CN110179711A - A kind of Essence and preparation method for repairing keratoderma barrier - Google Patents
A kind of Essence and preparation method for repairing keratoderma barrier Download PDFInfo
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- CN110179711A CN110179711A CN201910557064.4A CN201910557064A CN110179711A CN 110179711 A CN110179711 A CN 110179711A CN 201910557064 A CN201910557064 A CN 201910557064A CN 110179711 A CN110179711 A CN 110179711A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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Abstract
The present invention relates to a kind of Essence for repairing keratoderma barrier, the Essence uses multiple lipid encapsulation ceramide, promotes skin high energy absorption, simulates sebum film form, realizes intensive moisturizing, water lock, improves water content of stratum corneum；The present invention selects the moisturizer such as a variety of natural plant extracts and Jojoba wax PEG-120 esters, significantly glossy skin, vertical existing vivid gloss can improve skin tired out sense, skin feel bullet profit is fine and smooth, isolation harmful environmental substance, protection skin；And natural plant extracts safety is higher, can be used in sensitive skin；Essence of the invention can greatly accelerate skin repair, and the skin for enabling cuticula impaired is more quickly restored to health status, can clearly be seen that keratoderma barrier recovery situation is good after using six days, the 7th day level close to healthy skin；And after using fortnight, skin can achieve skin gully and understand, surface is restored from faulted condition without the situation obviously damaged.
Description
Technical field
The invention belongs to skin care fields, and in particular to it is a kind of repair keratoderma barrier Essence and its preparation side
Method.
Background technique
Naturally occurring lamellar gel phase lipid structure, the protection for being difficult to permeate is provided for skin in keratoderma
Layer, protects the skin from external irritant, while reducing excessive water and being lost and provide good hydratability, softness for skin
Degree, elasticity and slickness degree.
But in daily life, because being influenced by ultraviolet light, external force or chemical etc., the layer of keratoderma
Shape structural disorder when dyskeratosis, will lead to the appearance of skin problem.Therefore the stratum corneum barrier damage for repairing skin has
Vital meaning.
However existing skin care item seldom have reparation keratoderma barrier or similar effect in the prior art, generally
It is kept the skin wet with skin care item to damage skin, then allows skin self-healing after the growth cycle of oneself.And according to the table of skin
Skin is metabolized the period, this process needs at least 28 days, and in the meantime, damaged skin is easy to by extraneous factor especially microorganism
It influences, and new problem occurs.
Summary of the invention
The purpose of the present invention is to provide a kind of Essences for repairing keratoderma barrier, so that impaired skin keratin
Layer barrier resume speed significantly provides, and substantially reduces probability of the damaged skin by secondary injury.
The present invention is realized by following means:
The present invention provides a kind of Essences for repairing keratoderma barrier, including hexapeptide -11, hydrolysis pyrenomycetes
(SCLEROTIUM ROLFSSII) glue, ring five dimethyl silicone polymer, silver, ceramide -3, plant extracts, polyalcohol, table
Face activating agent, moisturizer, water；
Preferably, the mass percentage of each ingredient is as follows: -11 0.1-0.2% of hexapeptide, hydrolysis pyrenomycetes
(SCLEROTIUM ROLFSSII) glue 0.1-0.5%, ring five dimethyl silicone polymer 0.5-0.8%, silver 0.1-0.5%, nerve
- 3 0.1-0.5% of amide, it plant extracts 0.01-2.4%, polyalcohol 0.1-16%, surfactant 0.01-1.44%, protects
Humectant 0.1-1.1%；
Preferably, the plant extracts is selected from close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf extract, product
Avenge careless (CENTELLAASIATICA) extract, polygonum cuspidate (POLYGONUM CUSPIDATUM) root extract, radix scutellariae
(SCUTELLARIA BAICALENSIS) root extract, tea (CAMELLIA SINENSIS) leaf extract, glycyrrhiza glabra
(GLYCYRRHIZA GLABRA) root extract, german chamomile (CHAMOMILLA RECUTITA) flower extract, rosemary
(ROSMARINUSOFFICINALIS) one of leaf extract, cloves (SYZYGIUM AROMATICUM) oil or a variety of；
Preferably, the polyalcohol is selected from one of glycerol, butanediol, propylene glycol, 1,2- hexylene glycol or a variety of；
Preferably, the surfactant is selected from cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, hydrogenation ovum
One of phosphatide, sucrose stearate, Natrulon H-10 stearate are a variety of；
Preferably, the moisturizer is selected from Sodium Hyaluronate, Jojoba wax PEG-120 esters, tetrahydro methylpyrimidine carboxylic acid
One of or it is a variety of；
Further, mass percent is also contained in the Essence for repairing keratoderma barrier is 0.1-0.5%
Preservative；
Preferably, the preservative is selected from parahydroxyacet-ophenone；
It further, is also 0.1-1.5%'s containing mass percent in the Essence of the multiple keratoderma barrier
Thickener；
Preferably, the thickener is in xanthan gum, Gantrez AN-119, glyceryl acrylate/acrylic copolymer
It is one or more；
Preferably, the Essence for repairing keratoderma barrier, the component comprising following mass percentage:
- 11 0.1-0.2% of hexapeptide,
Pyrenomycetes (SCLEROTIUM ROLFSSII) glue 0.1-0.5% is hydrolyzed,
Ring five dimethyl silicone polymer 0.5-0.8%,
Silver-colored 0.1-0.5%,
- 3 0.1-0.5% of ceramide,
Close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf extract 1-2%,
Centella (CENTELLAASIATICA) extract 0.01-0.05%,
Polygonum cuspidate (POLYGONUM CUSPIDATUM) root extract 0.01-0.05%,
Radix scutellariae (SCUTELLARIA BAICALENSIS) root extract 0.01-0.05%,
Tea (CAMELLIA SINENSIS) leaf extract 0.01-0.05%,
Glycyrrhiza glabra (GLYCYRRHIZA GLABRA) root extract 0.01-0.05%,
German chamomile (CHAMOMILLA RECUTITA) flower extract 0.01-0.05%,
Rosemary (ROSMARINUSOFFICINALIS) leaf extract 0.01-0.05%,
Cloves (SYZYGIUM AROMATICUM) oil 0.01-0.05%,
Glycerol 10-11%,
Butanediol 2-4%,
Propylene glycol 0.1-0.5%,
1,2- hexylene glycol 0.1-0.5%,
Cetostearyl alcohol olive oleate 0.2-0.4%,
The smooth olive oleate 0.1-0.2% of sorb,
Hydrolecithin 0.3-0.8%,
Sucrose stearate 0.01-0.02%,
Natrulon H-10 stearate 0.01-0.02%,
Sodium Hyaluronate 0.1-0.3%,
Jojoba wax PEG-120 esters 0.1-0.3%,
Tetrahydro methylpyrimidine carboxylic acid 0.1-0.5%,
Parahydroxyacet-ophenone 0.1-0.5%,
Xanthan gum 0.1-0.5%,
Gantrez AN-119 0.1-0.5%,
Glyceryl acrylate/acrylic copolymer 0.1-0.5%,
Water.
Invention further provides the preparation method of the Essence of above-mentioned reparation keratoderma barrier, the preparation sides
Method includes the following steps:
(1) each raw material is weighed by above-mentioned formula and mass percent；
(2) glycerol, Sodium Hyaluronate, water are added in water phase agitated kettle, stirring is warming up to 80-85 DEG C and keeps the temperature 30min；
Cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, ring five dimethyl silicone polymer are added in oily phase agitated kettle, stirred
It mixes and is warming up to 80-85 DEG C and keeps the temperature 5min；
(3) under the conditions of 80-85 DEG C of temperature, water phase is pumped into emulsion pot and is stirred, revolving speed 30-50rpm；It is then turned on
Vacuum pump, then it is mutually pumped into emulsion pot and opens homogenizer by oily, revolving speed 3000rpm keeps 5min；
(4) stirring is cooled to 50 DEG C, and close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf extract, nerve is added
Amide 3, sucrose stearate, Natrulon H-10 stearate, hexapeptide -11, parahydroxyacet-ophenone, hydrolysis pyrenomycetes
(SCLEROTIUM ROLFSSII) glue, centella (CENTELLAASIATICA) extract, polygonum cuspidate (POLYGONUM
CUSPIDATUM) root extract, radix scutellariae (SCUTELLARIA BAICALENSIS) root extract, tea (CAMELLIA
SINENSIS) leaf extract, glycyrrhiza glabra (GLYCYRRHIZA GLABRA) root extract, german chamomile (CHAMOMILLA
RECUTITA) flower extract, rosemary (ROSMARINUSOFFICINALIS) leaf extract, tetrahydro methylpyrimidine carboxylic acid, glycerol
Acrylate/acrylic copolymer, silver, cloves (SYZYGIUM AROMATICUM) oil, stir evenly, after the assay was approved, filtering
It discharges filling.
The present invention has the effect that compared with the existing technology
(1) present invention uses multiple lipid encapsulation ceramide, promotes skin high energy absorption, simulates sebum film form, real
Now intensive moisturizing, improves water content of stratum corneum at water lock；
(2) present invention selects the moisturizer such as a variety of natural plant extracts and Jojoba wax PEG-120 esters, Neng Gouxian
Glossy skin is write, existing vivid gloss is found, improves skin tired out sense, skin feel bullet profit is fine and smooth, and harmful environmental substance, protection is isolated
Skin；And natural plant extracts safety is higher, can be used in sensitive skin；
(3) Essence of the invention can greatly accelerate skin repair, and the skin for enabling cuticula impaired is relatively quickly extensive
Health status is arrived again, and it is good to can clearly be seen keratoderma barrier recovery situation after using of the invention Essence six days
It is good, the 7th day level close to healthy skin；And using after fortnight, skin can achieve skin gully and understand, surface without
The situation obviously damaged, restores from faulted condition.
Detailed description of the invention
Fig. 1 is healthy skin state diagram, and wherein 1a is skin condition at test point 1, and 1b is skin condition at test point 2.
Fig. 2 is the state diagram of test point 1 and test point 2 after barrier breakdown 0.5h, and wherein 2a is test point 1, and 2b is to survey
Pilot 2.
Fig. 3 is the state diagram for carrying out treated the 1st day test point 1 and test point 2, and wherein 3a is test point 1, and 3b is to survey
Pilot 2.
Fig. 4 is the state diagram for carrying out treated the 2nd day test point 1 and test point 2, and it is survey that wherein 4a, which is test point Isosorbide-5-Nitrae b,
Pilot 2.
Fig. 5 is the state diagram for carrying out treated the 4th day test point 1 and test point 2, and wherein 5a is test point 1, and 5b is to survey
Pilot 2.
Fig. 6 is the state diagram for carrying out treated the 6th day test point 1 and test point 2, and wherein 6a is test point 1, and 6b is to survey
Pilot 2.
Fig. 7 is the state diagram for carrying out treated the 7th day test point 1 and test point 2, and wherein 7a is test point 1, and 7b is to survey
Pilot 2.
Fig. 8 is the state diagram for carrying out treated the 14th day test point 1 and test point 2, and wherein 8a is test point 1, and 8b is
Test point 2.
Fig. 9 is that Essence TEWL of the present invention improves experimental result.
Specific embodiment
Below in conjunction with the embodiment of the present invention and Figure of description, technical solution in the embodiment of the present invention carries out clear
Chu is fully described by, it is clear that described embodiment is only a part of the embodiment of the present invention, rather than whole implementation
Example.Based on the embodiments of the present invention, obtained by those of ordinary skill in the art without making creative efforts
Every other embodiment, shall fall within the protection scope of the present invention.
Embodiment 1
A kind of Essence for repairing keratoderma barrier, composition and mass percent are as follows:
Hexapeptide -11 0.1%,
Pyrenomycetes (SCLEROTIUM ROLFSSII) glue 0.1% is hydrolyzed,
Ring five dimethyl silicone polymer 0.8%,
Silver 0.5%,
Ceramide -3 0.5%,
Close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf extract 1%,
Centella (CENTELLAASIATICA) extract 0.01%,
Polygonum cuspidate (POLYGONUM CUSPIDATUM) root extract 0.01%,
Radix scutellariae (SCUTELLARIA BAICALENSIS) root extract 0.05%,
Tea (CAMELLIA SINENSIS) leaf extract 0.05%,
Glycyrrhiza glabra (GLYCYRRHIZA GLABRA) root extract 0.05%,
German chamomile (CHAMOMILLA RECUTITA) flower extract 0.01%,
Rosemary (ROSMARINUSOFFICINALIS) leaf extract 0.01%,
Cloves (SYZYGIUM AROMATICUM) oil 0.01%,
Glycerol 10%,
Butanediol 2%,
Propylene glycol 0.1%,
1,2- hexylene glycol 0.1%,
Cetostearyl alcohol olive oleate 0.3%,
The smooth olive oleate 0.2% of sorb,
Hydrolecithin 0.3%,
Sucrose stearate 0.02%,
Natrulon H-10 stearate 0.02%,
Sodium Hyaluronate 0.1%,
Jojoba wax PEG-120 esters 0.1%,
Tetrahydro methylpyrimidine carboxylic acid 0.1%,
Parahydroxyacet-ophenone 0.2%,
Xanthan gum 0.1%,
Gantrez AN-119 0.1%,
Glyceryl acrylate/acrylic copolymer 0.1%,
Surplus is water.
The Essence of above-mentioned reparation keratoderma barrier, is prepared via a method which to obtain:
(1) each raw material is weighed by above-mentioned formula and mass percent；
(2) glycerol, butanediol, Sodium Hyaluronate, xanthan gum, water are added in water phase agitated kettle, stirring is warming up to 80-85
DEG C and keep the temperature 30min；Cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, ring five dimethyl silicone polymer are added
In oily phase agitated kettle, stirring is warming up to 80-85 DEG C and keeps the temperature 5min；
(3) under the conditions of 80-85 DEG C of temperature, water phase is pumped into emulsion pot and is stirred, revolving speed 30-50rpm；It is then turned on
Vacuum pump, then it is mutually pumped into emulsion pot and opens homogenizer by oily, revolving speed 3000rpm keeps 5min；
(4) stirring be cooled to 50 DEG C, be added close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf extract, flash
Bar wax PEG-120 esters, Cer NP, hydrolecithin, sucrose stearate, Natrulon H-10 stearate, hexapeptide -11,
1,2- hexylene glycol, parahydroxyacet-ophenone, hydrolysis pyrenomycetes (SCLEROTIUM ROLFSSII) glue, centella
(CENTELLAASIATICA) extract, polygonum cuspidate (POLYGONUM CUSPIDATUM) root extract, radix scutellariae (SCUTELLARIA
BAICALENSIS) root extract, tea (CAMELLIA SINENSIS) leaf extract, glycyrrhiza glabra (GLYCYRRHIZA
GLABRA) root extract, german chamomile (CHAMOMILLA RECUTITA) flower extract, rosemary
(ROSMARINUSOFFICINALIS) leaf extract, tetrahydro methylpyrimidine carboxylic acid, propylene glycol, Gantrez AN-119, glycerol propylene
Acid esters/acrylic copolymer, silver, cloves (SYZYGIUM AROMATICUM) oil, stir evenly, after the assay was approved, filtering and discharging
It is filling.
Embodiment 2
A kind of Essence for repairing keratoderma barrier, composition and mass percent are as follows:
Hexapeptide -11 0.2%,
Pyrenomycetes (SCLEROTIUM ROLFSSII) glue 0.3% is hydrolyzed,
Ring five dimethyl silicone polymer 0.6%,
Silver 0.3%,
Ceramide -3 0.3%,
Close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf extract 1%,
Centella (CENTELLAASIATICA) extract 0.01%,
Polygonum cuspidate (POLYGONUM CUSPIDATUM) root extract 0.01%,
Radix scutellariae (SCUTELLARIA BAICALENSIS) root extract 0.05%,
Tea (CAMELLIA SINENSIS) leaf extract 0.05%,
Glycyrrhiza glabra (GLYCYRRHIZA GLABRA) root extract 0.05%,
German chamomile (CHAMOMILLA RECUTITA) flower extract 0.01%,
Rosemary (ROSMARINUSOFFICINALIS) leaf extract 0.01%,
Cloves (SYZYGIUM AROMATICUM) oil 0.01%,
Glycerol 11%,
Butanediol 4%,
Cetostearyl alcohol olive oleate 0.3%,
Hydrolecithin 0.3%,
Natrulon H-10 stearate 0.02%,
Sodium Hyaluronate 0.1%,
Jojoba wax PEG-120 esters 0.3%,
Parahydroxyacet-ophenone 0.2%,
Xanthan gum 0.2%,
Gantrez AN-119 0.4%,
Surplus is water.
The Essence of above-mentioned reparation keratoderma barrier, is prepared via a method which to obtain:
(1) each raw material is weighed by above-mentioned formula and mass percent；
(2) glycerol, butanediol, Sodium Hyaluronate, xanthan gum, water are added in water phase agitated kettle, stirring is warming up to 80-85
DEG C and keep the temperature 30min；Cetostearyl alcohol olive oleate, ring five dimethyl silicone polymer are added in oily phase agitated kettle, stirring
It is warming up to 80-85 DEG C and keeps the temperature 5min；
(3) under the conditions of 80-85 DEG C of temperature, water phase is pumped into emulsion pot and is stirred, revolving speed 30-50rpm；It is then turned on
Vacuum pump, then it is mutually pumped into emulsion pot and opens homogenizer by oily, revolving speed 3000rpm keeps 5min；
(4) stirring be cooled to 50 DEG C, be added close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf extract, flash
Bar wax PEG-120 esters, Cer NP, hydrolecithin, Natrulon H-10 stearate, hexapeptide -11, parahydroxyacet-ophenone,
Hydrolyze pyrenomycetes (SCLEROTIUM ROLFSSII) glue, centella (CENTELLAASIATICA) extract, polygonum cuspidate
(POLYGONUM CUSPIDATUM) root extract, radix scutellariae (SCUTELLARIA BAICALENSIS) root extract, tea
(CAMELLIA SINENSIS) leaf extract, glycyrrhiza glabra (GLYCYRRHIZA GLABRA) root extract, german chamomile
(CHAMOMILLA RECUTITA) flower extract, rosemary (ROSMARINUSOFFICINALIS) leaf extract, PVM/MA are total
Polymers, silver, cloves (SYZYGIUM AROMATICUM) oil, stir evenly, after the assay was approved, filtering and discharging is filling.
Embodiment 3
A kind of Essence for repairing keratoderma barrier, composition and mass percent are as follows:
Hexapeptide -11 0.2%,
Pyrenomycetes (SCLEROTIUM ROLFSSII) glue 0.5% is hydrolyzed,
Ring five dimethyl silicone polymer 0.8%,
Silver 0.2%,
Ceramide -3 0.5%,
Close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf extract 1%,
Centella (CENTELLAASIATICA) extract 0.01%,
Polygonum cuspidate (POLYGONUM CUSPIDATUM) root extract 0.01%,
Radix scutellariae (SCUTELLARIA BAICALENSIS) root extract 0.05%,
Tea (CAMELLIA SINENSIS) leaf extract 0.05%,
Glycyrrhiza glabra (GLYCYRRHIZA GLABRA) root extract 0.05%,
German chamomile (CHAMOMILLA RECUTITA) flower extract 0.01%,
Rosemary (ROSMARINUSOFFICINALIS) leaf extract 0.01%,
Cloves (SYZYGIUM AROMATICUM) oil 0.01%,
Glycerol 11%,
Cetostearyl alcohol olive oleate 0.2%,
The smooth olive oleate 0.2% of sorb,
Sucrose stearate 0.02%,
Natrulon H-10 stearate 0.01%,
Sodium Hyaluronate 0.3%,
Tetrahydro methylpyrimidine carboxylic acid 0.5%,
Parahydroxyacet-ophenone 0.2%,
Glyceryl acrylate/acrylic copolymer 0.3%,
Surplus is water.
The Essence of above-mentioned reparation keratoderma barrier, is prepared via a method which to obtain:
(1) each raw material is weighed by above-mentioned formula and mass percent；
(2) glycerol, Sodium Hyaluronate, water are added in water phase agitated kettle, stirring is warming up to 80-85 DEG C and keeps the temperature 30min；
Cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, ring five dimethyl silicone polymer are added in oily phase agitated kettle, stirred
It mixes and is warming up to 80-85 DEG C and keeps the temperature 5min；
(3) under the conditions of 80-85 DEG C of temperature, water phase is pumped into emulsion pot and is stirred, revolving speed 30-50rpm；It is then turned on
Vacuum pump, then it is mutually pumped into emulsion pot and opens homogenizer by oily, revolving speed 3000rpm keeps 5min；
(4) stirring is cooled to 50 DEG C, and close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf extract, nerve is added
Amide 3, sucrose stearate, Natrulon H-10 stearate, hexapeptide -11, parahydroxyacet-ophenone, hydrolysis pyrenomycetes
(SCLEROTIUM ROLFSSII) glue, centella (CENTELLAASIATICA) extract, polygonum cuspidate (POLYGONUM
CUSPIDATUM) root extract, radix scutellariae (SCUTELLARIA BAICALENSIS) root extract, tea (CAMELLIA
SINENSIS) leaf extract, glycyrrhiza glabra (GLYCYRRHIZA GLABRA) root extract, german chamomile (CHAMOMILLA
RECUTITA) flower extract, rosemary (ROSMARINUSOFFICINALIS) leaf extract, tetrahydro methylpyrimidine carboxylic acid, glycerol
Acrylate/acrylic copolymer, silver, cloves (SYZYGIUM AROMATICUM) oil, stir evenly, after the assay was approved, filtering
It discharges filling.
Verify example
(1) subjects skin surface is chosen and is used as test point at two, wherein the state of test point 1 and test point 2 is distinguished
As illustrated in figs. 1A and ib；
(2) barrier breakdown is carried out to the skin at test point 1 and test point 2.Wherein Skin barrier destruction method are as follows: will
30% aqueous solution of K12 (lauryl sodium sulfate), is infiltrated with non-woven fabrics, spreads on skin test point 0.5 hour, and clear water washes away.
Skin is carried out after 0.5 hour to take pictures；The state of test point 1 and test point 2 after destroying 0.5h is respectively such as Fig. 2 a and Fig. 2 b
It is shown；
(3) to after barrier breakdown test point 1 and test point 2 be respectively adopted the embodiment of the present invention preparation Essence and water
It is handled.Processing method are as follows: smear Essence or water uniformly on skin test point, absorption respectively uses one sooner or later
It is secondary；
(4) the 1,2,4,6,7,14th day after having been treated is respectively using Digital Microscope U500x to skin
Skin surface state carries out photograph observation, while applying Delfin VAPOMETER (TEWL- transepidermal water loss value measuring instrument, Finland
Delfin company produces) 1 skin surface percentage of water loss of test point is measured.Test result is as shown in figs. 3-9.
Be clear that from test result, using prepared by the present invention repair keratoderma barrier Essence,
Skin barrier maintenance can greatly be accelerated；And TEWL (transepidermal water loss) value of skin significantly reduces, and indicates that skin barrier obtains
It repairs.
The comparison with comparative example aluminium copper can see through the foregoing embodiment, compared to the control sample for using clear water, make
Reparation keratoderma barrier can be clearly seen that keratoderma screen in Essence the 6th day prepared by the present invention
Barrier recovery situation is good, the 7th day level close to healthy skin；Fortnight can achieve skin using the skin for planting extraction essence
Skin gully understands that surface is restored from faulted condition without the situation obviously damaged.And use the control sample of clear water can also be clear
Clear sees skin injury situation.The Essence energy of reparation keratoderma barrier prepared by the present invention can be defined accordingly
Greatly accelerate skin repair, the skin for enabling cuticula impaired is more quickly restored to health status.
Claims (10)
1. a kind of Essence for repairing keratoderma barrier, which is characterized in that including hexapeptide -11, hydrolysis Scleroglucan, ring five
Dimethyl silicone polymer, silver, ceramide -3, plant extracts, polyalcohol, surfactant, moisturizer, water.
2. the Essence according to claim 1 for repairing keratoderma barrier, which is characterized in that the quality hundred of each ingredient
Divide content as follows: -11 0.1-0.2% of hexapeptide, hydrolysis Scleroglucan 0.1-0.5%, ring five dimethyl silicone polymer 0.5-
0.8%, silver 0.1-0.5%, -3 0.1-0.5% of ceramide, plant extracts 0.01-2.4%, polyalcohol 0.1-16%, table
Face activating agent 0.01-1.44%, moisturizer 0.1-1.1%.
3. the Essence according to claim 2 for repairing keratoderma barrier, it is characterised in that: the plant extracts
Selected from close Luo Mu leaf extract, Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tea extract, glycyrrhiza glabra
One of root extract, german chamomile flower extract, rosemary leaf extract, caryophyllus oil are a variety of.
4. the Essence according to claim 2 for repairing keratoderma barrier, it is characterised in that: the polyalcohol is selected from
One of glycerol, butanediol, propylene glycol, 1,2- hexylene glycol are a variety of.
5. the Essence according to claim 2 for repairing keratoderma barrier, it is characterised in that: the surfactant
It is hard selected from cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, hydrolecithin, sucrose stearate, Natrulon H-10
One of resin acid ester is a variety of.
6. the Essence according to claim 2 for repairing keratoderma barrier, it is characterised in that: the moisturizer is selected from
One of Sodium Hyaluronate, Jojoba wax PEG-120 esters, tetrahydro methylpyrimidine carboxylic acid are a variety of.
7. the Essence according to claim 2 for repairing keratoderma barrier, it is characterised in that: the reparation skin angle
The preservative for being also 0.1-0.5% containing mass percent in the Essence of matter layer barrier.
8. the Essence according to claim 7 for repairing keratoderma barrier, it is characterised in that: the preservative is selected from
Parahydroxyacet-ophenone.
9. the Essence according to claim 2 for repairing keratoderma barrier, it is characterised in that: the multiple skin keratin
The thickener for being also 0.1-1.5% containing mass percent in the Essence of layer barrier.
10. the Essence according to claim 9 for repairing keratoderma barrier, it is characterised in that: the thickener choosing
From one of xanthan gum, Gantrez AN-119, glyceryl acrylate/acrylic copolymer or a variety of.
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| CN201910557064.4A CN110179711A (en) | 2019-06-25 | 2019-06-25 | A kind of Essence and preparation method for repairing keratoderma barrier |
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| CN201910557064.4A CN110179711A (en) | 2019-06-25 | 2019-06-25 | A kind of Essence and preparation method for repairing keratoderma barrier |
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| CN110974736A (en) * | 2019-12-27 | 2020-04-10 | 杭州菲丝凯化妆品有限公司 | Essence milk and production process thereof |
| CN111419761A (en) * | 2020-05-12 | 2020-07-17 | 广州怡嘉生物科技有限公司 | Universal moisturizing mask liquid |
| CN111616992A (en) * | 2020-04-02 | 2020-09-04 | 广州一一生物技术有限公司 | Skin barrier repair compound, skin base fluid and preparation method thereof |
| CN112451448A (en) * | 2020-12-18 | 2021-03-09 | 广东丸美生物技术股份有限公司 | Skin care matrix with anti-allergy and repairing effects, preparation method thereof and skin care product |
| CN113018231A (en) * | 2021-02-24 | 2021-06-25 | 佛山市奥姿美生物科技有限公司 | Cosmetic oil capable of repairing skin barrier |
| FR3125713A1 (en) * | 2021-07-29 | 2023-02-03 | L'oreal | SKIN CARE COMPOSITION |
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| CN112451448A (en) * | 2020-12-18 | 2021-03-09 | 广东丸美生物技术股份有限公司 | Skin care matrix with anti-allergy and repairing effects, preparation method thereof and skin care product |
| CN113018231A (en) * | 2021-02-24 | 2021-06-25 | 佛山市奥姿美生物科技有限公司 | Cosmetic oil capable of repairing skin barrier |
| FR3125713A1 (en) * | 2021-07-29 | 2023-02-03 | L'oreal | SKIN CARE COMPOSITION |
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