CN110078978A - 用于制备粘弹性交联透明质酸的组合物和利用该组合物制得的交联透明质酸 - Google Patents
用于制备粘弹性交联透明质酸的组合物和利用该组合物制得的交联透明质酸 Download PDFInfo
- Publication number
- CN110078978A CN110078978A CN201811531607.7A CN201811531607A CN110078978A CN 110078978 A CN110078978 A CN 110078978A CN 201811531607 A CN201811531607 A CN 201811531607A CN 110078978 A CN110078978 A CN 110078978A
- Authority
- CN
- China
- Prior art keywords
- hyaluronic acid
- cross
- linked
- composition
- linked hyaluronic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 128
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 127
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 118
- 239000000203 mixture Substances 0.000 title claims abstract description 61
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 15
- 238000004132 cross linking Methods 0.000 claims description 13
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 238000000227 grinding Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical group C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 claims description 4
- 239000002002 slurry Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 abstract description 11
- 230000002051 biphasic effect Effects 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 9
- 102000004190 Enzymes Human genes 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 8
- 229940088598 enzyme Drugs 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 7
- 229940014041 hyaluronate Drugs 0.000 description 7
- 239000000243 solution Substances 0.000 description 6
- 108010003272 Hyaluronate lyase Proteins 0.000 description 4
- 102000001974 Hyaluronidases Human genes 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229960002773 hyaluronidase Drugs 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 239000012670 alkaline solution Substances 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 238000010298 pulverizing process Methods 0.000 description 3
- 230000035484 reaction time Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000007838 tissue remodeling Effects 0.000 description 3
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000008521 reorganization Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
- 229940099552 hyaluronan Drugs 0.000 description 1
- VJVOFLWZDWLHNR-MRCUWXFGSA-N icosan-9-yl (z)-docos-13-enoate Chemical compound CCCCCCCCCCCC(CCCCCCCC)OC(=O)CCCCCCCCCCC\C=C/CCCCCCCC VJVOFLWZDWLHNR-MRCUWXFGSA-N 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- NHGXDBSUJJNIRV-UHFFFAOYSA-M tetrabutylammonium chloride Chemical compound [Cl-].CCCC[N+](CCCC)(CCCC)CCCC NHGXDBSUJJNIRV-UHFFFAOYSA-M 0.000 description 1
- 230000030968 tissue homeostasis Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Materials Engineering (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020130032956A KR101869988B1 (ko) | 2013-03-27 | 2013-03-27 | 점탄성 히알루론산 가교물 제조용 조성물, 및 이를 이용하여 얻은 히알루론산 가교물 |
| KR10-2013-0032956 | 2013-03-27 | ||
| CN201310631346.7A CN104072814A (zh) | 2013-03-27 | 2013-11-29 | 用于制备粘弹性交联透明质酸的组合物和利用该组合物制得的交联透明质酸 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310631346.7A Division CN104072814A (zh) | 2013-03-27 | 2013-11-29 | 用于制备粘弹性交联透明质酸的组合物和利用该组合物制得的交联透明质酸 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110078978A true CN110078978A (zh) | 2019-08-02 |
Family
ID=51594442
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811531607.7A Pending CN110078978A (zh) | 2013-03-27 | 2013-11-29 | 用于制备粘弹性交联透明质酸的组合物和利用该组合物制得的交联透明质酸 |
| CN201310631346.7A Pending CN104072814A (zh) | 2013-03-27 | 2013-11-29 | 用于制备粘弹性交联透明质酸的组合物和利用该组合物制得的交联透明质酸 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310631346.7A Pending CN104072814A (zh) | 2013-03-27 | 2013-11-29 | 用于制备粘弹性交联透明质酸的组合物和利用该组合物制得的交联透明质酸 |
Country Status (10)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115279798A (zh) * | 2020-03-10 | 2022-11-01 | 玫帝托克斯股份有限公司 | 交联透明质酸，以及其用途 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160268291A1 (en) * | 2015-03-13 | 2016-09-15 | Kabushiki Kaisha Toshiba | Semiconductor device and manufacturing method of semiconductor device |
| KR101720426B1 (ko) * | 2015-09-01 | 2017-04-14 | (주)시지바이오 | 히알루론산 조성물 및 그의 제조방법 |
| RU2769398C1 (ru) * | 2018-07-06 | 2022-03-31 | ЭлДжи КЕМ, ЛТД. | Наполнитель с гиалуроновой кислотой, имеющий высокую вязкоупругость и высокую когезию |
| RU2770541C1 (ru) * | 2018-07-10 | 2022-04-18 | ЭлДжи КЕМ, ЛТД. | Наполнитель с гиалуроновой кислотой, имеющий высокую способность лифтинга и низкую силу инъекции |
| WO2020130685A1 (ko) | 2018-12-21 | 2020-06-25 | 주식회사 엘지화학 | 우수한 필링 특성을 갖는 히알루론산 하이드로겔을 포함하는 필러 |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1207744A (zh) * | 1995-11-15 | 1999-02-10 | 生化学株式会社 | 光固化交联透明质酸凝胶及其制备方法 |
| CN101244290A (zh) * | 2007-11-30 | 2008-08-20 | 顾其胜 | 一种用于组织填充的交联透明质酸微粒凝胶的制备方法 |
| CN101538377A (zh) * | 2008-03-20 | 2009-09-23 | 上海昊海生物科技有限公司 | 一种交联透明质酸凝胶及其制备方法 |
| CN101626754A (zh) * | 2007-02-15 | 2010-01-13 | 株式会社太平洋 | 化学交联的透明质酸水凝胶纳米颗粒及其制备方法 |
| CN101724164A (zh) * | 2008-10-31 | 2010-06-09 | 科妍生物科技股份有限公司 | 交联透明质酸的制造方法 |
| CN101759881A (zh) * | 2008-10-08 | 2010-06-30 | 上海建华精细生物制品有限公司 | 一种医用交联透明质酸钠凝胶衍生产品及其制备方法 |
| CN102120833A (zh) * | 2011-01-10 | 2011-07-13 | 深圳市资福药业有限公司 | 一种透明质酸盐凝胶颗粒及其制备方法 |
| CN102188712A (zh) * | 2010-03-04 | 2011-09-21 | 上海其胜生物制剂有限公司 | 一种可注射用凝胶微粒的制备方法 |
| CN102952275A (zh) * | 2011-08-19 | 2013-03-06 | 上海建华精细生物制品有限公司 | 一种双相技术运用的透明质酸凝胶及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5827937A (en) * | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
| FR2811996B1 (fr) * | 2000-07-19 | 2003-08-08 | Corneal Ind | Reticulation de polysaccharide(s), preparation d'hydrogel(s) ; polysaccharide(s) et hydrogel(s) obtenus,leurs utilisations |
| SE0401182D0 (sv) * | 2004-05-05 | 2004-05-05 | Q Med Ab | Novel use of a viscoelastic composition |
| EP1818344A4 (en) * | 2004-11-15 | 2012-04-18 | Shiseido Co Ltd | METHOD FOR SYNTHESIZING RETICULATED HYALURONIC ACID GEL |
-
2013
- 2013-03-27 KR KR1020130032956A patent/KR101869988B1/ko active Active
- 2013-11-13 TW TW102141213A patent/TWI522134B/zh active
- 2013-11-14 MY MYPI2013702159A patent/MY169325A/en unknown
- 2013-11-15 TR TR2013/13318A patent/TR201313318A2/tr unknown
- 2013-11-26 MX MX2013013828A patent/MX366526B/es active IP Right Grant
- 2013-11-28 BR BR102013030668A patent/BR102013030668B1/pt active IP Right Grant
- 2013-11-29 CN CN201811531607.7A patent/CN110078978A/zh active Pending
- 2013-11-29 AR ARP130104435A patent/AR093689A1/es active IP Right Grant
- 2013-11-29 CN CN201310631346.7A patent/CN104072814A/zh active Pending
- 2013-11-29 RU RU2013153007/13A patent/RU2568998C2/ru active
- 2013-12-02 IN IN3773MU2013 patent/IN2013MU03773A/en unknown
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1207744A (zh) * | 1995-11-15 | 1999-02-10 | 生化学株式会社 | 光固化交联透明质酸凝胶及其制备方法 |
| CN101626754A (zh) * | 2007-02-15 | 2010-01-13 | 株式会社太平洋 | 化学交联的透明质酸水凝胶纳米颗粒及其制备方法 |
| CN101244290A (zh) * | 2007-11-30 | 2008-08-20 | 顾其胜 | 一种用于组织填充的交联透明质酸微粒凝胶的制备方法 |
| CN101538377A (zh) * | 2008-03-20 | 2009-09-23 | 上海昊海生物科技有限公司 | 一种交联透明质酸凝胶及其制备方法 |
| CN101759881A (zh) * | 2008-10-08 | 2010-06-30 | 上海建华精细生物制品有限公司 | 一种医用交联透明质酸钠凝胶衍生产品及其制备方法 |
| CN101724164A (zh) * | 2008-10-31 | 2010-06-09 | 科妍生物科技股份有限公司 | 交联透明质酸的制造方法 |
| CN102188712A (zh) * | 2010-03-04 | 2011-09-21 | 上海其胜生物制剂有限公司 | 一种可注射用凝胶微粒的制备方法 |
| CN102120833A (zh) * | 2011-01-10 | 2011-07-13 | 深圳市资福药业有限公司 | 一种透明质酸盐凝胶颗粒及其制备方法 |
| CN102952275A (zh) * | 2011-08-19 | 2013-03-06 | 上海建华精细生物制品有限公司 | 一种双相技术运用的透明质酸凝胶及其制备方法 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115279798A (zh) * | 2020-03-10 | 2022-11-01 | 玫帝托克斯股份有限公司 | 交联透明质酸，以及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR102013030668A8 (pt) | 2018-05-08 |
| IN2013MU03773A (enrdf_load_html_response) | 2015-08-07 |
| KR101869988B1 (ko) | 2018-06-21 |
| MY169325A (en) | 2019-03-21 |
| AR093689A1 (es) | 2015-06-17 |
| BR102013030668A2 (pt) | 2015-08-04 |
| TWI522134B (zh) | 2016-02-21 |
| MX2013013828A (es) | 2014-09-26 |
| MX366526B (es) | 2019-07-11 |
| CN104072814A (zh) | 2014-10-01 |
| RU2013153007A (ru) | 2015-06-10 |
| KR20140117956A (ko) | 2014-10-08 |
| TW201436827A (zh) | 2014-10-01 |
| RU2568998C2 (ru) | 2015-11-20 |
| BR102013030668B1 (pt) | 2020-04-07 |
| TR201313318A2 (tr) | 2014-10-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10207024B2 (en) | Biodegradable single-phase cohesive hydrogels | |
| CN110078978A (zh) | 用于制备粘弹性交联透明质酸的组合物和利用该组合物制得的交联透明质酸 | |
| EP3381438B2 (en) | Composition for injection of hyaluronic acid, containing hyaluronic acid derivative and dna fraction, and use thereof | |
| CN104086788B (zh) | 一种注射用修饰透明质酸钠凝胶 | |
| CN101528780B (zh) | 通过"点击化学"交联而获得的透明质酸衍生物 | |
| CN104327311B (zh) | 一种透明质酸复合交联水凝胶及其制备方法 | |
| CN113164652A (zh) | 具有优异的填充剂性能的包含透明质酸水凝胶的填充剂 | |
| AU2013276844A1 (en) | Method of preparing a composition based on hyaluronic acid | |
| CN108478875A (zh) | 一种交联透明质酸凝胶微球的制备方法及其应用 | |
| WO2017001057A1 (en) | Method of preparing a composition based on hyaluronic acid | |
| JP6561133B2 (ja) | 生体適合性組成物及びこの製造方法 | |
| KR20150110843A (ko) | 물리적 반응에 의한 히알루론산 하이드로겔의 제조 방법 | |
| CN116159192B (zh) | 一种可注射止血防黏连水凝胶及其制备方法 | |
| JP6648142B2 (ja) | グリコサミノグリカンおよびタンパク質を含む組成物 | |
| CN116251231B (zh) | 一种注射用美容填充材料及其制备方法 | |
| KR20150044862A (ko) | 이온성 가교된 히알루론산 조직수복재 | |
| KR20200046649A (ko) | 혼합상 히알루론산 제조방법 | |
| HK1235322A1 (en) | Composition containing glycosaminoglycans and proteins | |
| HK1150772B (en) | Biodegradable single-phase cohesive hydrogel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |