CN110115381A - A kind of the lycopene composition and its production method of energy strengthen immunity - Google Patents
A kind of the lycopene composition and its production method of energy strengthen immunity Download PDFInfo
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- CN110115381A CN110115381A CN201810148846.8A CN201810148846A CN110115381A CN 110115381 A CN110115381 A CN 110115381A CN 201810148846 A CN201810148846 A CN 201810148846A CN 110115381 A CN110115381 A CN 110115381A
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- lycopene
- prepared
- strengthen immunity
- glue
- composition
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- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 title claims abstract description 30
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 title claims abstract description 30
- 235000012661 lycopene Nutrition 0.000 title claims abstract description 30
- 239000001751 lycopene Substances 0.000 title claims abstract description 30
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 title claims abstract description 30
- 229960004999 lycopene Drugs 0.000 title claims abstract description 30
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 title claims abstract description 30
- 230000036039 immunity Effects 0.000 title claims abstract description 18
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 239000002775 capsule Substances 0.000 claims abstract description 9
- 235000013871 bee wax Nutrition 0.000 claims abstract description 8
- 239000012166 beeswax Substances 0.000 claims abstract description 8
- 229940087603 grape seed extract Drugs 0.000 claims abstract description 8
- 235000002532 grape seed extract Nutrition 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 239000001717 vitis vinifera seed extract Substances 0.000 claims abstract description 8
- 235000021388 linseed oil Nutrition 0.000 claims abstract description 5
- 239000000944 linseed oil Substances 0.000 claims abstract description 5
- 239000008601 oleoresin Substances 0.000 claims abstract description 5
- 239000003292 glue Substances 0.000 claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 239000007901 soft capsule Substances 0.000 claims description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
- 108010010803 Gelatin Proteins 0.000 claims description 7
- 229920000159 gelatin Polymers 0.000 claims description 7
- 239000008273 gelatin Substances 0.000 claims description 7
- 235000019322 gelatine Nutrition 0.000 claims description 7
- 235000011852 gelatine desserts Nutrition 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000007493 shaping process Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000003860 storage Methods 0.000 claims description 6
- 239000001993 wax Substances 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 5
- 229920000573 polyethylene Polymers 0.000 claims description 4
- 239000008213 purified water Substances 0.000 claims description 4
- 239000004408 titanium dioxide Substances 0.000 claims description 4
- 241000220317 Rosa Species 0.000 claims description 3
- 239000000084 colloidal system Substances 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- 238000011068 loading method Methods 0.000 claims description 3
- -1 natural VE Substances 0.000 claims description 3
- 239000003921 oil Substances 0.000 claims description 3
- 235000019198 oils Nutrition 0.000 claims description 3
- 239000008188 pellet Substances 0.000 claims description 3
- 238000005453 pelletization Methods 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000004513 sizing Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 7
- 238000005457 optimization Methods 0.000 abstract description 2
- 239000000049 pigment Substances 0.000 abstract description 2
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- 230000002335 preservative effect Effects 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 241000699670 Mus sp. Species 0.000 description 12
- 241000699666 Mus <mouse, genus> Species 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 9
- 241000287828 Gallus gallus Species 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 210000000822 natural killer cell Anatomy 0.000 description 3
- 230000000242 pagocytic effect Effects 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000003228 hemolysin Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 210000003024 peritoneal macrophage Anatomy 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- BUCXEFZXWKUCCY-UHFFFAOYSA-N 4-methyl-3-(2-phenylethyl)-1,2,4-oxadiazol-5-one Chemical compound O1C(=O)N(C)C(CCC=2C=CC=CC=2)=N1 BUCXEFZXWKUCCY-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
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- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
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- 102000036639 antigens Human genes 0.000 description 1
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- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 235000012730 carminic acid Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000002864 food coloring agent Nutrition 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 238000011990 functional testing Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 235000001497 healthy food Nutrition 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004995 male reproductive system Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 238000002229 photoelectron microspectroscopy Methods 0.000 description 1
- 230000007180 physiological regulation Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a kind of lycopene composition of energy strengthen immunity, every 500 grams of the lycopene composition is prepared by the raw material of following weight: 10% lycopene oleoresin 50, grape seed extract 100, natural VE 50, linseed oil 290, beeswax 10.The application utmostly ensure that synergistic effect of the main component in terms of improving body immunity, it is ensured that the effect of strengthen immunity of the present invention by optimization dosage of each component.Capsule material used in this application does not add any pigment and preservative, and safety is good, can effectively prevent the loss of effective component, and product is easy to carry and use.
Description
Technical field
The present invention relates to technical field of health care food, and in particular to a kind of lycopene composition of energy strengthen immunity,
The invention further relates to the production methods of the soft capsule of lycopene.
Background technique
Lycopene is a kind of natural, has superior physiological regulation function, anti-oxidation function to human body
It is 2 times of beta carotene, singlet-oxygen quenching rate constant is 100 times of vitamin E.Lycopene itself has extremely strong
Removing free radical ability, have anti-cancer, anti-aging, it is antifatigue, adjustment human body sub-health status, raising male reproductive system
The effect of the multiple efficacies such as function, have " plant gold " titles it can be with effectively preventing because of aging, caused by immunity degradation respectively
Kind of disease, its concern by countries in the world expert.Therefore, lycopene is the functional natural colorants for having very much exploitation future.
Currently, visible many lycopene capsules products in the market, but all come with some shortcomings: such as each ingredient ratio of content
Example is improper, is easily layered so as to cause content, influences product quality；For another example contain some synthetic food colors and anti-corrosion in capsule material
Agent, long-term use can generate certain side effect to human body.
Summary of the invention
It is an object of the invention to overcome the deficiencies of the prior art and provide it is a kind of formula it is reasonable, convenient to take, can significantly mention
The lycopene composition of high immunity.
To realize that the above purpose of the present invention, the present invention adopt the following technical scheme that:
A kind of lycopene composition of energy strengthen immunity, every 500 grams of the lycopene composition is by following weight
Raw material be prepared: 10% lycopene oleoresin 50, grape seed extract 100, natural VE 50, linseed oil
290, beeswax 10.
The lycopene composition of the application is preferably made as soft capsule preparation, and the capsule skin of the soft capsule is by following weight
Raw material be prepared and (matched by 500 grams of lycopene content): it is gelatin 300, glycerol 150, titanium dioxide 1, carmine
0.3, purified water 300.
A kind of production method of the lycopene composition of energy strengthen immunity of the application, includes the following steps:
(1) it is sieved
Grape seed extract is taken to sieve with 100 mesh sieve rear spare；
(2) glue is prepared
The preheating of openingization glue tank recirculated water, by glycerol, purified water, titanium dioxide and famille rose setting glue tank, is heated to 60
After~65 DEG C, gelatin stirring is added, until gelatin all dissolves；Temperature rises to 70 DEG C, is vacuumized with -0.08~-0.07Mpa de-
Bubble, plastic emitting obtains glue after filtering, keeps the temperature under the conditions of 55~60 DEG C spare；
(3) feed liquid is prepared
Linseed oil and beeswax are set in material-compound tank, are heated to 65 ± 2 DEG C of temperature, melt beeswax completely and is mixed
It is even, oily wax liquor is obtained, is cooled to 40 ± 2 DEG C, lycopene oleoresin, natural VE, grape seed extract is then added, with
Oily wax liquor stirs evenly, and sets in colloid mill, grinds 2 times, with -0.08~-0.07Mp vacuumizing and defoaming, discharging, stand for standby use；
(4) pelleting, sizing
Machine on prepared glue and feed liquid is subjected to compacting pelletization with soft capsule pellet press, adjusting every loading amount is
0.5g, pelleting process are kept for 18~26 DEG C of room temperature, relative humidity 30%~45%；It is carried out shaping after pelleting, shaping process is kept
18~26 DEG C of room temperature, relative humidity 30%~45%, 2~4h of time；
(5) it washes ball, drying, pick ball
Ball is washed with 95% edible ethanol, cleans the oil on capsule and pill surface；25~28 DEG C of temperature, relative humidity 30%~
Under conditions of 40%, dry 24~30h；It is unqualified to reject big piller, special-shaped ball, flat ball, apparent wire mark ball, air pocket ball etc.
Useless ball；
(6) it packs, examine, storage
It is packed with oral stable medicinal polythene bottle with high density, every bottle built-in 90；It extracts sample to test, examines and close
After lattice, storage.
Inner packaging material is oral stable medicinal polythene bottle with high density, and quality meets national drug packing container (material
Material) standard YBB00122002 requirement.
Compared with prior art, the device have the advantages that it is as follows:
The application utmostly ensure that main component in terms of improving body immunity by optimization dosage of each component
Synergistic effect, it is ensured that the effect of strengthen immunity of the present invention.The lycopene of the application high, pollution-free, nothing with content
The advantages that peculiar smell, high bioactivity, other raw materials and consumptions meet relevant regulations, and used raw material is that country allows institute
Healthy food material.
In addition, capsule material used in this application does not add any pigment and preservative, safety is good, can effectively prevent effectively at
The loss divided, and product is easy to carry and use.
Specific embodiment
Of the invention for ease of understanding, it is as follows that the present invention enumerates embodiment.Unless specific instructions, various raw materials of the invention are equal
It can be by being commercially available；Or it is prepared according to the conventional method of this field.Unless otherwise defined or described herein, made herein
All professional and scientific terms are identical as meaning known to the art technology skillfully person of entering.Furthermore it is any with it is recorded interior
Holding similar or impartial method and material can be applied to the method for the present invention.Unless otherwise stated, institute used herein
There are professional and scientific terms identical as meaning known to those skilled in the art.
A kind of soft capsule of lycopene of energy strengthen immunity, by the formula of 1000 (0.5g/), each Ingredient Amount is such as
Under:
Production process is specific as follows:
(1) it is sieved
Grape seed extract is taken to sieve with 100 mesh sieve rear spare；
(2) glue is prepared
The preheating of openingization glue tank recirculated water, by glycerol, purified water, titanium dioxide and famille rose setting glue tank, is heated to 60
After~65 DEG C, gelatin stirring is added, until gelatin all dissolves；Temperature rises to 70 DEG C, is vacuumized with -0.08~-0.07Mpa de-
Bubble, plastic emitting obtains glue after filtering, keeps the temperature under the conditions of 55~60 DEG C spare；
(3) feed liquid is prepared
Linseed oil and beeswax are set in material-compound tank, are heated to 65 ± 2 DEG C of temperature, melt beeswax completely and is mixed
It is even, oily wax liquor is obtained, is cooled to 40 ± 2 DEG C, lycopene oleoresin, natural VE, grape seed extract is then added, with
Oily wax liquor stirs evenly, and sets in colloid mill, grinds 2 times, with -0.08~-0.07Mp vacuumizing and defoaming, discharging, stand for standby use；
(4) pelleting, sizing
Machine on prepared glue and feed liquid is subjected to compacting pelletization with soft capsule pellet press, adjusting every loading amount is
0.5g, pelleting process are kept for 18~26 DEG C of room temperature, relative humidity 30%~45%；It is carried out shaping after pelleting, shaping process is kept
18~26 DEG C of room temperature, relative humidity 30%~45%, 2~4h of time；
(5) ball, drying are washed
Ball is washed with 95% edible ethanol, cleans the oil on capsule and pill surface；25~28 DEG C of temperature, relative humidity 30%~
Under conditions of 40%, dry 24~30h；
(6) it packs, examine, storage
It is packed with oral stable medicinal polythene bottle with high density, every bottle built-in 90；It extracts sample to test, examines and close
After lattice, storage.
By soft capsule of lycopene made from the present embodiment, following strengthen immunity functional test test is carried out:
1, foundation: " health food is examined and assessment technique specification " version in 2003.
2, animal packet: SPF grades of male Balb/c mouse are used, blank control group, low dose group (0.33g/ are divided into
Kg.bw), middle dose group (0.67g/kg.bw) and high dose group (1.00g/kg.bw)；Stomach-filling once a day, continuous gavage 30
It.
3, Testing index include: internal organs/weight ratio, ConA induction mouse lymphocyte transformation experiment (mtt assay), late
Hair style allergy (DTH, toes thicken method), serum hemolysin measurement (Hemagglutination Method), (Jerne changes antibody-producting cell detection
Good slide method), Turnover of Mouse Peritoneal Macrophages chicken red blood cell experiment (half intracorporal method), mouse carbonic clearance experiment, NK cell activity survey
Fixed (determination of lactate dehydrogenase method).
4, variance analysis, heterogeneity of variance order data statistics: are carried out with 3.1 statistical package of PEMS for Windows
And inspection statistics.
5, result
Kind of orally administration mouse (Balb/c) 0.33g/kg.bw, 0.67g/kg.bw and 1.00g kg.bw dosage respectively
After Lycopene soft capsule 30 days, have no that this inspection product have adverse effect to mouse weight and weight gain.
In mice organs/weight ratio measurement, each dosage group is compared with control group mice, spleen/weight ratio and chest
Gland/weight ratio there are no significant difference (P > 0.05).
In mouse delayed hair allergy experiment, antigen attack after 24 hours, each dosage group compared with control group mice,
Its swelling degree of the paw dramatically increases (P < 0.01).
In mouse lymphocyte transformation experiment (mtt assay), each dosage group is compared with control group mice, optical density difference
Difference that there are no significant (P > 0.05).
In mice serum hemolysin test experience, each dosage group is compared with control group mice, and antibody product is without aobvious
It writes sex differernce (P > 0.05).
In antibody-producting cell detection experiment, for each dosage group compared with control group mice, antibody-producting cell number is equal
There was no significant difference (P > 0.05).
For each dosage group compared with control group mice, abdominal cavity is huge in Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell experiment
Phagocyte swallows the phagocytic percentage and phagocytic index there are no significant difference (P > 0.05) of chicken red blood cell.
In the experiment of mouse carbonic clearance, each dosage group is compared with control group mice, and there are no significant by the clear phagocytic index a of carbon
Difference (P > 0.05).
In NK cells in mice activity rate measurement experiment, for 1.00g kg.bw dosage group compared with control group mice, NK is thin
Cytoactive rate is without significant difference (P > 0.05)；0.33g kg.bw and 0.67g kg.bw dosage group compared with control group mice,
NK cell activity rate dramatically increases (P < 0.01).
Therefore, according to evaluation criterion it is believed that the soft capsule of lycopene of the application has the function of strengthen immunity.
The Applicant declares that person of ordinary skill in the field is on the basis of the above embodiments, by above-described embodiment
The concrete content point value of component, is combined with the technical solution of Summary, thus the new numberical range generated, and
One of record scope of the invention, the application are to keep specification concise, no longer enumerate these numberical ranges.
Claims (3)
1. it is a kind of can strengthen immunity lycopene composition, which is characterized in that every 500 grams of the lycopene composition by
The raw material of following weight is prepared:
2. a kind of lycopene composition of energy strengthen immunity as described in claim 1, which is characterized in that the composition
For soft capsule, by the every 500 grams of calculating of content, the capsule skin of the soft capsule is prepared by the raw material of following weight:
3. a kind of production method of the lycopene composition of energy strengthen immunity as claimed in claim 2, which is characterized in that
Include the following steps:
(1) it is sieved
Grape seed extract is taken to sieve with 100 mesh sieve rear spare；
(2) glue is prepared
The preheating of openingization glue tank recirculated water, by glycerol, purified water, titanium dioxide and famille rose setting glue tank, is heated to 60~65
After DEG C, gelatin stirring is added, until gelatin all dissolves；Temperature rises to 70 DEG C, with -0.08~-0.07Mpa vacuumizing and defoaming, mistake
Plastic emitting obtains glue after filter, keeps the temperature under the conditions of 55~60 DEG C spare；
(3) feed liquid is prepared
Linseed oil and beeswax are set in material-compound tank, 65 ± 2 DEG C of temperature is heated to, so that beeswax is melted and is uniformly mixed completely, obtain
Oily wax liquor is cooled to 40 ± 2 DEG C, lycopene oleoresin, natural VE, grape seed extract is then added, with oily wax liquor
It stirs evenly, sets in colloid mill, grind 2 times, with -0.08~-0.07Mp vacuumizing and defoaming, discharging, stand for standby use；
(4) pelleting, sizing
Machine on prepared glue and feed liquid is subjected to compacting pelletization with soft capsule pellet press, adjusting every loading amount is 0.5g, pressure
Ball process is kept for 18~26 DEG C of room temperature, relative humidity 30%~45%；It is carried out shaping after pelleting, shaping process holding room temperature 18~
26 DEG C, relative humidity 30%~45%, 2~4h of time；
(5) ball, drying are washed
Ball is washed with 95% edible ethanol, cleans the oil on capsule and pill surface；In 25~28 DEG C of temperature, relative humidity 30%~40%
Under the conditions of, dry 24~30h；
(6) it packs, examine, storage
It is packed with oral stable medicinal polythene bottle with high density, every bottle built-in 90；It extracts sample to test, it is qualified to examine
Afterwards, it is put in storage.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991365A (en) * | 2020-08-15 | 2020-11-27 | 盈姿生物科技(上海)有限公司 | Lycopene soft capsule and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897441A (en) * | 2010-07-09 | 2010-12-01 | 晨光生物科技集团天津有限公司 | Soft capsule of lycopene |
| CN102511821A (en) * | 2011-12-30 | 2012-06-27 | 新疆医科大学 | Composite lipid-lowering soft capsule preparation prepared by lycopene and grapestone extracts and preparation method of composite lipid-lowering soft capsule preparation |
| CN102824371A (en) * | 2012-08-23 | 2012-12-19 | 石药集团中奇制药技术（石家庄）有限公司 | Propolis-lycopene composition and preparation method thereof |
| CN103478522A (en) * | 2013-08-21 | 2014-01-01 | 山东福胶集团有限公司 | Donkey-hide gelatin and propolis soft capsules and preparation method thereof |
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2018
- 2018-02-05 CN CN201810148846.8A patent/CN110115381A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897441A (en) * | 2010-07-09 | 2010-12-01 | 晨光生物科技集团天津有限公司 | Soft capsule of lycopene |
| CN102511821A (en) * | 2011-12-30 | 2012-06-27 | 新疆医科大学 | Composite lipid-lowering soft capsule preparation prepared by lycopene and grapestone extracts and preparation method of composite lipid-lowering soft capsule preparation |
| CN102824371A (en) * | 2012-08-23 | 2012-12-19 | 石药集团中奇制药技术（石家庄）有限公司 | Propolis-lycopene composition and preparation method thereof |
| CN103478522A (en) * | 2013-08-21 | 2014-01-01 | 山东福胶集团有限公司 | Donkey-hide gelatin and propolis soft capsules and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991365A (en) * | 2020-08-15 | 2020-11-27 | 盈姿生物科技(上海)有限公司 | Lycopene soft capsule and preparation method thereof |
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