CN110448504A - It is a kind of with instant compact, long-acting anti-ageing composition and preparation method thereof - Google Patents
It is a kind of with instant compact, long-acting anti-ageing composition and preparation method thereof Download PDFInfo
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- CN110448504A CN110448504A CN201910819779.2A CN201910819779A CN110448504A CN 110448504 A CN110448504 A CN 110448504A CN 201910819779 A CN201910819779 A CN 201910819779A CN 110448504 A CN110448504 A CN 110448504A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention discloses a kind of with instant compact, long-acting anti-ageing composition and preparation method thereof, belong to cosmetic technical field, technical points: a kind of with instant compact, long-acting anti-ageing composition, in percentage by weight, its raw material includes following component: peach rouge 40-60%, barley seed 25-40%, poria cocos sclerotium 15-30% and surplus are water.Preparation method includes: crushing, extraction, filtering, micro-filtration, ultrafiltration, and is prepared.The present invention is not only simple to operate, but also has instant compact, long-acting anti-ageing, the multiple effects such as moisturizing, but also have the advantages that stability it is good, it is low in cost, using simple.
Description
Technical field
The invention belongs to cosmetic technical fields, more specifically, it relates to a kind of with immediately compact, long-acting anti-ageing
Composition and preparation method thereof.
Background technique
Skin subjects ultraviolet light, drying, bad cosmetics thorn as the physical barriers between organism and external environment
Wrinkle caused by the various pressure due to caused by external environment such as sharp, bacterium and the stress of itself, aging is formed, elasticity drops
It is low.In recent years, the people for paying close attention to anti-aging product is more and more, and consumer gradually rises to extensively anti-ageing function understanding
Adopted level, anti-aging has been not limited solely to smoothing wrinkle, compact, increases collagen, and pre- anti-wrinkle etc. also includes skin water
Profit, the colour of skin are promoted, and pore is fine and smooth, glossy penetrating, and the tender equal demands of exquisiteness are also added to the anti-ageing scope of broad sense.
Existing crease-resistant raw material includes vitamin a compound, signal peptide, hyaluronic acid, collagen currently on the market
Deng other high molecular reactive objects etc., all there is the disadvantages of application difficult, use cost is expensive, such as: Tretinoin, 1986 Nian Mei
State's dermatology publication first can describe its and treat the report of skin photoage validity on magazine, but irritation is big, to light,
Heat and air all do not tolerate, and stability is poor；And Shiseido ends today all in research Vitamin A preparation, to it from 1989
Structure of modification, package or sustained release, be all the compromise to this double-edged sword of Tretinoin.
The signal peptide of early stage simultaneously, production technology are monopolized by the external major company such as Sederma, ISP, Lipotec, at present
Until, the producer that the country can make polypeptide is also few, the effect of these undeniable polypeptides, but expensive, and use cost is high,
Many producers are allowed to hang back, consumer also can only can just buy the product of such effect in high-end product.And hyaluronic acid
External application differs greatly with injection effect, and there are greater risks for injection；Human-like collagen is all fermentable sources, price at present
Reach the several times of hyaluronic acid.
Therefore we it is necessary to go to study novel instant compact, long-acting anti-ageing, the multiple effects such as moisturizing, stability
It is good, low in cost, using simple raw material.
Summary of the invention
In view of the deficienciess of the prior art, the purpose of the present invention one is that providing one kind has immediately compact, long-acting resist
The composition to decline has the function of instant compact, long-acting anti-ageing, tender skin.
To achieve the above object one, the present invention provides the following technical scheme that a kind of with immediately compact, long-acting anti-ageing
Composition, in percentage by weight, raw material include following component:
Further, in percentage by weight, raw material include following component:
By using above-mentioned technical proposal, peach rouge is the tree being secreted in the barks such as rosaceous plant peach or mountain peach
Rouge also known as peach oil, peach rouge, peach blossom tear, peach gum, peach are solidifying.It is peach naturally secret, or under external force to be used for self-healing
Wound and the substance generated.Main group of above-mentioned peach rouge becomes galactolipin, rhamnose, phlorose aldehydic acid etc., it, which has, mends
Water is protected and the effect of toxin expelling, and the smooth and high resilience for enabling to skin to become lightens the stain and crease-resistant anti-aging effect.And
Barley seed is a kind of cereal crop of grass family Hordeum, because the separation of the glume shell inside and outside and the bare grain for it, therefore also known as naked barley,
Wheat, barley.Barley seed contains beta glucan, dietary fiber, vitamin B1, vitamin B2, niacin, vitamin E, and
The mineral elements such as inorganic elements calcium, phosphorus, iron, copper, zinc and trace elements of selenium.Wherein, the molecular structure of beta glucan, it is one
Stickiness polysaccharide kind linear without branch, β-D- gluco-pyranose units are connected by β-(1,3) and β-(Isosorbide-5-Nitrae) glycosidic bond and
At.Beta glucan molecule in barley seed, because the presence of β-(1,3) key, can allow glucan be dissolved in water, therefore its energy
The moisture-retaining capacity of above-mentioned composition (i.e. in cosmetic material system) can obviously be improved.
Secondly poria cocos sclerotium, also known as beautiful spirit, Fu spirit, Wan Linggui, Fu Tu.It is the dry of quasi- shelf fungus section fungi poria cocos sclerotium
Dry sclerotium, to colonize in the fungi plant on pine roots, crust dark brown, the inside white or pink.Poria cocos sclerotium has battalion
Feeding skin, bright and clean skin, whitening go wrinkle, eliminate the effect of spot and delay skin aging.
Thus peach rouge active material coating on the skin after, can in barley seed beta glucan and poria cocos sclerotium
Active material polymerization, the polymer of above-mentioned formation sprawls and reticulates structure on the skin, polymerization film formation, can be with after smearing manually
It effectively evens up, unfold wrinkle, improve the effect of its instant compact, long-acting anti-ageing and tender skin.
In view of the deficienciess of the prior art, the purpose of the present invention two is that providing one kind has immediately compact, long-acting resist
The preparation method of the composition to decline, it is not only easy to operate, and the raw material of application are simple, low in cost, stablizes；But also have
There are the multiple efficacies such as instant compact, long-acting anti-ageing, moisturizing.
To achieve the above object two, the present invention also provides following technical solutions: one kind has immediately compact, long-acting anti-ageing
Composition preparation method, crushing, extraction, filtering and preparation including raw material.
Further, including following operating procedure:
Step 1: crushing: barley seed and poria cocos sclerotium being taken to crush；
Step 2: extracting: water being added in peach rouge, barley seed and poria cocos sclerotium, impregnates at least 1h, complex enzyme is added and is mentioned
Extract operation obtains crude extract after removing residue；
Step 3: filtering: filtrate is obtained by filtration after crude extract sedimentation；
Step 4: micro-filtration: filtrate operates to obtain diffusate through micro-filtration, and then plus water continues micro-filtration, until the total amount etc. of diffusate
In filtrate primary quantity obtained in step 3；
Step 5: ultrafiltration: the diffusate that step 4 is obtained removes clear liquid, leaves dope through ultrafiltration；
Step 6: preparing: by the dope in above-mentioned steps, being made into deionized water and be equivalent to the 10% of crude drug.
By using above-mentioned technical proposal, above-mentioned barley seed, poria cocos sclerotium and this kind of raw material of peach rouge are to adopt naturally
Plant is raw material, green and pollution-free, is mentioned using the complex enzyme (such as glue enzyme, cellulase and protease) of plant
It takes, can effectively digest raw material (i.e. medicinal material), the effective component in raw material is enabled to be adequately broken out；Then again
Using primary filtration, micro-filtration and ultrafiltration, i.e., a variety of filter types are used cooperatively, and can not only effectively sieve complex enzyme, effectively real
It is efficiently separated between existing enzyme and filtrate (or dope or diffusate)；And can also remove in filtrate and not allow substance,
The stimulation of above-mentioned insoluble substance confrontation skin is reduced, the molecular weight for obtaining filtrate is relatively low, may advantageously facilitate to skin
Absorption.
Further, in step 1, the granular size of the barley seed and poria cocos sclerotium that obtain after crushing is controlled in 80-
Between 120 mesh.
Due to barley seed has shell and poria cocos sclerotium is into bulk, it is lower to directly adopt multiplex-enzyme extraction efficiency, passes through
By adopting the above technical scheme, it can effectively improve the contact between complex enzyme and above-mentioned barley seed, poria cocos sclerotium after pulverization process
Area substantially increases the efficiency and quality of enzymatic hydrolysis.
Further, in step 2, the complex enzyme is the cellulose of the pectase of 0.5-2w/w%, 0.5-2w/w%
Two or more in the protease of enzyme and 0.5-1w/w%.
Further, cellulase is C1 enzyme, Cx enzyme and β glucosidase；C1 enzyme is the enzyme initially to work to cellulose,
Destroy the crystalline texture of cellulose chain；Cx enzyme is to act on cellulose, decomposition β-Isosorbide-5-Nitrae-glycosidic bond fiber through C1 enzyme activation
Plain enzyme；Cellobiose, cellotriose and other low molecule cellodextrins can be decomposed into glucose by β glucosidase.
Further, protease is plant rennet, preferably papain.
By using above-mentioned technical proposal, rich in there is this substance of pectin, cellulose and protein in natural plants, use
Complex enzyme (pectase, cellulase and protease) extracts, and can effectively improve the enzymolysis to raw material, improve original
The highly efficient release of active constituent (i.e. effective component) in material.
Further, in step 2, temperature control when extraction is at 0-85 DEG C, extraction time 2-3h.
Further, at the extraction, preferable Extracting temperature is 50-55 DEG C.
Further, in step 2, pH is 3-6.5 when extraction, and preferable pH is 4.5-5.5.
By using above-mentioned technical proposal, pectase is obtained by the fermented purification of aspergillus niger.Pectase is mainly used for fruit
The juicing and clarification of vegetable juice beverage and fruit wine have good effect to pectin is decomposed.The suitable temperature of pectase is 15-55 DEG C
Left and right, optimum temperature are 50 DEG C；PH is 3-6.And the complicated enzyme system that cellulase is made of a variety of hydrolases, nature
In many fungies can eccrine fiber element enzyme.The suitable temperature of cellulase is 28-30 DEG C, pH 4.5-6.5.
In addition, protease is the intracorporal fermentoid (enzyme) of biology, they being capable of effective decomposing protein.Decomposition method is
Interrupt those peptide bonds that amino acid is connected to polypeptide chain.Wherein, papain is extracted from pawpaw and is obtained, most suitable
Temperature is 55 DEG C or so.Thus can 50-55 DEG C at a temperature of, at the pH of 4.5-5.5, complex enzyme activity it is most strong.
Further, in step 4, the aperture of filter membrane is 30nm, and the pressure of micro-filtration control is 2-4bar, in 50-85
At a temperature of DEG C, micro-filtration is operated until diffusate no longer oozes out.
By using above-mentioned technical proposal, pressurization micro-filtration operation is carried out under the filter membrane in the aperture 30nm, is effectively increased
The efficiency of filtering.
Further, in step 5, the molecular cut off of filter membrane is controlled in 5000D, the pressure 8- of Filtration Control
12bar carries out ultrafiltration at a temperature of 50-85 DEG C.
By using above-mentioned technical proposal, pressurized operation is carried out in ultra-filtration process, can effectively be carried out guaranteeing ultra micro
On the basis of, also it is improved the efficiency of ultra micro.
Further, it in step 6, is additionally added weight percent and is the preservative of 0.3%-1%, and carry out at sterilizing
Reason；The preservative is selected from one of methylparaben, Chlorphenesin, Phenoxyethanol, fragrant fresh ketone, hexylene glycol or a variety of.
It is further preferred that it is that 0.15% methylparaben and 0.15% chlorobenzene are sweet that preservative, which includes weight percent,
Ether.
By using above-mentioned technical proposal, the preservatives such as methylparaben, Chlorphenesin are added, composition can be improved
Holding time.
Of the invention is a kind of with instant application of compact, the long-acting anti-ageing composition in daily field, especially newborn
Liquid, essence lotion, the application in skin lotion.
In conclusion the invention has the following advantages:
1, the present invention has instant compact, long-acting anti-ageing, the multiple effects such as moisturizing, but also the good, cost with stability
It is cheap, using simple advantage；
2, natural botanical source will not generate pollution, highly-safe；
3, optimize, be used cooperatively using a variety of filter types, can not only effectively sieve complex enzyme, effectively realize enzyme and filtrate
It is efficiently separated between (or dope or diffusate)；And the substance of not allowing in filtrate can also be removed, reduction is above-mentioned not
The stimulation of tolerant confrontation skin, the molecular weight for obtaining filtrate is relatively low, may advantageously facilitate the absorption to skin.
Detailed description of the invention
Fig. 1 is a kind of process flow chart of preparation method with instant compact, long-acting anti-ageing composition.
Specific embodiment
Invention is further described in detail with reference to embodiments.
One, EXAMPLE Example 1: it is a kind of with instant compact, long-acting anti-ageing composition, in percentage by weight,
Its raw material includes that peach rouge 50%, barley seed 30%, poria cocos sclerotium 20% and surplus are water.
Preparation method, as shown in Figure 1, including following operating procedure:
Step 1: crush: model WF-180 Universalpulverizer micromill (producer be Jiangyin alliance create mechanical equipment have
Limit company) in barley seed and poria cocos sclerotium be added carry out crushing operation, the granular size of obtained barley seed and poria cocos sclerotium is equal
In 80-120 mesh.
Step 2: extracting: by raw material (the i.e. smashed barley seed of peach rouge, the 30kg of 50kg and the 20kg powder of 100kg
Poria cocos sclerotium after broken) 1h is impregnated in the deionized water of 3000kg, then add the pectase of 1kg, the cellulase of 1kg
With the papain of 0.6kg；Then using traditional Chinese medicine extraction filtering and concentrating outer circulation device, (producer is Hefei film science and technology general clearly again
Co., Ltd) at 65 DEG C 2h is extracted, through filter (purpose ceramic-film filter that producer is Hefei Qing Pumo Science and Technology Ltd.)
Crude extract can be obtained after removing residue.
A kind of plant extract device of Patent No. CN201620115696.7 can also be used in specific production process.
Step 3: filtering: the crude extract in step 2 being stood 30 minutes, through B870 after substance settles in crude extract at this time
Model plate and frame polypropylene filter plate (emerging source environmental protection) is filtered, and obtains filtrate.
Step 4: micro-filtration: by the above-mentioned filtrate filter membrane of retention aperture 30nm, operating pressure 4bar, temperature is kept
At 65 DEG C, until micro-filtration to diffusate no longer oozes out, the water for then supplementing equivalent continues micro-filtration, until the amount of diffusate is equal to
The amount of beginning filtrate.
Step 5: ultrafiltration: filtrate obtained in step 4, using molecular cut off for the filter membrane of 5000D, operation pressure
Power is 10bar, and temperature carries out ultrafiltration at 65 DEG C, removes the clear liquid filtered down, leaves dope.
Step 6: preparing: by the dope in above-mentioned steps, being made into deionized water and be equivalent to the 10% of crude drug, be added
The methylparaben of 0.15W/W% and the Chlorphenesin of 0.15W/W%, and in 95 DEG C of sterilizing 30min.
Embodiment 2: a kind of with instant compact, long-acting anti-ageing composition, in percentage by weight, raw material packet
Including peach rouge 40%, barley seed 30%, poria cocos sclerotium 30% and surplus is water.
Preparation method includes following operating procedure:
Step 1: crush: model WF-180 Universalpulverizer micromill (producer be Jiangyin alliance create mechanical equipment have
Limit company) in barley seed and poria cocos sclerotium be added carry out crushing operation, the granular size of obtained barley seed and poria cocos sclerotium is equal
In 80-120 mesh.
Step 2: extracting: by raw material (the i.e. smashed barley seed of peach rouge, the 30kg of 40kg and the 30kg powder of 100kg
Poria cocos sclerotium after broken) 1.5h is impregnated in the deionized water of 3000kg, then add the pectase of 2kg, the fiber of 0.5kg
The papain of plain enzyme and 0.5kg；Then using traditional Chinese medicine extraction filtering and concentrating outer circulation device, (producer is Hefei film general clearly again
Science and Technology Ltd.) at 85 DEG C 2.5h is extracted, through filter, (producer is the ceramic membrane mistake of Hefei Qing Pumo Science and Technology Ltd.
Filter) remove residue after crude extract can be obtained.
A kind of plant extract device of Patent No. CN201620115696.7 can also be used in specific production process.
Step 3: filtering: the crude extract in step 2 being stood 45 minutes, through B870 after substance settles in crude extract at this time
Model plate and frame polypropylene filter plate (emerging source environmental protection) is filtered, and obtains filtrate.
Step 4: micro-filtration: by the above-mentioned filtrate filter membrane of retention aperture 30nm, operating pressure 3bar, temperature is kept
At 50 DEG C, until micro-filtration to diffusate no longer oozes out, the water for then supplementing equivalent continues micro-filtration, until the amount of diffusate is equal to
The amount of beginning filtrate.
Step 5: ultrafiltration: filtrate obtained in step 4, using molecular cut off for the filter membrane of 5000D, operation pressure
Power is 12bar, and temperature carries out ultrafiltration at 50 DEG C, removes the clear liquid filtered down, leaves dope.
Step 6: preparing: by the dope in above-mentioned steps, being made into deionized water and be equivalent to the 10% of crude drug, be added
The methylparaben of 0.15W/W% and the Chlorphenesin of 0.15W/W%, and in 95 DEG C of sterilizing 30min.
Embodiment 3: a kind of with instant compact, long-acting anti-ageing composition, in percentage by weight, raw material packet
Including peach rouge 60%, barley seed 25%, poria cocos sclerotium 15% and surplus is water.
Preparation method includes following operating procedure:
Step 1: crush: model WF-180 Universalpulverizer micromill (producer be Jiangyin alliance create mechanical equipment have
Limit company) in barley seed and poria cocos sclerotium be added carry out crushing operation, the granular size of obtained barley seed and poria cocos sclerotium is equal
In 80-120 mesh.
Step 2: extracting: by raw material (the i.e. smashed barley seed of peach rouge, the 25kg of 60kg and the 15kg powder of 100kg
Poria cocos sclerotium after broken) 2.5h is impregnated in the deionized water of 3000kg, then add the pectase of 2kg, the cellulose of 2kg
The papain of enzyme and 1kg；Then using traditional Chinese medicine extraction filtering and concentrating outer circulation device, (producer is Hefei film science and technology general clearly again
Co., Ltd) at 50 DEG C 3h is extracted, through filter (purpose ceramic-film filter that producer is Hefei Qing Pumo Science and Technology Ltd.)
Crude extract can be obtained after removing residue.
Step 3: filtering: the crude extract in step 2 being stood 60 minutes, through B870 after substance settles in crude extract at this time
Model plate and frame polypropylene filter plate (emerging source environmental protection) is filtered, and obtains filtrate.
Step 4: micro-filtration: by the above-mentioned filtrate filter membrane of retention aperture 30nm, operating pressure 2bar, temperature is kept
At 85 DEG C, until micro-filtration to diffusate no longer oozes out, the water for then supplementing equivalent continues micro-filtration, until the amount of diffusate is equal to
The amount of beginning filtrate.
Step 5: ultrafiltration: filtrate obtained in step 4, using molecular cut off for the filter membrane of 5000D, operation pressure
Power is 8bar, and temperature carries out ultrafiltration at 85 DEG C, removes the clear liquid filtered down, leaves dope.
Step 6: preparing: by the dope in above-mentioned steps, being made into deionized water and be equivalent to the 10% of crude drug, be added
The methylparaben of 0.15W/W% and the Chlorphenesin of 0.15W/W%, and in 95 DEG C of sterilizing 30min.
Two, comparative example comparative example 1: it is a kind of with instant compact, long-acting anti-ageing composition, it is different from embodiment 1 it
Be in: its formula is consistent with embodiment 1, but preparation method is different.
Formula is: in percentage by weight, raw material include peach rouge 50%, barley seed 30%, poria cocos sclerotium
20% and surplus be water.
The preparation method of above-mentioned comparative example 1, includes the following steps:
1. extracting: by raw material (the i.e. smashed barley seed of peach rouge, the 30kg of 50kg and the smashed Fu of 20kg of 100kg
Siberian cocklebur sclerotium) in 95 DEG C of stirrings extraction 3h of deionized water of 3000kg, residue is removed, crude extract is obtained；
2. refrigeration: above-mentioned crude extract is put into 4 DEG C of freezer, refrigerates 10h；
3. filtering: carrying out diatomite through plate and frame diatomaceous earth filter (producer is Shandong Gongda Machine Co., Ltd.) and mix native mistake
Filter；
4. preparing: being made into deionized water and be equivalent to the 10% of crude drug, the methylparaben and 0.15W/ of 0.15W/W% is added
The Chlorphenesin of W%, and in 95 DEG C of sterilizing 30min, the as extracting solution of this programme.
Comparative example 2: it is a kind of with instant compact, long-acting anti-ageing composition, difference from example 1 is that: its
Formula is consistent with embodiment 1, but preparation method is different.
Formula is: in percentage by weight, raw material include peach rouge 50%, barley seed 30%, poria cocos sclerotium
20% and surplus be water.
The preparation method of above-mentioned comparative example 1, includes the following steps:
1. extracting: by raw material (the i.e. smashed barley seed of peach rouge, the 30kg of 50kg and the smashed Fu of 20kg of 100kg
Siberian cocklebur sclerotium) in 40 DEG C of stirrings extraction 1h of deionized water of 2000kg, merge crude extract；
2. refrigeration: above-mentioned crude extract is put into 4 DEG C of freezer, refrigerates 5h；
3. filtering: using filtered through gauze；
It prepares: being made into deionized water and be equivalent to the 10% of crude drug, the methylparaben that weight percent is 0.15W/W% is added
With the Chlorphenesin of 0.15W/W%, and in 95 DEG C of sterilizing 30min, the as extracting solution of this programme.
Three, testing inspection analysis test one: instant tightening effect experimental test object:
S1, the embodiment 1-3 for taking 50W/W% respectively, there is instant compact, long-acting anti-ageing combination obtained in comparative example 1-2
Object and 50ml deionized water are spare.
S2, by table 1 toner proportion by A phase raw material (i.e. deionized water, glycerol, methyl propanediol, methyl hydroxybenzoate and
Chlorphenesin) main cooker is sequentially added, stirring is warming up to 85 DEG C of 10min, keeps dissolution of raw material complete；2,50 DEG C of addition B phases are cooled to
Raw material (i.e. has instant compact, long-acting anti-ageing composition and panthenol) obtained in the embodiment 1 of 50W/W%, stirring is equal
It is even, test specimen 1 can be obtained.
S3, will there is instant compact, long-acting anti-ageing composition obtained in the embodiment 1 of the 50W/W% in B phase raw material
Successively change into the embodiment 2 of equivalent, embodiment 3, comparative example 1, have obtained in comparative example 2 it is immediately compact, long-acting anti-ageing
Composition and deionized water.Then test specimen 2, test specimen 3, control sample are successively obtained according to the preparation method in S2
Product 2 and blank control group.
1 toner formula of table
Test method: the female volunteers for finding 60 40-60 years old healths at random (did not participated in and appointed for nearly three months
What drug, the clinical assay of cosmetics or health care product: using random, double blind, control method) this experiment is participated in, often
Group 10 allows volunteer to smear 1-3 containing test specimen, control sample 1-2 and blank control group at canthus respectively.
Then by volunteer's self-appraisal, (having instant tightening effect is 10 points, is 0 point without instant tightening effect, is calculated equal
Value) and silica gel stamp in the experimental data of wrinkle number and length illustrate compact effect immediately.
Remarks: in table 2-2, * * indicates that conspicuousness is high, P < 0.01；* significant difference, P < 0.05 are indicated.
Test result: as shown in table 2-1 and table 2-2, at 8.0 points or more, wrinkle becomes the self-appraisal score of test specimen 1-3
It is obvious that the self-appraisal of control sample is scored at 3.3 and 3.7, wrinkle tails off for few variation, and the self-appraisal of blank control group is scored at 0, wrinkle
Line variation is unobvious.Thus illustrating test specimen 1-3 and control sample 1-2 is with certain instant tightening effect；But
The instant tightening effect of test specimen 1-3 obviously protrudes, and the instant tightening effect of test specimen 1-3 is better than control sample 1-2
Instant tightening effect.The immediately compact effect of the present invention has the lower meaning of apparent statistics it can be seen from above result.
The self-appraisal result of table 2-1 volunteer
| Sample | Self-appraisal score |
| Blank control group | 0 |
| Test specimen 1 | 9.3 |
| Test specimen 2 | 8.3 |
| Test specimen 3 | 8.0 |
| Control sample 1 | 3.7 |
| Control sample 2 | 3.3 |
Table 2-2 stamp analyzes result
| Sample | Wrinkle number | Wrinkle length |
| Blank control group | 0 | 0 |
| Test specimen 1 | - 9.3%** | - 13.5%** |
| Test specimen 2 | - 8.5%** | - 11.8%** |
| Test specimen 3 | - 8.2%** | - 11.6%** |
| Control sample 1 | - 3.5%* | - 2.9% |
| Control sample 2 | - 3.7%* | - 1.9% |
Test two: skin elasticity testing experiment object:
S1, the embodiment 1-3 for taking 12W/W% respectively, there is instant compact, long-acting anti-ageing combination obtained in comparative example 1-2
Object and 50ml deionized water are spare.
S2, by the emulsion proportion of table 3-1 by water phase (i.e. deionized water, glycerol, butanediol, Sodium Hyaluronate, methyl hydroxybenzoate
And Chlorphenesin) main cooker is added, stirring is opened, and be warming up to 85 DEG C；Then 2 (cetostearyl alcohols, Emulgade will be premixed again
Sucro (BASF), Phosphoric acid monohexadecyl ester potassium, saualane, caprylic/capric triglyceride, isononyl isononanoate, Butyrospermum parkii fruit
Rouge and EMT10 (match Bick)) oil cauldron, heating stirring to 85 DEG C of addition haematococcus and AVC stirrings point to after being completely dissolved is added
Main cooker is added after dissipating uniformly, is added premix 3 (i.e. DC345 (Tao Shi) and CM1000 (Wa Ke)) after homogeneous 3min, continues homogeneous
Cool down after 3min.Finally be cooled to 40 DEG C of addition C phase raw materials (i.e. rough gentian double factor antiallergic plain (gal energy), obtained in embodiment 1
With instant compact, long-acting anti-ageing composition and flavoring rose essence), it stirs to being uniformly dispersed, it can test specimen 1.
S3, will there is instant compact, long-acting anti-ageing composition obtained in the embodiment 1 of the 12W/W% in C phase raw material
Successively change into the embodiment 2 of equivalent, embodiment 3, comparative example 1, have obtained in comparative example 2 it is immediately compact, long-acting anti-ageing
Composition and deionized water.Then test specimen 2, test specimen 3, control sample are successively obtained according to the preparation method in S2
Product 2 and blank control group.
Table 3-1 emulsion formulations
Test method: 30 health volunteers participate in this experiment (being different personnel from the above experiment), and men and women is not
Limit, the age between 50-65 years old, every group of 5 members.And nearest three moonsets of 30 health volunteers (i.e. subject)
Any drug was participated in, the clinical assay of cosmetics or health care product: using random, double blind, control method.
Specific steps are as follows:
1, the region of Instrument measuring is identified in subject's left and right arm with ready template in advance, each area size is
2.5cm2；
2, any one of subject in the random 5 regions difference swab sample 1-3 and control sample 1-2 of left and right arms
Blank control is smeared in sample, remaining 2 regions；
3, the blank district of removing left and right arm is marked in all test sections with skin marking pen, is respectively used once sooner or later, even
Continuous to use 4 months samples, sample usage amount is 1.5-2mg/cm2；
3, other any skin care item or drug cannot be used in 30d；
4, this test equipment is Corneometer (CK), skin elasticity tester；Testing time point is that sample uses preceding and sample
After product use 4 months (control group is before sample is smeared, and specimen sample 1-3 and control sample 1-2 are using testing after 4 months),
Skin is first eluted with water before test, is measured that (laboratory ambient temperature is controlled 22 ± 2 after skin is dry after 30min again
DEG C, relative humidity is 50 ± 5%)；
5, original rule of life is kept during testing.
The formula of detection are as follows: R5=Ur/Ue
Wherein, Ur refers to the part of the fast quick-recovery of skin, and Ue refers to the part quickly bounced due to suction.
Remarks: in the first time circulation of skin test, elastic part in skin recovery process with plus negative pressure during
The ratio between elastic part, it is closer with 1, illustrate that skin elasticity is better.
In table 3-2: * * indicates that conspicuousness is high, P < 0.01；* significant difference, P < 0.05 are indicated.
Test result: such as table 3-2 it is found that the numerical value of the R5 of test specimen 1-3 is all larger than 0.8, the skin of test specimen 1-3
Viscoplasticity is than increasing obvious, P < 0.01 before smearing；And the R5 of control sample 1-2 changes unobvious, P < 0.05, numerical value is maintained at
0.79 or so.Test specimen 1-3, which has, it can be seen from above result increases skin elasticity, and long-acting anti-ageing effect has
It is apparent to count lower meaning.
Table 3-2 skin viscoplasticity test result
Test three: promote the expression experimental test object of collagen ColI: taking 50 grams of embodiment 1-3 and comparative example respectively
There is instant compact, long-acting anti-ageing composition obtained in 1-2, be successively placed in 5 clean beakers, number consecutively is beaker
A-e, the deionized water that 50ml is then added in first 3 clean beaker a-c respectively is uniformly mixed, respectively as test specimen 1-
3；The deionized water that 50ml is added in intermediate 2 clean beaker d-e is uniformly mixed, respectively as control sample 1-2；Then will
The deionized water of 50ml is added in 6th clean beaker f, after mixing, as blank control group.
Test method:
1, Fibroblast cell-culture to logarithmic phase is obtained into cell suspension with trypsase cell dispersion, counted；
2,96 orifice plates are inoculated according to 1 × 104/ml, every hole is added 200 μ l, is separately added into the test specimen 1-3 of 100 μ g/ml
With control sample 1-2 or blank control group；
3, culture is for 24 hours afterwards with the expression of the method detection ColI mRNA of RT-PCR.
Remarks: in table 4, * * indicates that conspicuousness is high, P < 0.01；* significant difference, P < 0.05 are indicated.
Test result: as shown in Table 4, the Col I/GAPDH numerical value of compared with blank control group, test specimen 1-3 is big
In 0.8, it is changed significantly, P < 0.01.And the Col I/GAPDH numerical value compared with blank control group of control sample 1-2, variation is not
Obviously, P < 0.05.Therefore test specimen 1-3 of the invention has significant promotion to make the expression of type i collagen in fibroblast
With further demonstrating has effects that increase skin elasticity.
The quantitative analysis results of table 4Col I
| Sample | Col I/GAPDH |
| Blank control group | 0.703±0.043 |
| Test specimen 1 | 0.928±0.059** |
| Test specimen 2 | 0.901±0.046** |
| Test specimen 3 | 0.882±0.078** |
| Control sample 1 | 0.759±0.033* |
| Control sample 2 | 0.748±0.078* |
Test four: skin shine testing experiment object:
S1, the embodiment 1-3 for taking 30W/W% respectively, there is instant compact, long-acting anti-ageing combination obtained in comparative example 1-2
Object and 50ml deionized water are spare.
S2, according to the essence lotion formula of table 5-1 by A phase raw material (i.e. deionized water and acrylic acid (ester) class/C10-30 alkane
Alcohol acrylate crosspolymers) at room temperature be swollen after be dispersed with stirring completely, obtain A phase mixture.Then again by B phase raw material
In glycerol, methyl propanediol, xanthan gum, methyl hydroxybenzoate and EDTA 2Na be sequentially added into beaker premix after, be added A phase mix
Object is closed, is stirred and heated to 80 DEG C to being completely dissolved, addition adds the remaining raw material Chlorphenesin raw material of B phase and stirs to complete
Dissolution, cooling.Then 65 DEG C of addition C phase raw materials (i.e. 10%NaOH aqueous solution) are cooled to, stirring is to being uniformly dispersed.End temperature
D phase is added at 45 DEG C or so for control (has instant compact, long-acting anti-ageing composition and PEG- obtained in embodiment 1
40 rilanit specials and flavoring rose essence), test specimen 1 can be obtained to being completely dissolved in stirring.
S3, will there is instant compact, long-acting anti-ageing composition obtained in the embodiment 1 of the 30W/W% in B phase raw material
Successively change into the embodiment 2 of equivalent, embodiment 3, comparative example 1, have obtained in comparative example 2 it is immediately compact, long-acting anti-ageing
Composition and deionized water.Then test specimen 2, test specimen 3, control sample are successively obtained according to the preparation method in S2
Product 2 and blank control group.
Table 5-1 essence lotion formula
Test method: this research is using the general chromascope Skin- based on CIE L*a*b* colour system in the world
Glossymeter GL200 (skin shine test probe), what L* value characterized is the brightness of skin, and variation indicates that product makes
With the variation of front and back skin shine, L* is bigger, and skin is brighter, conversely, skin color is more obscure.In addition the L* and b* by measuring
ITAo can be calculated, can also be used to evaluation lightening effect.
Experimental design compares control group (i.e. the toner of table 1) He Yongtian using blank control, random, double blind method
Add the L* value and ITAo value of the skin before and after the essence lotion of 50% embodiment and comparative example.Tested volunteer's number is 60 people (30-
60 years old, be different personnel from the above experiment), wherein 26 people of male, 14 people of women.Volunteer is dry skin, and skin is opposite
It is coarse obscure, non-allergic constitution, and test position, without scar or hair, during test, tested volunteer is respectively in left forearm
It smears the toner of table 1 or the essence lotion containing embodiment and comparative example respectively with right forearm, smears one respectively sooner or later daily
Secondary (dosage 4mg/cm2), test period is 8 weeks.Skin is first eluted with water before test, after skin is dry after 30min again into
Row measurement (at 22 ± 2 DEG C, relative humidity is 50 ± 5% for laboratory ambient temperature control).
Remarks: in table 5-2, * * indicates that conspicuousness is high, P < 0.01；* significant difference, P < 0.05 are indicated.
Test result: such as table 5-2 it is found that compared with the control group, behind 8 weeks of specimen sample 1-3 L* value between 58-63,
Skin is bright；And ITAoNumerical value between 38-44, at this time known to specimen sample 1-3 L* value and ITAoVariation is obvious, P < 0.01.
Compared with the control group, L* value is between 54-57 after 8 weeks in control sample 1-2, and ITAoNumerical value 36-37 it
Between, the L* value and ITA of control sample 1-2oChange less obvious, P < 0.05.By table 5-2 it is found that 1-3 pairs of specimen sample of the present invention
The expression of type i collagen has significant facilitation in fibroblast, and further demonstrating has effects that increase skin elasticity.
Table 5-2L* value and ITAoAs a result
Specific embodiment is only explanation of the invention, is not limitation of the present invention, those skilled in the art
It can according to need the modification that not creative contribution is made to the present embodiment after reading this specification, but as long as in this hair
All by the protection of Patent Law in bright scope of the claims.
Claims (10)
1. a kind of with instant compact, long-acting anti-ageing composition, which is characterized in that in percentage by weight, raw material
Including following component:
Peach rouge 40-60%；
Barley seed 25-40%；
Poria cocos sclerotium 15-30%；
Surplus is water.
2. according to claim 1 a kind of with instant compact, long-acting anti-ageing composition, which is characterized in that according to weight
Percentages are measured, raw material include following component:
Peach rouge 40-50%；
Barley seed 30%；
Poria cocos sclerotium 20-30%；
Surplus is water.
3. a kind of a kind of preparation method with instant compact, long-acting anti-ageing composition according to claim 1 or 2,
It is characterised in that it includes the crushing of raw material, extraction, filtering and preparation.
4. a kind of preparation method with instant compact, long-acting anti-ageing composition according to claim 3, feature exist
In, including following operating procedure:
Step 1: crushing: barley seed and poria cocos sclerotium being taken to crush；
Step 2: extracting: water being added in peach rouge, barley seed and poria cocos sclerotium, impregnates at least 1h, complex enzyme is added and is mentioned
Extract operation obtains crude extract after removing residue；
Step 3: filtering: filtrate is obtained by filtration after crude extract sedimentation；
Step 4: micro-filtration: filtrate operates to obtain diffusate through micro-filtration, and then plus water continues micro-filtration, until the total amount etc. of diffusate
In filtrate primary quantity obtained in step 3；
Step 5: ultrafiltration: the diffusate that step 4 is obtained removes clear liquid, leaves dope through ultrafiltration；
Step 6: preparing: by the dope in above-mentioned steps, being made into deionized water and be equivalent to the 10% of crude drug.
5. a kind of preparation method with instant compact, long-acting anti-ageing composition according to claim 4, feature exist
In in step 1, the granular size of the barley seed obtained after crushing and poria cocos sclerotium is controlled between 80-120 mesh.
6. a kind of preparation method with instant compact, long-acting anti-ageing composition according to claim 4, feature exist
In in step 2, the complex enzyme is the cellulase and 0.5-1 w/ of the pectase of 0.5-2 w/w %, 0.5-2 w/w %
Two or more in the protease of w %.
7. a kind of preparation method with instant compact, long-acting anti-ageing composition according to claim 6, feature exist
In in step 2, temperature control when extraction is at 0-85 DEG C, extraction time 2-3h.
8. a kind of preparation method with instant compact, long-acting anti-ageing composition according to claim 4, feature exist
In, in step 4, the aperture of filter membrane is 30nm, and the pressure of micro-filtration control is 2-4bar, at a temperature of 50-85 DEG C, micro-filtration
Operation is until diffusate no longer oozes out.
9. a kind of preparation method with instant compact, long-acting anti-ageing composition according to claim 4, feature exist
In in step 5, the molecular cut off of filter membrane is controlled in 5000D, the pressure 8-12bar of Filtration Control, in 50-85 DEG C of temperature
Degree is lower to carry out ultrafiltration.
10. a kind of preparation method with instant compact, long-acting anti-ageing composition according to claim 4, feature
It is, in step 6, is additionally added weight percent and is the preservative of 0.3%-1%, and carry out sterilization treatment；The preservative choosing
From one of methylparaben, Chlorphenesin, Phenoxyethanol, fragrant fresh ketone, hexylene glycol or a variety of.
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| CN112451437A (en) * | 2020-12-03 | 2021-03-09 | 广东柏俐臣生物科技有限公司 | Moisturizing composition, cosmetic and preparation method thereof |
| CN113274305A (en) * | 2021-06-23 | 2021-08-20 | 植物医生(广东)生物科技有限公司 | Instant firming wrinkle-removing whitening mask liquid and preparation method and application thereof |
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| CN113274305A (en) * | 2021-06-23 | 2021-08-20 | 植物医生(广东)生物科技有限公司 | Instant firming wrinkle-removing whitening mask liquid and preparation method and application thereof |
| CN113274305B (en) * | 2021-06-23 | 2023-02-03 | 植物医生(广东)生物科技有限公司 | Instant firming, wrinkle-removing and whitening mask liquid as well as preparation method and application thereof |
| CN115154404A (en) * | 2022-09-06 | 2022-10-11 | 广东迪美新材料科技有限公司 | Plant composition with tightening and anti-aging functions and preparation method and application thereof |
| CN115154404B (en) * | 2022-09-06 | 2022-11-11 | 广东迪美新材料科技有限公司 | Plant composition with tightening and anti-aging effects and preparation method and application thereof |
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Application publication date: 20191115 |