CN1100099A - 喹啉基-二氢吡啶酯类化合物及其制备和作为药物的用途 - Google Patents

喹啉基-二氢吡啶酯类化合物及其制备和作为药物的用途 Download PDF

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Publication number
CN1100099A
CN1100099A CN94104954A CN94104954A CN1100099A CN 1100099 A CN1100099 A CN 1100099A CN 94104954 A CN94104954 A CN 94104954A CN 94104954 A CN94104954 A CN 94104954A CN 1100099 A CN1100099 A CN 1100099A
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CN
China
Prior art keywords
carbon atoms
group
groups
substituted
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN94104954A
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English (en)
Chinese (zh)
Inventor
J·施托尔特富斯
S·戈德曼
A·施特劳布
M·比切姆
R·格罗斯
S·赫比什
J·胡特
H·-P·朗丁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of CN1100099A publication Critical patent/CN1100099A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN94104954A 1993-04-27 1994-04-27 喹啉基-二氢吡啶酯类化合物及其制备和作为药物的用途 Pending CN1100099A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4313697.4 1993-04-27
DE4313697A DE4313697A1 (de) 1993-04-27 1993-04-27 Chinolyl-dihydropyridinester, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln

Publications (1)

Publication Number Publication Date
CN1100099A true CN1100099A (zh) 1995-03-15

Family

ID=6486455

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94104954A Pending CN1100099A (zh) 1993-04-27 1994-04-27 喹啉基-二氢吡啶酯类化合物及其制备和作为药物的用途

Country Status (16)

Country Link
US (1) US5508406A (cg-RX-API-DMAC7.html)
EP (1) EP0622368A1 (cg-RX-API-DMAC7.html)
JP (1) JPH06321938A (cg-RX-API-DMAC7.html)
CN (1) CN1100099A (cg-RX-API-DMAC7.html)
AU (1) AU675497B2 (cg-RX-API-DMAC7.html)
CA (1) CA2121999A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ99694A3 (cg-RX-API-DMAC7.html)
DE (1) DE4313697A1 (cg-RX-API-DMAC7.html)
FI (1) FI941913L (cg-RX-API-DMAC7.html)
HU (1) HUT70483A (cg-RX-API-DMAC7.html)
IL (1) IL109436A0 (cg-RX-API-DMAC7.html)
NO (1) NO941520L (cg-RX-API-DMAC7.html)
NZ (1) NZ260381A (cg-RX-API-DMAC7.html)
SK (1) SK47794A3 (cg-RX-API-DMAC7.html)
TW (1) TW273552B (cg-RX-API-DMAC7.html)
ZA (1) ZA942881B (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7080698A (en) * 1997-04-25 1998-11-24 Ajinomoto Co., Inc. Novel dihydropyridine derivative
TW200519091A (en) * 2003-09-10 2005-06-16 Synta Pharmaceuticals Corp Dihydropyridine compounds for treating or preventing metabolic disorders
EP2294062B1 (en) * 2008-06-09 2013-08-21 Bayer Intellectual Property GmbH Substituted 4- (indazolyl) -1,4-dihydropyridines and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
DE2752820A1 (de) * 1977-11-26 1979-05-31 Bayer Ag Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
US5204472A (en) * 1990-04-06 1993-04-20 Bayer Aktiengesellschaft Quinoline and isoquinoline intermediates
DE4011105A1 (de) * 1990-04-06 1991-10-10 Bayer Ag Neue 4-chinolyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4011695A1 (de) * 1990-04-11 1991-10-17 Bayer Ag Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung
DE4117750A1 (de) * 1991-05-30 1992-12-24 Bayer Ag Neue 2-amino-5-cyano-1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4118707A1 (de) * 1991-06-07 1992-12-10 Bayer Ag Pharmazeutische verwendung von 3-formyl-1,4-dihydropyridinen, neue verbindungen und verfahren zu ihrer herstellung
DE4134760A1 (de) * 1991-10-22 1993-07-08 Bayer Ag Aryl-chinolyl-substituierte 1,4-dihydropyridin-dicarbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4313692A1 (de) * 1993-04-27 1994-11-03 Bayer Ag 3-Chinolyl substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
DE4313691A1 (de) * 1993-04-27 1994-11-03 Bayer Ag 2,6-Disubstituierte 4-Chinolyl-dihydropyridine

Also Published As

Publication number Publication date
AU5922194A (en) 1994-11-03
NO941520L (no) 1994-10-28
DE4313697A1 (de) 1994-11-03
NZ260381A (en) 1996-02-27
SK47794A3 (en) 1995-04-12
HUT70483A (en) 1995-10-30
JPH06321938A (ja) 1994-11-22
FI941913A0 (fi) 1994-04-25
IL109436A0 (en) 1994-07-31
CA2121999A1 (en) 1994-10-28
US5508406A (en) 1996-04-16
CZ99694A3 (en) 1994-11-16
TW273552B (cg-RX-API-DMAC7.html) 1996-04-01
HU9401201D0 (en) 1994-08-29
AU675497B2 (en) 1997-02-06
NO941520D0 (cg-RX-API-DMAC7.html) 1994-04-26
ZA942881B (en) 1995-01-16
EP0622368A1 (de) 1994-11-02
FI941913A7 (fi) 1994-10-28
FI941913L (fi) 1994-10-28

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C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication