CN111356454A - 含有双环铂的组合产品、其制备方法及其用途 - Google Patents

含有双环铂的组合产品、其制备方法及其用途 Download PDF

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CN111356454A
CN111356454A CN201880074343.9A CN201880074343A CN111356454A CN 111356454 A CN111356454 A CN 111356454A CN 201880074343 A CN201880074343 A CN 201880074343A CN 111356454 A CN111356454 A CN 111356454A
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dicycloplatin
patient
cancer
acid
combination
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CN111356454B (zh
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刘晓忠
李雄
靳奇峰
郑和校
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Hunan Medoncare Medicine Technology Co ltd
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Hunan Medoncare Medicine Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/28Compounds containing heavy metals
    • A61K31/282Platinum compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
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    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0013Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group without a metal-carbon linkage
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    • A61K31/194Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
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    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • A61K38/063Glutathione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542Carboxylic acids, e.g. a fatty acid or an amino acid
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    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235Saturated compounds containing more than one carboxyl group
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    • C07C65/03Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
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    • C07C65/05Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
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    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
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    • C07F15/0093Platinum compounds without a metal-carbon linkage

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  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

本发明涉及含有双环铂的组合产品、所述组合产品在制备用于治疗和/或预防疼痛、炎症和与病毒相关的疾病的药物中的用途以及制备所述组合产品的方法。

Description

PCT国内申请,说明书已公开。

Claims (51)

  1. PCT国内申请,权利要求书已公开。
CN201880074343.9A 2017-11-21 2018-11-19 含有双环铂的组合产品、其制备方法及其用途 Active CN111356454B (zh)

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CN201711164023 2017-11-21
CN2017111640236 2017-11-21
PCT/CN2018/116213 WO2019101040A1 (zh) 2017-11-21 2018-11-19 含有双环铂的组合产品、其制备方法及其用途

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CN1311183A (zh) * 2000-03-03 2001-09-05 杨旭清 一种抗肿瘤的双二羧酸二氨络铂衍生物及其药物组合物
CN101677984A (zh) * 2007-04-16 2010-03-24 纽罗图恩股份公司 地来西坦在治疗慢性疼痛中的应用
WO2016172393A1 (en) * 2015-04-22 2016-10-27 Syn-Nat Products Enterprise LLC Co-crystal composition and its pharmaceutical use
WO2016187191A1 (en) * 2015-05-18 2016-11-24 Medoc Pharmaceutical Co., Ltd. A pharmaceutical co-crystal and use thereof

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US7566798B2 (en) 2003-08-13 2009-07-28 University Of South Florida Platinum complexes and methods of use
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CN104127402B (zh) * 2014-08-15 2019-08-30 北京默加农生物技术发展有限公司 双环铂在制备抗病毒药物和抗菌药物中的应用
EP3280408B1 (en) * 2015-04-10 2019-10-23 Syn-Nat Products Enterprise LLC Process for the preparation of dicycloplatin
JP2018517759A (ja) * 2015-06-19 2018-07-05 シン−ナット プロダクツ エンタープライズ エルエルシー カルボプラチンを含む組成物及び用途
US10428099B2 (en) * 2015-06-25 2019-10-01 Syn-Nat Products Enterprise LLC Pharmaceutical co-crystal composition and use thereof
JP7038653B2 (ja) * 2015-10-05 2022-03-18 ニューカナ パブリック リミテッド カンパニー 併用療法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1311183A (zh) * 2000-03-03 2001-09-05 杨旭清 一种抗肿瘤的双二羧酸二氨络铂衍生物及其药物组合物
CN101677984A (zh) * 2007-04-16 2010-03-24 纽罗图恩股份公司 地来西坦在治疗慢性疼痛中的应用
WO2016172393A1 (en) * 2015-04-22 2016-10-27 Syn-Nat Products Enterprise LLC Co-crystal composition and its pharmaceutical use
WO2016187191A1 (en) * 2015-05-18 2016-11-24 Medoc Pharmaceutical Co., Ltd. A pharmaceutical co-crystal and use thereof

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MX2020005310A (es) 2020-10-08
IL274785A (en) 2020-07-30
AU2018372753A1 (en) 2020-05-28
US20200361973A1 (en) 2020-11-19
CN111356454B (zh) 2023-04-07
JP7356438B2 (ja) 2023-10-04
KR20200090170A (ko) 2020-07-28
CA3082295A1 (en) 2019-05-31
WO2019101040A1 (zh) 2019-05-31
RU2020116704A (ru) 2021-12-22
EP3714881A1 (en) 2020-09-30
JP2021504452A (ja) 2021-02-15
AU2018372753B2 (en) 2024-03-21
EP3714881A4 (en) 2021-09-01

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