CN110004208A - 利用可编程核酸探针的高通量且高度多路复用的成像 - Google Patents
利用可编程核酸探针的高通量且高度多路复用的成像 Download PDFInfo
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- C12Q1/6804—Nucleic acid analysis using immunogens
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
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- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
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- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
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- C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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| WO2024168093A2 (en) * | 2023-02-08 | 2024-08-15 | Toreador Therapeutics, Inc. | Super-resolution microscopy (srm) multiplexing with cleavable moieties |
| EP4450971A1 (en) * | 2023-04-21 | 2024-10-23 | Leica Microsystems CMS GmbH | Marker for analysing a biological sample |
| CN116990271B (zh) * | 2023-06-29 | 2025-09-16 | 四川大学 | 基于比率荧光的四氢大麻酚及其代谢物的可视化检验方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102007221A (zh) * | 2006-11-30 | 2011-04-06 | 霍洛基克公司 | 通过用抗切割探针形成切割结构而检测靶核酸的方法 |
| US20130171631A1 (en) * | 2009-10-26 | 2013-07-04 | Claus Becker | Conjugates of nucleotides and method for the application thereof |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4421891C2 (de) | 1994-06-23 | 1996-05-15 | Helmut Prof Dr Med Feucht | Verfahren zum Nachweis von komplementaktivierenden IgG-Antikörpern gegen HLA-DR-Antigene |
| US5491063A (en) * | 1994-09-01 | 1996-02-13 | Hoffmann-La Roche Inc. | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
| DE19709348C2 (de) | 1996-05-29 | 1999-07-01 | Schubert Walter Dr Md | Automatisches Multi-Epitop-Ligand-Kartierungsverfahren |
| DE19717904A1 (de) | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| US20100081134A1 (en) | 1997-07-21 | 2010-04-01 | Mirkin Chad A | Bio-barcode based detection of target analytes |
| US6083486A (en) | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
| AU4976699A (en) | 1998-07-10 | 2000-02-01 | Chromagen, Inc. | Novel fluorogenic substrates for hydrolytic enzymes |
| US6573043B1 (en) | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
| WO2000034527A2 (en) | 1998-12-11 | 2000-06-15 | The Regents Of The University Of California | Targeted molecular bar codes |
| WO2000058507A1 (en) | 1999-03-30 | 2000-10-05 | Solexa Ltd. | Polynucleotide sequencing |
| AU2246601A (en) | 1999-08-30 | 2001-04-10 | Illumina, Inc. | Methods for improving signal detection from an array |
| WO2001023610A2 (en) | 1999-09-29 | 2001-04-05 | Solexa Ltd. | Polynucleotide sequencing |
| GB0002389D0 (en) | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
| DE10014685B4 (de) | 2000-03-24 | 2004-07-01 | Schubert, Walter, Dr. | Verfahren zur Identifizierung von zellspezifischen Zielstrukturen |
| US20020142310A1 (en) | 2000-04-07 | 2002-10-03 | Leif Andersson | Variants of the human AMP-activated protein kinase gamma 3 subunit |
| US20020106648A1 (en) | 2000-05-05 | 2002-08-08 | Lizardi Paul M. | Highly multiplexed reporter carrier systems |
| AU2001267191A1 (en) | 2000-06-06 | 2001-12-17 | Tm Bioscience Corporation | Capture moieties for nucleic acids and uses thereof |
| US20030044353A1 (en) | 2001-01-05 | 2003-03-06 | Ralph Weissleder | Activatable imaging probes |
| US20050230255A1 (en) | 2001-03-30 | 2005-10-20 | Sumner Lloyd W | Silver destaining method |
| US7219016B2 (en) | 2001-04-20 | 2007-05-15 | Yale University | Systems and methods for automated analysis of cells and tissues |
| US20020173053A1 (en) | 2001-04-27 | 2002-11-21 | Bassam Damaj | Multiple simultaneous antigen detection by immunohistochemistry |
| AU2002319613A1 (en) | 2001-07-19 | 2003-03-03 | Signet Laboratories, Inc. | Human tissue specific drug screening procedure |
| US8323903B2 (en) | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
| WO2003061711A2 (en) | 2002-01-16 | 2003-07-31 | Visen Medical, Inc. | Chromophore probes for optical imaging |
| JP4061401B2 (ja) | 2002-03-07 | 2008-03-19 | 国立大学法人九州大学 | Ｄｎａの自己組織化によるｄｎａナノケージ及びその製造方法、並びにそれを用いたｄｎａナノチューブ、分子キャリアー |
| WO2003100101A1 (en) | 2002-05-28 | 2003-12-04 | U.S. Genomics, Inc. | Methods and apparati using single polymer analysis |
| AU2003291249A1 (en) | 2002-12-18 | 2004-07-29 | Aclara Biosciences, Inc. | Multiplexed immunohistochemical assays using molecular tags |
| US20040241776A1 (en) | 2003-05-22 | 2004-12-02 | Agdia, Inc. | Multiplex enzyme-linked immunosorbent assay for detecting multiple analytes |
| US20050064435A1 (en) | 2003-09-24 | 2005-03-24 | Xing Su | Programmable molecular barcodes |
| US20050074781A1 (en) | 2003-10-02 | 2005-04-07 | Herbert von Schroeder | Nucleic acid braided J-probes |
| US20050287578A1 (en) | 2004-06-28 | 2005-12-29 | Exagen Diagnostics, Inc. | Methods for RNA fluorescence in situ hybridization |
| US20060024678A1 (en) | 2004-07-28 | 2006-02-02 | Helicos Biosciences Corporation | Use of single-stranded nucleic acid binding proteins in sequencing |
| EP1886145A2 (en) | 2005-05-03 | 2008-02-13 | Applera Corporation | Fluorescent detection system and dye set for use therewith |
| EP1896617B1 (en) | 2005-05-31 | 2013-01-02 | Life Technologies Corporation | Multiplex amplification of short nucleic acids |
| US20070048759A1 (en) | 2005-06-10 | 2007-03-01 | Dan Luo | Detection of target molecules with labeled nucleic acid detection molecules |
| US7842793B2 (en) | 2005-06-14 | 2010-11-30 | The California Institute Of Technology | Methods of making nucleic acid nanostructures |
| US20060292616A1 (en) | 2005-06-23 | 2006-12-28 | U.S. Genomics, Inc. | Single molecule miRNA-based disease diagnostic methods |
| US7494776B2 (en) * | 2005-07-07 | 2009-02-24 | Beckman Coulter, Inc. | Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands |
| EP1963531B1 (en) | 2005-12-23 | 2011-09-21 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
| WO2007092538A2 (en) | 2006-02-07 | 2007-08-16 | President And Fellows Of Harvard College | Methods for making nucleotide probes for sequencing and synthesis |
| US7838302B2 (en) | 2006-08-07 | 2010-11-23 | President And Fellows Of Harvard College | Sub-diffraction limit image resolution and other imaging techniques |
| US7741045B2 (en) | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
| US8305579B2 (en) | 2006-11-16 | 2012-11-06 | Thomas Pirrie Treynor | Sequential analysis of biological samples |
| US20100216978A1 (en) | 2007-04-17 | 2010-08-26 | Dsna-Farber Cancer Institute Inc. | Wireframe nanostructures |
| US20080287668A1 (en) | 2007-05-14 | 2008-11-20 | Tihamer Thomas Toth-Fejel | Nanostructures and methods of making |
| WO2008144562A1 (en) | 2007-05-16 | 2008-11-27 | California Institute Of Technology | A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways |
| US8481714B2 (en) | 2007-11-19 | 2013-07-09 | Japan Advanced Institute Of Science And Technology | Light-responsive artificial nucleotide having photo-crosslinking ability |
| WO2009085218A1 (en) | 2007-12-21 | 2009-07-09 | President And Fellows Of Harvard College | Sub-diffraction limit image resolution in three dimensions |
| US9340416B2 (en) | 2008-08-13 | 2016-05-17 | California Institute Of Technology | Polynucleotides and related nanoassemblies, structures, arrangements, methods and systems |
| US9677125B2 (en) * | 2009-10-21 | 2017-06-13 | General Electric Company | Detection of plurality of targets in biological samples |
| US9315857B2 (en) * | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| US20120004132A1 (en) * | 2010-07-02 | 2012-01-05 | Affymetrix, Inc. | Detection of Nucleic Acids and Proteins |
| US8877438B2 (en) | 2010-07-20 | 2014-11-04 | California Institute Of Technology | Self-assembled polynucleotide structure |
| WO2012051386A2 (en) * | 2010-10-14 | 2012-04-19 | Meso Scale Technologies, Llc | Reagent storage in an assay device |
| EP2633080B1 (en) | 2010-10-29 | 2018-12-05 | President and Fellows of Harvard College | Method of detecting targets using fluorescently labelled nucleic acid nanotube probes |
| US20130123121A1 (en) | 2010-11-22 | 2013-05-16 | The University Of Chicago | Methods and/or Use of Oligonucleotide-Bead Conjugates for Assays and Detections |
| US20120178081A1 (en) | 2010-12-31 | 2012-07-12 | Affymetrix. Inc. | Methods of Labeling Cells, Labeled Cells, and uses Thereof |
| US8759036B2 (en) | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
| AU2013202354A1 (en) | 2012-06-18 | 2014-01-16 | Speedx Pty Ltd | Target detection and signal amplification |
| WO2014028538A2 (en) * | 2012-08-13 | 2014-02-20 | William Marsh Rice University | Multiplexed in situ molecular analyses and programmable molecular probes for regulated signal amplification |
| WO2014071361A1 (en) | 2012-11-05 | 2014-05-08 | Rubicon Genomics | Barcoding nucleic acids |
| EP3988671A1 (en) | 2013-02-20 | 2022-04-27 | Emory University | Compositions for sequencing nucleic acids in mixtures |
| KR102168813B1 (ko) | 2013-03-08 | 2020-10-22 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 효소 정지 방법 |
| CN106062211A (zh) | 2013-12-15 | 2016-10-26 | 哈佛学院院长等 | 与光学超分辨率图案化相关的方法和组合物 |
| EP4245859A3 (en) | 2014-03-11 | 2023-11-08 | President and Fellows of Harvard College | High-throughput and highly multiplexed imaging with programmable nucleic acid probes |
-
2015
- 2015-03-11 EP EP23176015.8A patent/EP4245859A3/en active Pending
- 2015-03-11 CA CA2932943A patent/CA2932943C/en active Active
- 2015-03-11 CN CN201910186444.1A patent/CN110004208A/zh active Pending
- 2015-03-11 KR KR1020167021588A patent/KR102313982B1/ko active Active
- 2015-03-11 BR BR112016018314A patent/BR112016018314A2/pt not_active Application Discontinuation
- 2015-03-11 WO PCT/US2015/020034 patent/WO2015138653A1/en not_active Ceased
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- 2015-03-11 EP EP20157624.6A patent/EP3686599B1/en active Active
- 2015-03-11 EP EP22151320.3A patent/EP4030166B1/en active Active
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- 2015-03-11 US US15/108,911 patent/US10294510B2/en active Active
- 2015-03-11 CN CN201580006969.2A patent/CN105980855B/zh active Active
- 2015-03-11 EP EP15762370.3A patent/EP3117214B1/en active Active
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- 2016-07-26 IL IL246962A patent/IL246962B/en active IP Right Grant
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- 2017-01-19 US US15/410,700 patent/US9944972B2/en active Active
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- 2018-03-23 US US15/934,031 patent/US10190151B2/en active Active
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- 2019-03-18 US US16/357,099 patent/US20190323061A1/en not_active Abandoned
-
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- 2020-08-28 JP JP2020144012A patent/JP7264856B2/ja active Active
- 2020-09-24 AU AU2020239730A patent/AU2020239730B2/en active Active
-
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- 2022-07-08 US US17/811,486 patent/US20230027974A1/en active Pending
-
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- 2023-02-24 JP JP2023027120A patent/JP7520172B2/ja active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102007221A (zh) * | 2006-11-30 | 2011-04-06 | 霍洛基克公司 | 通过用抗切割探针形成切割结构而检测靶核酸的方法 |
| US20130171631A1 (en) * | 2009-10-26 | 2013-07-04 | Claus Becker | Conjugates of nucleotides and method for the application thereof |
Non-Patent Citations (1)
| Title |
|---|
| RALF JUNGMANN等: "Multiplexed 3d cellular super-resolution imaging with dnA-PAint and exchange-PAINT", 《NATURE METHODS》 * |
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