CN104107269A - Functional blood sugar-reduction health product and preparation method thereof - Google Patents
Functional blood sugar-reduction health product and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a functional blood sugar-reduction health product and a preparation method thereof. The functional blood sugar-reduction health product has blood sugar-reduction assistant functions and comprises hesperetin, balsam pear, American ginseng extract and wolfberry extract. The functional blood sugar-reduction health product comprises the edible and medical materials having blood sugar-reduction effects, is safe and effective and can be used for a long time. The functional blood sugar-reduction health product can be processed to form enteric coated tablets or enteric coated capsules. The preparation method comprises that the above raw materials and water and ethanol as solvents can be processed to form extract, the extract is subjected to spray drying so that extract powder is obtained, the extract powder is processed to form tablets or capsules, and the tablets or capsules are coated. An animal functional test proves that the functional blood sugar-reduction health product has blood sugar-reduction assistant health functions and is suitable for being eaten by diabetes for a long time.
Description
Technical field
The present invention relates to a kind of functional health-caring product capable of reducing blood sugar, relate in particular to a kind of functional health-caring product capable of reducing blood sugar for non-insulin-dependent diabetes mellitus (NIDDM), belong to natural health material application.
Background technology
Diabetes are the common metabolic diseases that caused by h and E factor interaction, clinical taking hyperglycemia as outstanding feature, common sympton has polydipsia, polyuria, polyphagia and becomes thin etc., if diabetes can not get effective treatment, can cause the infringement of health multisystem.Diabetes are one of important diseases that threaten human health, and wherein 90～95% belong to type 2 diabetes mellitus.According to World Health Organization (WHO) (WHO) report prediction, type 2 diabetes mellitus patient in the whole world in 2025 can reach 3.33 hundred million, the patient who dies from every year diabetes relevant disease has 3,000,000 people, more prevalent along with the increase of population in the world aging degree and unhealthy life style, to the year two thousand thirty, the number of dying from every year diabetes relevant disease also will increase by 2/3rds.China has become the second big country that diabetics absolute number in the world's is only second to India, diabetics due to 80% is in developing country, the diabetes of sustainable growth and complication thereof have become serious public health problem, also be the problem of a restriction development simultaneously, nearly 500,000,000 people are being faced with the following high-risk risk of suffering from diabetes, and onset diabetes presents the trend of rejuvenation.
Although current science is advanced by leaps and bounds, medical research is maked rapid progress, and global diabetologist all, in the method for unremitting effort research radical cure diabetes, is limited to current medical science level, and diabetes remain a kind of disease that can not effect a radical cure.It treats difficult point not in diabetes itself, but is the complication that diabetes cause.Aspect medicine, the Western medicine for the treatment of diabetes is mainly sulfonylureas drugs for diabetes, biguanides and insulin at present, and these a few class medicine blood sugar reducing functions are fast, good effect, but toxic and side effects is large, and obvious to organ injuries such as Liver and kidney.Therefore, diabetics not only expects that medical science develops treatment diabetes effective medicine, is also concerned about diabetes are had to the health product that assosting effect toxic and side effects is little.The object of auxiliary hyperglycemic class health product is not in order to treat, but improves symptom in order to realize, and prevents and delay the effect of complication.
Four of main flow kinds of blood sugar lowering natural extracts respectively in the market: Fructus Momordicae charantiae (main active is " Fructus Momordicae charantiae glucoside " and " Fructus Momordicae charantiae peptide "); India's Largeleaf Gymnema (main component is " gymnemic acid "); Calabash Fructus Crotonis (main component is trigonella bean gum); Cortex Cinnamomi powder (main component is " cinnamic acid ").
Summary of the invention
The object of the invention is for non-insulin-dependent diabetes mellitus (NIDDM) crowd provides a kind of effect remarkable, be applicable to the functional health care product with auxiliary hyperglycemic effect of long-term taking.
Implementation procedure of the present invention is as follows:
A kind of health product with auxiliary hyperglycemic function, taking hesperetin, Fructus Momordicae charantiae extract, Radix Panacis Quinquefolii extract and wolfberry fruit extract as primary raw material, each component is counted by weight: 150～230 parts of hesperetins, 100～200 parts of Fructus Momordicae charantiae extracts, 20～80 parts of Radix Panacis Quinquefolii extracts, 100～200 parts of wolfberry fruit extracts.
Preferred technical scheme is: 200 parts of hesperetins, 150 parts of Fructus Momordicae charantiae extracts, 50 parts of Radix Panacis Quinquefolii extracts, 150 parts of wolfberry fruit extracts.
The dosage form that above-mentioned health product can be prepared is enteric coated tablet or enteric coated capsule.
Described enteric coated tablet preparation process is as follows:
(1) weigh dry each raw material according to proportioning, make extractum taking water and ethanol as solvent, the dry extract powder of making of spraying, crosses 80 mesh sieves;
(2) extract powder and microcrystalline Cellulose are mixed, sieved granulation;
(3) granule after sieving is dried to the rear 16 mesh sieve granulate of crossing;
(4) finally add magnesium stearate, make tablet;
(5) select enteric solubility film coating pre-mix dose to carry out coating as coating material, polishing is dried and is made the functional blood sugar lowering health-care tablet of enteric film coating.
Described enteric coated capsule preparation process is as follows:
(1) weigh dry each raw material according to proportioning, make extractum taking water and ethanol as solvent, the dry extract powder of making of spraying, crosses 80 mesh sieves;
(2) get extract powder and add 75% ethanol wet-method extrusion granulation, then particle drying to water content is less than to 5%, 40 mesh sieve granulate;
(3) select enteric solubility film coating pre-mix dose as coating material, granule is carried out coating and dried;
(4) dried granule is passed through to capsule filling machine filled capsules, the capsule of having loaded is placed in to buffing machine polishing, reject damaged capsule, pack and obtain enteric Jiangtang capsule.
In above-mentioned enteric coated tablet and enteric coated capsule preparation, the water that step (1) is described and the ratio of ethanol are 4:1.
In the preparation of above-mentioned enteric coated tablet, the content of the described microcrystalline Cellulose of step (2) is 20%, and loss on drying must not exceed 5%.
Above-mentioned health product are used in preparation treatment diabetes medicament or health product, particularly type 2 diabetes mellitus.
Hesperetin (hesperetin) in component of the present invention is the one of flavanone, is the main pharmacodynamics composition of Rutaceae citrus plant fruit.Its multifunctionality causes people's concern, and hesperetin itself just has more pharmaceutical properties, as it has the effects such as hyperglycemia, anticancer, antibacterial, antifungal and antiviral.Hesperetin source is comparatively extensive, be mainly from Hesperidin hydrolysis, and Hesperidin can extract and obtain from the Fruit Peel sarcocarp such as Citrus.Modern pharmacological research shows that in hesperetin, Hesperidin isoreactivity material has remarkable hypoglycemic activity.Because the low price of hesperetin is efficient, it is increased day by day in blood sugar lowering field attention rate.
Fructus Momordicae charantiae has another name called balsam pear, is cucurbitaceous plant, and abnormal smells from the patient hardship, nontoxic, cold in nature, enters the heart, liver, spleen, lung meridian.There is clearing summer heat, improving eyesight removing toxic substances, reducing pressure and sugar, diuresis removing heat from blood, separate that labor clears away heart-fire, effect of QI invigorating tonifying YANG.The Compendium of Material Medica of the Ming Dynasty claims, Fructus Momordicae charantiae can " except pathogenic heat, separate tired, improving eyesight clears away heart-fire ".It also has good blood sugar lowering, antiviral and anti-cancer effect.The composition that plays hypoglycemic activity in Fructus Momordicae charantiae is mainly divided into two classes by its character: a class is alkaloid, as Fructus Momordicae charantiae glucoside, Fructus Momordicae charantiae saponin etc.; Another kind of is protein peptide, be in Fructus Momordicae charantiae content at most, the most significant part of blood sugar decreasing effect.Fructus Momordicae charantiae can promote the composition of insulin secretion, has and helps to control blood glucose, the effect of prevent diabetes.Fructus Momordicae charantiae is a kind of pure natural plant ingredients, by activating insulin, activating Insulin receptor INSR, improves insulin effective rate of utilization and regulates blood glucose, thereby realize the object that blood glucose is expressed according to the human normal physiology natural law, and be free from side effects.
Fructus Momordicae charantiae extract in component of the present invention is the bioactive ingredients extracting from fresh special bitter melon seed plumule, has significant adjusting blood glucose effect.Extracting method: Fructus Momordicae charantiae extract is that whole part extracts, and is that to be dried Fructus Momordicae charantiae be raw material, taking water as solvent, 10 times of water gaging boilings are extracted three times, each 2 hours, merge the extracting solution of three times, concentration and evaporation water is to the extractum of proportion d=1.10-1.15, spraying is dry, obtains Fructus Momordicae charantiae extract powder, through pulverizing, sieve, mix, packaging, obtains Fructus Momordicae charantiae extract finished product.
Radix Panacis Quinquefolii extract in component of the present invention is through 70% ethanol extraction, concentrated, dry making.Radix Panacis Quinquefolii is the one of Radix Ginseng, derives from the dry root of Araliaceae Radix Panacis Quinquefolii Panax quinquefolium L..Radix Panacis Quinquefolii has YIN nourishing and QI supplementing, the mind calming and mentality promoting and clearing away heat and promoting production of body fluid, the double effects that pathogenic fire reducing is relieved summer heat.Modern medicine study proves, Radix Panacis Quinquefolii has resisting fatigue, defying age, shock, raising thinking, improves memory and endocrine regulation, enhancing body immunity and improve the effects such as cardiovascular function.Radix Panacis Quinquefolii extract can reduce blood glucose, regulates insulin secretion, promote carbohydrate metabolism and lipid metabolism, treatment diabetes are had to certain assosting effect.
Wolfberry fruit extract in component of the present invention is to extract as extracting solution using water, and extracting method comprises Fructus Lycii alcoholic solution pretreatment, through pretreated Fructus Lycii distilled water extraction.Fructus Lycii is the dry fruit of plant of Solanaceae lycium barbarum (Lycium barbarum L).Nature and flavor are sweet flat, have nourishing the liver and kidney, and effect " Jing Yue's complete work book on Chinese herbal medicine just " of replenishing vital essence to improve eyesight claims it " especially only to quench one's thirst ".Modern pharmacological research wolfberry fruit extract has the multiple physiological functions such as the immunity of enhancing, blood sugar lowering, blood fat reducing, anti-fatty liver, antitumor, defying age, anti-stress.Active component lycium barbarum polysaccharide in medicine wolfberry fruit extract, the trend that serum insulin levels is improved, and have the function of repairing damaged islet cells and promoting pancreatic cell regeneration.Lycium barbarum polysaccharide can obviously strengthen the activity of SOD in damaged islet cells, improves the oxidation resistance of islet cells.
The eighteen incompatible medicaments of above-mentioned composition and Chinese medicine, nineteen medicaments of mutual restraint does not conflict.Above-mentioned composition all has effect of lowering blood sugar, and stack is used can strengthen effect of lowering blood sugar, can also tonify Qi of the kidney, promoting the production of body fluid to quench thirst, grows spleen lung moistening, replenishing vital essence to improve eyesight, and the tonify deficiency of regulating the flow of vital energy, interior-heat is quenched one's thirst, and strengthening body improves body immunity.
Above-mentioned composition is the material of integration of edible and medicinal herbs, has effect of lowering blood sugar, can make functional blood sugar reducing health product through science compatibility, and dosage form can be tablet, capsule.For ensureing that one of the effective ingredient of Fructus Momordicae charantiae Fructus Momordicae charantiae peptide is not hydrolyzed and loses function of reducing blood sugar at gastric, blood sugar reducing health product of the present invention are preferably made enteric coated tablet or enteric coated capsule.
The using method of functional hypoglycemia healthcare food of the present invention: type 2 diabetes mellitus crowd takes each dosage form blood sugar reducing health product of being made up of compound hypoglycemic composition of the present invention, each serving with 2 capsules or 2 tablets of tablets, every day 2 times, sooner or later respectively once, edible on an empty stomach.
The present invention is according to pathology and the metabolic characteristic of non-insulin-dependent diabetes mellitus (NIDDM), by activating insulin, activating Insulin receptor INSR, regulate insulin secretion and improve insulin effective rate of utilization, promote carbohydrate metabolism and lipid metabolism to regulate blood glucose, and then the generation of complication prevention.Compared with prior art, the present invention is taking hesperetin, Fructus Momordicae charantiae extract, Radix Panacis Quinquefolii extract, wolfberry fruit extract as primary raw material, by science compatibility, suitable processes forms, through the evidence of animal function assessment, this product has the health care of assistant hypoglycemic to non-insulin-dependent diabetes mellitus (NIDDM) diabetes patient, be a kind of effective, have no side effect, blood sugar reducing health product that cost is low.
Detailed description of the invention
Below in conjunction with specific embodiment, technical solution of the present invention is described:
Embodiment 1: the functional blood sugar lowering tablet of enteric film coating
The functional blood sugar lowering tablet of a kind of enteric film coating, described health-caring product capable of reducing blood sugar is made up of following composition: hesperetin (purchased from Shaanxi Hui Ke plant development corporation, Ltd.) 100g, Fructus Momordicae charantiae extract (purchased from Shaanxi Ang Sheng biological medicine Science and Technology Ltd.) 75g, Radix Panacis Quinquefolii extract (purchased from Ningbo Dong Te Chemical Co., Ltd.) 25g, wolfberry fruit extract (purchased from Ningbo Dong Te Chemical Co., Ltd.) 75g.
The preparation method of the above-mentioned functional blood sugar lowering tablet of enteric film coating with blood sugar reducing function is as follows:
(1) weigh dry each raw material according to proportioning, each raw material is placed in to container, make extractum taking water and ethanol (4:1) as solvent, the dry extract powder of making of spraying, crosses 80 mesh sieves;
(2) get extract powder and microcrystalline Cellulose and put in mixer and mix, the content of microcrystalline Cellulose is 20%, and loss on drying must not exceed 5%, by the granulation of sieving of the extract powder obtaining and microcrystalline cellulose mixt;
(3) granule after sieving is laid on drip pan, thickness is in 1cm left and right, and it is dry that drip pan is placed in 50 DEG C of air dry ovens.After drying, cross 16 mesh sieve granulate;
(4) finally add magnesium stearate, and whole mixture is stirred 5 minutes, mixture is pressed into tablet with conventional pelleter;
(5) select enteric solubility film coating pre-mix dose to carry out coating as coating material, polishing is dried and is made the functional blood sugar lowering health-care tablet of enteric film coating.
Embodiment 2: the functional blood sugar lowering health-care tablet of enteric film coating
The functional blood sugar lowering health-care tablet of a kind of enteric film coating, described blood sugar lowering, blood fat reducing health products are made up of following composition: hesperetin 100g, Fructus Momordicae charantiae extract 85g, Radix Panacis Quinquefolii extract 25g, wolfberry fruit extract 65g.
Preparation method as described in Example 1.
Embodiment 3: enteric film coating blood sugar lowering tablet
The functional blood sugar lowering health-care tablet of a kind of enteric film coating, described blood sugar lowering, blood fat reducing health products are made up of following composition: hesperetin 100g, Fructus Momordicae charantiae extract 65g, Radix Panacis Quinquefolii extract 25g, wolfberry fruit extract 85g.
Preparation method as described in Example 1.
Embodiment 4: enteric Jiangtang capsule agent
The functional blood sugar lowering health-care tablet of a kind of enteric film coating, described blood sugar lowering, blood fat reducing health products are made up of following composition: hesperetin 100g, Fructus Momordicae charantiae extract 75g, Radix Panacis Quinquefolii extract 25g, wolfberry fruit extract 75g.
The preparation method of the above-mentioned enteric Jiangtang capsule agent with assistant hypoglycemic effect is as follows:
(1) weigh dry each raw material according to proportioning, each raw material is placed in to container, make extractum taking water and ethanol (4:1) as solvent, the dry extract powder of making of spraying, crosses 80 mesh sieves;
(2) get extract powder and add 75% ethanol wet-method extrusion granulation, then granule is laid on drip pan, thickness is in 1cm left and right, and it is dry that drip pan is placed in 50 DEG C of air dry ovens, and granule water content must not exceed 5%.After drying, cross 40 mesh sieve granulate;
(3) select enteric solubility film coating pre-mix dose, as coating material, granule is carried out to coating, and dry;
(4) dried granule is passed through to capsule filling machine, filled capsules, is placed in buffing machine polishing by the capsule of having loaded, and rejects damaged capsule, packs and obtain enteric Jiangtang capsule.
Embodiment 5: enteric Jiangtang capsule agent
Compound auxiliary hyperglycemic has health product for effect for reducing blood fat concurrently, and described blood sugar lowering, blood fat reducing health products are made up of following composition: hesperetin 100g, Fructus Momordicae charantiae extract 85g, Radix Panacis Quinquefolii extract 25g, wolfberry fruit extract 65g.
Preparation method as described in Example 4.
Embodiment 6: enteric Jiangtang capsule agent
A kind of compound auxiliary hyperglycemic has the health product of effect for reducing blood fat concurrently, described blood sugar lowering, blood fat reducing health products are made up of following composition: hesperetin 100g, Fructus Momordicae charantiae extract 65g, Radix Panacis Quinquefolii extract 25g, wolfberry fruit extract 85g, taking these four kinds of components as functional mass, the preparation method of capsule is processed into Jiangtang capsule routinely.
Preparation method as described in Example 4.
Embodiment 7: auxiliary hyperglycemic function zoopery
The present invention has carried out auxiliary hyperglycemic function zoopery, and proved health promoting product safety non-toxic, has auxiliary hyperglycemic function to animal, and experimentation and result are as follows:
1. experiment material and condition: 50 of clean level male SD rats, body weight (180 ± 20) g, provided by the Fourth Military Medical University of P.L.A's Experimental Animal Center, SD rat sub-cage rearing is indoor in laboratory animal, 4～5, every cage, 20 ± 2 DEG C of room temperatures, relative humidity 60 ± DEG C, raise with normal diet the water of freely ingesting.Except experiment without other pessimal stimulations.Streptozotocin (Streptozocin, STZ), is produced by Sigma company of the U.S., purchased from Wei Jin bio tech ltd, Shanghai.High fat (high sugar) feedstuff, oneself is prepared.
2. STZ type 2 diabetes mellitus Establishment of Rat Model and administration: high fat diet induction adds low dose of streptozotocin (Streptozocin, STZ).Before modeling, feed with high fat (high sugar) feedstuff, induce insulin resistant.
High fat (high sugar) feed ingredient: wherein containing 10 sucrose, 10 Adeps Sus domesticas, 5 cholesterol.By basic Mus feedstuff with sucrose, refining Adeps Sus domestica and egg yolk in making high-sugar-fat-diet than collocation: its ratio is Adeps Sus domestica 18, sucrose 20, egg yolk 3, normal feedstuff 59.
After the rat laundering period, get at random 10 as Normal group, all the other 40 give high glucose and high fat feedstuff.High glucose and high fat forage feed, after one month, is given amount 40mg by the every kg of body weight, before disposable celiac injection STZ(injection, dissolves STZ with citrate buffer solution with the concentration of 0.1g/l).Normal group normal diet is fed one month, then injects equivalent citrate buffer solution.After injection 72h, get blood from rat tail vein, centrifugalize serum, measure fasting glucose and insulin level, blood glucose value 16.5mmol/L person is defined as to diabetes model rat, be divided at random again matched group, model group, metformin (0.1g/kg) group, functional blood sugar lowering health-care tablet (Preparation Example 1) heavy dose of (0.20g/kg) and low dose of (0.10g/kg) group, each medication group adopts gastric infusion, matched group and model group give same volume distilled water, once a day, continuous 30 days, after last administration, use pentobarbital sodium 40mg/kg dosage intraperitoneal injection of anesthesia rat, get blood from rat aorta, centrifugalize serum, method is measured fasting glucose, insulin, blood fat (TC, the biochemical indicator such as TG), serum glucose glucose oxidase method, serum total cholesterol, enzymatic assays SOD activity for triglyceride, measure MDA with xanthine oxidase, by thiobarbituricacidα-TBA method.Serum insulin is pressed radioimmunology scheme and is measured.
3. measurement result
3.1 impacts of functional hypoglycemia healthcare food on blood glucose in diabetic rats level
By the heavy dose of group of the known functional hypoglycemia healthcare food of table 1 in administration after 30 days, serum glucose and model group relatively have significance poor (P<0.05), blood sugar reducing function intensity is similar to metformin, small dose group blood glucose also has downward trend, and the functional hypoglycemia healthcare food of results suggest has obvious blood sugar reducing function to STZ blood glucose in diabetic rats.
3.2 impacts of functional hypoglycemia healthcare food on blood lipid level
As shown in Table 2, give after STZ diabetes rat gavage energy health-caring product capable of reducing blood sugar 30d, can the heavy dose of group of property health-caring product capable of reducing blood sugar all there is obvious reducing effect to serum total cholesterol and content of triglyceride, small dose group also has certain reduction trend, and results suggest energy health-caring product capable of reducing blood sugar has certain effect for reducing fat to STZ diabetes rat.
3.3 impacts of functional hypoglycemia healthcare food on STZ diabetes rat serum insulin levels
From table 3; after injection STZ; diabetes rat serum insulin obviously declines; after administration 30d; be increased significantly with the heavy dose of group of model group comparison functionality hypoglycemia healthcare food rat blood serum insulin level; small dose group also has rising trend, but not obvious. and the functional hypoglycemia healthcare food of results suggest has certain protective effect to the damage of islet cells due to STZ.
This experimental result shows: there were significant differences compared with rat matched group for functional health-caring product capable of reducing blood sugar group of the present invention, functions health-caring product capable of reducing blood sugar can significantly reduce blood glucose in diabetic rats value due to STZ, also can significantly reduce Triglycerides in Serum and cholesterol levels, to improve blood fat, rising insulin level, and the damage that alleviates islet cells, confirm that functional health-caring product capable of reducing blood sugar has blood sugar lowering, has the effect of blood fat reducing concurrently.
Embodiment 8: the contrast test of blood sugar reducing function
Probe into the blood sugar reducing function of functional hypoglycemia healthcare food and single extract, as shown in table 4 on the impact of STZ diabetes rat insulin level.
Experimental result shows: the functional health-caring product capable of reducing blood sugar group of the present invention has notable difference compared with single extract group, the more single extract of functions health-caring product capable of reducing blood sugar is more remarkable to diabetes rat blood sugar reducing function due to STZ, confirms that the functional health-caring product capable of reducing blood sugar hypoglycemic effect after four kinds of extract combination is better than one-component.
Claims (9)
1. there are health product for auxiliary hyperglycemic function, it is characterized in that each component counts by weight: 150～230 parts of hesperetins, 100～200 parts of Fructus Momordicae charantiae extracts, 20～80 parts of Radix Panacis Quinquefolii extracts, 100～200 parts of wolfberry fruit extracts.
2. there are according to claim 1 the health product of auxiliary hyperglycemic function, it is characterized in that each component counts by weight: 200 parts of hesperetins, 150 parts of Fructus Momordicae charantiae extracts, 50 parts of Radix Panacis Quinquefolii extracts, 150 parts of wolfberry fruit extracts.
3. according to the health product described in claim 1 or 2 with auxiliary hyperglycemic function, the dosage form that it is characterized in that described health product is enteric coated tablet or enteric coated capsule.
4. described in claim 3, there is the preparation method of auxiliary hyperglycemic function health product, it is characterized in that enteric coated tablet preparation process is as follows:
(1) weigh dry each raw material according to proportioning, make extractum taking water and ethanol as solvent, the dry extract powder of making of spraying, crosses 80 mesh sieves;
(2) extract powder and microcrystalline Cellulose are mixed, sieved granulation;
(3) granule after sieving is dried to the rear 16 mesh sieve granulate of crossing;
(4) finally add magnesium stearate to make tablet;
(5) select enteric solubility film coating pre-mix dose to carry out coating as coating material, polishing is dried and is made the functional blood sugar lowering health-care tablet of enteric film coating.
5. described in claim 3, there is the preparation method of auxiliary hyperglycemic function health product, it is characterized in that enteric coated capsule preparation process is as follows:
(1) weigh dry each raw material according to proportioning, make extractum taking water and ethanol as solvent, the dry extract powder of making of spraying, crosses 80 mesh sieves;
(2) get extract powder and add 75% ethanol wet-method extrusion granulation, then particle drying to water content is less than to 5%, 40 mesh sieve granulate;
(3) select enteric solubility film coating pre-mix dose as coating material, granule is carried out coating and dried;
(4) dried granule is passed through to capsule filling machine filled capsules, the capsule of having loaded is placed in to buffing machine polishing, reject damaged capsule, pack and obtain enteric Jiangtang capsule.
6. according to the preparation method described in claim 4 or 5 with auxiliary hyperglycemic function health product, it is characterized in that: the water that step (1) is described and the volume ratio of ethanol are 4:1.
7. the preparation method with auxiliary hyperglycemic function health product according to claim 4, is characterized in that: the described microcrystalline cellulose cellulose content of step (2) is 20%, and loss on drying is no more than 5%.
8. the application of health product in preparation treatment diabetes medicament or health product described in claim 1.
9. application according to claim 8, described diabetes are type 2 diabetes mellitus.
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| CN104397716A (en) * | 2014-12-10 | 2015-03-11 | 韦星平 | Hypoglycemic natural food additive |
| CN105395706A (en) * | 2015-11-30 | 2016-03-16 | 重庆宏洋生物科技有限公司 | Health care product for diabetes |
| CN106982885A (en) * | 2017-04-19 | 2017-07-28 | 湖南华诚生物资源股份有限公司 | A kind of arhat fruit cookie and preparation method thereof |
| CN107173812A (en) * | 2017-07-14 | 2017-09-19 | 贵州省苑博生态农业开发有限公司 | A kind of Kiwi fruit health product and preparation method thereof |
| CN108783414A (en) * | 2018-05-04 | 2018-11-13 | 中南大学 | A kind of Guava Leaf health-caring product capable of reducing blood sugar and preparation method thereof |
| CN109362940A (en) * | 2018-10-12 | 2019-02-22 | 常同喜 | A kind of preparation method of marine collagen peptide and antihypelipidemic preparation |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109362940A (en) * | 2018-10-12 | 2019-02-22 | 常同喜 | A kind of preparation method of marine collagen peptide and antihypelipidemic preparation |
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