CN110402150A - 一种预防和治疗骨质疏松的药物及其用途 - Google Patents

一种预防和治疗骨质疏松的药物及其用途 Download PDF

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Publication number
CN110402150A
CN110402150A CN201780078120.5A CN201780078120A CN110402150A CN 110402150 A CN110402150 A CN 110402150A CN 201780078120 A CN201780078120 A CN 201780078120A CN 110402150 A CN110402150 A CN 110402150A
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CN
China
Prior art keywords
plasminogen
osteoporosis
mouse
bone
subject
Prior art date
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Pending
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CN201780078120.5A
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English (en)
Inventor
李季男
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Talengen Institute of Life Sciences Co Ltd
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Talengen Institute of Life Sciences Co Ltd
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Application filed by Talengen Institute of Life Sciences Co Ltd filed Critical Talengen Institute of Life Sciences Co Ltd
Publication of CN110402150A publication Critical patent/CN110402150A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

本发明提供了纤溶酶原用于预防和/或治疗骨质疏松及其相关病症的用途。本发明还提供了预防和/或治疗骨质疏松的药物及制品。

Description

PCT国内申请，说明书已公开。

Claims (35)

  1. PCT国内申请，权利要求书已公开。
CN201780078120.5A 2016-12-15 2017-12-15 一种预防和治疗骨质疏松的药物及其用途 Pending CN110402150A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/110163 2016-12-15
CN2016110163 2016-12-15
PCT/CN2017/116592 WO2018108165A1 (zh) 2016-12-15 2017-12-15 一种预防和治疗骨质疏松的药物及其用途

Publications (1)

Publication Number Publication Date
CN110402150A true CN110402150A (zh) 2019-11-01

Family

ID=62558036

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780078120.5A Pending CN110402150A (zh) 2016-12-15 2017-12-15 一种预防和治疗骨质疏松的药物及其用途

Country Status (7)

Country Link
US (1) US20190365871A1 (zh)
EP (1) EP3556381A4 (zh)
JP (1) JP2020502102A (zh)
CN (1) CN110402150A (zh)
CA (1) CA3047298C (zh)
TW (1) TW201828976A (zh)
WO (1) WO2018108165A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111870689A (zh) * 2020-08-12 2020-11-03 武汉真福医药股份有限公司 一种纳豆激酶在治疗骨质疏松药物中的应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102159896B1 (ko) 2010-04-13 2020-09-25 지이 비디오 컴프레션, 엘엘씨 샘플 배열 멀티트리 세부분할에서 계승
US11938172B2 (en) 2017-06-19 2024-03-26 Talengen International Limited Method for regulating and controlling GLP-1/GLP-1R and drug
CA3123318A1 (en) 2017-12-15 2019-06-20 Talengen International Limited Method and drug for preventing or treating osteoarthritis
CN110596406B (zh) * 2019-10-30 2021-05-07 河北工业大学 Tmem16a作为骨质疏松的标志物及其应用、骨质疏松诊断试剂盒和药物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040235728A1 (en) * 2001-11-08 2004-11-25 Stoch Selwyn Aubrey Compositions and methods for treating osteoporosis
CA2539445A1 (en) * 2003-09-30 2005-04-07 Snow Brand Milk Products Co., Ltd. Agent for promoting osteogenesis and/or inhibiting bone resorption
CN1856319A (zh) * 2003-09-30 2006-11-01 雪印乳业株式会社 骨生成促进和/或骨吸收抑制剂
CN102154253A (zh) * 2011-01-06 2011-08-17 郑州大学 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DK2275119T3 (da) 1995-07-27 2013-11-11 Genentech Inc Stabil, isotonisk lyofiliseret proteinformulering
JP5188523B2 (ja) * 2010-03-03 2013-04-24 雪印メグミルク株式会社 骨形成促進及び骨吸収抑制剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040235728A1 (en) * 2001-11-08 2004-11-25 Stoch Selwyn Aubrey Compositions and methods for treating osteoporosis
CA2539445A1 (en) * 2003-09-30 2005-04-07 Snow Brand Milk Products Co., Ltd. Agent for promoting osteogenesis and/or inhibiting bone resorption
CN1856319A (zh) * 2003-09-30 2006-11-01 雪印乳业株式会社 骨生成促进和/或骨吸收抑制剂
CN102154253A (zh) * 2011-01-06 2011-08-17 郑州大学 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BUTERA D等: "plasminogen isoform 1 precursor [Homo sapiens]", 《GENBANK》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111870689A (zh) * 2020-08-12 2020-11-03 武汉真福医药股份有限公司 一种纳豆激酶在治疗骨质疏松药物中的应用

Also Published As

Publication number Publication date
TW201828976A (zh) 2018-08-16
US20190365871A1 (en) 2019-12-05
WO2018108165A1 (zh) 2018-06-21
CA3047298C (en) 2023-12-12
EP3556381A4 (en) 2020-09-23
JP2020502102A (ja) 2020-01-23
EP3556381A1 (en) 2019-10-23
CA3047298A1 (en) 2018-06-21

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