CN110078842A - 皱盖假芝多糖f212的制备方法和用于预防和/或治疗乳腺癌的应用 - Google Patents
皱盖假芝多糖f212的制备方法和用于预防和/或治疗乳腺癌的应用 Download PDFInfo
- Publication number
- CN110078842A CN110078842A CN201910437189.3A CN201910437189A CN110078842A CN 110078842 A CN110078842 A CN 110078842A CN 201910437189 A CN201910437189 A CN 201910437189A CN 110078842 A CN110078842 A CN 110078842A
- Authority
- CN
- China
- Prior art keywords
- breast cancer
- berk
- pat
- polysaccharide
- amauroderma ruda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241001480533 Amauroderma Species 0.000 title claims abstract description 68
- 150000004676 glycans Chemical class 0.000 title claims abstract description 66
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 66
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 66
- 206010006187 Breast cancer Diseases 0.000 title claims abstract description 53
- 208000026310 Breast neoplasm Diseases 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims abstract description 10
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims abstract description 9
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims abstract description 9
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims abstract description 7
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims abstract description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 7
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims abstract description 7
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims abstract description 7
- 150000002772 monosaccharides Chemical class 0.000 claims abstract description 7
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims abstract description 6
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims abstract description 6
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000008103 glucose Substances 0.000 claims abstract description 6
- 230000000694 effects Effects 0.000 claims description 17
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000004480 active ingredient Substances 0.000 claims description 12
- 238000012216 screening Methods 0.000 claims description 11
- 230000036541 health Effects 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 7
- 238000010828 elution Methods 0.000 claims description 7
- 239000011780 sodium chloride Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 229920002271 DEAE-Sepharose Polymers 0.000 claims description 5
- 239000006286 aqueous extract Substances 0.000 claims description 5
- 235000009508 confectionery Nutrition 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000005119 centrifugation Methods 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 239000003480 eluent Substances 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 239000013049 sediment Substances 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 2
- 230000002062 proliferating effect Effects 0.000 claims description 2
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 abstract description 36
- 230000000259 anti-tumor effect Effects 0.000 abstract description 7
- 238000011160 research Methods 0.000 abstract description 6
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 abstract description 4
- 231100000252 nontoxic Toxicity 0.000 abstract description 4
- 230000003000 nontoxic effect Effects 0.000 abstract description 4
- 210000004027 cell Anatomy 0.000 description 24
- 201000011510 cancer Diseases 0.000 description 10
- 241000233866 Fungi Species 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 210000004881 tumor cell Anatomy 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 3
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 3
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 238000002329 infrared spectrum Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- 244000000231 Sesamum indicum Species 0.000 description 2
- 235000003434 Sesamum indicum Nutrition 0.000 description 2
- 238000005903 acid hydrolysis reaction Methods 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 239000003560 cancer drug Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000004043 dyeing Methods 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 206010055031 vascular neoplasm Diseases 0.000 description 2
- 235000012973 Ceratotheca sesamoides Nutrition 0.000 description 1
- 240000009274 Ceratotheca sesamoides Species 0.000 description 1
- 240000008397 Ganoderma lucidum Species 0.000 description 1
- 235000001637 Ganoderma lucidum Nutrition 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 241000414067 Inonotus obliquus Species 0.000 description 1
- 241000149440 Lentinus tuber-regium Species 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 description 1
- 208000009956 adenocarcinoma Diseases 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- -1 causes leucocyte Substances 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N ferric oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 102000027450 oncoproteins Human genes 0.000 description 1
- 108091008819 oncoproteins Proteins 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 108091007466 transmembrane glycoproteins Proteins 0.000 description 1
- 230000005760 tumorsuppression Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Materials Engineering (AREA)
- Nutrition Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Sustainable Development (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (8)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910437189.3A CN110078842B (zh) | 2019-05-24 | 2019-05-24 | 皱盖假芝多糖f212的制备方法和用于预防和/或治疗乳腺癌的应用 |
PCT/CN2019/090763 WO2020237724A1 (zh) | 2019-05-24 | 2019-06-11 | 皱盖假芝多糖f212的制备方法和用于预防和/或治疗乳腺癌的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910437189.3A CN110078842B (zh) | 2019-05-24 | 2019-05-24 | 皱盖假芝多糖f212的制备方法和用于预防和/或治疗乳腺癌的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110078842A true CN110078842A (zh) | 2019-08-02 |
CN110078842B CN110078842B (zh) | 2021-08-10 |
Family
ID=67421654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910437189.3A Active CN110078842B (zh) | 2019-05-24 | 2019-05-24 | 皱盖假芝多糖f212的制备方法和用于预防和/或治疗乳腺癌的应用 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN110078842B (zh) |
WO (1) | WO2020237724A1 (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102258563A (zh) * | 2010-05-28 | 2011-11-30 | 浦元清 | 一种抗癌药物组合物和一种中药组合物 |
CN104725521A (zh) * | 2015-03-31 | 2015-06-24 | 广东省微生物研究所 | 一种皱盖假芝单峰多糖f212及其制备方法和应用 |
CN108753869A (zh) * | 2018-06-26 | 2018-11-06 | 广东省微生物研究所(广东省微生物分析检测中心) | 一种皱盖假芝胞外多糖的制备方法及应用 |
-
2019
- 2019-05-24 CN CN201910437189.3A patent/CN110078842B/zh active Active
- 2019-06-11 WO PCT/CN2019/090763 patent/WO2020237724A1/zh active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102258563A (zh) * | 2010-05-28 | 2011-11-30 | 浦元清 | 一种抗癌药物组合物和一种中药组合物 |
CN104725521A (zh) * | 2015-03-31 | 2015-06-24 | 广东省微生物研究所 | 一种皱盖假芝单峰多糖f212及其制备方法和应用 |
CN108753869A (zh) * | 2018-06-26 | 2018-11-06 | 广东省微生物研究所(广东省微生物分析检测中心) | 一种皱盖假芝胞外多糖的制备方法及应用 |
Non-Patent Citations (3)
Title |
---|
CHUNWEI JIAO等: "Anticancer Activity of Amauroderma rude", 《PLOS ONE》 * |
HONGHUI PAN等: "Purification and identification of a polysaccharide from medicinal mushroom Amauroderma rude with immunomodulatory activity and inhibitory effect on tumor growth", 《ONCOTARGET》 * |
国家药典委员会编: "《中华人民共和国药典 临床用药须知 中药饮片卷》", 30 September 2017, 中国医药科技出版社 * |
Also Published As
Publication number | Publication date |
---|---|
WO2020237724A1 (zh) | 2020-12-03 |
CN110078842B (zh) | 2021-08-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104710538B (zh) | 一种三七花阿拉伯半乳聚糖及其制备方法和用途 | |
CN104592323B (zh) | 一种双水相萃取苹果渣中根皮苷的方法 | |
CN106668321A (zh) | 一种人参枸杞子组合物的制备方法及其产品和应用 | |
CN101829138B (zh) | 一种用于增强人体内免疫调节功能的组合物与它们的用途 | |
CN102584963A (zh) | 一种活性灵芝多糖肽对照品、制备方法及应用 | |
CN107722131B (zh) | 一种具有显著辅助抗肿瘤活性的全灵芝孢子粉精制多糖及其制备方法和应用 | |
CN100369936C (zh) | 明党参多糖硫酸酯化物和制备方法及其应用 | |
CN101962402B (zh) | 一种黄芪糖蛋白及其制备方法和用途 | |
CN103113489B (zh) | 一种新疆骏枣多糖提纯的方法 | |
CN109251253A (zh) | 一种掌叶覆盆子多糖及其制备方法和在制备肝脏细胞脂毒性损伤抑制剂中的应用 | |
CN106083950B (zh) | 一种从红景天中提取红景天甙的方法 | |
CN110078842A (zh) | 皱盖假芝多糖f212的制备方法和用于预防和/或治疗乳腺癌的应用 | |
CN105315382B (zh) | 由双孢蘑菇罐头加工废水中提取纯化的活性多糖及其提取纯化工艺和应用 | |
CN104107388B (zh) | 一种提高免疫力抗肿瘤的复方中药组合物及其制备方法和用途 | |
CN107188985B (zh) | 一种附子多糖的制备方法和新用途 | |
CN102276754A (zh) | 红芪多糖中的硫酸酯葡聚糖及其制备方法和应用 | |
CN110156904A (zh) | 紫甘薯多糖在制备抗肺癌药物中的应用 | |
CN113717296B (zh) | 一种杜仲酸性多糖、提取方法及其在制备抗结肠癌药物中的应用 | |
CN103169752B (zh) | 一种木鳖子提取物及其制备方法和用途 | |
CN109354629A (zh) | 一种中性三七多糖的提取纯化方法及应用 | |
CN108314745A (zh) | 一种制备桦褐孔菌多糖的方法 | |
CN103554289A (zh) | 北苍术多糖及提取方法及在制备抗肿瘤药物中的用途 | |
CN107397765A (zh) | 一种破壁灵芝孢子提取物及其提取方法和应用 | |
CN113956375A (zh) | 一种熟地黄均一多糖及其制备方法和抗抑郁作用 | |
CN106946998A (zh) | 一种天然抗氧化剂灰喇叭菌多糖ccpp‑1及其制备方法和用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: 510070 No. 58, courtyard, No. 100, Xianlie Middle Road, Yuexiu District, Guangzhou, Guangdong Province Patentee after: Institute of Microbiology, Guangdong Academy of Sciences Patentee after: GUANGDONG YUEWEI EDIBLE FUNGI TECHNOLOGY Co.,Ltd. Address before: 510070 courtyard, No. 100, Xianlie Middle Road, Yuexiu District, Guangzhou City, Guangdong Province Patentee before: GUANGDONG INSTITUTE OF MICROBIOLOGY (GUANGDONG DETECTION CENTER OF MICROBIOLOGY) Patentee before: GUANGDONG YUEWEI EDIBLE FUNGI TECHNOLOGY Co.,Ltd. |
|
OL01 | Intention to license declared | ||
OL01 | Intention to license declared |