|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4245051A
(en)
|
1978-03-30 |
1981-01-13 |
Rockefeller University |
Human serum plasminogen activator
|
|
IE52535B1
(en)
|
1981-02-16 |
1987-12-09 |
Ici Plc |
Continuous release pharmaceutical compositions
|
|
US4658830A
(en)
|
1984-08-08 |
1987-04-21 |
Survival Technology, Inc. |
Method and apparatus for initiating reperfusion treatment by an unattended individual undergoing heart attack symptoms
|
|
DE3515869A1
(de)
|
1985-05-03 |
1986-11-13 |
Bayer Ag, 5090 Leverkusen |
Verfahren zur herstellung optisch aktiver azolderivate
|
|
JPS62153224A
(ja)
|
1985-12-27 |
1987-07-08 |
Green Cross Corp:The |
プラスミノゲン製剤
|
|
GB8721951D0
(en)
|
1987-09-18 |
1987-10-28 |
Thrombosis Research Trust |
Organic compounds
|
|
JP2764264B2
(ja)
|
1987-10-01 |
1998-06-11 |
株式会社ミドリ十字 |
線溶活性増強剤
|
|
WO1994001128A1
(en)
|
1992-07-01 |
1994-01-20 |
Beth Israel Hospital Boston |
Enhancement of thrombolytic therapy with deglycosylated plasminogen
|
|
US5520912A
(en)
|
1993-07-02 |
1996-05-28 |
Immuno Aktiengesellschaft |
Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen
|
|
DK125693D0
(enExample)
|
1993-11-05 |
1993-11-05 |
Novo Nordisk As |
|
|
DE4411143C2
(de)
|
1994-03-30 |
1996-08-01 |
Immuno Ag |
Thrombosemittel
|
|
DK1516628T3
(da)
|
1995-07-27 |
2013-09-08 |
Genentech Inc |
Stabil, isotonisk lyofiliseret proteinformulering
|
|
WO1999000420A1
(en)
|
1997-06-26 |
1999-01-07 |
Karolinska Innovations Ab |
Kringle domains 1-5 of plasminogen, capable of modulating angiogenesis in vivo
|
|
US7317003B2
(en)
|
1998-09-04 |
2008-01-08 |
National University Of Singapore |
Small peptides having anti-angiogenic and endothelial cell inhibition activity
|
|
US6465424B1
(en)
|
1999-02-17 |
2002-10-15 |
Bristol-Myers Squibb Company |
Anti-angiogenic agent and method for inhibiting angiogenesis
|
|
AU3605800A
(en)
|
1999-02-24 |
2000-09-14 |
Henry Ford Health System |
An anti-angiogenic kringle protein and its mutants
|
|
US6899877B2
(en)
|
1999-03-09 |
2005-05-31 |
Minu, L.L.C. |
Process for generating plasmin in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina
|
|
US7544500B2
(en)
|
1999-11-13 |
2009-06-09 |
Talecris Biotherapeutics, Inc. |
Process for the production of a reversibly inactive acidified plasmin composition
|
|
US6964764B2
(en)
|
1999-11-13 |
2005-11-15 |
Talecris Biotherapeutics, Inc. |
Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
|
|
US20020159992A1
(en)
|
2000-09-29 |
2002-10-31 |
Jack Henkin |
Antiangiogenic polypeptides and methods for inhibiting angiogenesis
|
|
US20030054988A1
(en)
|
2000-11-02 |
2003-03-20 |
Weidong-Richard Ji |
Modified plasminogen related peptide fragments and their use as angiogenesis inhibitors
|
|
DE60230046D1
(de)
|
2001-08-10 |
2009-01-08 |
Novartis Ag |
Peptide, die atherosklerotische schädigungen binden
|
|
US7067492B2
(en)
|
2001-09-06 |
2006-06-27 |
Omnio Ab |
Method of promoting healing of a tympanic membrane perforation
|
|
CN1408431A
(zh)
|
2001-09-21 |
2003-04-09 |
北京华兴生生物技术有限公司 |
治疗与新生血管生成相关疾病的基因工程药物
|
|
US7202066B2
(en)
|
2002-01-29 |
2007-04-10 |
Carrington Laboratories, Inc. |
Combination of a growth factor and a protease enzyme
|
|
AU2003210137A1
(en)
|
2002-02-06 |
2003-09-02 |
N-Zyme Biotec Gmbh |
Method for producing recombinant proteins in micro-organisms
|
|
US20050124036A1
(en)
|
2002-02-06 |
2005-06-09 |
Rudy Susilo |
Method for producing recombinant proteins in micro-organisms
|
|
US20030199464A1
(en)
|
2002-04-23 |
2003-10-23 |
Silviu Itescu |
Regeneration of endogenous myocardial tissue by induction of neovascularization
|
|
CN1668312A
(zh)
|
2002-05-13 |
2005-09-14 |
洛杉矶儿童医院 |
疤痕疙瘩和其它的皮肤或内部的创伤或损伤中异常疤痕形成的处理和抑制
|
|
EP1556413A4
(en)
|
2002-05-17 |
2009-07-08 |
Esperion Therapeutics Inc |
METHODS AND COMPOSITIONS FOR TREATING ISCHEMIC REPERFUSION
|
|
CN100469370C
(zh)
|
2002-12-06 |
2009-03-18 |
法布罗根股份有限公司 |
一种稳定HIFα的制剂在制备调节脂肪代谢的药物中的应用
|
|
MXPA05006287A
(es)
|
2002-12-10 |
2005-09-08 |
Wyeth Corp |
Derivados de acido indoloxo-acetilaminoacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1).
|
|
CN1451746A
(zh)
|
2003-03-20 |
2003-10-29 |
广州市启源生物科技有限公司 |
人纤溶酶原Kringle 5缺失突变重组多肽
|
|
WO2005026127A1
(ja)
|
2003-09-11 |
2005-03-24 |
Institute Of Medicinal Molecular Design. Inc. |
プラスミノゲンアクチベータインヒビター-1阻害剤
|
|
WO2005028690A1
(en)
|
2003-09-24 |
2005-03-31 |
Alstom Technology Ltd |
Braze alloy and the use of said braze alloy
|
|
JP4740531B2
(ja)
|
2003-09-30 |
2011-08-03 |
雪印乳業株式会社 |
骨吸収抑制剤
|
|
EP2246417B1
(en)
|
2004-04-22 |
2015-01-21 |
Grifols Therapeutics Inc. |
Recombinantly modified plasmin
|
|
US8357147B2
(en)
|
2005-08-17 |
2013-01-22 |
Spinal Restoration, Inc. |
Method for repairing intervertebral discs
|
|
FR2882654B1
(fr)
|
2005-03-01 |
2007-04-27 |
Servier Lab |
Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques
|
|
WO2006095713A1
(ja)
|
2005-03-08 |
2006-09-14 |
Institute Of Medicinal Molecular Design. Inc. |
プラスミノゲンアクチベータインヒビター-1阻害剤
|
|
WO2006102395A2
(en)
|
2005-03-22 |
2006-09-28 |
Medstar Health Inc |
Delivery systems and methods for diagnosing and treating cardiovascular diseases
|
|
US20060257391A1
(en)
|
2005-05-11 |
2006-11-16 |
Bausch & Lomb Incorporated |
Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions
|
|
JPWO2007111242A1
(ja)
|
2006-03-24 |
2009-08-13 |
ロート製薬株式会社 |
メタボリック症候群改善剤
|
|
MX2009002226A
(es)
|
2006-08-28 |
2009-09-07 |
Omnio Healer Ab |
Candidatos contra infeccion.
|
|
ES2453496T3
(es)
|
2006-08-28 |
2014-04-08 |
Omnio Healer Ab |
Diana farmacológica novedosa de prevención y tratamiento de enfermedad periodontal, mejora de la cicatrización de heridas periodontales y promoción de la salud oral
|
|
JP2010506957A
(ja)
|
2006-10-20 |
2010-03-04 |
ダウ グローバル テクノロジーズ インコーポレイティド |
メタボリックシンドロームを予防または処置するための水溶性セルロース誘導体の使用
|
|
CN101219219B
(zh)
|
2007-01-10 |
2013-02-13 |
北京普罗吉生物科技发展有限公司 |
包含血管抑素或其片段的复合物、其制备方法及应用
|
|
CN101015686B
(zh)
|
2007-02-06 |
2010-05-19 |
中国人民解放军军事医学科学院基础医学研究所 |
一种溶栓药物增效剂及其制备方法
|
|
AR067446A1
(es)
|
2007-07-11 |
2009-10-14 |
Otsuka Pharma Co Ltd |
Un medicamento para tratar higado graso que comprende cilostazol
|
|
WO2009054439A1
(ja)
|
2007-10-23 |
2009-04-30 |
Institute Of Medicinal Molecular Design, Inc. |
Pai-1産生抑制剤
|
|
US20090239868A1
(en)
|
2007-10-23 |
2009-09-24 |
Institute Of Medical Molecular Design, Inc. |
Inhibitor of pai-1 production
|
|
WO2009073471A1
(en)
|
2007-11-29 |
2009-06-11 |
Talecris Biotherapeutics, Inc. |
Recombinantly modified plasmin
|
|
MX2010007586A
(es)
|
2008-01-09 |
2011-02-22 |
Intrexon Corp |
Inhibidores terapeuticos de la funcion del inhibidor del activador de plasminogeno 1 y metodos de uso.
|
|
WO2010076655A1
(en)
|
2008-12-30 |
2010-07-08 |
Ikfe Gmbh |
Biomarkers for adipose tissue activity
|
|
US20120053222A1
(en)
|
2009-01-23 |
2012-03-01 |
Mark Gorrell |
Novel Metabolic Disease Therapy
|
|
DK2607348T3
(da)
|
2009-03-31 |
2021-05-25 |
Renascience Inc |
Inhibitor af plasminogenaktivatorinhibitor-1
|
|
EP2424561A2
(en)
|
2009-04-30 |
2012-03-07 |
Catherine Blondel |
Methods for treating ocular conditions
|
|
JP5909182B2
(ja)
|
2009-08-12 |
2016-04-26 |
コーネル ユニヴァーシティー |
代謝性症候群を予防し又は治療するための方法
|
|
CN101628113B
(zh)
|
2009-08-18 |
2012-01-04 |
南京农业大学 |
蚯蚓纤溶酶抗肝纤维化的应用
|
|
CN101897925B
(zh)
|
2009-12-16 |
2015-04-29 |
成都百康医药工业药理毒理研究院 |
一种治疗代谢综合症的药物组合物
|
|
WO2011139974A2
(en)
|
2010-05-03 |
2011-11-10 |
Abbott Laboratories |
Anti-pai-1 antibodies and methods of use thereof
|
|
CN102121023B
(zh)
|
2010-12-22 |
2012-07-04 |
中山大学 |
突变型人纤溶酶原kringle5及其制备方法及应用
|
|
CN103384722B
(zh)
|
2011-01-05 |
2016-11-16 |
斯路姆基因公司 |
纤溶酶原和纤溶酶变体
|
|
CN102154253A
(zh)
|
2011-01-06 |
2011-08-17 |
郑州大学 |
具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途
|
|
AU2012223171B2
(en)
|
2011-03-03 |
2015-07-16 |
Tersus Pharmaceuticals, LLC |
Compositions and methods comprising C16:1n7-palmitoleate
|
|
CN102199587B
(zh)
|
2011-03-24 |
2013-06-19 |
广东药学院 |
人纤溶酶原功能性突变体及其制备方法和应用
|
|
EP2704736A4
(en)
|
2011-03-30 |
2016-07-20 |
Univ Texas |
METHOD AND COMPOSITIONS FOR TARGETING ADIPOSE CELLS IN MAMMALS
|
|
CN102188699A
(zh)
|
2011-05-06 |
2011-09-21 |
南京农业大学 |
一种治疗动脉粥样硬化的药物组合物及其制备方法和应用
|
|
US20120058537A1
(en)
|
2011-07-27 |
2012-03-08 |
Fereidoun Mahboudi |
Chimeric truncated and mutant variant of tissue plasminogen activator (t-pa) resistant to plasminogen activator inhibitor-1
|
|
WO2013024074A1
(en)
|
2011-08-12 |
2013-02-21 |
Thrombogenics N.V. |
Plasminogen and plasmin variants
|
|
CN102532326B
(zh)
|
2011-11-18 |
2017-06-09 |
南京大学 |
一种肿瘤靶向的人纤溶酶原Kringle5变体及其应用
|
|
CN103656630B
(zh)
|
2012-09-11 |
2015-07-08 |
江苏仁寿药业有限公司 |
一种提纯动物药材中纤溶酶并制备成中药组合物的方法
|
|
WO2014070983A1
(en)
|
2012-10-31 |
2014-05-08 |
The Regents Of The University Of Michigan |
Plasminogen activator-1 inhibitors and methods of use thereof
|
|
US9134326B2
(en)
|
2013-03-14 |
2015-09-15 |
Battelle Memorial Institute |
Biomarkers for liver fibrosis
|
|
CN104274449A
(zh)
|
2013-07-11 |
2015-01-14 |
无锡信达医疗器械有限公司 |
治疗肥胖症的药物组合物
|
|
TW201722994A
(zh)
|
2013-08-13 |
2017-07-01 |
賽諾菲公司 |
胞漿素原活化素抑制劑-1(pai-1)之抗體及其用途
|
|
CN112142845A
(zh)
|
2013-08-13 |
2020-12-29 |
赛诺菲 |
纤溶酶原激活剂抑制剂-1(pai-1)的抗体及其用途
|
|
US20160199466A1
(en)
|
2013-08-20 |
2016-07-14 |
Trustees Of Dartmouth College |
Methods For Treating Tissue Fibrosis
|
|
TWI801331B
(zh)
|
2015-11-03 |
2023-05-11 |
美商波麥堤克生物治療股份有限公司 |
纖維蛋白溶酶原缺乏症之纖維蛋白溶酶原替代療法
|
|
WO2017101871A1
(zh)
|
2015-12-18 |
2017-06-22 |
深圳瑞健生命科学研究院有限公司 |
一种预防和治疗心血管病的新方法
|
|
CA3008694C
(en)
|
2015-12-18 |
2022-11-29 |
Talengen International Limited |
Use of plasminogen for preventing or treating diabetic nerve injury and related disorders thereof
|
|
JP6682008B2
(ja)
|
2015-12-18 |
2020-04-15 |
タレンゲン インターナショナル リミテッドTalengen International Limited |
糖尿病性腎症を予防及び治療するための方法
|
|
EP3391901B1
(en)
|
2015-12-18 |
2023-07-05 |
Talengen International Limited |
Plasminogen for use in treating liver tissue damage
|
|
DK3395359T5
(da)
|
2015-12-18 |
2024-09-23 |
Talengen Int Ltd |
Plasminogen til anvendelse til forebyggelse eller behandling af akut trombose og kronisk trombose
|
|
US20190328850A1
(en)
|
2016-12-15 |
2019-10-31 |
Talengen International Limited |
Method for preventing and treating lipid metabolism disorders and related diseases thereof
|
|
TW201829448A
(zh)
|
2016-12-15 |
2018-08-16 |
大陸商深圳瑞健生命科學硏究院有限公司 |
纖溶酶原在製備預防或治療肥胖症及疾病倂發的肥胖的藥物中的用途
|
|
TWI677348B
(zh)
|
2016-12-15 |
2019-11-21 |
大陸商深圳瑞健生命科學研究院有限公司 |
一種改善心臟病變的方法
|
|
TWI714862B
(zh)
|
2017-06-19 |
2021-01-01 |
大陸商深圳瑞健生命科學硏究院有限公司 |
一種調控glp-1/glp-1r的方法和藥物
|
|
TWI868051B
(zh)
|
2017-06-23 |
2025-01-01 |
美商波麥堤克生物治療股份有限公司 |
與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
|