CA2867621A1 - Fast diagnosis and personalized treatments for acne - Google Patents

Fast diagnosis and personalized treatments for acne Download PDF

Info

Publication number
CA2867621A1
CA2867621A1 CA2867621A CA2867621A CA2867621A1 CA 2867621 A1 CA2867621 A1 CA 2867621A1 CA 2867621 A CA2867621 A CA 2867621A CA 2867621 A CA2867621 A CA 2867621A CA 2867621 A1 CA2867621 A1 CA 2867621A1
Authority
CA
Canada
Prior art keywords
seq
acnes
acne
strain
locus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2867621A
Other languages
English (en)
French (fr)
Inventor
Huiying Li
Shuta Tomida
Robert L. Modlin
Jeffery F. Miller
Sorel T. Fitz-Gibbon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of CA2867621A1 publication Critical patent/CA2867621A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/0208Specific bacteria not otherwise provided for
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/05Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/00032Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2867621A 2012-03-17 2013-03-15 Fast diagnosis and personalized treatments for acne Abandoned CA2867621A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261612290P 2012-03-17 2012-03-17
US61/612,290 2012-03-17
PCT/US2013/032551 WO2013142378A1 (en) 2012-03-17 2013-03-15 Fast diagnosis and personalized treatments for acne

Publications (1)

Publication Number Publication Date
CA2867621A1 true CA2867621A1 (en) 2013-09-26

Family

ID=49223275

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2867621A Abandoned CA2867621A1 (en) 2012-03-17 2013-03-15 Fast diagnosis and personalized treatments for acne

Country Status (9)

Country Link
US (5) US20150086581A1 (enExample)
EP (3) EP3692999A1 (enExample)
JP (3) JP2015512255A (enExample)
CN (2) CN110055320A (enExample)
AU (3) AU2013235340B2 (enExample)
BR (1) BR112014023005A2 (enExample)
CA (1) CA2867621A1 (enExample)
SG (1) SG11201405783VA (enExample)
WO (1) WO2013142378A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021016347A1 (en) * 2019-07-22 2021-01-28 The Regents Of The University Of California Compositions and methods for treating skin infections and other diseases

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9457077B2 (en) 2009-11-18 2016-10-04 Katherine Rose Kovarik Method and system for targeting the microbiome to promote health and treat allergic and inflammatory diseases
US9585920B2 (en) 2011-02-04 2017-03-07 Katherine Rose Kovarik Method and system for treating cancer cachexia
US12533312B2 (en) 2011-02-04 2026-01-27 Seed Health, Inc. Method and system for preventing sore throat in humans
US10583033B2 (en) 2011-02-04 2020-03-10 Katherine Rose Kovarik Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US10512661B2 (en) 2011-02-04 2019-12-24 Joseph E. Kovarik Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
US10086018B2 (en) 2011-02-04 2018-10-02 Joseph E. Kovarik Method and system for reducing the likelihood of colorectal cancer in a human being
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11273187B2 (en) 2015-11-30 2022-03-15 Joseph E. Kovarik Method and system for reducing the likelihood of developing depression in an individual
US10010568B2 (en) 2011-02-04 2018-07-03 Katherine Rose Kovarik Method and system for reducing the likelihood of a spirochetes infection in a human being
US10245288B2 (en) 2011-02-04 2019-04-02 Joseph E. Kovarik Method and system for reducing the likelihood of developing NASH in an individual diagnosed with non-alcoholic fatty liver disease
US12279989B2 (en) 2011-02-04 2025-04-22 Seed Health, Inc. Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US10314865B2 (en) 2011-02-04 2019-06-11 Katherine Rose Kovarik Method and system for treating cancer and other age-related diseases by extending the healthspan of a human
US10548761B2 (en) 2011-02-04 2020-02-04 Joseph E. Kovarik Method and system for reducing the likelihood of colorectal cancer in a human being
US11523934B2 (en) 2011-02-04 2022-12-13 Seed Health, Inc. Method and system to facilitate the growth of desired bacteria in a human's mouth
US9730967B2 (en) 2011-02-04 2017-08-15 Katherine Rose Kovarik Method and system for treating cancer cachexia
US10842834B2 (en) 2016-01-06 2020-11-24 Joseph E. Kovarik Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
US11357722B2 (en) 2011-02-04 2022-06-14 Seed Health, Inc. Method and system for preventing sore throat in humans
US10085938B2 (en) 2011-02-04 2018-10-02 Joseph E. Kovarik Method and system for preventing sore throat in humans
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US12257272B2 (en) 2015-12-24 2025-03-25 Seed Health, Inc. Method and system for reducing the likelihood of developing depression in an individual
US11191665B2 (en) 2011-02-04 2021-12-07 Joseph E. Kovarik Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US9987224B2 (en) 2011-02-04 2018-06-05 Joseph E. Kovarik Method and system for preventing migraine headaches, cluster headaches and dizziness
US10111913B2 (en) 2011-02-04 2018-10-30 Joseph E. Kovarik Method of reducing the likelihood of skin cancer in an individual human being
US10835560B2 (en) 2013-12-20 2020-11-17 Joseph E. Kovarik Reducing the likelihood of skin cancer in an individual human being
US10940169B2 (en) 2015-11-30 2021-03-09 Joseph E. Kovarik Method for reducing the likelihood of developing cancer in an individual human being
US11419903B2 (en) 2015-11-30 2022-08-23 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US10687975B2 (en) 2011-02-04 2020-06-23 Joseph E. Kovarik Method and system to facilitate the growth of desired bacteria in a human's mouth
EP2734621B1 (en) 2011-07-22 2019-09-04 President and Fellows of Harvard College Evaluation and improvement of nuclease cleavage specificity
EP3692999A1 (en) * 2012-03-17 2020-08-12 The Regents of the University of California Fast diagnosis and personalized treatments for acne
EP3011046A4 (en) 2013-06-18 2017-03-01 Prodermiq, Inc. Customized skin care products and personal care products based on the analysis of skin flora
US10633714B2 (en) 2013-07-21 2020-04-28 Pendulum Therapeutics, Inc. Methods and systems for microbiome characterization, monitoring and treatment
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
US9340800B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College Extended DNA-sensing GRNAS
US9322037B2 (en) 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
JP2016536021A (ja) 2013-11-07 2016-11-24 エディタス・メディシン,インコーポレイテッド CRISPR関連方法および支配gRNAのある組成物
US20150165054A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11213552B2 (en) 2015-11-30 2022-01-04 Joseph E. Kovarik Method for treating an individual suffering from a chronic infectious disease and cancer
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11642382B2 (en) 2013-12-20 2023-05-09 Seed Health, Inc. Method for treating an individual suffering from bladder cancer
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US11672835B2 (en) 2013-12-20 2023-06-13 Seed Health, Inc. Method for treating individuals having cancer and who are receiving cancer immunotherapy
US12318377B2 (en) 2013-12-20 2025-06-03 Seed Health, Inc. Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US12329783B2 (en) 2013-12-20 2025-06-17 Seed Health, Inc. Method and system to improve the health of a person's skin microbiome
US11026982B2 (en) 2015-11-30 2021-06-08 Joseph E. Kovarik Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11529379B2 (en) 2013-12-20 2022-12-20 Seed Health, Inc. Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US12246043B2 (en) 2013-12-20 2025-03-11 Seed Health, Inc. Topical application to treat acne vulgaris
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
EP3139939B1 (en) * 2014-05-07 2023-09-06 The Regents of The University of California Compositions and methods for treating skin and mucous membrane diseases
CA2950945A1 (en) 2014-06-17 2015-12-23 Xycrobe Therapeutics, Inc. Genetically modified bacteria and methods for genetic modification of bacteria
CA2956224A1 (en) 2014-07-30 2016-02-11 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
AU2015308910B2 (en) 2014-08-27 2017-12-07 Caribou Biosciences, Inc. Methods for increasing Cas9-mediated engineering efficiency
US9703929B2 (en) 2014-10-21 2017-07-11 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics
US10410749B2 (en) 2014-10-21 2019-09-10 uBiome, Inc. Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions
US10169541B2 (en) 2014-10-21 2019-01-01 uBiome, Inc. Method and systems for characterizing skin related conditions
WO2016168350A1 (en) * 2015-04-13 2016-10-20 uBiome, Inc. Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions
EP3285872A4 (en) * 2015-04-20 2019-02-20 S-Biomedic NV METHOD AND COMPOSITIONS FOR CHANGING THE COMPOSITION OF SKIN MICROBIOMA WITH COMPLEX MIXTURES OF BACTERIAL BARS
JP6046849B1 (ja) * 2015-07-21 2016-12-21 TAK−Circulator株式会社 身体状態の評価方法、情報の提示方法、および身体状態を改善又は予防する物質のスクリーニング方法
AU2016301963A1 (en) 2015-08-06 2018-02-15 Ares Genetics Gmbh Genetic resistance prediction against antimicrobial drugs in microorganism using structural changes in the genome
WO2017044871A1 (en) * 2015-09-09 2017-03-16 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for eczema
EP3346911A4 (en) * 2015-09-09 2019-05-08 Ubiome Inc. METHOD AND COMPOSITIONS FOR MICROBIOMA DIAGNOSTICS AND THERAPEUTIC FOR INFECTION DISEASE AND OTHERS SUFFERING TO THE USE OF ANTIBIOTICS
CA3006044A1 (en) * 2015-09-09 2017-03-16 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with cerebro-craniofacial health
EP3350761B1 (en) 2015-09-17 2023-12-20 Prodermiq, Inc. Predicting skin age based on the analysis of skin flora and lifestyle data
EP4434589A3 (en) 2015-10-23 2025-05-14 President and Fellows of Harvard College Evolved cas9 proteins for gene editing
JP6872222B2 (ja) * 2015-11-04 2021-05-19 学校法人慶應義塾 対象物の使用者を判定する方法
GB2544481B (en) * 2015-11-16 2019-12-11 Century International Enterprises Ltd A wearable article and a method for producing a wearable article
US10568916B2 (en) 2015-11-30 2020-02-25 Joseph E. Kovarik Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
US10933128B2 (en) 2015-11-30 2021-03-02 Joseph E. Kovarik Method and system for protecting honey bees from pesticides
US11529412B2 (en) 2015-11-30 2022-12-20 Seed Health, Inc. Method and system for protecting honey bees from pesticides
US10086024B2 (en) 2015-11-30 2018-10-02 Joseph E. Kovarik Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
US12239706B2 (en) 2015-11-30 2025-03-04 Seed Health, Inc. Method and system for protecting monarch butterflies from pesticides
US10675347B2 (en) 2015-11-30 2020-06-09 Joseph E. Kovarik Method and system for protecting honey bees from fipronil pesticides
EP3411011B1 (en) * 2016-02-05 2024-09-18 The Regents of the University of California Compositions and methods for promoting skin health
US11504404B2 (en) 2016-02-24 2022-11-22 Crown Laboratories, Inc. Skin probiotic formulation
KR20190017751A (ko) 2016-04-21 2019-02-20 네이키드 바이옴, 인크. 피부 장애의 치료를 위한 조성물 및 방법
US20190336542A1 (en) * 2016-04-21 2019-11-07 Naked Biome, Inc. Synthetic bacteria and methods of use
CA3022294A1 (en) * 2016-04-25 2017-11-02 uBiome, Inc. Method and system for characterizing skin-related conditions
EP3243907A1 (en) * 2016-05-13 2017-11-15 Curetis GmbH Stable pan-genomes and their use
WO2017200873A1 (en) 2016-05-15 2017-11-23 The Regents Of The University Of California Compositions and methods for treating acne
CN106167820A (zh) * 2016-05-19 2016-11-30 胤安国际(辽宁)基因科技股份有限公司 鉴定或辅助鉴定痤疮丙酸杆菌的专用引物及其应用
KR101961076B1 (ko) * 2016-07-08 2019-03-21 카오카부시키가이샤 핵산 시료의 조제 방법
CN113481294B (zh) * 2016-07-08 2024-03-12 花王株式会社 核酸样品的制备方法
JP7231935B2 (ja) 2016-08-03 2023-03-08 プレジデント アンド フェローズ オブ ハーバード カレッジ アデノシン核酸塩基編集因子およびそれらの使用
US11661590B2 (en) 2016-08-09 2023-05-30 President And Fellows Of Harvard College Programmable CAS9-recombinase fusion proteins and uses thereof
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
AU2017342543B2 (en) 2016-10-14 2024-06-27 President And Fellows Of Harvard College AAV delivery of nucleobase editors
CA3040814A1 (en) * 2016-10-19 2018-04-26 S-Biomedic Nv Methods and compositions for changing the composition of the skin microbiome using complex mixtures of bacterial strains
JP6815006B2 (ja) 2016-11-01 2021-01-20 株式会社桃谷順天館 アクネ菌株選択的抗菌剤
WO2018089337A1 (en) * 2016-11-08 2018-05-17 The Regents Of The University Of California Compositions and methods for treating skin diseases and maintaining healthy skin
US11915795B2 (en) * 2016-12-23 2024-02-27 The Regents Of The University Of California Method and device for digital high resolution melt
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
CN110662556A (zh) 2017-03-09 2020-01-07 哈佛大学的校长及成员们 癌症疫苗
US11898179B2 (en) 2017-03-09 2024-02-13 President And Fellows Of Harvard College Suppression of pain by gene editing
WO2018165621A1 (en) 2017-03-10 2018-09-13 Prodermiq, Inc. Customized skin care products and personal care products based on the analysis of skin flora
JP2020510439A (ja) 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ シトシンからグアニンへの塩基編集因子
WO2018176009A1 (en) 2017-03-23 2018-09-27 President And Fellows Of Harvard College Nucleobase editors comprising nucleic acid programmable dna binding proteins
EP3612200A4 (en) * 2017-04-21 2020-12-30 Phi Therapeutics, Inc. COMPOSITIONS CONTAINING BACTERIOPHAGES OF PROPIONIBACTERIUM ACNES INTENDED FOR THE TREATMENT OF ACNE
US11560566B2 (en) 2017-05-12 2023-01-24 President And Fellows Of Harvard College Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
US11732274B2 (en) 2017-07-28 2023-08-22 President And Fellows Of Harvard College Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE)
WO2019139645A2 (en) 2017-08-30 2019-07-18 President And Fellows Of Harvard College High efficiency base editors comprising gam
KR20200121782A (ko) 2017-10-16 2020-10-26 더 브로드 인스티튜트, 인코퍼레이티드 아데노신 염기 편집제의 용도
WO2019079612A1 (en) * 2017-10-20 2019-04-25 Naked Biome, Inc. SYSTEMS AND METHODS OF BACTERIAL DETECTION AND TREATMENT
US20210177920A1 (en) * 2017-12-05 2021-06-17 Biomx Ltd. Bacteriophage treatment for acne and biofilms
US12406749B2 (en) 2017-12-15 2025-09-02 The Broad Institute, Inc. Systems and methods for predicting repair outcomes in genetic engineering
US12157760B2 (en) 2018-05-23 2024-12-03 The Broad Institute, Inc. Base editors and uses thereof
US12522807B2 (en) 2018-07-09 2026-01-13 The Broad Institute, Inc. RNA programmable epigenetic RNA modifiers and uses thereof
WO2020055547A2 (en) 2018-08-18 2020-03-19 Seed Health, Inc. Methods and compositions for honey bee health
WO2020092453A1 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Nucleobase editors comprising geocas9 and uses thereof
US20220002782A1 (en) * 2018-11-01 2022-01-06 Kao Corporation Method for preparing nucleic acid derived from skin cell of subject
KR102913696B1 (ko) * 2018-11-16 2026-01-16 에스-바이오메딕 엔브이 산화 스트레스 관련 피부 질환 및 피부 노화의 치료 및 산화 스트레스 관련 피부 질환의 진단을 위한 조성물
WO2020154500A1 (en) 2019-01-23 2020-07-30 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
MX2021011426A (es) 2019-03-19 2022-03-11 Broad Inst Inc Metodos y composiciones para editar secuencias de nucleótidos.
WO2020214842A1 (en) 2019-04-17 2020-10-22 The Broad Institute, Inc. Adenine base editors with reduced off-target effects
EP3981012A4 (en) * 2019-07-10 2023-07-19 Jiang, Ruowei SYSTEMS AND METHODS FOR PROCESSING IMAGES FOR SKIN ANALYSIS AND VISUALIZATION OF SKIN ANALYSIS
ES3004013T3 (en) * 2019-07-12 2025-03-11 Biomerieux Sa Method for identification and epidemiological surveillance of a bacterial focus
US11578354B2 (en) 2019-07-16 2023-02-14 Meliolabs Inc. Methods and devices for single-cell based digital high resolution melt
US12435330B2 (en) 2019-10-10 2025-10-07 The Broad Institute, Inc. Methods and compositions for prime editing RNA
WO2021087415A1 (en) * 2019-10-31 2021-05-06 University Of Maryland, College Park Method of treating infections by bacteriolytic enzymes and manufacture thereof
WO2021226558A1 (en) 2020-05-08 2021-11-11 The Broad Institute, Inc. Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
CA3183350A1 (en) 2020-06-23 2021-12-30 Thomas M. Hitchcock Probiotic skin formulations
KR20230159468A (ko) * 2021-03-19 2023-11-21 패러렐 헬스, 인크. 마이크로바이옴 식별 및 박테리오파지 제제
CN113066533B (zh) * 2021-04-02 2023-04-04 欧蒙医学诊断(中国)有限公司 一种mNGS病原体数据分析方法
IL324411A (en) 2023-05-05 2026-01-01 Sanofi Pasteur Inc Preparations for use in the treatment of acne
CN118737269B (zh) * 2024-08-30 2024-11-19 墨卓生物科技(浙江)有限公司 在单细胞微生物基因组测序结果中区分菌株的方法

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU670777B2 (en) 1992-04-16 1996-08-01 Ortho Pharmaceutical Corporation Aqueous gel vehicles for retinoids
US5836999A (en) 1995-09-28 1998-11-17 Esc Medical Systems Ltd. Method and apparatus for treating psoriasis using pulsed electromagnetic radiation
EP0895534A1 (en) 1996-04-15 1999-02-10 Nymox Corporation Compositions containing bacteriophages and methods of using bacteriophages to treat infections
JPH11171783A (ja) 1997-08-15 1999-06-29 Vetoquinol Sa 所定の動物に関して細胞性免疫と体重増加を生じる濃度でのバクテリアの経口投与
EP1078104B1 (de) * 1998-05-22 2002-10-09 Creatogen Aktiengesellschaft Nachweis von antibiotikumresistenzen in mikroorganismen
US6726913B1 (en) 1999-10-15 2004-04-27 The Van Kampen Group, Inc. Treatment of dermal tumors, warts, and viral infections of the respiratory tract in humans using heat-killed P. acnes
CA2407352A1 (en) 2000-04-21 2001-11-01 Corixa Corporation Compositions and methods for the therapy and diagnosis of acne vulgaris
US20030092163A1 (en) * 2001-07-26 2003-05-15 Collins John Kevin Probiotic bifidobacterium strains
WO2003033515A1 (en) * 2001-10-15 2003-04-24 Corixa Corporation Compositions and methods for the therapy and diagnosis of acne vulgaris
US20040157837A1 (en) 2002-11-07 2004-08-12 Serbedzija George N. Combinations for the treatment of fungal infections
NZ539076A (en) * 2005-03-29 2008-05-30 Blis Technologies Ltd Skin treatment compositions
JP5127708B2 (ja) * 2005-07-12 2013-01-23 マイクレオス べスローテン フェンノートシャップ バクテリオファージ及びその使用
US20070269813A1 (en) 2005-11-03 2007-11-22 Dewhirst Floyd E Methods and arrays for identifying human microflora
JP5201818B2 (ja) * 2006-11-10 2013-06-05 キヤノン株式会社 プローブセット、プローブ固定担体及び遺伝子検査方法
WO2009018447A2 (en) 2007-07-31 2009-02-05 New York University Diagnostic and treatment methods for characterizing bacterial microbiota in skin conditions
EP2082736A1 (fr) * 2008-01-23 2009-07-29 Jean Hilaire Saurat Composition pharmaceutique à usage topique
US20090269764A1 (en) * 2008-02-19 2009-10-29 Gen-Probe Incorporated Compositions and methods for detection of propionibacterium acnes nucleic acid
CN102307562A (zh) 2008-12-05 2012-01-04 加利福尼亚大学董事会 处理痤疮丙酸杆菌的方法和组合物
US9457077B2 (en) * 2009-11-18 2016-10-04 Katherine Rose Kovarik Method and system for targeting the microbiome to promote health and treat allergic and inflammatory diseases
MY167069A (en) * 2010-05-27 2018-08-09 Kenichiro Hasumi Antigen peptide and use thereof
EP3692999A1 (en) * 2012-03-17 2020-08-12 The Regents of the University of California Fast diagnosis and personalized treatments for acne
EP2664919A1 (fr) * 2012-05-15 2013-11-20 Jean Hilaire Saurat Une méthode pour identifier les ligands du récepteur AhR possédant une activité sebosuppressive thérapeutique
EP2885421A1 (en) * 2012-07-13 2015-06-24 L'Oréal SA Method of in vitro diagnosing a pellicular state in a subject and related applications
MX2015001751A (es) 2012-08-07 2015-11-13 Topgenix Inc Composicion topica comprendiendo bacterias transformadas que expresan un compuesto de interes.
US8906668B2 (en) * 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
AU2014212004B2 (en) * 2013-02-04 2018-09-20 Société des Produits Nestlé S.A. Compositions for treating or preventing or reducing the severity of clostridium difficile related diseases
KR102611070B1 (ko) * 2013-11-25 2023-12-07 세레스 테라퓨틱스, 인코포레이티드 상승적 박테리아 조성물 및 그것의 생산 방법 및 용도
US9737592B1 (en) * 2014-02-14 2017-08-22 David Gordon Bermudes Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment
EP3139939B1 (en) 2014-05-07 2023-09-06 The Regents of The University of California Compositions and methods for treating skin and mucous membrane diseases
CA2950945A1 (en) * 2014-06-17 2015-12-23 Xycrobe Therapeutics, Inc. Genetically modified bacteria and methods for genetic modification of bacteria
WO2017023680A1 (en) * 2015-07-31 2017-02-09 The Regents Of The University Of California Mycobacterium lysterase: a novel treatment for acne
EP3411011B1 (en) * 2016-02-05 2024-09-18 The Regents of the University of California Compositions and methods for promoting skin health
KR20190017751A (ko) * 2016-04-21 2019-02-20 네이키드 바이옴, 인크. 피부 장애의 치료를 위한 조성물 및 방법
WO2017200873A1 (en) * 2016-05-15 2017-11-23 The Regents Of The University Of California Compositions and methods for treating acne
CA3040814A1 (en) * 2016-10-19 2018-04-26 S-Biomedic Nv Methods and compositions for changing the composition of the skin microbiome using complex mixtures of bacterial strains
US20210177920A1 (en) * 2017-12-05 2021-06-17 Biomx Ltd. Bacteriophage treatment for acne and biofilms
CA3183350A1 (en) * 2020-06-23 2021-12-30 Thomas M. Hitchcock Probiotic skin formulations

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021016347A1 (en) * 2019-07-22 2021-01-28 The Regents Of The University Of California Compositions and methods for treating skin infections and other diseases

Also Published As

Publication number Publication date
AU2013235340A1 (en) 2014-10-16
US20170058328A1 (en) 2017-03-02
EP3692999A1 (en) 2020-08-12
JP2019050833A (ja) 2019-04-04
CN104364394B (zh) 2019-02-22
US20190316183A1 (en) 2019-10-17
WO2013142378A1 (en) 2013-09-26
US20240117446A1 (en) 2024-04-11
EP2825676A1 (en) 2015-01-21
WO2013142378A9 (en) 2014-01-23
CN104364394A (zh) 2015-02-18
BR112014023005A2 (pt) 2017-07-18
AU2020227049A1 (en) 2020-09-17
AU2013235340B2 (en) 2019-05-23
AU2019219817A1 (en) 2019-09-12
JP2015512255A (ja) 2015-04-27
US10364473B2 (en) 2019-07-30
CN110055320A (zh) 2019-07-26
EP3360560A1 (en) 2018-08-15
EP2825676B1 (en) 2017-12-20
EP2825676A4 (en) 2015-09-30
US11692229B2 (en) 2023-07-04
SG11201405783VA (en) 2014-10-30
JP2021013395A (ja) 2021-02-12
HK1207402A1 (en) 2016-01-29
US20210123092A1 (en) 2021-04-29
US20150086581A1 (en) 2015-03-26

Similar Documents

Publication Publication Date Title
US20240117446A1 (en) Fast diagnosis and personalized treatments for acne
Fittipaldi et al. Full-genome dissection of an epidemic of severe invasive disease caused by a hypervirulent, recently emerged clone of group A Streptococcus
Liu et al. The diversity and host interactions of Propionibacterium acnes bacteriophages on human skin
Chaguza et al. Mechanisms and impact of genetic recombination in the evolution of Streptococcus pneumoniae
Meehan et al. Molecular epidemiology of group B streptococci in Ireland reveals a diverse population with evidence of capsular switching
Lu et al. Comparative analysis of the full genome of Helicobacter pylori isolate Sahul64 identifies genes of high divergence
Howell et al. The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis
Tokajian et al. Molecular characterization of Staphylococcus aureus in Lebanon
Schindler et al. Group B streptococcus virulence factors associated with different clinical syndromes: Asymptomatic carriage in pregnant women and early-onset disease in the newborn
HK40011589A (en) Fast diagnosis and personalized treatments for acne
Speck et al. Characterization of Streptococcus equi subsp. ruminatorum isolated from spotted hyenas (Crocuta crocuta) and plains zebras (Equus burchelli), and identification of a M-like protein (SrM) encoding gene
HK1207402B (zh) 痤疮的快速诊断和个体化治疗
Khan Detailed genomic and antimicrobial resistance comparison of UK Streptococcus agalactiae isolates from adults to those of diverse global origins
JP2009515525A (ja) Usa300市中感染メチシリン−耐性黄色ブドウ球菌の同定
Schiff The Bacterial and Viral Complexity of Postinfectious Hydrocephalus in Uganda
Alexander Using Whole Genome Sequencing to Study the Epidemiology and Comparative Genomics of Streptococcus equi from the United States
Watkins et al. 233. The Epidemiology, Genomics, and Evolution of Staphylococcus aureus in Northeast Ohio
Mir et al. Research Article Supershed Escherichia coli O157: H7 Has Potential for Increased Persistence on the Rectoanal Junction Squamous Epithelial Cells and Antibiotic Resistance
Gill Evolutionary drivers of the rise and fall of a dominant hybrid MRSA, ST239
Muhamed The molecular characterisation of Group A Streptococcus among children with phyryngitis in the Vanguard community (Bonteheuwel
Roussado et al. Streptococcus agalactiae in neonatal infections–a changing population?
Proud Examining the Role of Transformation in the Acquisition of Resistance and Rescue of Genomes from Oxidative Stress
Moloney Molecular typing of Irish Streptococcus equi ssp equi strains
Cohen et al. I nt er na t io nal Jo ur na l of Infectious Diseases
Zdziarski et al. Host Imprints on Bacterial Genomes—Rapid

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180314

FZDE Discontinued

Effective date: 20210831