CN101954064A - Composition for whitening and removing spots and preparation method thereof - Google Patents
Composition for whitening and removing spots and preparation method thereof Download PDFInfo
- Publication number
- CN101954064A CN101954064A CN2010102925672A CN201010292567A CN101954064A CN 101954064 A CN101954064 A CN 101954064A CN 2010102925672 A CN2010102925672 A CN 2010102925672A CN 201010292567 A CN201010292567 A CN 201010292567A CN 101954064 A CN101954064 A CN 101954064A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- glutathion
- whitening
- hypromellose
- semi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a composition for whitening and removing spots, and belongs to the field of health foods. The composition is an oral preparation, and comprises the following substances in part by weight: 20 to 70 parts of glutathione, 10 to 50 parts of pearl powder, 10 to 50 parts of grape seed extract, 5 to 20 parts of vitamin E and 5 to 20 parts of vitamin C. The composition effectively inhibits the activity of tyrosinase and inhibits the synthesis of melanin so as to whiten skin. The composition does not contain components banned for pregnant and lactating women, so the composition has the advantages of wider applicable user range and higher safety. The composition can be prepared into capsules, tablets and granules.
Description
Technical field
The invention belongs to the health food technology field, particularly a kind of compositions of oral whitening and speckle dispelling.
Background technology
In the daily life people irregular owing to life, accept reasons such as Exposure to Sunlight, endocrine disturbance for a long time, cause the skin of face blackening easily, phenomenon such as mottle occurs.Skin darkening and mottle are caused by melanin deposition.Melanin is a kind of protein, is present in the middle of the cell of skin basal layer, and the melanin of this moment is not melanin truly, but chromoplast.Chromoplast secretion Mai Laning pigment, when ultraviolet radiation to skin, skin will be in the state of " self-protection ", stimulates the Mai Laning pigment by ultraviolet, activates the activity of tryrosinase, protects our Skin Cell.Tyrosine reaction in tryrosinase and the blood generates DOPA, and DOPA discharges melanin through being oxidized to the DOPA quinone.Melanin via the moving layer by layer of cellular metabolism, has arrived the skin epidermal area and has formed shapes such as freckle, sunburn, black speck again.
Existing whitening and speckle dispelling product contains mostly can suppress the composition that melanin forms, by suppressing the generation that melanic formation prevents skin darkening and mottle.
In realizing process of the present invention, the inventor finds that there is following defective at least in prior art: the very high and large contingent of probability of chloasma appears in gestation and women breast-feeding their children, contain the composition that gestation and women breast-feeding their children should not use in the existing product mostly, as alpha-lipoic acid etc., cause product to be suitable for that crowd's scope is little, safety is low.
Summary of the invention
The embodiment of the invention provides a kind of compositions that is used for whitening and speckle dispelling, can safety skin whitening, reduce or eliminate mottle.
The technical scheme taked of the present invention is to achieve these goals:
A kind of compositions that is used for whitening and speckle dispelling comprises following substances in parts by weight:
Glutathion 20-70 part, Margarita powder 10-50 part, Semen Vitis viniferae extract 10-50 part, vitamin E 5-20 part and vitamin C 5-20 part.
The described compositions that is used for whitening and speckle dispelling comprises following substances in parts by weight: glutathion 40-60 part, Margarita powder 20-40 part, Semen Vitis viniferae extract 20-40 part, vitamin E 10-15 part and vitamin C 10-15 part.
The described compositions that is used for whitening and speckle dispelling comprises following substances in parts by weight: glutathion 20-70 part, Margarita powder 10-50 part, Semen Vitis viniferae extract 10-50 part, vitamin E 5-20 part, vitamin C 5-20 part, maltose alcohol 0-20 part, hypromellose 1-5 part.
Described glutathion is selected from least a in reduced glutathion and the oxidized form of glutathione.
Described Margarita powder is selected from least a in common Margarita powder and the water soluble Margarita ultrafine powder.
Another technical scheme provided by the invention is:
Preparation is used for the first method of the compositions of whitening and speckle dispelling, and concrete steps are:
(1) takes by weighing glutathion 20-70 part, Margarita powder 10-50 part, Semen Vitis viniferae extract 10-50 part, vitamin E 5-20 part, vitamin C 5-20 part;
(2) glutathion, water soluble Margarita ultrafine powder, Semen Vitis viniferae extract, vitamin E and the vitamin C that takes by weighing is put in the mixer, mixes 10-30min, get semi-finished product;
(3) semi-finished product are tested;
(4) semi-finished product after the assay was approved are filled in the hard capsule, make finished capsule product.
Preparation is used for the second method of whitening spot-eliminating composition, and concrete steps are:
(1) takes by weighing glutathion 20-70 part, Margarita powder 10-50 part, Semen Vitis viniferae extract 10-50 part, vitamin E 5-20 part, vitamin C 5-20 part, hypromellose 1-5 part;
(2) the binding agent hypromellose that takes by weighing is made into 5% hypromellose aqueous solution;
(3) glutathion that takes by weighing, common Margarita powder, Semen Vitis viniferae extract, vitamin E and vitamin C are placed in the mixer, mix 10-30min, get mixed powder;
(4) 5% hypromellose aqueous solution is joined in the described mixed powder, the hypromellose aqueous solution of mixed powder and 5% is stirred, after system granule, the drying semi-finished product;
(5) semi-finished product are tested;
(6) with the semi-finished product that are up to the standards tablet machine tabletting, make finished tablet.
Preparation is used for the third method of whitening spot-eliminating composition, and concrete steps are:
(1) takes by weighing glutathion 20-70 part, Margarita powder 10-50 part, Semen Vitis viniferae extract 10-50 part, vitamin E 5-20 part, vitamin C 5-20 part, maltose alcohol 0-20 part, hypromellose 1-5 part;
(2) the binding agent hypromellose that takes by weighing is made into 5% hypromellose aqueous solution;
(3) oxidized form of glutathione that takes by weighing, common Margarita powder, Semen Vitis viniferae extract, vitamin E, vitamin C and maltose alcohol are placed in the mixer, mix 10-30min, get mixed powder;
(4) 5% hypromellose solution is joined in the described mixed powder, make granule after the hypromellose aqueous solution of mixed powder and 5% is stirred, granule is carried out drying make semi-finished product;
(5) semi-finished product are tested;
(6), make the finished particle preparation of every bag of heavy 1.0g with the semi-finished product pack that is up to the standards
The effect of each component of compositions is in the embodiment of the invention:
(1) glutathion is the tripeptides by glutamic acid, cysteine and glycine be combined into, and the sulfydryl on the cysteine is its active group.Sulfydryl on the cysteine, easily and heavy metallic salt complexations such as iodoacetic acid, mustard gas, lead, hydrargyrum, arsenic, thereby glutathion has the integration Detoxication.Glutathion can combine with some drugs (as acetaminophen), toxin (as free radical, heavy metal) etc., makes it can participate in biotransformation, thereby deleterious poisonous substance in the body is converted into harmless material, excretes external.
Glutathion has reduced form (GSH) and two kinds of forms of oxidized form (GSSH), can be counted as total hinge of opposing free radical in the human body, it can remove free radical, also reducible other antioxidants, make other antioxidants such as vitamin A, vitamin C, vitamin E etc., can use by recirculation.Glutathion is the restraint of tyrosinase activity effectively, thereby suppresses melanic synthetic, plays the effect of skin-whitening.
(2) Margarita powder just is used as skin care good product since ancient times, the effect of record in the Compendium of Material Medica " Margarita has moist skin, nourishes appearance ".
(3) Semen Vitis viniferae extract is a pure natural substance, is one of efficient antioxidants of the plant origin found so far, and superpower antioxidation efficient has the removing free radical, reduces the melanin deposition effect.
(4) vitamin C, vitamin E and glutathion and usefulness can improve the effect of glutathion.Vitamin C also is a kind of important antioxidants in the body.Vitamin C energy restraint of tyrosinase activity for oral administration prevents that melanin from generating.
Have good synergism between each component of compositions in the embodiment of the invention, the wherein reducible vitamin C of glutathion, vitamin E etc. can use by recirculation it, have improved the utilization rate of vitamin C, vitamin E; Though Margarita powder has good beauty functions, but only use Margarita powder not reach ideal cosmetic result, Margarita powder plays conduit, to there be pharmaceutically-active cosmetics to share competence exertion with some other and go out effect, the use of Margarita powder, can make in the compositions other each components be more conducive to absorb, thereby improve the utilization rate of other components of compositions; The superpower non-oxidizability of Semen Vitis viniferae extract makes it both as nutrition enhancer, again as natural antiseptic agent, has improved security of products; Vitamin C, vitamin E and glutathion and usefulness can improve the effect of glutathion.
The beneficial effect that the technical scheme that the embodiment of the invention provides is brought is: the compositions of the embodiment of the invention has good whitening and speckle dispelling effect, because the compositions of the embodiment of the invention does not contain gestation and women breast-feeding their children are forbidden composition, thereby suitable crowd is wider, safety is higher.
The specific embodiment
For making the purpose, technical solutions and advantages of the present invention clearer, below embodiment of the present invention is described further in detail.
Raw material source in the various embodiments of the present invention:
Glutathion is bought the consonance fermentation company from Japan, Margarita powder is bought from Hangzhou Baoxing Industrial Co., Ltd., Semen Vitis viniferae extract is bought from east, Huizhou plant health Science and Technology Ltd., vitamin E is bought from the Xinchang newly and is become the vitamin company limited, vitamin C is bought from Dongbei Pharmaceutical General Factory, hypromellose is bought from Dow Chemical, and maltose alcohol is bought from French Roquette Freres.
Embodiment 1
One, preparing product
1, take by weighing raw material:
Take by weighing reduced glutathion 20g, water soluble Margarita ultrafine powder 50g, Semen Vitis viniferae extract 10g, vitamin E 20g, vitamin C 5g.
2, preparation process:
(1) reduced glutathion 20g, water soluble Margarita ultrafine powder 50g, Semen Vitis viniferae extract 10g, vitamin E 20g and the vitamin C 5g that takes by weighing is put in the mixer, mixes 10min, get semi-finished product.
(2) semi-finished product are tested: detect whether mix homogeneously of mixture according to prior art, in blender, continues to mix stirring 5-10 minute as unmixed even need.
(3) semi-finished product after the assay was approved are filled in the hard capsule, make finished capsule product, the heavy 0.5g of the content of every finished capsule product.
Two, the freckle effect of embodiment 1 product experiment:
1, experiment condition:
1. participate in experimenter's selected condition:
Age: 20-40 year
Sex: woman
Require: face has chloasma
2. participate in the experiment number: 30 people
3. service time: 2 months
4. using method and use amount: every day, oral present embodiment product was 2
2, experimental result:
The freckle effect tables of data of table 1 embodiment 1 product
With reference to table 1, experimental result shows that the freckle effect of embodiment 1 product is good, and the speckle dispelling total effective rate is 66.7%.
Embodiment 2
One, preparing product
1, take by weighing raw material:
Take by weighing reduced glutathion 50g, common Margarita powder 30g, Semen Vitis viniferae extract 30g, vitamin E 15g, vitamin C 15g, hypromellose 1.5g.
2, preparation process
(1) the binding agent hypromellose 1.5g that takes by weighing is mixed with 5% hypromellose aqueous solution.
(2) reduced glutathion 50g, common Margarita powder 30g, Semen Vitis viniferae extract 30g, vitamin E 15g and the vitamin C 15g that takes by weighing is placed in the mixer, mixes 20min, get mixed powder.
(3) 5% hypromellose aqueous solution is joined in the described mixed powder, the hypromellose aqueous solution of mixed powder and 5% is stirred, system granule, 55 ℃ of dryings after 4 hours semi-finished product.
(4) semi-finished product are tested.
(5), make the finished tablet of every heavy 0.5g with the semi-finished product that are up to the standards tablet machine tabletting.
Two, the whitening effect of embodiment 2 products experiment:
1, experiment condition is substantially the same manner as Example 1, and different is:
Require: the dark yellow blackout of the colour of skin;
Using method and use amount: every day, oral present embodiment product was 2.
2, experimental result:
The whitening effect tables of data of table 2 embodiment 2 products
Three, the freckle effect of embodiment 2 products experiment:
1, experiment condition is substantially the same manner as Example 1, and different is:
Using method and use amount: every day, oral present embodiment product was 2.
2, experimental result:
Table 3 embodiment 2 product freckle effect tables of data
With reference to table 2 and table 3, experimental result shows, the whitening of embodiment 2 products, freckle effect are good, and the total effective rate of whitening is 93.3%, and the speckle dispelling total effective rate is 86.7%.
Embodiment 3
One, preparing product
1, take by weighing raw material:
Take by weighing oxidized form of glutathione 70g, common Margarita powder 10g, Semen Vitis viniferae extract 50g, vitamin E 5g, Catergen 0g, maltose alcohol 14g, hypromellose 1.5g.
2, preparation process:
(1) the binding agent hypromellose 1.5g that takes by weighing is made into 5% hypromellose aqueous solution.
(2) oxidized form of glutathione 70g, common Margarita powder 10g, Semen Vitis viniferae extract 50g, vitamin E 5g, vitamin C 20g and the maltose alcohol 14g that takes by weighing is placed in the mixer, mix 30min, get mixed powder, maltose alcohol is in order to regulate the product mouthfeel herein.
(3) 5% hypromellose solution is joined in the described mixed powder, make granule after the hypromellose aqueous solution of mixed powder and 5% is stirred, granule is carried out drying make semi-finished product.
(4) semi-finished product are tested.
(5), make the finished particle preparation of every bag of heavy 1.0g with the semi-finished product pack that is up to the standards.
Two, the whitening effect of embodiment 3 products experiment:
1, experiment condition is substantially the same manner as Example 1, and different is:
Require: the dark yellow blackout of the colour of skin;
Using method and use amount: every day, oral present embodiment product was 1 bag.
2, experimental result:
The whitening effect tables of data of table 4 embodiment 3 products
With reference to table 4, experimental result shows that the whitening function of embodiment 3 products is obvious, and the total effective rate of whitening is 86.6%.
Embodiment 4
One, preparing product
1, take by weighing raw material:
Take by weighing reduced glutathion 50g, water soluble Margarita ultrafine powder 15g, Semen Vitis viniferae extract 15g, vitamin E 10g, vitamin C 10g.
2, preparation process is identical with embodiment 1.The heavy 0.5g of every capsules content.
Two, freckle effect contrast experiment:
Embodiment 4 is carried out effect relatively with existing whitening and speckle dispelling product Lucida-DS capsule, and Lucida-DS capsule lot number is 168015L, buys from Philippine Mercury pharmacy (Mercury Drug).
Concrete experimentation is as follows:
1. participate in experimenter's selected condition:
Age: 30-40 year
Sex: woman
Require: face has chloasma, and single chloasma maximum area is 4cm
2-6cm
2
2. participate in the experiment number: 30 people (15 people Lucida-DS capsules, 15 people product of the present invention)
3. service time: 2 months
4. use sample: Lucida-DS capsule, present embodiment product
5. using method and use amount: every day 1 of oral Lucida-DS capsule or 2 of oral present embodiment products every day (the Lucida-DS capsule contains glutathion, and it is identical with the glutathion amount of taking 2 picked-ups of present embodiment product to take 1 of Lucida-DS capsule)
6. experimental index: write down the variation of single chloasma maximum area, if single chloasma maximum area reduces 20%-49% and then is designated as effectively, as if single chloasma maximum area reduce 〉=50% be designated as produce effects.
7. contrast and experiment:
Table 5 embodiment 4 products and Lucida-DS capsule freckle effect correction data table
With reference to table 5, experimental result shows that the freckle effect of embodiment 4 products is more obvious than Lucida-DS capsule, and the speckle dispelling effective percentage is higher 26.6 percentage points than Lucida-DS capsule.
Embodiment 5
1, take by weighing raw material:
Take by weighing oxidized form of glutathione 20g, reduced glutathion 20g, water soluble Margarita ultrafine powder 40g, Semen Vitis viniferae extract 25g, vitamin E 7.5g, vitamin C 17.5g.
2, preparation process is identical with embodiment 2.
Embodiment 6
1, take by weighing raw material:
Take by weighing reduced glutathion 30g, water soluble Margarita ultrafine powder 25g, Semen Vitis viniferae extract 40g, vitamin e1 2.5g, vitamin C 7.5g.
2, preparation process is identical with embodiment 2.
Product to embodiment 5 and embodiment 6 has all carried out the experiment of whitening and speckle dispelling effect, and concrete experimental technique is identical with embodiment 2.The total effective rate of whitening of embodiment 5 is 86.7%, and the speckle dispelling total effective rate is 93.3%; The total effective rate of whitening of embodiment 6 is 86.7%, and the speckle dispelling total effective rate is 80%.
In sum, the compositions whitening and speckle dispelling of the embodiment of the invention is respond well, especially embodiment 2 and embodiment 5 best results; Can find by the contrast experiment, the compositions freckle effect of the embodiment of the invention obviously is better than the capsular freckle effect of Lucida-DS, and do not contain gestation in the compositions of the embodiment of the invention and women breast-feeding their children are forbidden composition, thereby suitable crowd is wider, safety is higher.
The above only is preferred embodiment of the present invention, and is in order to restriction the present invention, within the spirit and principles in the present invention not all, any modification of being done, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. compositions that is used for whitening and speckle dispelling is characterized in that: comprise following substances in parts by weight:
Glutathion 20-70 part, Margarita powder 10-50 part, Semen Vitis viniferae extract 10-50 part, vitamin E 5-20 part and vitamin C 5-20 part.
2. the compositions that is used for whitening and speckle dispelling according to claim 1 is characterized in that: comprise following substances in parts by weight: glutathion 40-60 part, Margarita powder 20-40 part, Semen Vitis viniferae extract 20-40 part, vitamin E 10-15 part and vitamin C 10-15 part.
3. the compositions that is used for whitening and speckle dispelling according to claim 1 is characterized in that: comprise following substances in parts by weight: glutathion 20-70 part, Margarita powder 10-50 part, Semen Vitis viniferae extract 10-50 part, vitamin E 5-20 part, vitamin C 5-20 part, maltose alcohol 0-20 part and hypromellose 1-5 part.
4. the compositions that is used for whitening and speckle dispelling according to claim 1 is characterized in that: described glutathion is selected from least a in reduced glutathion and the oxidized form of glutathione.
5. the compositions that is used for whitening and speckle dispelling according to claim 1 is characterized in that: described Margarita powder is selected from least a in common Margarita powder and the water soluble Margarita ultrafine powder.
6. prepare the described method for compositions that is used for whitening and speckle dispelling, it is characterized in that: concrete steps are:
(1) takes by weighing glutathion 20-70 part, Margarita powder 10-50 part, Semen Vitis viniferae extract 10-50 part, vitamin E 5-20 part, vitamin C 5-20 part;
(2) glutathion, water soluble Margarita ultrafine powder, Semen Vitis viniferae extract, vitamin E and the vitamin C that takes by weighing is put in the mixer, mixes 10-30min, get semi-finished product;
(3) semi-finished product are tested;
(4) semi-finished product after the assay was approved are filled in the hard capsule, make finished capsule product.
7. prepare the described method for compositions that is used for whitening and speckle dispelling, it is characterized in that: concrete steps are:
(1) takes by weighing glutathion 20-70 part, Margarita powder 10-50 part, Semen Vitis viniferae extract 10-50 part, vitamin E 5-20 part, vitamin C 5-20 part, hypromellose 1-5 part;
(2) the binding agent hypromellose that takes by weighing is made into 5% hypromellose aqueous solution;
(3) glutathion that takes by weighing, common Margarita powder, Semen Vitis viniferae extract, vitamin E and vitamin C are placed in the mixer, mix 10-30min, get mixed powder;
(4) 5% hypromellose aqueous solution is joined in the described mixed powder, the hypromellose aqueous solution of mixed powder and 5% is stirred, after system granule, the drying semi-finished product;
(5) semi-finished product are tested;
(6) with the semi-finished product that are up to the standards tablet machine tabletting, make finished tablet.
8. prepare the described method for compositions that is used for whitening and speckle dispelling, it is characterized in that: concrete steps are:
(1) takes by weighing glutathion 20-70 part, Margarita powder 10-50 part, Semen Vitis viniferae extract 10-50 part, vitamin E 5-20 part, vitamin C 5-20 part, maltose alcohol 0-20 part, hypromellose 1-5 part;
(2) the binding agent hypromellose that takes by weighing is made into 5% hypromellose aqueous solution;
(3) oxidized form of glutathione that takes by weighing, common Margarita powder, Semen Vitis viniferae extract, vitamin E, vitamin C and maltose alcohol are placed in the mixer, mix 10-30min, get mixed powder;
(4) 5% hypromellose solution is joined in the described mixed powder, make granule after the hypromellose aqueous solution of mixed powder and 5% is stirred, granule is carried out drying make semi-finished product;
(5) semi-finished product are tested;
(6), make the finished particle preparation of every bag of heavy 1.0g with the semi-finished product pack that is up to the standards.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102925672A CN101954064B (en) | 2010-09-25 | 2010-09-25 | Composition for whitening and removing spots and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102925672A CN101954064B (en) | 2010-09-25 | 2010-09-25 | Composition for whitening and removing spots and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101954064A true CN101954064A (en) | 2011-01-26 |
| CN101954064B CN101954064B (en) | 2013-03-20 |
Family
ID=43481820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102925672A Active CN101954064B (en) | 2010-09-25 | 2010-09-25 | Composition for whitening and removing spots and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101954064B (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579699A (en) * | 2012-02-23 | 2012-07-18 | 南京辰逸生物科技有限公司 | Composition with function of removing chloasma and preparation method thereof |
| CN103006920A (en) * | 2011-12-14 | 2013-04-03 | 西安泰科迈医药科技有限公司 | Chloasma-removing pure traditional Chinese medicine composition and preparation method thereof |
| CN103099205A (en) * | 2013-02-21 | 2013-05-15 | 汤臣倍健股份有限公司 | Grape seed tablet and preparation method thereof |
| CN104397686A (en) * | 2014-11-07 | 2015-03-11 | 柳城县天地自然食品有限公司 | Skincare health care product with pearls and preparation method thereof |
| CN105535025A (en) * | 2016-01-14 | 2016-05-04 | 无锡瑞博美容咨询服务有限公司 | Skin tendering and whitening nutrient solution and skin tendering and whitening composition |
| CN107028868A (en) * | 2017-06-06 | 2017-08-11 | 丛地召 | A kind of pure natural whitening spot-removing suncream |
| CN107397697A (en) * | 2017-08-30 | 2017-11-28 | 永安康健药业（武汉）有限公司 | A kind of whitening spot-eliminating composition and its application |
| CN108703287A (en) * | 2018-05-28 | 2018-10-26 | 郑州市云鼎汇砂生物科技有限公司 | A kind of whitening enzyme beverage and preparation method thereof containing small-molecular peptides Yu a variety of enzymes |
| CN109464359A (en) * | 2018-11-21 | 2019-03-15 | 佛山科学技术学院 | Skin care item and preparation method thereof containing bird's nest peptide |
| CN109998114A (en) * | 2019-04-03 | 2019-07-12 | 江西安顺堂生物科技有限公司 | A kind of anti-oxidant, skin whitening, Eradicates spot health care product |
| CN111902422A (en) * | 2018-03-30 | 2020-11-06 | 株式会社钟化 | Solid composition containing oxidized glutathione and method for producing same |
| CN112568352A (en) * | 2020-02-29 | 2021-03-30 | 河北康平健康产业有限责任公司 | Anti-oxidation beauty-maintaining and young-keeping mulberry and lycium ruthenicum solid beverage and preparation method thereof |
| CN113853114A (en) * | 2019-03-29 | 2021-12-28 | 株式会社钟化 | Composition comprising glutathione for application to leaves of plants |
| CN117694540A (en) * | 2024-02-06 | 2024-03-15 | 北京青颜博识健康管理有限公司 | Natural-source oral whitening composition and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1544039A (en) * | 2003-11-14 | 2004-11-10 | 深圳市仁德堂实业有限公司 | Fat-reducing speckle-removing cosmetic mixture and its capsule |
| CN101112237A (en) * | 2007-08-31 | 2008-01-30 | 北京因科瑞斯医药科技有限公司 | Health products having a function of dispelling chloasma |
| CN101653256A (en) * | 2009-06-09 | 2010-02-24 | 厦门市丝浓食品有限公司 | Producing method of health product capsule for beautifying face and moistering lotion |
-
2010
- 2010-09-25 CN CN2010102925672A patent/CN101954064B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1544039A (en) * | 2003-11-14 | 2004-11-10 | 深圳市仁德堂实业有限公司 | Fat-reducing speckle-removing cosmetic mixture and its capsule |
| CN101112237A (en) * | 2007-08-31 | 2008-01-30 | 北京因科瑞斯医药科技有限公司 | Health products having a function of dispelling chloasma |
| CN101653256A (en) * | 2009-06-09 | 2010-02-24 | 厦门市丝浓食品有限公司 | Producing method of health product capsule for beautifying face and moistering lotion |
Non-Patent Citations (2)
| Title |
|---|
| 《岭南皮肤性病科杂志》 20040331 邓景航等 还原型谷胱甘肽联合维生素C治疗黄褐斑疗效观察 第11卷, 第1期 2 * |
| 《放射免疫学杂志》 20051231 李清等 维生素EC复合剂治疗黄褐斑前后血清LPO、SOD值的相关性研究 第18卷, 第5期 2 * |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006920A (en) * | 2011-12-14 | 2013-04-03 | 西安泰科迈医药科技有限公司 | Chloasma-removing pure traditional Chinese medicine composition and preparation method thereof |
| CN103006920B (en) * | 2011-12-14 | 2015-05-06 | 西安泰科迈医药科技有限公司 | Chloasma-removing pure traditional Chinese medicine composition and preparation method thereof |
| CN102579699A (en) * | 2012-02-23 | 2012-07-18 | 南京辰逸生物科技有限公司 | Composition with function of removing chloasma and preparation method thereof |
| CN103099205A (en) * | 2013-02-21 | 2013-05-15 | 汤臣倍健股份有限公司 | Grape seed tablet and preparation method thereof |
| CN104397686A (en) * | 2014-11-07 | 2015-03-11 | 柳城县天地自然食品有限公司 | Skincare health care product with pearls and preparation method thereof |
| CN105535025A (en) * | 2016-01-14 | 2016-05-04 | 无锡瑞博美容咨询服务有限公司 | Skin tendering and whitening nutrient solution and skin tendering and whitening composition |
| CN107028868A (en) * | 2017-06-06 | 2017-08-11 | 丛地召 | A kind of pure natural whitening spot-removing suncream |
| CN107397697A (en) * | 2017-08-30 | 2017-11-28 | 永安康健药业（武汉）有限公司 | A kind of whitening spot-eliminating composition and its application |
| CN107397697B (en) * | 2017-08-30 | 2020-05-12 | 永安康健药业（武汉）有限公司 | Whitening and freckle removing composition and application thereof |
| CN111902422A (en) * | 2018-03-30 | 2020-11-06 | 株式会社钟化 | Solid composition containing oxidized glutathione and method for producing same |
| JP7319247B2 (en) | 2018-03-30 | 2023-08-01 | 株式会社カネカ | Solid composition containing oxidized glutathione and method for producing the same |
| JPWO2019189733A1 (en) * | 2018-03-30 | 2021-04-01 | 株式会社カネカ | Solid composition containing oxidized glutathione and method for producing the same |
| CN108703287B (en) * | 2018-05-28 | 2021-06-29 | 郑州市云鼎汇砂生物科技有限公司 | Whitening enzyme beverage containing small molecular peptides and multiple enzymes and preparation method thereof |
| CN108703287A (en) * | 2018-05-28 | 2018-10-26 | 郑州市云鼎汇砂生物科技有限公司 | A kind of whitening enzyme beverage and preparation method thereof containing small-molecular peptides Yu a variety of enzymes |
| CN109464359A (en) * | 2018-11-21 | 2019-03-15 | 佛山科学技术学院 | Skin care item and preparation method thereof containing bird's nest peptide |
| CN113853114A (en) * | 2019-03-29 | 2021-12-28 | 株式会社钟化 | Composition comprising glutathione for application to leaves of plants |
| CN113853114B (en) * | 2019-03-29 | 2024-06-11 | 株式会社钟化 | Composition comprising glutathione for application to leaves of plants |
| CN109998114A (en) * | 2019-04-03 | 2019-07-12 | 江西安顺堂生物科技有限公司 | A kind of anti-oxidant, skin whitening, Eradicates spot health care product |
| CN112568352A (en) * | 2020-02-29 | 2021-03-30 | 河北康平健康产业有限责任公司 | Anti-oxidation beauty-maintaining and young-keeping mulberry and lycium ruthenicum solid beverage and preparation method thereof |
| CN117694540A (en) * | 2024-02-06 | 2024-03-15 | 北京青颜博识健康管理有限公司 | Natural-source oral whitening composition and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101954064B (en) | 2013-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101954064B (en) | Composition for whitening and removing spots and preparation method thereof | |
| US5925348A (en) | Methods utilizing compositions containing sacred lotus (methyltransferase) to treat aging skin | |
| CN101524377B (en) | Composite of wall-breaking lucidum spore powder and cyclodextrin and preparation method thereof | |
| CN107397697B (en) | Whitening and freckle removing composition and application thereof | |
| CN102188332A (en) | Cosmetic containing oceanic shellfish active peptide and preparation method and application thereof | |
| CN103479551A (en) | Toner and preparation method | |
| CN102355884A (en) | Agent for preventing, inhibiting, or ameliorating skin aging due to buildup of advanced glycation end products | |
| CN106420491A (en) | Multifunctional skin care product with effects of whitening skin, removing freckles, preserving moisture and removing wrinkle and preparation method of multifunctional skin care product | |
| CN103520013A (en) | Skin-whitening and freckle-removing formula and preparation method for gel thereof | |
| CN100396303C (en) | Deer fetus-pearl capsule | |
| CN102836110A (en) | Whitening mask | |
| US20170209486A1 (en) | Health-care preparation simultaneously with magnesium supplement and antioxidant functions and preparation method thereof | |
| CN104013537B (en) | Composition is used in the efficiency maintenance of filler | |
| CN101861960B (en) | Pearl freckle dispelling aesthetic health care food | |
| CN106215175A (en) | Phycocyanin vitamin C compound effervescent tablet and preparation method thereof | |
| CN115444134A (en) | Blueberry lutein ester chewable tablet and preparation method thereof | |
| CN112156048A (en) | Natural whitening face cleaning powder and preparation method thereof | |
| CN113616532A (en) | Portable solid toning lotion and preparation method thereof | |
| CN113826891A (en) | Composition containing compound vitamin and tabletting preparation method and application thereof | |
| CN105769659A (en) | Edible collagen membrane and preparation method thereof | |
| CN105476911A (en) | Whitening cosmetics containing arbutin, tangerine powder and radix glycyrrhizae extract | |
| CN104286832B (en) | A kind of health products and preparation method thereof with develop immunitypty, functions of removing chloasma effect | |
| CN103479553A (en) | Essence and preparation method | |
| TW202120065A (en) | Anti-blue light dermal topical composition and applications thereof comprising terephthalylidene dicamphor sulfonic acid as an effective ingredient for anti-blue light | |
| KR101057017B1 (en) | Anti-hair loss soap containing natural extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |