CN110035718B - 胃内滞留系统 - Google Patents

胃内滞留系统 Download PDF

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Publication number
CN110035718B
CN110035718B CN201780073458.1A CN201780073458A CN110035718B CN 110035718 B CN110035718 B CN 110035718B CN 201780073458 A CN201780073458 A CN 201780073458A CN 110035718 B CN110035718 B CN 110035718B
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China
Prior art keywords
arm
erodible
stomach
arms
gastric
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CN201780073458.1A
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Chinese (zh)
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CN110035718A (zh
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阿夫沙洛姆·本梅纳开姆
爱兰·扎利特
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Clexio Bioscience Ltd
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Clexio Bioscience Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/41—Devices for promoting penis erection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6871—Stomach
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/50—Prostheses not implantable in the body
    • A61F2002/5016—Prostheses not implantable in the body adjustable
    • A61F2002/5036—Prostheses not implantable in the body adjustable self-adjustable, e.g. self-learning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/41—Devices for promoting penis erection
    • A61F2005/412—Devices for promoting penis erection by vacuum means

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Reproductive Health (AREA)
  • Nursing (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Soil Working Implements (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780073458.1A 2016-12-02 2017-12-04 胃内滞留系统 Active CN110035718B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662429095P 2016-12-02 2016-12-02
US62/429,095 2016-12-02
US201662430166P 2016-12-05 2016-12-05
US62/430,166 2016-12-05
PCT/US2017/064417 WO2018102799A1 (en) 2016-12-02 2017-12-04 Gastric residence system

Publications (2)

Publication Number Publication Date
CN110035718A CN110035718A (zh) 2019-07-19
CN110035718B true CN110035718B (zh) 2021-04-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780073458.1A Active CN110035718B (zh) 2016-12-02 2017-12-04 胃内滞留系统

Country Status (7)

Country Link
US (3) US10737079B2 (https=)
EP (1) EP3547974B1 (https=)
JP (1) JP7071748B2 (https=)
CN (1) CN110035718B (https=)
ES (1) ES2966736T3 (https=)
IL (1) IL266377B2 (https=)
WO (1) WO2018102799A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11576859B2 (en) 2015-10-23 2023-02-14 Lyndra Therapeutics, Inc. Gastric residence systems for sustained release of therapeutic agents and methods of use thereof
CA3006999A1 (en) * 2015-12-01 2017-06-08 Clexio Biosciences Ltd. Gastric retentive devices
WO2017100367A1 (en) 2015-12-08 2017-06-15 Lyndra, Inc. Geometric configurations for gastric residence systems
CN109310639A (zh) 2016-05-27 2019-02-05 林德拉有限公司 用于胃驻留系统的材料结构
JP2019532947A (ja) 2016-09-30 2019-11-14 リンドラ，インコーポレイティド アダマンタン系薬物の持続的送達のための胃内滞留システム
CN110035718B (zh) 2016-12-02 2021-04-06 克雷西奥生物科技有限公司 胃内滞留系统
CA3066658A1 (en) 2017-06-09 2018-12-13 Lyndra, Inc. Gastric residence systems with release rate-modulating films
CN111587088A (zh) * 2017-11-28 2020-08-25 麻省理工学院 胃驻留电子装置
WO2019111132A1 (en) 2017-12-04 2019-06-13 Clexio Biosciences Ltd. Long acting gastric residence system
US12303659B2 (en) * 2018-11-15 2025-05-20 Massachusetts Institute Of Technology Thermally controlled reconfigurable medical devices
BR112021018496A2 (pt) * 2019-03-20 2021-11-30 Lyndra Therapeutics Inc Cápsulas e revestimento de cápsula para formas de dosagem de residência gástrica
AU2020242062B2 (en) * 2019-03-20 2025-12-11 Nortiva Bio, Inc. Coatings for gastric residence dosage forms
US11389398B2 (en) 2019-05-14 2022-07-19 Clexio Biosciences Ltd. Gastroretentive treatment of nocturnal symptoms and morning akinesia in subjects with parkinson's disease
MX2022003803A (es) * 2019-10-01 2022-06-29 Rani Therapeutics Llc Dispositivo autodimensionable para suministrar una formulación a una pared de lumen.
US20220387312A1 (en) * 2019-11-08 2022-12-08 Lyndra Therapeutics, Inc. Gastric residence systems having arms with controlled stiffness for improved gastric residence
WO2021092486A1 (en) * 2019-11-08 2021-05-14 Lyndra, Inc. Formulations for release-rate modulating films for gastric residence systems
KR102391865B1 (ko) * 2020-04-03 2022-04-27 재단법인대구경북과학기술원 약물 전달 디바이스
IL300939A (en) * 2020-08-30 2023-04-01 Teva Pharma Devices and methods for administering a drug with retention in the stomach
IL305602A (en) * 2021-03-02 2023-11-01 Teva Pharma Retentive devices for gastrointestinal tract
WO2022195476A1 (en) 2021-03-15 2022-09-22 Clexio Biosciences Ltd. Gastroretentive devices for assessment of intragastric conditions
CA3229117A1 (en) 2021-08-19 2023-02-23 Dorit MIMROD Method of treating parkinson's disease
CN115518052B (zh) * 2022-09-22 2024-01-02 江苏集萃新型药物制剂技术研究所有限公司 胃滞留制剂及其制备方法
WO2024134599A1 (en) * 2022-12-21 2024-06-27 Teva Pharmaceutical Industries Ltd. Emptying monitoring system for gastrointestinal tract devices

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0415671A2 (en) * 1989-08-31 1991-03-06 Yamanouchi Pharmaceutical Co. Ltd. Gastric retention device
CN1324232A (zh) * 1998-10-30 2001-11-28 Lts勒曼治疗系统股份公司 具有延长胃滞留作用之可膨胀的胃滞留性治疗系统
CN1571663A (zh) * 2001-10-19 2005-01-26 伊莱利利公司 治疗的剂型、装置和方法
CN1750813A (zh) * 2003-02-19 2006-03-22 尼莫科学有限公司 用于胃肠道和泌尿生殖道的自展装置
CN1960711A (zh) * 2004-03-25 2007-05-09 太阳医药工业有限公司 胃内滞留系统
CN101888828A (zh) * 2007-07-27 2010-11-17 蒂宝制药公司 脉冲胃滞留剂型
WO2015191920A1 (en) * 2014-06-11 2015-12-17 Massachusetts Institute Of Technology Residence structures and related methods
CN105168174A (zh) * 2010-03-10 2015-12-23 因卡伯实验室有限责任公司 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1318259A (en) 1919-10-07 Resilient wheel
AU449029B2 (en) 1969-08-28 1974-04-17 Commonwealth Scientific And Industrial Research Organisation Device for administration to ruminants
US4220153A (en) 1978-05-08 1980-09-02 Pfizer Inc. Controlled release delivery system
US4735804A (en) 1985-05-10 1988-04-05 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
JPS6226215A (ja) * 1985-05-10 1987-02-04 メルク　エンド　カムパニ−　インコ−ポレ−テツド 一定に制御した時間内胃中に保持できる薬剤移送装置
CA1273872A (en) 1985-05-10 1990-09-11 Larry J. Caldwell Drug delivery device which can be retained in the stomach for a controlled period of time
US4767627A (en) 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US5002772A (en) * 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
IT1282650B1 (it) 1996-02-19 1998-03-31 Jagotec Ag Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici
IL133196A0 (en) 1999-11-29 2001-03-19 Yissum Res Dev Co Gastroretentive controlled release pharmaceutical dosage forms
US6753011B2 (en) 2000-01-14 2004-06-22 Osmotica Corp Combined diffusion/osmotic pumping drug delivery system
DE60123384T2 (de) 2000-02-04 2007-08-02 DepoMed, Inc., Menlo Park Dosierungsform des typs "hülle und kern" mit einer wirkstofffreisetzung, die sich der nullten ordnung annähert
AR030557A1 (es) 2000-04-14 2003-08-27 Jagotec Ag Una tableta en multicapa de liberacion controlada y metodo de tratamiento
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
CA2409552A1 (en) 2001-10-25 2003-04-25 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
US6723340B2 (en) 2001-10-25 2004-04-20 Depomed, Inc. Optimal polymer mixtures for gastric retentive tablets
US20050202090A1 (en) 2002-01-03 2005-09-15 Clarke Allan J. Novel pharmaceutical dosage forms and method for producing same
GB0214013D0 (en) 2002-06-18 2002-07-31 Euro Celtique Sa Pharmaceutical product
US20050013863A1 (en) 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
IL166183A0 (en) 2005-01-06 2006-01-15 Yissum Res Dev Co Novel diagnostic and imaging techniques of the gi tract
CA2613178A1 (en) 2005-07-15 2007-01-25 Kissei Pharmaceutical Co., Ltd. Sustained release preparation
US8187633B2 (en) 2005-11-03 2012-05-29 Sun Pharma Advanced Research Company Limited Controlled release coated tablets having prolonged gastric retention
CA2635313C (en) 2005-12-29 2013-12-31 Osmotica Corp. Triple combination release multi-layered tablet
EP2997953B1 (en) 2006-01-18 2018-12-26 Intec Pharma Ltd. Delivery device for oral intake of an agent
WO2007093999A1 (en) 2006-02-15 2007-08-23 Intec Pharma Ltd. A gastro-retentive system for the delivery of macromolecules
WO2007106957A1 (en) 2006-03-21 2007-09-27 Laboratoires Smb S.A. Multiple units controlled-release floating dosage forms
US9579227B2 (en) 2006-03-29 2017-02-28 Eat Little Inc. Ingestible implement for weight control
CA2673485A1 (en) 2007-01-15 2008-07-24 Kissei Pharmaceutical Co., Ltd. Gastric retention-type sustained-release levodopa preparation
EP2219624A2 (en) 2007-11-08 2010-08-25 Glaxo Group Limited Pharmaceutical formulations
CN102149369B (zh) 2008-04-18 2016-08-10 因泰克制药有限公司 卡比多巴/左旋多巴胃滞留给药
EP2133071A1 (en) 2008-06-09 2009-12-16 Université de la Méditerranée Process for making gastroretentive dosage forms
JP2012500230A (ja) 2008-08-18 2012-01-05 北京天衡▲薬▼物研究院 胃内滞留薬物放出システム及びその製造方法と使用
US20110268666A1 (en) 2008-09-29 2011-11-03 Yissum Research Development Company of the Research University of Jerusalem, Ltd. Novel gastroretentive delivery system
US20110066175A1 (en) 2009-05-07 2011-03-17 Rainbow Medical Ltd. Gastric anchor
EP2490677A2 (en) 2009-10-19 2012-08-29 Intec Pharma Ltd. Novel gastroretentive dosage forms of poorly soluble drugs
WO2011090724A2 (en) 2009-12-29 2011-07-28 Impax Laboratories, Inc. Gastroretentive solid oral dosage forms with lipid-based low-density excipient
CN101919803A (zh) 2010-07-16 2010-12-22 钟术光 一种控释制剂
WO2012006963A1 (zh) 2010-07-16 2012-01-19 Zhong Shuguang 在控释制剂中的聚合物增强剂
US9941319B2 (en) 2010-10-13 2018-04-10 Monolithic 3D Inc. Semiconductor and optoelectronic methods and devices
WO2012059815A1 (en) 2010-11-01 2012-05-10 Intec Pharma Ltd. Accordion pill comprising levodopa for an improved treatment of parkinson's disease symptoms
US20130072869A1 (en) * 2011-09-15 2013-03-21 The Johns Hopkins University Intra-Gastric Timed-Release Drug Delivery System
WO2013054285A1 (en) 2011-10-11 2013-04-18 Ranbaxy Laboratories Limited A gastroretentive dosage system and process of preparation thereof
KR101461332B1 (ko) 2013-08-02 2014-11-13 삼성전기주식회사 센서용 검출모듈 및 이를 구비하는 각속도 센서
US9016811B2 (en) 2013-08-05 2015-04-28 Concealment Solutions Inc. Apparatus for concealing household objects
EP3091962B1 (en) * 2013-12-05 2022-06-08 Epitomee Medical Ltd. Retentive devices and systems for in-situ release of pharmaceutical active agents
WO2015187746A1 (en) 2014-06-02 2015-12-10 Teva Pharmaceutical Industries Ltd. Expandable gastroretentive dosage form
CA3007165A1 (en) 2015-12-02 2017-06-08 Clexio Biosciences Ltd. Device for preparing gastroretentive dosage forms
CN110035718B (zh) 2016-12-02 2021-04-06 克雷西奥生物科技有限公司 胃内滞留系统

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0415671A2 (en) * 1989-08-31 1991-03-06 Yamanouchi Pharmaceutical Co. Ltd. Gastric retention device
CN1324232A (zh) * 1998-10-30 2001-11-28 Lts勒曼治疗系统股份公司 具有延长胃滞留作用之可膨胀的胃滞留性治疗系统
CN1571663A (zh) * 2001-10-19 2005-01-26 伊莱利利公司 治疗的剂型、装置和方法
CN1750813A (zh) * 2003-02-19 2006-03-22 尼莫科学有限公司 用于胃肠道和泌尿生殖道的自展装置
CN1960711A (zh) * 2004-03-25 2007-05-09 太阳医药工业有限公司 胃内滞留系统
CN101888828A (zh) * 2007-07-27 2010-11-17 蒂宝制药公司 脉冲胃滞留剂型
CN105168174A (zh) * 2010-03-10 2015-12-23 因卡伯实验室有限责任公司 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂
WO2015191920A1 (en) * 2014-06-11 2015-12-17 Massachusetts Institute Of Technology Residence structures and related methods

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IL266377A (en) 2019-06-30
US20200030589A1 (en) 2020-01-30
CN110035718A (zh) 2019-07-19
JP2019536800A (ja) 2019-12-19
IL266377B1 (en) 2023-06-01
US20230080008A1 (en) 2023-03-16
JP7071748B2 (ja) 2022-05-19
IL266377B2 (en) 2023-10-01
ES2966736T3 (es) 2024-04-24
EP3547974A1 (en) 2019-10-09
WO2018102799A1 (en) 2018-06-07
EP3547974B1 (en) 2023-11-15
US10737079B2 (en) 2020-08-11
US20200376242A1 (en) 2020-12-03
US11577061B2 (en) 2023-02-14

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