CN107519213A - A kind of strong immune composition of shield stomach containing Hericium erinaceus extract and preparation method thereof - Google Patents
A kind of strong immune composition of shield stomach containing Hericium erinaceus extract and preparation method thereof Download PDFInfo
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- CN107519213A CN107519213A CN201710743756.9A CN201710743756A CN107519213A CN 107519213 A CN107519213 A CN 107519213A CN 201710743756 A CN201710743756 A CN 201710743756A CN 107519213 A CN107519213 A CN 107519213A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A kind of strong immune composition of shield stomach containing Hericium erinaceus extract and preparation method thereof, the composition soft is made by the component of following parts by weight：Hericium erinaceus extract：12 20 parts, Ganodenna Lucidum P.E：20 12 parts, maize germ oil：65 parts, 3 parts of beeswax.The preparation method of the above-mentioned strong immune composition of shield stomach, the Hericium erinaceus and Ganodenna Lucidum P.E use ultrasonic wave extraction, membrane filtration and microwave drying process.The result of study prompting shield strong immune composition soft capsule of stomach has protection gastric mucosa, anti-gastric-ulcer, the biological action of strengthen immunity.
Description
Technical field
The present application relates to a kind of composition soft, especially a kind of shield stomach with the extract containing Hericium erinaceus is exempted from by force
The epiphyte composition soft capsule and its preparation method of epidemic disease, belong to Medicines and Health Product technical field.
Background technology
Immunity, it is the defense mechanism of human body itself, just as the soldier in human body, identifies and eliminate any of external intrusion
Foreign matter（Virus, bacterium etc.）, processing aging, damage, death, the own cells of denaturation（Including cancerous tumor cell etc.）, and identification
It is human bioequivalence and the physiological reaction for excluding " dissident " with the ability of processing vivo mutations cell and virus infected cell.Daily
The damaging cells and cancer cell etc. of many can all be produced in our human bodies, but why we do not fall ill or suffered from cancer at once
, because our immune system can remove a number of mutant cell daily, just because of the protection of immunity, Wo Mencai
It is not readily susceptible to the injury in the external world.Once immune system can not normally play protective effect, body just easily causes bacterium, disease
Poison, fungi etc. infect and accelerate cell mutation or canceration.If immunity is low for a long time, our immune system with regard to powerless or
Have little time to remove exotic invasive germ and in vivo caused by all cancer cells, it is gently then in poor health liable to illness, it is heavy then suffer from cancer.
So immunity is to influence the key factor of disease development, hypoimmunity is basic caused by disease.Enhancing is immune to be
Prevent the best method of germ and cancer cell invasion.
Spleen is important lymphoid organ, just as one " filter ", when occurring germ, antigen, foreign matter, protozoon in blood
When, macrophage, lymphocyte in spleen will be eaten up；With hematopoiesis, hemofiltration, removing aging haemocyte and participate in exempting from
The functions such as epidemic disease reaction, manufacture immune substance, it is known as the title of " human body blood bank ".Stomach with spleen phase table, often taste connection claim, be collectively referred to as
The foundation of acquired constitution, source of generating QI and blood.The traditional Chinese medical science thinks " people is using stomach Qi as this ", and taste by force then all contain by the five internal organs, and the weak then the five internal organs of taste are all
Decline, immunologic function declines.Therefore the impaired then Yi Shengzhu diseases of taste, thus support good taste be health, away from disease especially
The important prerequisite of cancer and guarantee.
Fungi refers to fructification or mycelium directly eats or makees medicinal fungi, and this kind of fungi is often macro fungi, i.e.,
Mushroom.Fungi is the very big monoid in living nature, belongs to plant kingdom originally, it is individually classified as a boundary, i.e. fungi now
Boundary.And medicine-food two-purpose bacterium refers to the trophism of existing food, there is the fungi of the double action of drug therapy again.Fungi polysaccharide
It is the active principle being widely present in medicinal fungi, it is the macromolecular compound being formed by connecting by multiple monosaccharide molecules, tool
There is extensive pharmacological activity.In the world, fungi polysaccharide is referred to as " biological respinse modifier ", is internationally recognized natural excellent
Immunomodulator, there is the characteristics of high activity, gently adjust, the balance of human immune system can be promoted.At present in animal experiment
And found in clinical practice, fungi polysaccharide mainly plays the role of 10 aspects：1. strengthen immunity；2. antitumor action；3. resist
Aging acts on；4. increasing leukocyte；5. remove free radical；6. improve liver detoxification ability；7. radioresistance and antimutagenic effect；⑧
The effect of anti-peptic ulcer；9. repair damaged cell and tissue；10. improve the keeping amount of hemoglobin.
At present, the research work of medicinal fungi class health food and medicine is just carried out extensively.
Ganoderma lucidum, have thousands of years of medicinal history in China, according to《Sheng Nong's herbal classic》Record：" master ties ganoderma lucidum in the heart, invigorating heart
Gas, bowl spares, increase intelligence, do not forget.Food long, make light of one's life by commiting suicide not old, macrobiosis angle ".Now by state approval for can medicine-food two-purpose new resources
Food,《Pharmacopoea Chinensis》、《U.S.'s herbal medicine allusion quotation》Include.Modern scientific research shows that the pharmacological component of ganoderma lucidum is very
It is abundant, rich in abundant GL-B wherein in Ganodenna Lucidum P.E（Ganodermalucidum polysaccharides,
GLP）, it is one of its most crucial medicinal ingredient, pharmacological action is extensive, can bidirectional modulation is immune, radioresistance, hypoglycemic, anti-ageing
Always, the influence to internal SOD, stimulate circulation and Auto-regulator metabolism etc. effect, cure the disease plant be related to each system of whole body,
Including coronary heart disease, asthma, acute hepatitis, chronic hepatitis, neurasthenia, diabetes, hyperthyroidism, refractory skin, rheumatism, ephritis, stomach and
Duodenal ulcer, tumour etc. are especially very notable to tumour, hepatic disease, insomnia and the preventive and therapeutic effect of aging.
Hericium erinaceus is called Hericium erinaceus, is only gained the name because exactly liking hedgehog hydnum.Meanwhile Hericium erinaceus is also medicinal material, mild-natured, taste
It is sweet, there are relieving the five internal organs, aid digestion, stomach invigorating, qi-restoratives, anticancer, kidney-nourishing essence.Hericium erinaceus contains 17 kinds of amino acid, and abundant is more
Sugared body, polypeptides matter and aliphatic amide substance, to a variety of alimentary canals such as chronic gastritis, gastric ulcer, stomach cancer, cancer of the esophagus
Disease, neurasthenia, tumour have good therapeutic effect.Largely medical science and pharmaceutical research show, hericium erinaceus fruiting body polysaccharide and bacterium
Mycelium polysaccharide, which has, to be improved immunity, antitumor, anti-aging, reducing blood lipid, anti-oxidant, radioresistance, protection liver and protects stomach to stick
Film, suppress helicobacter pylori（Hp）Etc. different physiological roles.Experimental study shows, hericium erinaceum polysaccharide is rich in Hericium erinaceus extract
With stronger immunoregulation effect, can from Mutiple Targets, multi-angle, play immunoregulation effect at many levels.Glossy ganoderma and hericium mushroom
Two kinds of medicinal fungi composition latest generation compound polyose products of nature and flavor identical, the more targets of complex polysaccharide energy of scientific compatibility prescription are more
Effect influences the not ipsilateral of immune system, human immunity is in dynamic equilibrium, snugly safeguards health, nourishing the stomach shield
Stomach, build up health, improve body health state, adjust gastrointestinal function.
The content of the invention
The present patent application is in view of the above-mentioned problems, providing a kind of shield stomach containing Hericium erinaceus extract, strengthen immunity
Epiphyte composition soft capsule and preparation method thereof.
Specifically, the present patent application provides a kind of containing the Hericium erinaceus extract shield strong immune composition soft capsule of stomach, institute
Composition soft is stated to be made by the component of following parts by weight：
Hericium erinaceus extract：12-20 parts, Ganodenna Lucidum P.E：20-12 parts, maize germ oil：65 parts, 3 parts of beeswax.
Further, the Hericium erinaceus extract includes hericium erinaceum polysaccharide, and Ganodenna Lucidum P.E includes GL-B.
Further, the hericium erinaceum polysaccharide and GL-B include glucan, glucose, fucose, xylose, sweet dew
Sugar and breast augmentation sugar.
Another purpose of the present patent application is to provide the preparation of above-mentioned shield stomach strengthen immunity epiphyte composition soft capsule
Method, the extract use ultrasonic extracting process.
Further, the supersonic extracting method of the Hericium erinaceus extract, including the steps：
Production procedure includes：Raw material crushes → fed intake → ultrasonic wave water extraction → membrane filtration → alcohol precipitation → microwave drying → packaging → inspection
Test
1st, crush：It is standby that raw material with pulverizer is crushed to 10-30 mesh；
2nd, feed intake：Crushed material is put into extraction pipeline；
3rd, ultrasonic wave water extraction：Raw material adds 8--10 times of purified water to carry out ultrasonic continuous adverse current extraction, and ultrasonic frequency is 2-3 ten thousand
Hertz, Extracting temperature is 50-60 DEG C, obtains water content 85-90% extract solution.
4th, concentrate：Through milipore filter（Molecular cut off lifts precision between 9-18 ten thousand）Filtering, only takes maximally effective molecule
Amount, remove the material and water less than 90,000 molecular weight, obtain water content 30-40% concentrate.
5th, alcohol precipitation：Concentrate adds 4 times of amount edible alcohols while stirring, stands 24h, removes supernatant；Centrifuge dripping obtains
Spirituosity amount 5-10% medicinal extract.
6. microwave drying：Medicinal extract load microwave charging tray, vacuumize drying, 40 DEG C of temperature -- 50 DEG C, 210 minutes time a left side
The right side, dry water content of matter≤6%；
7. packaging：The mesh of dried object 80 pulverizes and sieves, packaging；
8. examine：Examine indices, all it is qualified enter storehouse；
9. a technique is about 1:30 withdrawal ratios.
The Ganodenna Lucidum P.E preparation method is same as above.
Further, described shield stomach enhancing immune composition soft capsule, it is the easy moisture absorption of high-precision polysaccharide, adds corn
Embryo oil plays harmonicity, and addition beeswax plays suspension effect, makes solid-liquid not stratified；It is coated with soft capsule rubber, flexible glue
Capsule rubber has good bioavilability, can rapidly, reliably and securely dissolve, soft capsule rubber adds auxiliary material by pharmagel
It is refined to form, soft capsule rubber formula rate：Gelatin, purified water, glycerine=100：100：40.
Shield stomach strengthen immunity composition described in the present patent application, processing preparation process is simple and practical, obtained combination
Thing is tests prove that the effect with solid protection taste, strengthen immunity.
Embodiment
Non- limit is carried out to shield stomach strengthen immunity composition soft described in the present patent application and preparation method thereof below
Describe to property processed, it is therefore an objective to be easy to the public to be best understood from the technical scheme.
Embodiment one
【Product formula】By produce 1000 intragranulars it is tolerant in terms of (0.3g/ grains)：
65 parts of maize germ oil 195g
3 parts of beeswax 9g
20 parts of Ganodenna Lucidum P.E 60g
12 parts of Hericium erinaceus extract 36g
__________________________________
It is made 1000（300 grams of meter）
【Glue formula】
Rubber formula rate：Gelatin, purified water, glycerine=100:100:40
Embodiment two
【Product formula】By produce 1000 intragranulars it is tolerant in terms of (0.3g/ grains)：
65 parts of maize germ oil 195g
3 parts of beeswax 9g
12 parts of Ganodenna Lucidum P.E 36g
20 parts of Hericium erinaceus extract 60g
___________________________________
It is made 1000（300 grams of meter）
【Glue formula】
Rubber formula rate：Gelatin, purified water, glycerine=100:100:40
Embodiment three
The ultrasonic preparation method of the Hericium erinaceus extract, including the steps：
Production procedure includes：Raw material crushes → fed intake → ultrasonic wave water extraction → membrane filtration → alcohol precipitation → microwave drying → packaging → inspection
Test
1st, crush：It is standby that raw material with pulverizer is crushed to 20 mesh；
2nd, feed intake：Crushed material is put into extraction pipeline；
3rd, ultrasonic wave water extraction：Raw material adds 10 times of purified waters to carry out ultrasonic continuous adverse current extraction, and ultrasonic frequency is 30,000 hertz,
Extracting temperature is 55 DEG C, obtains water content 85-90% extract solution.
4th, concentrate：Through milipore filter（Molecular cut off lifts precision between 9-18 ten thousand）Filtering, only takes maximally effective point
Son amount, removes the material and water less than 90,000 molecular weight, obtains water content 30-40% concentrate.
5th, alcohol precipitation：Concentrate adds 4 times of amount edible alcohols while stirring, stands 24h, removes supernatant；Centrifuge dripping obtains
Spirituosity amount 5-10% medicinal extract.
6. microwave drying：Medicinal extract loads microwave charging tray, vacuumizes drying, temperature 50 C, 210 minutes or so time, dries
Water content of matter≤6%；
7. packaging：The mesh of dried object 80 pulverizes and sieves, packaging；
8. examine：Examine indices, all it is qualified enter storehouse；
9. a technique is about 1:30 withdrawal ratios.
Example IV
The preparation method of the Ganodenna Lucidum P.E is the same as Hericium erinaceus extract.
Embodiment five
The shield stomach strengthen immunity composition soft preparation method, including the steps：
1. change glue：By gelatin, water, glycerine with 100：100：40 ratio, changes glue in jacketed pan.By purified water, glycerine, bright
Glue, sequentially add in stainless steel jacketed pan, agitating and heating 1.5~2 hours under vacuum, temperature is 70~80 DEG C, makes its whole
Melting, carry out being concentrated under reduced pressure into regulation moisture under the conditions of vacuum is less than -0.06MPa, and bubble in glue is extracted out, glue
After filtering in 50~60 DEG C of preservations, discharged with pressurized with compressed air.Glue quality requirement：Moisture 40%.
2. dispensing, grinding, degassing：Accurately weighed by prescription through examining qualified maize germ oil, be heated to add at 70 DEG C
Enter beeswax, fully add Ganodenna Lucidum P.E, Hericium erinaceus extract after dissolving, uniform 30min is mixed in agitator.In colloid mill
Grinding three times, puts the gas (being carried out under the conditions of vacuum is less than -0.06MPa) sloughed in vacuum kettle in material.
3. pelleting：Glue and dispensing are extruded into qualified soft capsule, 0.3g/ grains through pellet press.Two are made automatically by pellet press
Bar adhesive tape, rotating mould is successively moved to, the flange of the nib of left and right revolving die starts to extrude on adhesive tape, bonded, and feed liquid is immediately
By between the quantitative adhesive tape of simultaneous implantation two of wedge injector alignment nib, because revolving die gyrates, nib flange is by two layers
The adhesive tape of parcel feed liquid is squeezed off, bonded and is pressed into formation capsule and pill in nib, and is peeled off, separated.
4.18-28 DEG C of cold air drying 4-6h, capsule is shaped.
5. wash ball：Soft capsule is washed away into surface oil with 95% edible alcohol, in triplicate.
6. dry：22-28 DEG C dries up, and goes out ball after 24h.
7. lamp inspection：Conformality ball is selected, removes non-conformality ball.Big piller, special-shaped ball, flat ball, thin-walled are removed through the artificial ball that picks
Ball, obvious wire mark ball, air pocket ball etc..
8. packaging：Soft capsule is bottled, 60 every bottle, stamps product batch number, date of manufacture, is labelled.Outer packing corrugation
Paper wrapper, per 96 bottles of case.
9. final inspection：Total check-in storehouse.Through quality inspection warehousing after passing.Load packing slip.
Explanation：Soft capsule workshop is carried out 300,000 grades of dust proof workshop workspaces.
Embodiment six
The animal experiment study of the shield stomach strengthen immunity composition soft
Using 4 week old Female nude mice 200, body weight 18-22g, every 40 mouse are one big group, totally five big groups.I group of progress is immunized
Carbonic clearance is tested;Lymphocyte transformation experiment, the determination of activity of NK cells of the mouse of II group of carry out ConA induction is immunized；It is immune
The dirty body ratio measurement of III group of carry out, half are bathed in blood value（HC50）Measure and antibody-producting cell measure；IV group of progress is immunized
Delayed allergy is tested；Immune V group of carry out Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell experiment.It is 40 small per big group
Mouse is randomly divided into 4 groups, first using alcohol induced acute gastric mucosal injury animal model, then exempts from enhancing described in test medicine
The basic, normal, high dosage group of epidemic disease composition point, i.e., 10mg/kg/ days（0.4 mg/ pcs/day）, 20mg/kg/ days（0.8 mg/ pcs/day）
With 40mg/kg/ days（1.6 mg/ pcs/day）.Separately set negative control group water（200ul/pcs/day）.Every group sets 10 nude mices.Each group
The gastric infusion in the 0th day, 1 time a day, continuous 30 days.Each group experiment mice is put to death after last dose.Use Spss11.0
Software is analyzed, and detects the changes of weight of mouse, the influence of immune function of mice and the degree of impairment of gastric mucosa.
Experimental result：Strengthen immune composition soft capsule Yong tri- Bamboo water described in test medicine to dissolve by concentration, medicine after dissolving
Liquid is in brown suspension shape solution；Experimental result is shown 20mg/kg/ days（0.8 mg/ pcs/day）With 40mg/kg/ days（1.6 mg/
Pcs/day）The shield stomach enhancing immune composition of dosage can significantly improve the delayed allergy of mouse, antibody-producting cell
The lymphocyte transformation ability of the mouse of number and ConA inductions, has preferable guarantor to ethanol induced mice acute gastric mucosal injury
Shield acts on, and ulcer index can be made substantially to reduce, and plays the role of to suppress total acid output, reduces pepsin activity, and aobvious amount
Effect relation；40mg/kg/ days（1.6 mg/ pcs/day）Dosage can significantly improve mouse spleen/body weight ratio, NK cytoactives and rush
Enter IL-2, TNF-α, IL-6, IFN-y secretion.
Conclusion：The result of study prompting shield stomach enhancing immune composition soft capsule, which has, protects gastric mucosa, anti-gastric-ulcer,
The effect of strengthen immunity.
Claims (5)
- A kind of 1. preparation method of the shield strong immune composition of stomach containing Hericium erinaceus extract, it is characterised in that：The preparation side Method includes the steps：（1）Prepare Hericium erinaceus extract：（1.1）Crush：It is standby that raw material is crushed to 10-30 mesh；（1.2）Feed intake：Crushed material is put into extraction pipeline；（1.3）Ultrasonic wave water extraction：Raw material adds 8--10 times of purified water to carry out ultrasonic continuous adverse current extraction, ultrasonic frequency 2-3 Ten thousand hertz, Extracting temperature is 50-60 DEG C, obtains water content 85-90% extract solution；（1.4）Concentration：Extract solution is through ultrafiltration membrance filter, acquisition water content 30-40% concentrate；（1.5）Alcohol precipitation：Concentrate adds 4 times of amount edible alcohols while stirring, stands 24h, removes supernatant；Centrifuge dripping, which obtains, to be contained Alcohol amount 5-10% medicinal extract；（1.6）Microwave drying：Medicinal extract loads microwave charging tray, vacuumizes drying, 40 DEG C of temperature -- and 50 DEG C, 210 minutes or so time, Dry water content of matter≤6%；（1.7）Packaging：The mesh of dried object 80 pulverizes and sieves, standby；（2）Ganodenna Lucidum P.E is prepared, using step（1）In method prepare Ganodenna Lucidum P.E；（3）Prepare composition soft：Take step（1）In Hericium erinaceus extract and step（2）The Ganodenna Lucidum P.E of middle preparation, Maize germ oil and beeswax are weighed, Hericium erinaceus extract, Ganodenna Lucidum P.E, maize germ oil and beeswax are according to weight ratio（12- 20）：（20-12）：65：3 ratio is well mixed to be produced;Soft capsule rubber formula rate：Gelatin, purified water, glycerine=100:100:40.
- 2. a kind of preparation method of shield strong immune composition of stomach containing Hericium erinaceus extract according to claim 1, its It is characterised by：Step（1.4）Middle ultrafiltration retaining molecular weight is 9-18 ten thousand.
- 3. the medicine that a kind of shield stomach containing Hericium erinaceus extract is immunized by force, it is characterised in that described medicine is included just like power Profit requires the composition soft described in 1-2 any claims.
- 4. medicine as claimed in claim 3, it is characterised in that described medicine is soft capsule.
- 5. the purposes for the composition soft that a kind of shield stomach described in claim 1-2 any claims is immunized by force, its feature It is, described composition soft is used to protect stomach and enhancing is immune.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110115356A (en) * | 2019-06-06 | 2019-08-13 | 广州市美澳健生物科技有限公司 | A kind of strengthen immunity and protection gastric mucosa composition and application method |
| CN115154583A (en) * | 2022-07-07 | 2022-10-11 | 北京美宝高科技有限责任公司 | Capsule for promoting gastrointestinal mucosa self-repair and protecting gastrointestinal function and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079045A (en) * | 2015-08-20 | 2015-11-25 | 山之灵（福建）生物科技有限公司 | Preparation containing hericium erinaceus and ganoderma lucidum and preparation method thereof |
| CN105641000A (en) * | 2015-06-01 | 2016-06-08 | 深圳市康道生物有限公司 | Antitumor composition containing grifola frondosus extract and preparation method thereof |
-
2017
- 2017-08-25 CN CN201710743756.9A patent/CN107519213A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641000A (en) * | 2015-06-01 | 2016-06-08 | 深圳市康道生物有限公司 | Antitumor composition containing grifola frondosus extract and preparation method thereof |
| CN105079045A (en) * | 2015-08-20 | 2015-11-25 | 山之灵（福建）生物科技有限公司 | Preparation containing hericium erinaceus and ganoderma lucidum and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110115356A (en) * | 2019-06-06 | 2019-08-13 | 广州市美澳健生物科技有限公司 | A kind of strengthen immunity and protection gastric mucosa composition and application method |
| CN115154583A (en) * | 2022-07-07 | 2022-10-11 | 北京美宝高科技有限责任公司 | Capsule for promoting gastrointestinal mucosa self-repair and protecting gastrointestinal function and preparation method thereof |
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