fructus lycii piece and its preparation technology for alleviating visual fatigue Download PDFInfo
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- CN107080239A CN107080239A CN201710267771.0A CN201710267771A CN107080239A CN 107080239 A CN107080239 A CN 107080239A CN 201710267771 A CN201710267771 A CN 201710267771A CN 107080239 A CN107080239 A CN 107080239A
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- fructus lycii
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
It is a kind of that there is the black fruit fructus lycii piece and its preparation technology for alleviating visual fatigue, mainly include black fruit fructus lycii piece prescription and preparation technology, it is characterised in that the black fruit fructus lycii piece prescription element carries out prescription by weight percentage：Black fruit fructus lycii 40% ~ 60%, the fruit of Chinese wolfberry 17% ~ 23%, sea-buckthorn 17% ~ 23%, cassia seed 6% ~ 14%.The black fruit fructus lycii piece preparation technology is included：（1）Each constituent of black fruit fructus lycii piece is carried out to crush standby；（2）In black fruit fructus lycii piece prescription ratio, each composition is mixed by equivalent mixing method of progressively increasing, until all mixings, after spin vibration sieve mixing, spin vibration sieve is 100 mesh, obtains black fruit fructus lycii piece prescription mixture；（3）Black fruit fructus lycii piece prescription mixture and dextrin, microcrystalline cellulose are mixed in proportion；（4）Using ethanol as binder, black fruit fructus lycii piece softwood is prepared；（5）Black fruit fructus lycii piece softwood is prepared into wet granular using extrusion granulator method, black fruit fructus lycii piece wet granular is obtained；（6）Black fruit fructus lycii piece wet granular is dried, whole grain classification is carried out to dried particle, black fruit fructus lycii piece particle is obtained；（7）Black fruit fructus lycii piece particle and magnesium stearate are well mixed, tabletting is carried out.
Description
Technical field
The present invention relates to a kind of black fruit fructus lycii piece and its preparation technology for having and alleviating visual fatigue.
Background technology
Visual fatigue, refers to that the long-term excessive anxiety activity of the organs of vision exceedes eye and whole body caused by its compensatory capacity
One group of symptom, belong to the feature visual fatigue of no organic disease, including symptom have：Eyes acid is swollen, eyes are dry and astringent, eyes
Pain, dim eyesight, the drowsiness, dimness of vision and visual impairment.
Eyes are most important organs in human sensory, are that the effect of human use's light perceives the receptor of extraneous things
Official.Light action makes its permissive cell excited in the organs of vision, and its information just produces vision after being processed through visual system.It is logical
Vision is crossed, people perceives size, light and shade, color, the sound of external object, obtains significant various letters of being survived to body
Breath, at least more than 80% external information is obtained through vision.
Modern society, the pressure of study, work and life forces people to need largely to obtain external information, and excess load is used
Eye, promotes kopiopia phenomenon generally existing, increasing people is in sub-health state.The symptom of visual fatigue is not only reflected in
The eyes portion organs of vision, and can cause many complication, such as katzeniammer, numb limb, have a pain in the back, it is tired weary
Power, reduction body immunity.
The problem of visual fatigue, is more and more occurred frequently, influences increasingly severe.Therefore, how to solve that people are daily to be had to eyes
Nursing problem is imitated, protect " window of soul " turns into the active demand of more and more people, while being also that the field is current urgently
One of problem to be solved.
Black fruit fructus lycii, many quil shrub black fruit fructus lyciis of Solanaceae Lycium（Lycium ruthenicum Murr.）Maturation
Fruit, it is described in successive dynasties medical skill ancient books and records such as《Uygur medicine will》、《Four doctor's allusion quotations》With《Jingzhubencao》, it is among the people to be commonly used for drop
Pressure, nourishing and fit keeping function, beautifying face and moistering lotion, are the nutritious supplementary pharmaceuticals of pure natural anti-aging.Black fruit fructus lycii is rich in anthocyanidin, its anthocyanidin
Content is considerably beyond blueberry, and up to 3690mg/100g, and anthocyanidin is the maximally effective antioxidant of mankind nowadays discovery, is a kind of
The functional component of visual fatigue can significantly be alleviated.
The fruit of Chinese wolfberry, Solanaceae Lycium lycium barbarum（Lycium barbarum L.）Ripening fruits, is a kind of medicine food
Dual-purpose rare traditional Chinese medicine, according to《Compendium of Materia Medica》Record, the fruit of Chinese wolfberry has the health care work(of " nourishing the liver, improving eyesight, hard muscles and bones go fatigue "
Effect.Contain abundant LBP-X, glycine betaine, carotenoid, trace element, a variety of essential amino acids and vitamin in matrimony vine
The effects such as composition, to alleviate visual fatigue have significantly act on.
Sea-buckthorn, Elaeangnaceae plant sea-buckthorn（Hippophae rhamnoides L .）Ripening fruits, is the Mongols, Tibetan
Conventional crude drugs, be a kind of medicine-food two-purpose it is precious in Tibetan medicine material, sour, puckery, warm-natured, return lung, liver, stomach, with " nourishing liver
The health-care efficacy of kidney, cough-relieving apophlegmatic, good efficacy to suffering from a deficiency of the kidney ".Flavone compound, vitamin, carotenoid and Wei Sheng are rich in sea-buckthorn
The effects such as plain class composition, to alleviate visual fatigue have significantly act on.
Cassia seed, legume Cassia（Cassia tora Linn.）Mature seed, be a kind of preciousness of medicine-food two-purpose
Chinese medicine, it is sweet, bitter, salty, it is slightly cold, is apt to enter liver, kidney, large intestine channel,《Sheng Nong's herbal classic》Record " long term usage energy strengthening the essence light, make light of one's life by commiting suicide ",
Health-care efficacy with " clear liver and improve vision, relax bowel ".Anthraquinone analog compound, carbohydrate, protein, amino are rich in cassia seed
Acid, trace element and fatty acid functional component, have significantly effect to alleviating visual fatigue.
The present invention combines the traditional composition of prescription principle of institute of traditional Chinese medicine and modern pharmacology research result, carries out reasonable compatibility, section
Learning prescription, there is provided with the notable black fruit fructus lycii piece and its preparation technology for alleviating visual fatigue.
The content of the invention
It is an object of the invention to provide a kind of new black fruit fructus lycii piece and its preparation technology, the black fruit fructus lycii piece has aobvious
Write the effect for alleviating visual fatigue.
It is a kind of that there is the black fruit fructus lycii piece for alleviating visual fatigue, the composition carry out group by weight percentage of the black fruit fructus lycii piece
Side：Black fruit fructus lycii 40% ~ 60%, the fruit of Chinese wolfberry 17% ~ 23%, sea-buckthorn 17% ~ 23%, cassia seed 6% ~ 14%.
Its preferred scheme is that the composition of the black fruit fructus lycii piece carries out prescription by weight percentage：Black fruit fructus lycii 50%, Chinese holly
Matrimony vine 20%, sea-buckthorn 20%, cassia seed 10%.
Its preferred scheme is that the composition of the black fruit fructus lycii piece carries out prescription by weight percentage：Black fruit fructus lycii 40%, Chinese holly
Matrimony vine 23%, sea-buckthorn 23%, cassia seed 14%.
Its preferred scheme is that the composition of the black fruit fructus lycii piece carries out prescription by weight percentage：Black fruit fructus lycii 60%, Chinese holly
Matrimony vine 17%, sea-buckthorn 17%, cassia seed 6%.
It is a further object to provide the preparation technology of above-mentioned black fruit fructus lycii piece.
A kind of to have the black fruit fructus lycii piece for alleviating visual fatigue, the main technique of the black fruit fructus lycii piece is included：
（1）Each constituent of black fruit fructus lycii piece prescription is subjected to ultralow temperature ultramicro grinding, it is -20 ~ -40 DEG C, broken wall to crush temperature
Rate 90% ~ 95%, obtains Ultramicro-powder standby；
（2）In black fruit fructus lycii piece prescription ratio, each composition is mixed by equivalent mixing method of progressively increasing, until all mixings, then
Spin vibration sieve mixing is crossed, spin vibration sieve is 100 mesh, obtains black fruit fructus lycii piece prescription mixture；
（3）Black fruit fructus lycii piece prescription mixture and dextrin, microcrystalline cellulose are mixed in following parts by weight ratio：Black fruit fructus lycii
5-10 parts of piece prescription mixture, 3 ~ 6 parts of dextrin, 2 ~ 4 parts of microcrystalline cellulose；
（4）Using 60% ~ 80% ethanol as binder, black fruit fructus lycii piece softwood is prepared；
（5）Black fruit fructus lycii piece softwood is prepared into wet granular using extrusion granulator method, black fruit fructus lycii piece wet granular is obtained, aperture of pelletizing
10 ~ 30 mesh sieves；
（6）Black fruit fructus lycii piece wet granular is dried, whole grain classification, whole grain mesh size 8 ~ 20 are carried out to dried particle
Mesh, obtains black fruit fructus lycii piece particle；
（7）Black fruit fructus lycii piece particle and magnesium stearate are well mixed, magnesium stearate adding proportion is 0.4% ~ 0.6%（w/w）, it is standby
With tabletting, tablet press machine revolution 15 ~ 40 rpm, 40 ~ 80N of pressure produce black fruit fructus lycii piece.
The primary raw material for the black fruit fructus lycii piece that the present invention is provided is respectively provided with the effect for significantly alleviating visual fatigue, and this black fruit Chinese holly
Qi piece is confirmed by pharmacodynamic study, after each primary raw material prescription, with the healthcare function for significantly alleviating visual fatigue.
The compatibility mechanism for the black fruit fructus lycii piece that the present invention is provided is as described below.
Contain abundant carotenoid, vitamin B in black fruit fructus lycii, fruit1, vitamin B2, vitamin C 73mg/
100g, also rich in inorganic elements such as Fe, Zn, Se, total reducing sugar 6.9%, total acid 0.735%, OPC 5.04%, dry fruit polyoses content
10.89% ~ 16.74%, anthocyanidin 3690mg/100g are can reach, with the work(for having nourishing the liver and kidney, supplement energy, improvement eyesight etc.
Effect, long-term consumption matrimony vine is beneficial to agility and longevity.
Matrimony vine, nutritive value enriches, per 100g matrimony vines（Aqueous 26.6%）12.09g containing protein, fat 0.39g, meals
Fiber 12.6g, carbohydrate 46.3g, carrotene 107mg, vitamin B10.2mg, vitamin B20.3mg, niacin
4.5mg, vitamin C 13mg, potassium 673mg, sodium 105.2mg, magnesium 37mg, iron 6.5mg, violent 0.79mg, zinc 1.5mg, copper 0.56mg,
Phosphorus 224mg, the μ g of selenium 1.67, it is immune with promoting also containing LBP-X, carotenoid, matrimony vine flavones, linoleic acid, amine etc.
Function, defence capability, the effect of liver protection and eyesight for improving body.
Contain beta carotene containing 580 ~ 800mg/100g of vitamin C, carotenoid 100mg/kg, seed oil in sea-buckthorn, fruit
484.5mg, vitamin E2 06.9mg, Cu0.04mg/100g, Zn0.18mg/100g, Fe2.56mg/100g, Mn0.05mg/
100g, flavones 600mg/100g, with relieving cough and reducing sputum, stomach strengthening and digestion promoting, promoting blood circulation to remove blood stasis, it is nourishing liver and kidney the effects such as.
Cassia seed, contains anthraquinone, naphtho- pyrrone, fatty acid compound and polysaccharide, amino acid, inorganic elements and protein
Deng Multiple components, Chrysophanol 0.27%, the effects such as with hypertension and hyperlipemia, liver-nourishing and eyesight-improving, ease constipation antibacterial.
Research both at home and abroad and application show that anthocyanidin, which has, to be improved eyesight, mitigate dizzy, protection capillary, promote to regard
Red blood cell, enhancing are to dark adaptability, improvement night vision, the adaptability for mitigating visual fatigue, improving low-light level.Cyanine
The dominant mechanism that element alleviates visual fatigue is：Anthocyanidin acts on retinal isomerase, increases the generating rate of rhodopsin, and
Rhodopsin as retinal visual cell photoactive substance, in the presence of light decompose produce visual effect, in the dark by regarding
Yellow aldehyde isomery Enzyme catalyzed synthesis.Thus, anthocyanidin increases the generation of rhodopsin by acting on retinal isomerase, improves
Sensitivity of the retina to light.
Carotenoid, is the general name of the important natural pigment of a class, mainly yellow including beta carotene, γ carrotene, leaf
Element, lycopene etc., its main Physiological Function to vision are as retinoids bioactivity and antioxidation activity.Class is recklessly
In radish element, majority has retinoids bioactivity, you can obtain retinol series compound by bioconversion in body
Activity, and retinol（That is vitamin A）It is nutrient needed by human, is main visual pigment precursor, to remains normal
Vision plays the role of important.Result of study shows, it is seen that the destruction of purple and blue light to retina is maximum in light, and class
Carotenoid mainly absorbs blue violet light, thus reduces the generation of photon excitation free radical, meanwhile, carotenoid has strong resist
Oxidation activity, can carry out removing in situ, effectively protection photosensitive cell is from free radical in the free radicals such as active oxygen eye occurred frequently
Damage.
Vision system, especially vision photosensitive system, are directly exposed to various light, are that the generation of body free radical is lived the most
One of place of jump, therefore, the supplement of antioxidant, the protection to vision photosensitive system have great importance.Study table
Bright, bioflavonoid compound, vitamin C, vitamin E, OPC, anthraquinone analog compound, plant source polysaccharide etc. are respectively provided with
Good antioxidation activity, the removing to vision system free radical, with extraordinary effect.
The black fruit fructus lycii piece that the present invention is provided is made up of black fruit fructus lycii, matrimony vine, sea-buckthorn and cassia seed, mainly passes through two ways
Footpath is alleviated to visual fatigue symptom, an approach be with the retinoid such as carotenoid active material and anthocyanidin etc. to regarding
Fatigue problem carries out the supplement of material, and an approach is to be regarded with antioxidants such as biological flavone, vitamin, OPCs to causing
The removing of fatigue substances.In addition, other factors for alleviating visual fatigue include the effect of metallic element in black fruit fructus lycii prescription（Such as
Zn, Se and Fe etc.）, it is linoleic effect and amino acid effect.Analyzed in terms of traditional Chinese medicine reason, be respectively provided with the work(of liver-nourishing and eyesight-improving
Effect, and it is various especially complement each other, material base is more clear and definite, and efficacy effect is also very prominent；Analyzed in terms of modern pharmacology,
Material with a variety of compositions and protection vision system, it is multi-pronged, a disease is controlled altogether, and pharmacological action is clear, it is theoretical ripe.Thus
As can be seen that of the invention compare with existing invention, have the advantage that：
（1）Prescription traditional Chinese medicine of the present invention clears clear, clear efficacy, and material base is clearly, and action effect is protruded, and is a maturation
And can marketing good recipe；
（2）The present invention is using black fruit fructus lycii, matrimony vine, sea-buckthorn and cassia seed as prescription, and prescription technique is simple, workable；
（3）The black fruit fructus lycii piece that the present invention is provided, is acted on visual fatigue is significantly alleviated, and easy to use.
The embodiment of form, further specifically to the above work of the present invention by the following examples
It is bright.But the scope that this should not be interpreted as to above-mentioned theme of the invention is only limitted to following embodiment.It is all above-mentioned interior based on the present invention
Hold realized technology and belong to the scope of the present invention.
Embodiment
Embodiment 1：It is a kind of that there is the black fruit fructus lycii piece and its preparation technology for alleviating visual fatigue.
（1）The composition of black fruit fructus lycii piece is subjected to compatibility by following weight：Black fruit fructus lycii 200g, fruit of Chinese wolfberry 80g, sea-buckthorn
80g, cassia seed 40g；（2）Each constituent of black fruit fructus lycii piece is subjected to ultralow temperature ultramicro grinding, it is -20 DEG C to crush temperature, is broken
Wall rate 95%, obtains Ultramicro-powder standby；（3）In black fruit fructus lycii piece prescription ratio, each composition is mixed by equivalent mixing method of progressively increasing
Close, until all mixings, after spin vibration sieve mixing, spin vibration sieve is 100 mesh, obtains black fruit fructus lycii piece prescription mixture；（4）Will be black
Fruit matrimony vine piece prescription mixture and dextrin, microcrystalline cellulose are mixed in following parts by weight ratio：Black fruit fructus lycii piece prescription is mixed
5 parts of thing, 3 parts of dextrin, 2 parts of microcrystalline cellulose；（5）Using 70% ethanol as binder, black fruit fructus lycii piece softwood is prepared；（6）Will be black
Fruit matrimony vine piece softwood prepares wet granular using extrusion granulator method, obtains black fruit fructus lycii piece wet granular, the mesh of aperture 20 of pelletizing；（7）Will
Black fruit fructus lycii piece wet granular is dried, and whole grain classification is carried out to dried particle, and the mesh of whole grain mesh size 20 obtains black fruit Chinese holly
Qi piece particle；（8）Black fruit fructus lycii piece particle and magnesium stearate are well mixed, magnesium stearate adding proportion is 0.5%, standby pressure
Piece, the rpm of tablet press machine revolution 20, pressure 40N, tablet format is 0.5g, produces black fruit fructus lycii piece A.
Embodiment 2：It is a kind of that there is the black fruit fructus lycii piece and its preparation technology for alleviating visual fatigue.
（1）The composition of black fruit fructus lycii prescription is subjected to compatibility by following weight：Black fruit fructus lycii 120g, fruit of Chinese wolfberry 69g, sea-buckthorn
69g, cassia seed 42g；（2）Each constituent of black fruit fructus lycii piece is subjected to ultralow temperature ultramicro grinding, it is -30 DEG C to crush temperature, is broken
Wall rate 95%, obtains Ultramicro-powder standby；（3）In black fruit fructus lycii piece prescription ratio, each composition is mixed by equivalent mixing method of progressively increasing
Close, until all mixings, after spin vibration sieve mixing, spin vibration sieve is 100 mesh, obtains black fruit fructus lycii piece prescription mixture；（4）Will be black
Fruit matrimony vine piece prescription mixture and dextrin, microcrystalline cellulose are mixed in following parts by weight ratio：Black fruit fructus lycii piece prescription is mixed
10 parts of thing, 4 parts of dextrin, 3 parts of microcrystalline cellulose；（5）Using 60% ethanol as binder, black fruit fructus lycii piece softwood is prepared；（6）Will
Black fruit fructus lycii piece softwood prepares wet granular using extrusion granulator method, obtains black fruit fructus lycii piece wet granular, the mesh sieve of aperture 30 of pelletizing；
（7）Black fruit fructus lycii piece wet granular is dried, whole grain classification is carried out to dried particle, the mesh of whole grain mesh size 20 is obtained
Black fruit fructus lycii piece particle；（8）Black fruit fructus lycii piece particle and magnesium stearate are well mixed, magnesium stearate adding proportion is 0.4%,
Standby tabletting, the rpm of tablet press machine revolution 40, pressure 60N, tablet format is 0.5g, produces black fruit fructus lycii piece B.
Embodiment 3：It is a kind of that there is the black fruit fructus lycii prescription and preparation for alleviating visual fatigue.
（1）The composition of black fruit fructus lycii prescription is subjected to compatibility by following weight：Black fruit fructus lycii 240g, fruit of Chinese wolfberry 68g, sea-buckthorn
68g, cassia seed 24g；（2）Each constituent of black fruit fructus lycii piece is subjected to ultralow temperature ultramicro grinding, it is -40 DEG C to crush temperature, is broken
Wall rate 93%, obtains Ultramicro-powder standby；（3）In black fruit fructus lycii piece prescription ratio, each composition is mixed by equivalent mixing method of progressively increasing
Close, until all mixings, after spin vibration sieve mixing, spin vibration sieve is 100 mesh, obtains black fruit fructus lycii piece prescription mixture；（4）Will be black
Fruit matrimony vine piece prescription mixture and dextrin, microcrystalline cellulose are mixed in following parts by weight ratio：Black fruit fructus lycii piece prescription is mixed
8 parts of thing, 6 parts of dextrin, 4 parts of microcrystalline cellulose；（5）Using 80% ethanol as binder, black fruit fructus lycii piece softwood is prepared；（6）Will be black
Fruit matrimony vine piece softwood prepares wet granular using extrusion granulator method, obtains black fruit fructus lycii piece wet granular, the mesh sieve of aperture 10 of pelletizing；（7）
Black fruit fructus lycii piece wet granular is dried, whole grain classification is carried out to dried particle, the mesh of whole grain mesh size 20 obtains black fruit
Matrimony vine piece particle；（8）Black fruit fructus lycii piece particle and magnesium stearate are well mixed, magnesium stearate adding proportion is 0.6%, standby
Tabletting, the rpm of tablet press machine revolution 30, pressure 80N, tablet format is 0.5g, produces black fruit fructus lycii piece C.
The remarkable efficacy of drug regimen of the present invention is expanded on further below by way of experimental example.
（1）Given the test agent：The gained black fruit fructus lycii piece A of the embodiment of the present invention 1 and placebo（Starch piece）.
（2）Subjects：Totally 140 people of the volunteer with visual fatigue symptom is selected, exclusion does not meet inclusive criteria, do not pressed
Regulation takes tested material, it is impossible to which judging effect or data, umbra does not ring effect or security judgement person, excludes to this product allergy
Person, gestation and women breast-feeding their children, removal system disease and Genetic eye diseases person, exclude with fundus oculi disease or are associated with painstaking effort
The diseases such as pipe, the cerebrovascular, liver, kidney and hemopoietic system.
（3）Instructions of taking：Efficiency test person is divided into 2 groups, every group 70 for 140 according to random, double blinding requirement（Effectively
The people of number of cases 121, the wherein people of test group 65, depart from 5 people；The people of control group 56, departs from 14 people）.Test group and control group press recommendation side
Method and recommended amounts take tested material, and 2 times a day, and 2 every time, dose is 1.0g, continuously takes 45d.
（4）Observation index：Reference《Health food is examined and assessment technique specification》2003 editions page 69 ~ 71 " alleviate visual fatigue
The regulation of functional check method ", observation index is divided into safety indexes and efficiency index, and starts and terminate each survey in test-meal
It is fixed 1 time.
（5）Visual fatigue symptom decision method（Sxemiquantitative integration method）：Effectively, symptom improves and differed before and after duration of photopic vision
≥0.1；Invalid, symptom and duration of photopic vision are without significant change.
（6）As a result：
1. test-meal crowd general status：Two groups of subjects are roughly the same regarding bright persistence, eyesight before test-meal, and comparativity is good；
2. the change of symptom total mark：The forward and backward difference of eye symptom total mark test-meal of test group reaches the pole level of signifiance（P ＜
0.01）, test group and control group the eye symptom total mark after test-meal also has significant difference（P ＜ 0.05）, it is shown in Table 1；
Eye symptom total mark changes between the forward and backward test group of the test-meal of table 1 and control group（Note：Compare in * groups between p ＜ 0.01, # groups
Compare p ＜ 0.05）
| Group | Number of cases | Before test-meal | After test-meal |
| Test group | 65 | 3.87±2.01 | 2.64±1.93 |
| Control group | 56 | 3.79±2.03 | 3.65±1.82 |
3. the change of duration of photopic vision：Duration of photopic vision is significantly improved after test group test-meal, with comparing difference before test-meal in extremely aobvious
Work property（P ＜ 0.01）, difference is also in pole significant relation compared with control group（P ＜ 0.01）, the forward and backward photopic vision of test group test-meal is lasting
It is 0.13 ± 0.05 to spend average raising value, is shown in Table 2；
The forward and backward duration of photopic vision change of the test-meal of table 2（Compare in * groups and compare p ＜ 0.01 between p ＜ 0.01, ## groups）
| Group | Number of cases | Before test-meal | After test-meal | Raising value |
| Test group | 65 | 0.52±0.06 | 0.65±0.09**,## | 0.13±0.05## |
| Control group | 56 | 0.53±0.08 | 0.52±0.04 | -0.01±0.07 |
4. total effectively result of determination：After test-meal, the total effective rate of test group is 53.8%, is compared with control group with pole significance difference
It is different（P ＜ 0.01）, it is shown in Table 3；
The forward and backward total effective rate result of determination of the test-meal of table 3（Compare p ＜ 0.01 between ## groups）
| Group | Number of cases | Effectively | It is invalid | Total effective rate/% |
| Test group | 65 | 35 | 30 | 53.8## |
| Control group | 56 | 4 | 52 | 7.1 |
5. conclusion：By the observation to safety indexes, it is found that subject's indices are showed no exception, associated safety after test-meal
Property index is in range of normal value, and subject is without other adverse reactions；Observed by efficiency index, find to try after test-meal
Test group symptom total mark, duration of photopic vision and a full availability to be obviously improved, difference reaches the pole level of signifiance, and average photopic vision is lasting
Degree improves 0.13 ± 0.05, according to《Health food is examined and assessment technique specification》2003 editions page 69 ~ 71 " alleviate visual fatigue work(
The regulation of the energy method of inspection ", it is believed that the black fruit fructus lycii piece that the present invention is provided has effects that to alleviate visual fatigue.
Claims (10)
1. a kind of have the black fruit fructus lycii piece and its preparation technology for alleviating visual fatigue, black fruit fructus lycii piece prescription and preparation are mainly included
Technique, it is characterised in that the black fruit fructus lycii piece prescription element carries out prescription by weight percentage：Black fruit fructus lycii 40% ~ 60%, Chinese holly
Matrimony vine 17% ~ 23%, sea-buckthorn 17% ~ 23%, cassia seed 6% ~ 14%.
2. it is according to claim 1 a kind of with the black fruit fructus lycii piece for alleviating visual fatigue, it is characterised in that the black fruit Chinese holly
Qi piece preparation technology is included：（1）Each constituent of black fruit fructus lycii piece is carried out to crush standby；（2）By black fruit fructus lycii piece prescription ratio
Example, each composition is mixed by equivalent mixing method of progressively increasing, until all mixings, are mixed, spin vibration sieve is 100 after spin vibration sieve
Mesh, obtains black fruit fructus lycii piece prescription mixture；（3）By black fruit fructus lycii piece prescription mixture and dextrin, microcrystalline cellulose in proportion
Mix；（4）Using ethanol as binder, black fruit fructus lycii piece softwood is prepared；（5）Black fruit fructus lycii piece softwood is used into extrusion granulator method
Wet granular is prepared, black fruit fructus lycii piece wet granular is obtained, the mesh of aperture 10 ~ 30 of pelletizing；（6）Black fruit fructus lycii piece wet granular is done
It is dry, whole grain classification is carried out to dried particle, the mesh of whole grain mesh size 8 ~ 20 obtains black fruit fructus lycii piece particle；（7）By black fruit Chinese holly
Qi piece particle and magnesium stearate are well mixed, carry out tabletting, tablet press machine revolution 15 ~ 40 rpm, 40 ~ 80N of pressure.
3. it is according to claim 2 a kind of with the black fruit fructus lycii piece preparation technology for alleviating visual fatigue, it is characterised in that powder
Broken use ultralow temperature ultramicro grinding, it is -20 ~ -40 DEG C, sporoderm-broken rate 90% ~ 95% to crush temperature.
4. it is according to claim 2 a kind of with the black fruit fructus lycii piece preparation technology for alleviating visual fatigue, it is characterised in that black
Fruit matrimony vine piece and dextrin, microcrystalline cellulose are mixed in following parts by weight ratio：5 ~ 10 parts of black fruit fructus lycii piece prescription mixture, paste
3 ~ 6 parts of essence, 2 ~ 4 parts of microcrystalline cellulose.
5. it is according to claim 2 a kind of with the black fruit fructus lycii piece preparation technology for alleviating visual fatigue, it is characterised in that viscous
Mixture is 60% ~ 80% ethanol, and preferably adhesive is 70% ethanol.
6. it is according to claim 2 a kind of with the black fruit fructus lycii piece preparation technology for alleviating visual fatigue, it is characterised in that hard
Fatty acid magnesium adding proportion is 0.4% ~ 0.6%（w/w）, preferably adding proportion is 0.5%.
7. it is according to claim 4 a kind of with the black fruit fructus lycii piece preparation technology for alleviating visual fatigue, it is characterised in that excellent
Black fruit fructus lycii piece and dextrin, the microcrystalline cellulose of choosing are mixed in following parts by weight ratio：Black fruit fructus lycii piece prescription mixture 5
Part, 3 parts of dextrin, 2 parts of microcrystalline cellulose.
8. it is according to claim 4 a kind of with the black fruit fructus lycii piece preparation technology for alleviating visual fatigue, it is characterised in that excellent
Black fruit fructus lycii piece and dextrin, the microcrystalline cellulose of choosing are mixed in following parts by weight ratio：Black fruit fructus lycii piece prescription mixture 10
Part, 4 parts of dextrin, 3 parts of microcrystalline cellulose.
9. it is according to claim 4 a kind of with the black fruit fructus lycii piece preparation technology for alleviating visual fatigue, it is characterised in that excellent
Black fruit fructus lycii piece and dextrin, the microcrystalline cellulose of choosing are mixed in following parts by weight ratio：Black fruit fructus lycii piece prescription mixture 8
Part, 6 parts of dextrin, 4 parts of microcrystalline cellulose.
10. a kind of made from any one methods described according to claim 1 ~ 9 have the black fruit Chinese holly for alleviating visual fatigue
Qi piece.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108378318A (en) * | 2018-01-23 | 2018-08-10 | 江苏道诚生物科技有限公司 | A kind of antifatigue of sea-buckthorn compound and preparation method thereof |
| CN109123674A (en) * | 2018-09-05 | 2019-01-04 | 江苏道诚生物科技有限公司 | A kind of black fruit fructus lycii compound alleviation visual fatigue piece and its preparation process |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709375A (en) * | 2005-06-27 | 2005-12-21 | 广州康采恩医药有限公司 | Chewing gum for radiation protection |
| CN103404856A (en) * | 2013-08-13 | 2013-11-27 | 青海睿元药物研究所有限责任公司 | Matrimony vine sheet produced by stack delaminated pressing and preparation method thereof |
| CN105231447A (en) * | 2015-10-28 | 2016-01-13 | 青海尤尼克生物技术有限公司 | Health-care lycium ruthenicum tablets capable of alleviating asthenopia |
-
2017
- 2017-04-21 CN CN201710267771.0A patent/CN107080239A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709375A (en) * | 2005-06-27 | 2005-12-21 | 广州康采恩医药有限公司 | Chewing gum for radiation protection |
| CN103404856A (en) * | 2013-08-13 | 2013-11-27 | 青海睿元药物研究所有限责任公司 | Matrimony vine sheet produced by stack delaminated pressing and preparation method thereof |
| CN105231447A (en) * | 2015-10-28 | 2016-01-13 | 青海尤尼克生物技术有限公司 | Health-care lycium ruthenicum tablets capable of alleviating asthenopia |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108378318A (en) * | 2018-01-23 | 2018-08-10 | 江苏道诚生物科技有限公司 | A kind of antifatigue of sea-buckthorn compound and preparation method thereof |
| CN109123674A (en) * | 2018-09-05 | 2019-01-04 | 江苏道诚生物科技有限公司 | A kind of black fruit fructus lycii compound alleviation visual fatigue piece and its preparation process |
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