CN1100725A - 取代的1，4-二氢吡啶类化合物及其制备方法与应用 - Google Patents

取代的1，4-二氢吡啶类化合物及其制备方法与应用 Download PDF

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Publication number
CN1100725A
CN1100725A CN94104685A CN94104685A CN1100725A CN 1100725 A CN1100725 A CN 1100725A CN 94104685 A CN94104685 A CN 94104685A CN 94104685 A CN94104685 A CN 94104685A CN 1100725 A CN1100725 A CN 1100725A
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China
Prior art keywords
carbon atoms
group
branched
optionally substituted
straight
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Pending
Application number
CN94104685A
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English (en)
Chinese (zh)
Inventor
A·施特劳布
S·戈德曼
J·施托尔特富斯
M·比切姆
R·格罗斯
S·赫比什
J·胡特
H·P·朗丁
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Bayer AG
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Bayer AG
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Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of CN1100725A publication Critical patent/CN1100725A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN94104685A 1993-04-27 1994-04-27 取代的1，4-二氢吡啶类化合物及其制备方法与应用 Pending CN1100725A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4313696A DE4313696A1 (de) 1993-04-27 1993-04-27 2-Amino-4-heteroaryl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
DEP4313696.6 1993-04-27

Publications (1)

Publication Number Publication Date
CN1100725A true CN1100725A (zh) 1995-03-29

Family

ID=6486454

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94104685A Pending CN1100725A (zh) 1993-04-27 1994-04-27 取代的1，4-二氢吡啶类化合物及其制备方法与应用

Country Status (17)

Country Link
US (2) US5434153A (enExample)
EP (1) EP0622365A1 (enExample)
JP (1) JPH06321943A (enExample)
CN (1) CN1100725A (enExample)
AU (1) AU671001B2 (enExample)
CA (1) CA2121963A1 (enExample)
CZ (1) CZ99594A3 (enExample)
DE (1) DE4313696A1 (enExample)
FI (1) FI941915A7 (enExample)
HU (1) HUT70540A (enExample)
IL (1) IL109439A0 (enExample)
NO (1) NO941519L (enExample)
NZ (1) NZ260385A (enExample)
PH (1) PH30808A (enExample)
RU (2) RU94014627A (enExample)
SK (1) SK47994A3 (enExample)
ZA (1) ZA942884B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2538188A1 (en) * 2003-09-10 2005-03-24 Synta Pharmaceuticals Corp. Dihydropyridine compounds for treating or preventing metabolic disorders
EP2398790B1 (en) 2009-02-18 2013-07-03 Bayer Intellectual Property GmbH Bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3946026A (en) * 1972-03-06 1976-03-23 Bayer Aktiengesellschaft 2-Amino-1,4-dihydropyridine derivatives
DE2242786A1 (de) * 1972-08-31 1974-03-14 Bayer Ag Verfahren zur herstellung von neuen 2-amino-1,4-dihydropyridinen mit einer carbonylfunktion sowie ihre verwendung als arzneimittel
US3989708A (en) * 1972-08-31 1976-11-02 Bayer Aktiengesellschaft 2-Amino-1,4-dihydropyridine derivatives
DE2639257A1 (de) * 1976-09-01 1978-03-02 Bayer Ag Aminoalkylidenamino-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3311003A1 (de) * 1983-03-25 1984-09-27 Bayer Ag, 5090 Leverkusen Chromon- und thiochromonsubstituierte 1,4-dihydropyridinlactone, mehrere verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4011106A1 (de) * 1990-04-06 1991-10-10 Bayer Ag Neue heterocyclisch substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5254692A (en) * 1990-04-06 1993-10-19 Bayer Aktiengesellschaft 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines
DE4117750A1 (de) * 1991-05-30 1992-12-24 Bayer Ag Neue 2-amino-5-cyano-1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4134760A1 (de) * 1991-10-22 1993-07-08 Bayer Ag Aryl-chinolyl-substituierte 1,4-dihydropyridin-dicarbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4202526A1 (de) * 1992-01-30 1993-08-05 Bayer Ag Neue 4-cinnolinyl- und 4-naphthyridinyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
US5434153A (en) 1995-07-18
NZ260385A (en) 1996-04-26
AU671001B2 (en) 1996-08-08
FI941915A7 (fi) 1994-10-28
NO941519D0 (enExample) 1994-04-26
JPH06321943A (ja) 1994-11-22
IL109439A0 (en) 1994-07-31
RU94014255A (ru) 1997-02-20
US5478937A (en) 1995-12-26
EP0622365A1 (de) 1994-11-02
DE4313696A1 (de) 1994-11-03
HUT70540A (en) 1995-10-30
SK47994A3 (en) 1994-12-07
PH30808A (en) 1997-10-17
CZ99594A3 (en) 1994-11-16
RU94014627A (ru) 1997-02-20
HU9401191D0 (en) 1994-07-28
ZA942884B (en) 1995-01-04
NO941519L (no) 1994-10-28
FI941915A0 (fi) 1994-04-25
AU5922294A (en) 1994-11-03
CA2121963A1 (en) 1994-10-28

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