CN107019218A - It is a kind of that there is the black fruit fructus lycii prescription and preparation for alleviating visual fatigue - Google Patents

It is a kind of that there is the black fruit fructus lycii prescription and preparation for alleviating visual fatigue Download PDF

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CN107019218A
CN107019218A CN201710267772.5A CN201710267772A CN107019218A CN 107019218 A CN107019218 A CN 107019218A CN 201710267772 A CN201710267772 A CN 201710267772A CN 107019218 A CN107019218 A CN 107019218A
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fructus lycii
prescription
black fruit
fruit fructus
preparation
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王洪伦
欧阳健
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Northwest Institute of Plateau Biology of CAS
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Northwest Institute of Plateau Biology of CAS
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention provides a kind of black fruit fructus lycii prescription and preparation for having and alleviating visual fatigue, black fruit fructus lycii prescription and preparation are mainly included.The black fruit fructus lycii prescription is prepared from according to a certain weight ratio by black fruit fructus lycii, the fruit of Chinese wolfberry, sea-buckthorn, cassia seed, and solid pharmaceutical preparation and liquid preparation can be made in it.

Description

It is a kind of that there is the black fruit fructus lycii prescription and preparation for alleviating visual fatigue
Technical field
The present invention relates to a kind of black fruit fructus lycii prescription and preparation for having and alleviating visual fatigue.
Background technology
Visual fatigue, refers to that the long-term excessive anxiety activity of the organs of vision exceedes eye and whole body caused by its compensatory capacity One group of symptom, belong to the feature visual fatigue of no organic disease, including symptom have：Eyes acid is swollen, eyes are dry and astringent, eyes Pain, dim eyesight, the drowsiness, dimness of vision and visual impairment.
Eyes are most important organs in human sensory, are that the effect of human use's light perceives the receptor of extraneous things Official.Light action makes its permissive cell excited in the organs of vision, and its information just produces vision after being processed through visual system.It is logical Vision is crossed, people perceives size, light and shade, color, the sound of external object, obtains significant various letters of being survived to body Breath, at least more than 80% external information is obtained through vision.
Modern society, the pressure of study, work and life forces people to need largely to obtain external information, and excess load is used Eye, promotes kopiopia phenomenon generally existing, increasing people is in sub-health state.The symptom of visual fatigue is not only reflected in The eyes portion organs of vision, and can cause many complication, such as katzeniammer, numb limb, have a pain in the back, it is tired weary Power, reduction body immunity.
The problem of visual fatigue, is more and more occurred frequently, influences increasingly severe.Therefore, how to solve that people are daily to be had to eyes Nursing problem is imitated, protect " window of soul " turns into the active demand of more and more people, while being also that the field is current urgently One of problem to be solved.
Black fruit fructus lycii, many quil shrub black fruit fructus lyciis of Solanaceae Lycium（Lycium ruthenicum Murr.）Maturation Fruit, it is described in successive dynasties medical skill ancient books and records such as《Uygur medicine will》、《Four doctor's allusion quotations》With《Jingzhubencao》, it is among the people to be commonly used for drop Pressure, nourishing and fit keeping function, beautifying face and moistering lotion, are the nutritious supplementary pharmaceuticals of pure natural anti-aging.Black fruit fructus lycii is rich in anthocyanidin, its anthocyanidin Content is considerably beyond blueberry, and up to 3690mg/100g, and anthocyanidin is the maximally effective antioxidant of mankind nowadays discovery, is a kind of The functional component of visual fatigue can significantly be alleviated.
The fruit of Chinese wolfberry, Solanaceae Lycium lycium barbarum（Lycium barbarum L.）Ripening fruits, is a kind of medicine food Dual-purpose rare traditional Chinese medicine, according to《Compendium of Materia Medica》Record, the fruit of Chinese wolfberry has the health care work(of " nourishing the liver, improving eyesight, hard muscles and bones go fatigue " Effect.Contain abundant LBP-X, glycine betaine, carotenoid, trace element, a variety of essential amino acids and vitamin in matrimony vine The effects such as composition, to alleviate visual fatigue have significantly act on.
Sea-buckthorn, Elaeangnaceae plant sea-buckthorn（Hippophae rhamnoides L .）Ripening fruits, is the Mongols, Tibetan Conventional crude drugs, be a kind of medicine-food two-purpose it is precious in Tibetan medicine material, sour, puckery, warm-natured, return lung, liver, stomach, with " nourishing liver The health-care efficacy of kidney, cough-relieving apophlegmatic, good efficacy to suffering from a deficiency of the kidney ".Flavone compound, vitamin, carotenoid and Wei Sheng are rich in sea-buckthorn The effects such as plain class composition, to alleviate visual fatigue have significantly act on.
Cassia seed, legume Cassia（Cassia tora Linn.）Mature seed, be a kind of preciousness of medicine-food two-purpose Chinese medicine, it is sweet, bitter, salty, it is slightly cold, is apt to enter liver, kidney, large intestine channel,《Sheng Nong's herbal classic》Record " long term usage energy strengthening the essence light, make light of one's life by commiting suicide ", Health-care efficacy with " clear liver and improve vision, relax bowel ".Anthraquinone analog compound, carbohydrate, protein, amino are rich in cassia seed Acid, trace element and fatty acid functional component, have significantly effect to alleviating visual fatigue.
The present invention combines the traditional composition of prescription principle of institute of traditional Chinese medicine and modern pharmacology research result, carries out reasonable compatibility, section Learning prescription, there is provided with the notable black fruit fructus lycii prescription and preparation for alleviating visual fatigue.
The content of the invention
It is an object of the invention to provide a kind of new black fruit fructus lycii prescription, the prescription has the work(for significantly alleviating visual fatigue Effect.
A kind of to have the black fruit fructus lycii prescription for alleviating visual fatigue, the composition of the black fruit fructus lycii prescription enters by weight percentage Row compatibility：Black fruit fructus lycii 40% ~ 60%, the fruit of Chinese wolfberry 17% ~ 23%, sea-buckthorn 17% ~ 23%, cassia seed 6% ~ 14%.
Its preferred scheme is that the composition of the black fruit fructus lycii prescription carries out compatibility by weight percentage：Black fruit fructus lycii 50%, The fruit of Chinese wolfberry 20%, sea-buckthorn 20%, cassia seed 10%.
Its preferred scheme is that the composition of the black fruit fructus lycii prescription carries out compatibility by weight percentage：Black fruit fructus lycii 40%, The fruit of Chinese wolfberry 23%, sea-buckthorn 23%, cassia seed 14%.
Its preferred scheme is that the composition of the black fruit fructus lycii prescription carries out compatibility by weight percentage：Black fruit fructus lycii 60%, The fruit of Chinese wolfberry 17%, sea-buckthorn 17%, cassia seed 6%.
It is a further object to provide the preparation and preparation process of above-mentioned black fruit fructus lycii prescription.
A kind of preparation with the black fruit fructus lycii prescription for alleviating visual fatigue, the preparation of the lycium ruthenicum prescription is oral system Agent, main formulation includes：Solid pharmaceutical preparation and liquid preparation.
A kind of preparation with the black fruit fructus lycii prescription for alleviating visual fatigue, described black fruit fructus lycii prescription solid pharmaceutical preparation is main Including：Powder, granule, tablet and hard capsule.
A kind of preparation with the black fruit fructus lycii prescription for alleviating visual fatigue, described black fruit fructus lycii prescription liquid preparation is main Including：Syrup and tincture.
A kind of preparation with the black fruit fructus lycii prescription for alleviating visual fatigue, the main work of described black fruit fructus lycii prescription powder Skill is included：Each composition in black fruit fructus lycii prescription is subjected to ultralow temperature ultramicro grinding, it is -20 ~ -40 DEG C, sporoderm-broken rate 90% to crush temperature ~ 95%, obtain Ultramicro-powder standby；In black fruit fructus lycii prescription ratio, each composition is mixed by equivalent mixing method of progressively increasing, until All mix, after spin vibration sieve mixing, obtain black fruit fructus lycii prescription mixture；By black fruit fructus lycii prescription mixture, method is divided by measure Dosage, that is, obtain black fruit fructus lycii prescription powder.
A kind of preparation with the black fruit fructus lycii prescription for alleviating visual fatigue, described black fruit fructus lycii prescription granule it is main Technique is included：Each composition in black fruit fructus lycii prescription is subjected to ultralow temperature ultramicro grinding, it is -20 ~ -40 DEG C, sporoderm-broken rate to crush temperature 90% ~ 95%, obtain Ultramicro-powder standby；In black fruit fructus lycii prescription ratio, each composition is mixed by equivalent mixing method of progressively increasing, directly To whole mixings, after spin vibration sieve mixing, black fruit fructus lycii prescription mixture is obtained；By black fruit fructus lycii prescription mixture and dextrin, Microcrystalline cellulose is mixed in proportion, and the ethanol using 60% ~ 80% prepares black fruit fructus lycii prescription softwood as binder；By black fruit Chinese holly Qi prescription softwood prepares wet granular using extrusion granulator method, obtains black fruit fructus lycii prescription wet granular；By wet of black fruit fructus lycii prescription Grain is dried, and carries out whole grain classification to dried particle, produces black fruit fructus lycii prescription granule.
A kind of preparation with the black fruit fructus lycii prescription for alleviating visual fatigue, the main work of described black fruit fructus lycii prescription tablet Skill is included：Each composition in black fruit fructus lycii prescription is subjected to ultralow temperature ultramicro grinding, it is -20 ~ -40 DEG C, sporoderm-broken rate 90% to crush temperature ~ 95%, obtain Ultramicro-powder standby；In black fruit fructus lycii prescription ratio, each composition is mixed by equivalent mixing method of progressively increasing, until All mix, after spin vibration sieve mixing, obtain black fruit fructus lycii prescription mixture；By black fruit fructus lycii prescription mixture and dextrin, micro- Crystalline cellulose is mixed in proportion, and the ethanol using 60% ~ 80% prepares black fruit fructus lycii prescription softwood as binder；By black fruit fructus lycii Prescription softwood prepares wet granular using extrusion granulator method, the mesh of aperture 10 ~ 30 of pelletizing, and obtains black fruit fructus lycii prescription wet granular；Will be black Fruit matrimony vine prescription wet granular is dried, and whole grain classification is carried out to dried particle, and the mesh of whole grain mesh size 8 ~ 20 obtains black fruit Matrimony vine prescription particle；Black fruit fructus lycii prescription particle and magnesium stearate are well mixed, magnesium stearate adding proportion is 0.4% ~ 0.6% （w/w）, tablet press machine 15 ~ 40rpm of revolution, 40 ~ 80N of pressure produce black fruit fructus lycii prescription tablet.
A kind of preparation with the black fruit fructus lycii prescription for alleviating visual fatigue, the master of described black fruit fructus lycii prescription hard capsule Technique is wanted to include：Each composition in black fruit fructus lycii prescription is subjected to ultralow temperature ultramicro grinding, it is -20 ~ -40 DEG C, broken wall to crush temperature Rate 90% ~ 95%, obtains Ultramicro-powder standby；In black fruit fructus lycii prescription ratio, each composition is mixed by equivalent mixing method of progressively increasing, Until all mixings, after spin vibration sieve mixing, obtain black fruit fructus lycii prescription mixture；By black fruit fructus lycii prescription mixture and paste Essence, microcrystalline cellulose are mixed in proportion, and the ethanol using 60% ~ 80% prepares black fruit fructus lycii prescription softwood as binder；By black fruit Matrimony vine prescription softwood prepares wet granular using extrusion granulator method, obtains black fruit fructus lycii prescription wet granular；Black fruit fructus lycii prescription is wet Particle is dried, and carries out whole grain classification to dried particle, obtains black fruit fructus lycii prescription particle；By black fruit fructus lycii prescription Grain and magnesium stearate are well mixed, and magnesium stearate adding proportion is 0.4% ~ 0.6%, and filling hard shell capsules obtain black fruit fructus lycii prescription Hard shell capsules.
A kind of preparation with the black fruit fructus lycii prescription for alleviating visual fatigue, described black fruit fructus lycii prescription syrup it is main Technique is included：Each composition in black fruit fructus lycii prescription is crushed, 20 ~ 60 mesh sieves is crossed, obtains fine powder standby；By black fruit fructus lycii group Square ratio, each composition is mixed by equivalent mixing method of progressively increasing, using water as solvent, by solid-liquid ratio 1:10~1:30 pairs of black fruit Chinese hollys Qi prescription is extracted, 20 ~ 40min of extraction time, ultrasonic power 150W ~ 500W, 45 ~ 55 DEG C of Extracting temperature, extracts 2 ~ 4 It is secondary, merge extract solution, low-temperature reduced-pressure is concentrated into 0.4 ~ 0.6 times of volume for merging extract solution, obtains black fruit fructus lycii prescription concentrate； Black fruit fructus lycii prescription concentrate is mixed with syrup, black fruit fructus lycii prescription syrup is produced.
A kind of preparation with the black fruit fructus lycii prescription for alleviating visual fatigue, the main work of described black fruit fructus lycii prescription tincture Skill is included：Each composition in black fruit fructus lycii prescription is crushed, 20 ~ 60 mesh sieves is crossed, obtains fine powder standby；By black fruit fructus lycii prescription Ratio, each composition is mixed by equivalent mixing method of progressively increasing, using ethanol as solvent, and concentration of alcohol is 30% ~ 80%, by solid-liquid ratio 1:10~1:30 pairs of black fruit fructus lycii prescriptions impregnate, 6 ~ 8h of dip time, impregnate 4 ~ 6 times, merge leachate, solubilizer constant volume To ormal weight, 24 hours are stood, filtering obtains black fruit fructus lycii prescription tincture.
The primary raw material for the black fruit fructus lycii prescription that the present invention is provided is respectively provided with the effect for significantly alleviating visual fatigue, and this black fruit Matrimony vine prescription and preparation are confirmed by pharmacodynamic study, after each primary raw material prescription, with the health care for significantly alleviating visual fatigue Function.
The compatibility mechanism for the black fruit fructus lycii prescription that the present invention is provided is as described below.
Contain abundant carotenoid, vitamin B in black fruit fructus lycii, fruit1, vitamin B2, vitamin C 73mg/ 100g, also rich in inorganic elements such as Fe, Zn, Se, total reducing sugar 6.9%, total acid 0.735%, OPC 5.04%, dry fruit polyoses content 10.89% ~ 16.74%, anthocyanidin 3690mg/100g are can reach, with the work(for having nourishing the liver and kidney, supplement energy, improvement eyesight etc. Effect, long-term consumption matrimony vine is beneficial to agility and longevity.
Matrimony vine, nutritive value enriches, per 100g matrimony vines（Aqueous 26.6%）12.09g containing protein, fat 0.39g, meals Fiber 12.6g, carbohydrate 46.3g, carrotene 107mg, vitamin B10.2mg, vitamin B20.3mg, niacin 4.5mg, vitamin C 13mg, potassium 673mg, sodium 105.2mg, magnesium 37mg, iron 6.5mg, violent 0.79mg, zinc 1.5mg, copper 0.56mg, Phosphorus 224mg, the μ g of selenium 1.67, it is immune with promoting also containing LBP-X, carotenoid, matrimony vine flavones, linoleic acid, amine etc. Function, defence capability, the effect of liver protection and eyesight for improving body.
Contain beta carotene containing 580 ~ 800mg/100g of vitamin C, carotenoid 100mg/kg, seed oil in sea-buckthorn, fruit 484.5mg, vitamin E2 06.9mg, Cu0.04mg/100g, Zn0.18mg/100g, Fe2.56mg/100g, Mn0.05mg/ 100g, flavones 600mg/100g, with relieving cough and reducing sputum, stomach strengthening and digestion promoting, promoting blood circulation to remove blood stasis, it is nourishing liver and kidney the effects such as.
Cassia seed, contains anthraquinone, naphtho- pyrrone, fatty acid compound and polysaccharide, amino acid, inorganic elements and protein Deng Multiple components, Chrysophanol 0.27%, the effects such as with hypertension and hyperlipemia, liver-nourishing and eyesight-improving, ease constipation antibacterial.
Research both at home and abroad and application show that anthocyanidin, which has, to be improved eyesight, mitigate dizzy, protection capillary, promote to regard Red blood cell, enhancing are to dark adaptability, improvement night vision, the adaptability for mitigating visual fatigue, improving low-light level.Cyanine The dominant mechanism that element alleviates visual fatigue is：Anthocyanidin acts on retinal isomerase, increases the generating rate of rhodopsin, and Rhodopsin as retinal visual cell photoactive substance, in the presence of light decompose produce visual effect, in the dark by regarding Yellow aldehyde isomery Enzyme catalyzed synthesis.Thus, anthocyanidin increases the generation of rhodopsin by acting on retinal isomerase, improves Sensitivity of the retina to light.
Carotenoid, is the general name of the important natural pigment of a class, mainly yellow including beta carotene, γ carrotene, leaf Element, lycopene etc., its main Physiological Function to vision are as retinoids bioactivity and antioxidation activity.Class is recklessly In radish element, majority has retinoids bioactivity, you can obtain retinol series compound by bioconversion in body Activity, and retinol（That is vitamin A）It is nutrient needed by human, is main visual pigment precursor, to remains normal Vision plays the role of important.Result of study shows, it is seen that the destruction of purple and blue light to retina is maximum in light, and class Carotenoid mainly absorbs blue violet light, thus reduces the generation of photon excitation free radical, meanwhile, carotenoid has strong resist Oxidation activity, can carry out removing in situ, effectively protection photosensitive cell is from free radical in the free radicals such as active oxygen eye occurred frequently Damage.
Vision system, especially vision photosensitive system, are directly exposed to various light, are that the generation of body free radical is lived the most One of place of jump, therefore, the supplement of antioxidant, the protection to vision photosensitive system have great importance.Study table Bright, bioflavonoid compound, vitamin C, vitamin E, OPC, anthraquinone analog compound, plant source polysaccharide etc. are respectively provided with Good antioxidation activity, the removing to vision system free radical, with extraordinary effect.
The black fruit fructus lycii prescription that the present invention is provided is made up of black fruit fructus lycii, matrimony vine, sea-buckthorn and cassia seed, mainly passes through two Approach is alleviated to visual fatigue symptom, and an approach is with the retinoid such as carotenoid active material and anthocyanidin etc. pair Visual fatigue problem carries out the supplement of material, and an approach is to causing with antioxidants such as biological flavone, vitamin, OPCs The removing of visual fatigue material.In addition, other factors for alleviating visual fatigue include the effect of metallic element in black fruit fructus lycii prescription（Such as Zn, Se and Fe etc.）, it is linoleic effect and amino acid effect.Analyzed in terms of traditional Chinese medicine reason, be respectively provided with the work(of liver-nourishing and eyesight-improving Effect, and it is various especially complement each other, material base is more clear and definite, and efficacy effect is also very prominent；Analyzed in terms of modern pharmacology, Material with a variety of compositions and protection vision system, it is multi-pronged, a disease is controlled altogether, and pharmacological action is clear, it is theoretical ripe.Thus As can be seen that of the invention compare with existing invention, have the advantage that：
（1）Prescription traditional Chinese medicine of the present invention clears clear, clear efficacy, and material base is clearly, and action effect is protruded, and is a maturation And can marketing good recipe；
（2）The present invention is using black fruit fructus lycii, matrimony vine, sea-buckthorn and cassia seed as prescription, and prescription technique is simple, workable；
（3）The black fruit fructus lycii prescription that the present invention is provided, is acted on visual fatigue is significantly alleviated, and easy to use.
The embodiment of form, further specifically to the above work of the present invention by the following examples It is bright.But the scope that this should not be interpreted as to above-mentioned theme of the invention is only limitted to following embodiment.It is all above-mentioned interior based on the present invention Hold realized technology and belong to the scope of the present invention.
Embodiment
Embodiment 1：It is a kind of that there is the black fruit fructus lycii prescription and preparation for alleviating visual fatigue.
（1）The composition of black fruit fructus lycii prescription is pressed into following weight just compatibility：Black fruit fructus lycii 100g, fruit of Chinese wolfberry 40g, sea-buckthorn 40g, cassia seed 20g；（2）Each component is subjected to ultralow temperature ultramicro grinding, it is -20 ~ -40 DEG C to crush temperature, sporoderm-broken rate 90% ~ 95%, obtain Ultramicro-powder standby；（3）Equivalent mixing method of progressively increasing is taken to be mixed in prescription ratio each Ultramicro-powder, until all Mix, after spin vibration sieve mixing, obtain black fruit fructus lycii prescription mixture；By the method point agent by measure of black fruit fructus lycii prescription mixture Amount, often wraps 10g, that is, obtains black fruit fructus lycii prescription powder A.
Embodiment 2：It is a kind of that there is the black fruit fructus lycii prescription and preparation for alleviating visual fatigue.
（1）The composition of black fruit fructus lycii prescription is pressed into following weight just compatibility：Black fruit fructus lycii 120g, fruit of Chinese wolfberry 69g, sea-buckthorn 69g, cassia seed 42g；（2）Each component is subjected to ultralow temperature ultramicro grinding, it is -20 ~ -40 DEG C to crush temperature, sporoderm-broken rate 90% ~ 95%, obtain Ultramicro-powder standby；（3）Equivalent mixing method of progressively increasing is taken to be mixed in prescription ratio each Ultramicro-powder, until all Mix, after spin vibration sieve mixing, obtain black fruit fructus lycii prescription mixture；By the method point agent by measure of black fruit fructus lycii prescription mixture Amount, often wraps 10g, that is, obtains black fruit fructus lycii prescription powder B.
Embodiment 3：It is a kind of that there is the black fruit fructus lycii prescription and preparation for alleviating visual fatigue.
（1）The composition of black fruit fructus lycii prescription is pressed into following weight just compatibility：Black fruit fructus lycii 240g, fruit of Chinese wolfberry 68g, sea-buckthorn 68g, cassia seed 24g；（2）Each component is subjected to ultralow temperature ultramicro grinding, it is -20 ~ -40 DEG C to crush temperature, sporoderm-broken rate 90% ~ 95%, obtain Ultramicro-powder standby；（3）Equivalent mixing method of progressively increasing is taken to be mixed in prescription ratio each Ultramicro-powder, until all Mix, after spin vibration sieve mixing, obtain black fruit fructus lycii prescription mixture；By the method point agent by measure of black fruit fructus lycii prescription mixture Amount, often wraps 10g, that is, obtains black fruit fructus lycii prescription powder C.
The remarkable efficacy of drug regimen of the present invention is expanded on further below by way of experimental example.
（1）Given the test agent：The gained black fruit fructus lycii powder A of the embodiment of the present invention 1 and placebo（Starch）.
（2）Subjects：Totally 140 people of the volunteer with visual fatigue symptom is selected, exclusion does not meet inclusive criteria, do not pressed Regulation takes tested material, it is impossible to which judging effect or data, umbra does not ring effect or security judgement person, excludes to this product allergy Person, gestation and women breast-feeding their children, removal system disease and Genetic eye diseases person, exclude with fundus oculi disease or are associated with painstaking effort The diseases such as pipe, the cerebrovascular, liver, kidney and hemopoietic system.
（3）Instructions of taking：Efficiency test person is divided into 2 groups, every group 70 for 140 according to random, double blinding requirement（Effectively The people of number of cases 118, the wherein people of test group 62, depart from 8 people；The people of control group 56, departs from 14 people）.Test group and control group press recommendation side Method and recommended amounts take tested material, and one time a day, every time 1 bag, and dose is 10g, continuously takes 30d.
（4）Observation index：Reference《Health food is examined and assessment technique specification》2003 editions page 69 ~ 71 " alleviate visual fatigue The regulation of functional check method ", observation index is divided into safety indexes and efficiency index, and starts and terminate each survey in test-meal It is fixed 1 time.
（5）Visual fatigue symptom decision method（Sxemiquantitative integration method）：Effectively, symptom improves and differed before and after duration of photopic vision ≥0.1；Invalid, symptom and duration of photopic vision are without significant change.
（6）As a result：
1. test-meal crowd general status：Two groups of subjects are roughly the same regarding bright persistence, eyesight before test-meal, and comparativity is good；
2. the change of symptom total mark：The forward and backward difference of eye symptom total mark test-meal of test group reaches the pole level of signifiance（P ＜ 0.01）, test group and control group total symptom total mark after test-meal also has significant difference（P ＜ 0.05）, it is shown in Table 1；
Eye symptom total mark changes between the forward and backward test group of the test-meal of table 1 and control group（Note：Compare in * groups between p ＜ 0.01, # groups Compare p ＜ 0.05）
Group Number of cases Before test-meal After test-meal
Test group 62 3.84±1.75 2.71±2.14**,##
Control group 56 3.79±2.03 3.65±1.82
3. the change of duration of photopic vision：Duration of photopic vision is significantly improved after test group test-meal, with comparing difference before test-meal in extremely aobvious Work property（P ＜ 0.01）, difference is also in pole significant relation compared with control group（P ＜ 0.01）, the forward and backward photopic vision of test group test-meal is lasting It is 0.12 ± 0.07 to spend average raising value, is shown in Table 2；
The forward and backward duration of photopic vision change of the test-meal of table 2（Compare in * groups and compare p ＜ 0.01 between p ＜ 0.01, ## groups）
Group Number of cases Before test-meal After test-meal Raising value
Test group 62 0.54±0.07 0.66±0.09**,## 0.12±0.07##
Control group 56 0.52±0.05 0.53±0.06 0.01±0.05
4. total effectively result of determination：After test-meal, the total effective rate of test group is 45.2%, is compared with control group with pole significance difference It is different（P ＜ 0.01）, it is shown in Table 3；
The forward and backward total effective rate result of determination of the test-meal of table 3（Compare p ＜ 0.01 between ## groups）
Group Number of cases Effectively It is invalid Total effective rate/%
Test group 62 28 34 45.2
Control group 56 4 52 7.0
5. conclusion：By the observation to safety indexes, it is found that subject's indices are showed no exception, associated safety after test-meal Property index is in range of normal value, and subject is without other adverse reactions；Observed by efficiency index, find to try after test-meal Test group symptom total mark, duration of photopic vision and a full availability to be obviously improved, difference reaches the pole level of signifiance, and average photopic vision is lasting Degree improves 0.12 ± 0.07, according to《Health food is examined and assessment technique specification》2003 editions page 69 ~ 71 " alleviate visual fatigue work( The regulation of the energy method of inspection ", it is believed that the black fruit fructus lycii prescription and powder that the present invention is provided have effects that to alleviate visual fatigue.

Claims (10)

1. a kind of have the black fruit fructus lycii prescription and preparation for alleviating visual fatigue, black fruit fructus lycii prescription and preparation are mainly included, it is special Levy and be, the composition of the black fruit fructus lycii prescription carries out compatibility by weight percentage：Black fruit fructus lycii 40% ~ 60%, the fruit of Chinese wolfberry 17% ~ 23%, sea-buckthorn 17% ~ 23%, cassia seed 6% ~ 14%.
A kind of there is the black fruit fructus lycii prescription for alleviating visual fatigue 2. according to claim 1, it is characterised in that it is preferred The composition of black fruit fructus lycii prescription carries out compatibility by weight percentage：Black fruit fructus lycii 50%, the fruit of Chinese wolfberry 20%, sea-buckthorn 20%, cassia seed 10%。
A kind of there is the black fruit fructus lycii prescription for alleviating visual fatigue 3. according to claim 1, it is characterised in that it is preferred The composition of black fruit fructus lycii prescription carries out compatibility by weight percentage：Black fruit fructus lycii 40%, the fruit of Chinese wolfberry 23%, sea-buckthorn 23%, cassia seed 14%。
A kind of there is the black fruit fructus lycii prescription for alleviating visual fatigue 4. according to claim 1, it is characterised in that it is preferred The composition of black fruit fructus lycii prescription carries out compatibility by weight percentage：Black fruit fructus lycii 60%, the fruit of Chinese wolfberry 17%, sea-buckthorn 17%, cassia seed 6%。
5. it is according to claim 1 a kind of with the black fruit fructus lycii composing prescription preparation for alleviating visual fatigue, it is characterised in that described The preparation of lycium ruthenicum prescription is oral formulations, and main formulation includes：Solid pharmaceutical preparation and liquid preparation.
6. it is according to claim 1 a kind of with the black fruit fructus lycii composing prescription preparation for alleviating visual fatigue, it is characterised in that described Black fruit fructus lycii prescription solid pharmaceutical preparation mainly include：Powder, granule, tablet and hard capsule.
7. it is according to claim 1 a kind of with the black fruit fructus lycii composing prescription preparation for alleviating visual fatigue, it is characterised in that described Black fruit fructus lycii prescription liquid preparation mainly include：Syrup and tincture.
8. it is according to claim 1 a kind of with the black fruit fructus lycii composing prescription preparation for alleviating visual fatigue, it is characterised in that described The main technique of black fruit fructus lycii prescription solid pharmaceutical preparation include：Crush, mix, sieve.
9. it is according to claim 1 a kind of with the black fruit fructus lycii composing prescription preparation for alleviating visual fatigue, it is characterised in that described The main technique of black fruit fructus lycii prescription liquid preparation include：Crush, mix, sieve, extract, concentrate.
10. a kind of made from any one methods described according to claim 1 ~ 9 have the black fruit Chinese holly for alleviating visual fatigue Qi composing prescription preparation.
CN201710267772.5A 2017-04-21 2017-04-21 It is a kind of that there is the black fruit fructus lycii prescription and preparation for alleviating visual fatigue Pending CN107019218A (en)

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CN108378318A (en) * 2018-01-23 2018-08-10 江苏道诚生物科技有限公司 A kind of antifatigue of sea-buckthorn compound and preparation method thereof
CN109170888A (en) * 2018-09-18 2019-01-11 广东时代食品与生命健康研究有限公司 A kind of anti-oxidant, anti-Fatigue Composition and preparation method thereof
CN111685249A (en) * 2020-06-15 2020-09-22 沈阳市和适保健食品科技有限责任公司 Chinese wolfberry beverage for relieving visual fatigue

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CN1709375A (en) * 2005-06-27 2005-12-21 广州康采恩医药有限公司 Chewing gum for radiation protection
CN103404856A (en) * 2013-08-13 2013-11-27 青海睿元药物研究所有限责任公司 Matrimony vine sheet produced by stack delaminated pressing and preparation method thereof
CN105231447A (en) * 2015-10-28 2016-01-13 青海尤尼克生物技术有限公司 Health-care lycium ruthenicum tablets capable of alleviating asthenopia

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CN1709375A (en) * 2005-06-27 2005-12-21 广州康采恩医药有限公司 Chewing gum for radiation protection
CN103404856A (en) * 2013-08-13 2013-11-27 青海睿元药物研究所有限责任公司 Matrimony vine sheet produced by stack delaminated pressing and preparation method thereof
CN105231447A (en) * 2015-10-28 2016-01-13 青海尤尼克生物技术有限公司 Health-care lycium ruthenicum tablets capable of alleviating asthenopia

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108378318A (en) * 2018-01-23 2018-08-10 江苏道诚生物科技有限公司 A kind of antifatigue of sea-buckthorn compound and preparation method thereof
CN109170888A (en) * 2018-09-18 2019-01-11 广东时代食品与生命健康研究有限公司 A kind of anti-oxidant, anti-Fatigue Composition and preparation method thereof
CN111685249A (en) * 2020-06-15 2020-09-22 沈阳市和适保健食品科技有限责任公司 Chinese wolfberry beverage for relieving visual fatigue

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Application publication date: 20170808