CN110152000A - 用于单独治疗肝脂肪变性或治疗伴有丙型肝炎病毒感染的肝脂肪变性的组合物 - Google Patents

用于单独治疗肝脂肪变性或治疗伴有丙型肝炎病毒感染的肝脂肪变性的组合物 Download PDF

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Publication number
CN110152000A
CN110152000A CN201910281848.9A CN201910281848A CN110152000A CN 110152000 A CN110152000 A CN 110152000A CN 201910281848 A CN201910281848 A CN 201910281848A CN 110152000 A CN110152000 A CN 110152000A
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effective amount
liver
ileum
hepatitis
ribavirin
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CN201910281848.9A
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Chinese (zh)
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J·深塔格
J·M·法耶德
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Individual
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Priority claimed from US12/932,633 external-priority patent/US9757346B2/en
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CN201910281848.9A 2011-03-02 2012-02-24 用于单独治疗肝脂肪变性或治疗伴有丙型肝炎病毒感染的肝脂肪变性的组合物 Pending CN110152000A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US12/932,633 US9757346B2 (en) 2008-09-03 2011-03-02 Compositions and methods for treating insulin resistance and non-insulin dependent diabetes mellitus (type II diabetes)
US12/932,633 2011-03-02
US201161480788P 2011-04-29 2011-04-29
US61/480,788 2011-04-29
US201161514174P 2011-08-02 2011-08-02
US61/514,174 2011-08-02
US201161551638P 2011-10-26 2011-10-26
US61/551,638 2011-10-26
CN201280021792.XA CN103635196B (zh) 2011-03-02 2012-02-24 用于单独治疗肝脂肪变性或治疗伴有丙型肝炎病毒感染的肝脂肪变性的组合物、治疗方法和诊断方法

Related Parent Applications (1)

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CN201280021792.XA Division CN103635196B (zh) 2011-03-02 2012-02-24 用于单独治疗肝脂肪变性或治疗伴有丙型肝炎病毒感染的肝脂肪变性的组合物、治疗方法和诊断方法

Publications (1)

Publication Number Publication Date
CN110152000A true CN110152000A (zh) 2019-08-23

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Application Number Title Priority Date Filing Date
CN201280021792.XA Expired - Fee Related CN103635196B (zh) 2011-03-02 2012-02-24 用于单独治疗肝脂肪变性或治疗伴有丙型肝炎病毒感染的肝脂肪变性的组合物、治疗方法和诊断方法
CN201910281848.9A Pending CN110152000A (zh) 2011-03-02 2012-02-24 用于单独治疗肝脂肪变性或治疗伴有丙型肝炎病毒感染的肝脂肪变性的组合物

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CN201280021792.XA Expired - Fee Related CN103635196B (zh) 2011-03-02 2012-02-24 用于单独治疗肝脂肪变性或治疗伴有丙型肝炎病毒感染的肝脂肪变性的组合物、治疗方法和诊断方法

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US (3) US9370528B2 (enExample)
EP (1) EP2680859B1 (enExample)
JP (3) JP6253991B2 (enExample)
KR (4) KR20190060879A (enExample)
CN (2) CN103635196B (enExample)
AU (3) AU2012223528A1 (enExample)
BR (1) BR112013022391A2 (enExample)
EA (1) EA201391262A1 (enExample)
IL (2) IL228259B (enExample)
WO (1) WO2012118712A2 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155772B2 (en) 2008-12-08 2015-10-13 Philip Morris Usa Inc. Soft, chewable and orally dissolvable and/or disintegrable products
US8828953B2 (en) 2009-04-20 2014-09-09 NaZura BioHealth, Inc. Chemosensory receptor ligand-based therapies
US20130273154A1 (en) * 2011-03-02 2013-10-17 Joseph M. Fayad Oral formulations Mimetic of Roux-en-Y gastric bypass actions on the ileal brake; Compositions, Methods of Treatment, Diagnostics and Systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hpperlipidemia, and type 2 diabetes
WO2012054523A2 (en) 2010-10-19 2012-04-26 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
EA201391262A1 (ru) 2011-03-02 2014-03-31 Джером Шентаг Композиция, способ лечения и диагностики стеатоза печени как самостоятельного заболевания или в комбинации с инфекцией гепатита с
US20180099001A1 (en) 2011-04-29 2018-04-12 Volant Holdings Gmbh Diagnostics and methods for treatment of non-alcoholic hepatic steatosis and hepatic steatohepatitis, and prevention of complications thereof
JP6203816B2 (ja) 2012-03-29 2017-09-27 セラバイオーム，エルエルシー 回腸及び虫垂に対して活性の胃腸部位特異的経口ワクチン接種製剤
JP2016506371A (ja) 2012-11-16 2016-03-03 ユニバーシティ カレッジ カーディフ コンサルタンツ リミテッド ヌクレオシドプロドラッグを調製する方法
CA2897448A1 (en) * 2013-01-08 2014-07-17 Jerome Schentag Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems
BR112015022936A2 (pt) 2013-03-14 2017-07-18 J Schentag Jerome vesículas de colestossoma para a incorporação de moléculas em quilomícrons
RU2015140610A (ru) 2013-03-14 2017-04-17 ТЕРАБАЙОМ, ЭлЭлСи Направленная доставка в желудочно-кишечный тракт пробиотических микроорганизмов и/или терапевтических средств
CA2903493C (en) * 2013-03-15 2022-05-31 Cedars-Sinai Medical Center Methods of diagnosis, selection, and treatment of diseases and conditions caused by or associated with methanogens
JP6797692B2 (ja) * 2014-02-20 2020-12-09 バクサート インコーポレイテッド 小腸送達のための製剤
EP3169331A4 (en) * 2014-07-17 2018-01-17 Jerome J. Schentag Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems
WO2016089814A1 (en) 2014-12-02 2016-06-09 Concert Pharmaceuticals, Inc. Deuterated analogues of daclatasvir
CA2988761A1 (en) 2015-06-12 2016-12-15 Vaxart, Inc. Formulations for small intestinal delivery of rsv and norovirus antigens
US10744070B2 (en) 2015-06-19 2020-08-18 University Of Southern California Enteral fast access tract platform system
CA2990230A1 (en) 2015-06-19 2016-12-22 University Of Southern California Compositions and methods for modified nutrient delivery
ES2928408T3 (es) 2016-04-11 2022-11-17 Genfit Métodos para el tratamiento de enfermedades fibróticas
US11400078B2 (en) * 2016-04-11 2022-08-02 Genfit Methods of treatment for cholestatic and fibrotic diseases
US10653678B2 (en) 2016-04-11 2020-05-19 Genfit Methods of treatment for cholestatic and fibrotic diseases
WO2017203367A2 (en) * 2016-05-22 2017-11-30 Volant Holdings Gmbh Diagnostics and methods for treatment of non-alcoholic hepatic steatosis and hepatic steatohepatitis, and prevention of complications thereof
US11040054B2 (en) 2016-11-14 2021-06-22 The Brigham And Women's Hospital, Inc. Estrogen sensing through GPER1 regulates normal and malignant liver growth
US11033534B2 (en) 2017-01-27 2021-06-15 Genfit Pharmaceutical compositions for combination therapy
US11191749B2 (en) * 2017-03-13 2021-12-07 Genfit Pharmaceutical compositions for combination therapy
GB2571749A (en) * 2018-03-07 2019-09-11 Anabio Tech Limited A method inducing satiety in a mammal
WO2020120519A1 (en) 2018-12-10 2020-06-18 Aphaia Pharma Ag Combinatorial oral treatment of metabolic disorders through orchestrated release of enterokines
HUE057346T2 (hu) 2018-12-10 2022-05-28 Aphaia Ip Ag Orális gyógyászati adagolási forma metabolikus rendellenességek és rokon betegségek enterokinek megtervezett felszabadításával történõ kezelésére
CN109568284B (zh) * 2018-12-29 2020-04-24 广东中润药物研发有限公司 一种替诺福韦艾拉酚胺肠溶片及其制备方法
CN110478357A (zh) * 2019-07-23 2019-11-22 哈尔滨医科大学 硝唑尼特及其体内代谢物在抗肥胖、降血脂、抗脂肪肝及抗动脉粥样硬化中的应用
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
TWI883391B (zh) 2020-02-18 2025-05-11 美商基利科學股份有限公司 抗病毒化合物
CN115135383B (zh) 2020-02-18 2024-06-11 吉利德科学公司 抗病毒化合物
JP2023537461A (ja) 2020-06-10 2023-09-01 アファイア アイピー アーゲー ゲル化剤と組み合わせて複数の剤形のエンテロカイン放出物質を含有する医薬組成物
JP7688152B2 (ja) 2021-04-16 2025-06-03 ギリアード サイエンシーズ， インコーポレイテッド アミドを使用してカルバヌクレオシドを調製する方法
KR20240049311A (ko) 2021-08-18 2024-04-16 길리애드 사이언시즈, 인코포레이티드 인지질 화합물 및 이의 제조 및 사용 방법
JP7109827B1 (ja) * 2021-11-16 2022-08-01 株式会社ハニック・ホワイトラボ 抗ウイルス剤
CN120500345A (zh) * 2022-09-01 2025-08-15 Hlb吉尼克斯股份有限公司 表达超氧化物歧化酶的芽孢杆菌属菌株、芽孢杆菌属菌株孢子和/或超氧化物歧化酶以及其用于预防或治疗纤维化疾病的用途
WO2025119939A1 (en) 2023-12-03 2025-06-12 Aphaia Pharma Ag Treatment of obesity and related conditions by circadian administration of enterokine-stimulating compositions
LU103233B1 (en) 2023-12-21 2025-06-24 Aphaia Ip Ag Treatment of obesity and related conditions by circadian administration of enterokine-stimulating compositions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1194831A (zh) * 1997-04-01 1998-10-07 李春华 利巴韦林大输液系列制剂
CN101291685A (zh) * 2005-08-19 2008-10-22 安米林药品公司 治疗糖尿病和降低体重的毒蜥外泌肽
WO2010027498A2 (en) * 2008-09-03 2010-03-11 New Science Holdings, Llc Compositions and methods for inducing satiety and treating non-insulin dependent diabetes emillitus, pre-diabetic symptoms, insulin resistance and related disease states and conditions

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51133489A (en) * 1975-05-14 1976-11-19 Tokyo Daigaku Process for producing microbial components of pseudomonas aeruginosa h aving antimicrobial and antitumor activities
US4544550A (en) 1982-10-05 1985-10-01 Rodolfo Almanzor Y Method for the treatment of diabetes
US5194464A (en) 1988-09-27 1993-03-16 Takeda Chemical Industries, Ltd. Enteric film and preparatoin thereof
US5769793A (en) 1989-09-08 1998-06-23 Steven M. Pincus System to determine a relative amount of patternness
US5120563A (en) * 1989-12-21 1992-06-09 The Procter & Gamble Company Food compositions containing reduced calorie fats and reduced calorie sugars
ATE219522T1 (de) * 1992-02-04 2002-07-15 Chiron Corp Hepatistherapeutikum
US5322697A (en) 1992-05-28 1994-06-21 Meyer James H Composition and method for inducing satiety
US5976548A (en) 1994-11-08 1999-11-02 Viva America Marketing, Inc. Nutritional supplement composition and use
AU766597B2 (en) * 1998-05-15 2003-10-16 Schering Corporation Combination therapy comprising ribavirin and interferon alpha in antiviral treatment naive patients having chronic hepatitis C infection
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
ES2350330T3 (es) 2000-06-07 2011-01-21 Watson Pharmaceuticals, Inc. Tratamiento de la hiperactividad del músculo liso con (r)-oxibutinina y (r)-desetiloxibutinina.
EP1499300B1 (en) 2002-04-29 2009-03-18 Supernus Pharmaceuticals, Inc. Pharmaceutical formulations with improved bioavailability
US20040062778A1 (en) 2002-09-26 2004-04-01 Adi Shefer Surface dissolution and/or bulk erosion controlled release compositions and devices
EP1462116A1 (en) 2003-03-29 2004-09-29 Villitech SARL Composition for treating the gastrointestinal tract
CA2566677A1 (en) 2004-05-13 2005-11-24 Intermune, Inc. Combination therapy for treating hepatitis virus infection
WO2006034463A2 (en) 2004-09-23 2006-03-30 Herbalife International, Inc. Herbal supplement to support weight loss
US20080064632A1 (en) 2004-09-24 2008-03-13 Amatruda John M Combination Therapy for the Treatment of Obesity
US20060093592A1 (en) 2004-10-04 2006-05-04 Nutracea Synbiotics
KR101174966B1 (ko) * 2005-05-31 2012-08-17 노파르티스 아게 철이 발병에 관여하는 간질환의 치료
JP2007001945A (ja) 2005-06-24 2007-01-11 Tsuneo Ozeki 癌治療剤
WO2007022518A2 (en) * 2005-08-19 2007-02-22 Amylin Pharmaceuticals, Inc. New uses of glucoregulatory proteins
ES2670856T3 (es) 2005-09-06 2018-06-01 Oramed Pharmaceuticals Inc. Métodos y composiciones para la administración oral de proteínas
US8394845B2 (en) 2006-10-30 2013-03-12 Hanall Biopharma Co., Ltd. Method of using combination preparation comprising angiotensin-II-receptor blocker and HMG-CoA reductase inhibitor
JP2010509363A (ja) 2006-11-08 2010-03-25 ノババックス，インコーポレイテッド 固体剤形の多相医薬組成物の製造方法
US7951789B2 (en) * 2006-12-28 2011-05-31 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
US20070172525A1 (en) 2007-03-15 2007-07-26 Ramesh Sesha Anti-diabetic combinations
BRPI0908292B1 (pt) 2008-05-05 2022-09-20 Oramed Ltd Métodos e composições para administração oral de exenatida
US9757346B2 (en) 2008-09-03 2017-09-12 Volant Holdings Gmbh Compositions and methods for treating insulin resistance and non-insulin dependent diabetes mellitus (type II diabetes)
WO2010045361A1 (en) 2008-10-17 2010-04-22 Metabolex, Inc. Methods of reducing small, dense ldl particles
US9339480B2 (en) 2008-11-26 2016-05-17 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of obesity and diabetes
CA2752232C (en) 2009-02-12 2016-11-22 Arqule, Inc. A composition comprising (-)-trans-3-(5,6-dihydro-4h-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1h-indol-3-yl) pyrrolidine-2, 5-dione in combination with a second anti-proliferative agent
CN102438599B (zh) 2009-03-04 2015-01-21 迈雅营养品有限公司 通过降低血糖水平来控制糖尿病的营养组合物和方法
RU2410108C1 (ru) 2009-08-03 2011-01-27 Государственное образовательное учреждение высшего профессионального образования "Орловский государственный технический университет" (ОрелГТУ) Способ скармливания пробиотика поросятам-сосунам
US8367418B2 (en) 2009-10-23 2013-02-05 Therasyn Sensors, Inc. Method and system to provide personalized pharmaceutical compositions and dosages
US8999721B2 (en) 2009-10-23 2015-04-07 Therabrake, Inc. Method and system to provide personalized pharmaceutical compositions and dosages
US20140294951A1 (en) 2011-10-26 2014-10-02 Joseph M. Fayad Oral formulations mimetic of Roux-en-Y gastric bypass actions on the ileal brake; Compositions, methods of treatment, diagnostics and systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hyperlipidemia, and T2D
US20130273154A1 (en) 2011-03-02 2013-10-17 Joseph M. Fayad Oral formulations Mimetic of Roux-en-Y gastric bypass actions on the ileal brake; Compositions, Methods of Treatment, Diagnostics and Systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hpperlipidemia, and type 2 diabetes
EA201391262A1 (ru) 2011-03-02 2014-03-31 Джером Шентаг Композиция, способ лечения и диагностики стеатоза печени как самостоятельного заболевания или в комбинации с инфекцией гепатита с
JP6203816B2 (ja) 2012-03-29 2017-09-27 セラバイオーム，エルエルシー 回腸及び虫垂に対して活性の胃腸部位特異的経口ワクチン接種製剤
CA2897448A1 (en) 2013-01-08 2014-07-17 Jerome Schentag Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1194831A (zh) * 1997-04-01 1998-10-07 李春华 利巴韦林大输液系列制剂
CN101291685A (zh) * 2005-08-19 2008-10-22 安米林药品公司 治疗糖尿病和降低体重的毒蜥外泌肽
WO2010027498A2 (en) * 2008-09-03 2010-03-11 New Science Holdings, Llc Compositions and methods for inducing satiety and treating non-insulin dependent diabetes emillitus, pre-diabetic symptoms, insulin resistance and related disease states and conditions

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