CN110055320A - 痤疮的快速诊断和个体化治疗 - Google Patents

痤疮的快速诊断和个体化治疗 Download PDF

Info

Publication number
CN110055320A
CN110055320A CN201910052894.1A CN201910052894A CN110055320A CN 110055320 A CN110055320 A CN 110055320A CN 201910052894 A CN201910052894 A CN 201910052894A CN 110055320 A CN110055320 A CN 110055320A
Authority
CN
China
Prior art keywords
acnes
strains
seq
acne
genome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910052894.1A
Other languages
English (en)
Chinese (zh)
Inventor
李慧英
S.托米达
R.L.莫林
J.F.米勒
S.T.费茨-吉邦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CALIFORNIA SENATE
Original Assignee
CALIFORNIA SENATE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CALIFORNIA SENATE filed Critical CALIFORNIA SENATE
Publication of CN110055320A publication Critical patent/CN110055320A/zh
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/0208Specific bacteria not otherwise provided for
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/05Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/00032Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201910052894.1A 2012-03-17 2013-03-15 痤疮的快速诊断和个体化治疗 Pending CN110055320A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261612290P 2012-03-17 2012-03-17
US61/612290 2012-03-17
CN201380025853.4A CN104364394B (zh) 2012-03-17 2013-03-15 痤疮的快速诊断和个体化治疗

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380025853.4A Division CN104364394B (zh) 2012-03-17 2013-03-15 痤疮的快速诊断和个体化治疗

Publications (1)

Publication Number Publication Date
CN110055320A true CN110055320A (zh) 2019-07-26

Family

ID=49223275

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201910052894.1A Pending CN110055320A (zh) 2012-03-17 2013-03-15 痤疮的快速诊断和个体化治疗
CN201380025853.4A Active CN104364394B (zh) 2012-03-17 2013-03-15 痤疮的快速诊断和个体化治疗

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201380025853.4A Active CN104364394B (zh) 2012-03-17 2013-03-15 痤疮的快速诊断和个体化治疗

Country Status (9)

Country Link
US (5) US20150086581A1 (enExample)
EP (3) EP2825676B1 (enExample)
JP (3) JP2015512255A (enExample)
CN (2) CN110055320A (enExample)
AU (3) AU2013235340B2 (enExample)
BR (1) BR112014023005A2 (enExample)
CA (1) CA2867621A1 (enExample)
SG (1) SG11201405783VA (enExample)
WO (1) WO2013142378A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109562048A (zh) * 2016-02-05 2019-04-02 加州大学评议会 用于促进皮肤健康的组合物和方法
CN113066533A (zh) * 2021-04-02 2021-07-02 欧蒙医学诊断(中国)有限公司 一种mNGS病原体数据分析方法
CN118737269A (zh) * 2024-08-30 2024-10-01 墨卓生物科技(浙江)有限公司 在单细胞微生物基因组测序结果中区分菌株的方法

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9457077B2 (en) 2009-11-18 2016-10-04 Katherine Rose Kovarik Method and system for targeting the microbiome to promote health and treat allergic and inflammatory diseases
US9585920B2 (en) 2011-02-04 2017-03-07 Katherine Rose Kovarik Method and system for treating cancer cachexia
US10842834B2 (en) 2016-01-06 2020-11-24 Joseph E. Kovarik Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US11419903B2 (en) 2015-11-30 2022-08-23 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US9730967B2 (en) 2011-02-04 2017-08-15 Katherine Rose Kovarik Method and system for treating cancer cachexia
US11357722B2 (en) 2011-02-04 2022-06-14 Seed Health, Inc. Method and system for preventing sore throat in humans
US11523934B2 (en) 2011-02-04 2022-12-13 Seed Health, Inc. Method and system to facilitate the growth of desired bacteria in a human's mouth
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US10111913B2 (en) 2011-02-04 2018-10-30 Joseph E. Kovarik Method of reducing the likelihood of skin cancer in an individual human being
US11191665B2 (en) 2011-02-04 2021-12-07 Joseph E. Kovarik Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US10085938B2 (en) 2011-02-04 2018-10-02 Joseph E. Kovarik Method and system for preventing sore throat in humans
US9987224B2 (en) 2011-02-04 2018-06-05 Joseph E. Kovarik Method and system for preventing migraine headaches, cluster headaches and dizziness
US12257272B2 (en) 2015-12-24 2025-03-25 Seed Health, Inc. Method and system for reducing the likelihood of developing depression in an individual
US10314865B2 (en) 2011-02-04 2019-06-11 Katherine Rose Kovarik Method and system for treating cancer and other age-related diseases by extending the healthspan of a human
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US10548761B2 (en) 2011-02-04 2020-02-04 Joseph E. Kovarik Method and system for reducing the likelihood of colorectal cancer in a human being
US10010568B2 (en) 2011-02-04 2018-07-03 Katherine Rose Kovarik Method and system for reducing the likelihood of a spirochetes infection in a human being
US10583033B2 (en) 2011-02-04 2020-03-10 Katherine Rose Kovarik Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US12279989B2 (en) 2011-02-04 2025-04-22 Seed Health, Inc. Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity
US11273187B2 (en) 2015-11-30 2022-03-15 Joseph E. Kovarik Method and system for reducing the likelihood of developing depression in an individual
US10245288B2 (en) 2011-02-04 2019-04-02 Joseph E. Kovarik Method and system for reducing the likelihood of developing NASH in an individual diagnosed with non-alcoholic fatty liver disease
US10086018B2 (en) 2011-02-04 2018-10-02 Joseph E. Kovarik Method and system for reducing the likelihood of colorectal cancer in a human being
US10835560B2 (en) 2013-12-20 2020-11-17 Joseph E. Kovarik Reducing the likelihood of skin cancer in an individual human being
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US10512661B2 (en) 2011-02-04 2019-12-24 Joseph E. Kovarik Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
US10687975B2 (en) 2011-02-04 2020-06-23 Joseph E. Kovarik Method and system to facilitate the growth of desired bacteria in a human's mouth
US10940169B2 (en) 2015-11-30 2021-03-09 Joseph E. Kovarik Method for reducing the likelihood of developing cancer in an individual human being
EP2734621B1 (en) 2011-07-22 2019-09-04 President and Fellows of Harvard College Evaluation and improvement of nuclease cleavage specificity
EP2825676B1 (en) 2012-03-17 2017-12-20 The Regents of The University of California Fast diagnosis and personalized treatments for acne
EP3011046A4 (en) 2013-06-18 2017-03-01 Prodermiq, Inc. Customized skin care products and personal care products based on the analysis of skin flora
JP6637885B2 (ja) 2013-07-21 2020-01-29 ペンデュラム セラピューティクス, インコーポレイテッド マイクロバイオームの特性解明、モニタリング、および処置のための方法およびシステム
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
US9340800B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College Extended DNA-sensing GRNAS
CA2930015A1 (en) 2013-11-07 2015-05-14 Editas Medicine, Inc. Crispr-related methods and compositions with governing grnas
US9840699B2 (en) 2013-12-12 2017-12-12 President And Fellows Of Harvard College Methods for nucleic acid editing
US11672835B2 (en) 2013-12-20 2023-06-13 Seed Health, Inc. Method for treating individuals having cancer and who are receiving cancer immunotherapy
US11213552B2 (en) 2015-11-30 2022-01-04 Joseph E. Kovarik Method for treating an individual suffering from a chronic infectious disease and cancer
US11529379B2 (en) 2013-12-20 2022-12-20 Seed Health, Inc. Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
US11642382B2 (en) 2013-12-20 2023-05-09 Seed Health, Inc. Method for treating an individual suffering from bladder cancer
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US12246043B2 (en) 2013-12-20 2025-03-11 Seed Health, Inc. Topical application to treat acne vulgaris
US11026982B2 (en) 2015-11-30 2021-06-08 Joseph E. Kovarik Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US12329783B2 (en) 2013-12-20 2025-06-17 Seed Health, Inc. Method and system to improve the health of a person's skin microbiome
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US12318377B2 (en) 2013-12-20 2025-06-03 Seed Health, Inc. Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
EP3139939B1 (en) * 2014-05-07 2023-09-06 The Regents of The University of California Compositions and methods for treating skin and mucous membrane diseases
CA2950945A1 (en) 2014-06-17 2015-12-23 Xycrobe Therapeutics, Inc. Genetically modified bacteria and methods for genetic modification of bacteria
WO2016022363A2 (en) 2014-07-30 2016-02-11 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
EP3186376B1 (en) 2014-08-27 2019-03-20 Caribou Biosciences, Inc. Methods for increasing cas9-mediated engineering efficiency
WO2016065075A1 (en) 2014-10-21 2016-04-28 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics
US10169541B2 (en) 2014-10-21 2019-01-01 uBiome, Inc. Method and systems for characterizing skin related conditions
US10410749B2 (en) 2014-10-21 2019-09-10 uBiome, Inc. Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions
WO2016168350A1 (en) * 2015-04-13 2016-10-20 uBiome, Inc. Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions
US10774305B2 (en) 2015-04-20 2020-09-15 S-Biomedic Nv Methods and compositions for changing the composition of the skin microbiome using complex mixtures of bacterial strains
JP6046849B1 (ja) * 2015-07-21 2016-12-21 TAK−Circulator株式会社 身体状態の評価方法、情報の提示方法、および身体状態を改善又は予防する物質のスクリーニング方法
AU2016301963A1 (en) 2015-08-06 2018-02-15 Ares Genetics Gmbh Genetic resistance prediction against antimicrobial drugs in microorganism using structural changes in the genome
CN108348166B (zh) * 2015-09-09 2022-06-03 普梭梅根公司 用于与抗生素使用相关的感染性疾病及其它健康状况的源自微生物群系的诊断及治疗方法和系统
US20190136298A1 (en) * 2015-09-09 2019-05-09 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for eczema
CN108348167B (zh) * 2015-09-09 2022-06-03 普梭梅根公司 用于脑-颅面健康相关病症的源自微生物群系的诊断及治疗方法和系统
EP3350761B1 (en) 2015-09-17 2023-12-20 Prodermiq, Inc. Predicting skin age based on the analysis of skin flora and lifestyle data
IL258821B (en) 2015-10-23 2022-07-01 Harvard College Nucleobase editors and their uses
JP6872222B2 (ja) * 2015-11-04 2021-05-19 学校法人慶應義塾 対象物の使用者を判定する方法
GB2544481B (en) * 2015-11-16 2019-12-11 Century International Enterprises Ltd A wearable article and a method for producing a wearable article
US10933128B2 (en) 2015-11-30 2021-03-02 Joseph E. Kovarik Method and system for protecting honey bees from pesticides
US12239706B2 (en) 2015-11-30 2025-03-04 Seed Health, Inc. Method and system for protecting monarch butterflies from pesticides
US10675347B2 (en) 2015-11-30 2020-06-09 Joseph E. Kovarik Method and system for protecting honey bees from fipronil pesticides
US11529412B2 (en) 2015-11-30 2022-12-20 Seed Health, Inc. Method and system for protecting honey bees from pesticides
US10086024B2 (en) 2015-11-30 2018-10-02 Joseph E. Kovarik Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
US10568916B2 (en) 2015-11-30 2020-02-25 Joseph E. Kovarik Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
WO2017147507A1 (en) 2016-02-24 2017-08-31 Xycrobe Therapeutics, Inc. Skin probiotic formulation
WO2017185018A1 (en) * 2016-04-21 2017-10-26 Naked Biome, Inc. Synthetic bacteria and methods of use
JP2019514885A (ja) * 2016-04-21 2019-06-06 ネイキッド バイオーム,インク. 皮膚障害の処置のための組成物および方法
CN109152803B (zh) * 2016-04-25 2022-09-23 普梭梅根公司 用于表征与皮肤相关的病症的方法和系统
EP3243907A1 (en) * 2016-05-13 2017-11-15 Curetis GmbH Stable pan-genomes and their use
JP2019514419A (ja) * 2016-05-15 2019-06-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 座瘡を処置するための組成物及び方法
CN106167820A (zh) * 2016-05-19 2016-11-30 胤安国际(辽宁)基因科技股份有限公司 鉴定或辅助鉴定痤疮丙酸杆菌的专用引物及其应用
WO2018008319A1 (ja) * 2016-07-08 2018-01-11 花王株式会社 核酸試料の調製方法
JP6231252B1 (ja) * 2016-07-08 2017-11-15 花王株式会社 核酸試料の調製方法
KR20250103795A (ko) 2016-08-03 2025-07-07 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 아데노신 핵염기 편집제 및 그의 용도
CA3033327A1 (en) 2016-08-09 2018-02-15 President And Fellows Of Harvard College Programmable cas9-recombinase fusion proteins and uses thereof
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
JP7588390B2 (ja) 2016-10-14 2024-11-22 プレジデント アンド フェローズ オブ ハーバード カレッジ 核酸塩基エディターのaav送達
ES2894498T3 (es) 2016-10-19 2022-02-14 S Biomedic Nv Métodos y composiciones para cambiar la composición del microbioma de la piel usando mezclas complejas de cepas bacterianas
JP6815006B2 (ja) 2016-11-01 2021-01-20 株式会社桃谷順天館 アクネ菌株選択的抗菌剤
EP3538119A4 (en) * 2016-11-08 2020-07-01 The Regents of The University of California COMPOSITIONS AND METHODS FOR TREATING SKIN DISEASES AND MAINTAINING HEALTHY SKIN
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
WO2018119443A1 (en) * 2016-12-23 2018-06-28 The Regents Of The University Of California Method and device for digital high resolution melt
CN110662556A (zh) 2017-03-09 2020-01-07 哈佛大学的校长及成员们 癌症疫苗
WO2018165504A1 (en) 2017-03-09 2018-09-13 President And Fellows Of Harvard College Suppression of pain by gene editing
JP2020510439A (ja) 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ シトシンからグアニンへの塩基編集因子
CN110753966A (zh) 2017-03-10 2020-02-04 普罗皮肤检测股份有限公司 基于皮肤菌群分析的定制化护肤产品和个人护理产品
BR112019019655A2 (pt) 2017-03-23 2020-04-22 Harvard College editores de nucleobase que compreendem proteínas de ligação a dna programáveis por ácido nucleico
KR102799152B1 (ko) * 2017-04-21 2025-04-23 파이 테라퓨틱스, 인크. 프로피오니박테리움 아크네스 박테리오파지를 포함하는 여드름 치료용 조성물
WO2018209320A1 (en) 2017-05-12 2018-11-15 President And Fellows Of Harvard College Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
JP2020534795A (ja) 2017-07-28 2020-12-03 プレジデント アンド フェローズ オブ ハーバード カレッジ ファージによって支援される連続的進化(pace)を用いて塩基編集因子を進化させるための方法および組成物
US11319532B2 (en) 2017-08-30 2022-05-03 President And Fellows Of Harvard College High efficiency base editors comprising Gam
KR20250107288A (ko) 2017-10-16 2025-07-11 더 브로드 인스티튜트, 인코퍼레이티드 아데노신 염기 편집제의 용도
WO2019079612A1 (en) * 2017-10-20 2019-04-25 Naked Biome, Inc. SYSTEMS AND METHODS OF BACTERIAL DETECTION AND TREATMENT
US20210177920A1 (en) * 2017-12-05 2021-06-17 Biomx Ltd. Bacteriophage treatment for acne and biofilms
WO2019118949A1 (en) 2017-12-15 2019-06-20 The Broad Institute, Inc. Systems and methods for predicting repair outcomes in genetic engineering
WO2019226953A1 (en) 2018-05-23 2019-11-28 The Broad Institute, Inc. Base editors and uses thereof
US12150967B2 (en) 2018-08-18 2024-11-26 Seed Health, Inc. Methods and compositions for honey bee health
WO2020092453A1 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Nucleobase editors comprising geocas9 and uses thereof
WO2020091044A1 (ja) * 2018-11-01 2020-05-07 花王株式会社 被験体の皮膚細胞に由来する核酸の調製方法
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
EP3942042A1 (en) 2019-03-19 2022-01-26 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
EP3956349A1 (en) 2019-04-17 2022-02-23 The Broad Institute, Inc. Adenine base editors with reduced off-target effects
EP3981012A4 (en) * 2019-07-10 2023-07-19 Jiang, Ruowei SYSTEMS AND METHODS FOR PROCESSING IMAGES FOR SKIN ANALYSIS AND FOR VISUALIZING SKIN ANALYSIS
ES3004013T3 (en) * 2019-07-12 2025-03-11 Biomerieux Sa Method for identification and epidemiological surveillance of a bacterial focus
EP3999624A4 (en) 2019-07-16 2023-02-22 Meliolabs Inc. METHODS AND DEVICES FOR SINGLE-BASED DIGITAL HIGH RESOLUTION MELT ANALYSIS
WO2021016347A1 (en) * 2019-07-22 2021-01-28 The Regents Of The University Of California Compositions and methods for treating skin infections and other diseases
US12435330B2 (en) 2019-10-10 2025-10-07 The Broad Institute, Inc. Methods and compositions for prime editing RNA
US20220380744A1 (en) * 2019-10-31 2022-12-01 University Of Maryland, College Park Method of treating infections by bacteriolytic enzymes and manufacture thereof
WO2021226558A1 (en) 2020-05-08 2021-11-11 The Broad Institute, Inc. Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
US12102710B2 (en) 2020-06-23 2024-10-01 Crown Laboratories, Inc. Probiotic skin formulations
WO2022198091A1 (en) * 2021-03-19 2022-09-22 Parallel Health, Inc. Microbiome identification and bacteriophage formulations

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060121015A1 (en) * 2001-07-26 2006-06-08 Alimentary Health Limited Probiotic bifidobacterium strains
WO2009105592A2 (en) * 2008-02-19 2009-08-27 Hogan James J Compositions and methods for detection of propionibacterium acnes nucleic acid
CN109689861A (zh) * 2016-05-15 2019-04-26 加州大学评议会 用于治疗痤疮的组合物和方法
CN110352065A (zh) * 2016-10-19 2019-10-18 S-生物医药有限公司 使用细菌菌株的复合混合物改变皮肤微生物组的组成的方法和组合物

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU670777B2 (en) 1992-04-16 1996-08-01 Ortho Pharmaceutical Corporation Aqueous gel vehicles for retinoids
US5836999A (en) 1995-09-28 1998-11-17 Esc Medical Systems Ltd. Method and apparatus for treating psoriasis using pulsed electromagnetic radiation
AU734420B2 (en) 1996-04-15 2001-06-14 Nymox Corporation Compositions containing bacteriophages and methods of using bacteriophages to treat infections
JPH11171783A (ja) 1997-08-15 1999-06-29 Vetoquinol Sa 所定の動物に関して細胞性免疫と体重増加を生じる濃度でのバクテリアの経口投与
AU763105B2 (en) * 1998-05-22 2003-07-10 Inzinta Trading Co. Ltd Demonstrating resistance to antibiotics in microorganisms
US6726913B1 (en) 1999-10-15 2004-04-27 The Van Kampen Group, Inc. Treatment of dermal tumors, warts, and viral infections of the respiratory tract in humans using heat-killed P. acnes
EP1278854A2 (en) 2000-04-21 2003-01-29 Corixa Corporation Compositions and methods for the therapy and diagnosis of acne vulgaris
WO2003033515A1 (en) * 2001-10-15 2003-04-24 Corixa Corporation Compositions and methods for the therapy and diagnosis of acne vulgaris
US20040157837A1 (en) 2002-11-07 2004-08-12 Serbedzija George N. Combinations for the treatment of fungal infections
NZ539076A (en) * 2005-03-29 2008-05-30 Blis Technologies Ltd Skin treatment compositions
WO2007007055A1 (en) * 2005-07-12 2007-01-18 The University Of Leeds Bacteriophage and their uses
WO2007056680A2 (en) 2005-11-03 2007-05-18 Forsyth Dental Infirmary For Children Methods and arrays for identifying human microflora
JP5201818B2 (ja) * 2006-11-10 2013-06-05 キヤノン株式会社 プローブセット、プローブ固定担体及び遺伝子検査方法
EP2184997A4 (en) 2007-07-31 2010-11-03 Univ New York DIAGNOSIS AND TREATMENT METHODS FOR THE CHARACTERIZATION OF BACTERIAL MICROORGANISMS IN SKIN DISEASES
EP2082736A1 (fr) * 2008-01-23 2009-07-29 Jean Hilaire Saurat Composition pharmaceutique à usage topique
CN102307562A (zh) 2008-12-05 2012-01-04 加利福尼亚大学董事会 处理痤疮丙酸杆菌的方法和组合物
US9457077B2 (en) * 2009-11-18 2016-10-04 Katherine Rose Kovarik Method and system for targeting the microbiome to promote health and treat allergic and inflammatory diseases
US8784830B2 (en) * 2010-05-27 2014-07-22 Kenichiro Hasumi Antigen peptide and use thereof
EP2825676B1 (en) * 2012-03-17 2017-12-20 The Regents of The University of California Fast diagnosis and personalized treatments for acne
EP2664919A1 (fr) * 2012-05-15 2013-11-20 Jean Hilaire Saurat Une méthode pour identifier les ligands du récepteur AhR possédant une activité sebosuppressive thérapeutique
WO2014009764A1 (en) * 2012-07-13 2014-01-16 L'oreal S.A. Method of in vitro diagnosing a pellicular state in a subject and related applications
AU2013299605A1 (en) 2012-08-07 2015-03-26 TopGeniX, Inc. Topical composition comprising transformed bacteria expressing a compound of interest
US8906668B2 (en) * 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
JP2016509003A (ja) * 2013-02-04 2016-03-24 セレス セラピューティクス インコーポレイテッド 組成物および方法
DK3074027T3 (da) * 2013-11-25 2025-03-17 Nestle Sa Synergistiske bakteriesammensætninger og fremgangsmåder til fremstilling og anvendelse heraf
US9737592B1 (en) * 2014-02-14 2017-08-22 David Gordon Bermudes Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment
EP3139939B1 (en) 2014-05-07 2023-09-06 The Regents of The University of California Compositions and methods for treating skin and mucous membrane diseases
CA2950945A1 (en) * 2014-06-17 2015-12-23 Xycrobe Therapeutics, Inc. Genetically modified bacteria and methods for genetic modification of bacteria
EP3328417A4 (en) * 2015-07-31 2019-02-06 The Regents of The University of California MYCOBACTERIUM LYSTERASE: A NEW TREATMENT FOR AKNE
KR20180123475A (ko) * 2016-02-05 2018-11-16 더 리전츠 오브 더 유니버시티 오브 캘리포니아 피부 건강을 촉진하기 위한 조성물 및 방법
JP2019514885A (ja) * 2016-04-21 2019-06-06 ネイキッド バイオーム,インク. 皮膚障害の処置のための組成物および方法
US20210177920A1 (en) * 2017-12-05 2021-06-17 Biomx Ltd. Bacteriophage treatment for acne and biofilms
US12102710B2 (en) * 2020-06-23 2024-10-01 Crown Laboratories, Inc. Probiotic skin formulations

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060121015A1 (en) * 2001-07-26 2006-06-08 Alimentary Health Limited Probiotic bifidobacterium strains
WO2009105592A2 (en) * 2008-02-19 2009-08-27 Hogan James J Compositions and methods for detection of propionibacterium acnes nucleic acid
CN109689861A (zh) * 2016-05-15 2019-04-26 加州大学评议会 用于治疗痤疮的组合物和方法
CN110352065A (zh) * 2016-10-19 2019-10-18 S-生物医药有限公司 使用细菌菌株的复合混合物改变皮肤微生物组的组成的方法和组合物

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BRUGGEMANN H ET AL: "The complete genome sequence of Propionibacterium acnes, a commensal of human skin", 《SCIENCE》 *
FARRAR MD, ET AL: "Genome sequence and analysis of a Propionibacterium acnes bacteriophage", 《J BACTERIOL》 *
FITZ-GIBBON S, ET AL: "Propionibacterium acnes strain populations in the human skin microbiome associated with acne", 《J INVEST DERMATOL》 *
LEYDEN JJ ET AL: "The evolving role of Propionibacterium acnes in acne", 《SEMIN CUTAN MED SURG》 *
MASAHIKO NAKAMURA, ET AL.: "Identification of Propionibacterium acnes by polymerase chain reaction for amplification of 16S ribosomal RNA and lipase genes", 《ANAEROBE》 *
MIURA Y, ET AL: "Quantitative PCR of Propionibacterium acnes DNA in samples aspirated from sebaceous follicles on the normal skin of subjects with or without acne", 《J MED DENT SCI》 *
SAMPEDRO MF, ET AL: "Species of Propionibacterium and Propionibacterium acnes phylotypes associated with orthopedic implants", 《DIAGN MICROBIOL INFECT DIS》 *
WOO PC ET AL: "Then and now: use of 16S rRNA gene sequencing for bacterial identification and discovery of novel bacteria in clinical microbiology laboratories", 《CLIN MICROBIOL INFECT》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109562048A (zh) * 2016-02-05 2019-04-02 加州大学评议会 用于促进皮肤健康的组合物和方法
CN113066533A (zh) * 2021-04-02 2021-07-02 欧蒙医学诊断(中国)有限公司 一种mNGS病原体数据分析方法
CN118737269A (zh) * 2024-08-30 2024-10-01 墨卓生物科技(浙江)有限公司 在单细胞微生物基因组测序结果中区分菌株的方法
CN118737269B (zh) * 2024-08-30 2024-11-19 墨卓生物科技(浙江)有限公司 在单细胞微生物基因组测序结果中区分菌株的方法

Also Published As

Publication number Publication date
WO2013142378A1 (en) 2013-09-26
WO2013142378A9 (en) 2014-01-23
JP2019050833A (ja) 2019-04-04
US11692229B2 (en) 2023-07-04
CA2867621A1 (en) 2013-09-26
JP2015512255A (ja) 2015-04-27
US10364473B2 (en) 2019-07-30
EP2825676A1 (en) 2015-01-21
US20170058328A1 (en) 2017-03-02
SG11201405783VA (en) 2014-10-30
AU2019219817A1 (en) 2019-09-12
EP2825676A4 (en) 2015-09-30
CN104364394B (zh) 2019-02-22
CN104364394A (zh) 2015-02-18
EP3360560A1 (en) 2018-08-15
JP2021013395A (ja) 2021-02-12
US20190316183A1 (en) 2019-10-17
HK1207402A1 (en) 2016-01-29
BR112014023005A2 (pt) 2017-07-18
US20150086581A1 (en) 2015-03-26
EP3692999A1 (en) 2020-08-12
EP2825676B1 (en) 2017-12-20
AU2020227049A1 (en) 2020-09-17
AU2013235340A1 (en) 2014-10-16
US20210123092A1 (en) 2021-04-29
US20240117446A1 (en) 2024-04-11
AU2013235340B2 (en) 2019-05-23

Similar Documents

Publication Publication Date Title
US20240117446A1 (en) Fast diagnosis and personalized treatments for acne
Fittipaldi et al. Full-genome dissection of an epidemic of severe invasive disease caused by a hypervirulent, recently emerged clone of group A Streptococcus
Springman et al. Pilus distribution among lineages of group b streptococcus: an evolutionary and clinical perspective
Meehan et al. Molecular epidemiology of group B streptococci in Ireland reveals a diverse population with evidence of capsular switching
Tokajian et al. Molecular characterization of Staphylococcus aureus in Lebanon
Opota et al. Genomics of the new species Kingella negevensis: diagnostic issues and identification of a locus encoding a RTX toxin
CA2991090A1 (en) Genetic testing for predicting resistance of gram-negative proteus against antimicrobial agents
AU2015404958A1 (en) Genetic testing for alignment-free predicting resistance of microorganisms against antimicrobial agents
CA2990894A1 (en) Genetic testing for predicting resistance of salmonella species against antimicrobial agents
Yan et al. Genetic features of livestock-associated Staphylococcus aureus ST9 isolates from Chinese pigs that carry the lsa (E) gene for quinupristin/dalfopristin resistance
Ahle et al. Comparison of three amplicon sequencing approaches to determine staphylococcal populations on human skin
HK40011589A (en) Fast diagnosis and personalized treatments for acne
Speck et al. Characterization of Streptococcus equi subsp. ruminatorum isolated from spotted hyenas (Crocuta crocuta) and plains zebras (Equus burchelli), and identification of a M-like protein (SrM) encoding gene
HK1207402B (zh) 痤疮的快速诊断和个体化治疗
Lim et al. Comparative genome analysis of multiple vancomycin-resistant Enterococcus faecium isolated from two fatal cases
Lindstedt Human Gut Colonisation by the Klebsiella pneumoniae Species Complex: Detection, Duration, Dynamics, and Microbiota Associations
Ladra et al. Parvimonas Micra Can Translocate From the Subgingival Sulcus of the Human Oral Cavity to Colorectal Adenocarcinoma
Schiff The Bacterial and Viral Complexity of Postinfectious Hydrocephalus in Uganda
Ene Exploring the Role of Lactobacillus jensenii and Lactobacillus mulieris in the Urogenital Tract
Elshaer et al. Detection of Pathogenicity Island-encoding Virulence Genes of Staphylococcus aureus Isolated from Various Clinical Sources
Alexander Using Whole Genome Sequencing to Study the Epidemiology and Comparative Genomics of Streptococcus equi from the United States
Arteaga Ortega et al. Genomic characterization of the non-O1/non-O139 Vibrio cholerae strain that caused a gastroenteritis outbreak in Santiago, Chile, 2018
Pongchaikul Comparative genomic approaches to understanding Achromobacter xylosoxidans
Gaiarsa EVOLUTION, COMPARATIVE GENOMICS AND GENOMIC EPIDEMIOLOGY OF BACTERIA OF PUBLIC HEALTH IMPORTANCE
Proud Examining the Role of Transformation in the Acquisition of Resistance and Rescue of Genomes from Oxidative Stress

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40011589

Country of ref document: HK

WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20190726

WD01 Invention patent application deemed withdrawn after publication