CN109984137A - A kind of composite bactericide - Google Patents
A kind of composite bactericide Download PDFInfo
- Publication number
- CN109984137A CN109984137A CN201711497993.8A CN201711497993A CN109984137A CN 109984137 A CN109984137 A CN 109984137A CN 201711497993 A CN201711497993 A CN 201711497993A CN 109984137 A CN109984137 A CN 109984137A
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- CN
- China
- Prior art keywords
- mefentrifluconazole
- thifluzamide
- suspending agent
- composite bactericide
- rice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to technical field of pesticide, it is related to a kind of composite bactericide, it is characterized in that containing mefentrifluconazole and thifluzamide two kinds of active components, the composition can be configured to the dosage forms such as suspending agent, suspoemulsion, microcapsule suspending agent, suspension seed-coating agent, dispersible oil-suspending agent, wettable powder, water dispersible granules, granule, with apparent synergistic effect, lasting period is long, environmentally friendly.
Description
Technical field
The invention belongs to technical field of pesticide, specifically containing mefentrifluconazole and thifluzamide
Composite bactericide.
Background technique
Mefentrifluconazole is the triazole bactericidal agent of BASF exploitation, chemical name are as follows: (2RS) -2- [4-
The fluoro- o-tolyl of (4- chlorophenoxy)-α, α, α-three] -1- (1H-1,2,4- triazol-1-yls) propan-2-ol, CAS accession number are as follows:
[1417782-03-6], trade name Revysol, wide spectrum, efficiently, interior suction, have and root out and protective effect, show excellent
Biological property, Revysol have outstanding bioactivity to the fungal disease of many more difficult prevention and treatments, are suitable for being permitted in world wide
More field crops and special crop, such as the industrial crops such as corn, cereal, soybean field crop and green pepper, grape, and will
Applied to lawn and seed treatment etc..It is reported that not only activity is higher by Revysol, but also possesses relative to other azoles fungicides
Preferable environmental characteristics, in addition it is more preferable than prothioconazoles and epoxiconazole preventive effect.Structural formula is as follows:
Thifluzamide (Thifluzamide) is novel less toxic, efficient, wide-spectrum bactericide, belongs to thiazole amide sterilization
Agent, thifluzamide are succinate dehydrogenase inhibitors, and the mechanism of action is by inhibiting succinic acid in germ tricarboxylic acid cycle
Dehydrogenase causes thallus dead, has strong uptake and translocation and long lasting effect.Show through field control effectiveness test result to rice line
Blight, wheat sharp eyespot have preferable control efficiency.The ingredient shows to have no rice, wheat by field efficacy experiment
Phytotoxicity occurs.
Rice sheath blight disease, also known as moire disease are one of the Major Diseases in current Rice Production.There is hair in rice producing region
It is raw, cause harm seriously in South Rice Region of China, prevent rice is more from the not plump paddy for earing or earing, causes Rice Yield Loss Caused.One
Rice main producing region banded sclerotial blight medicament is largely reused since straight, is improved Disease Resistance, is caused rice sheath blight disease year after year serious
Occur.
Since various regions pesticide abuse causes resistance increasing, the lasting raising of the dosage of pesticide.However larger dose
Pesticide abuse causes to make havoc of environment, does not also play due effect well.Pass through our experimental study table
It is bright, mefentrifluconazole is compounded with thifluzamide, there is apparent synergistic effect in a certain range, it can be very
Good overcomes the shortcomings of existing product, improves drug effect, reduces usage amount, increases economic efficiency.
Summary of the invention
The object of the present invention is to provide a kind of bactericidal composition with synergistic effect and safety and environmental protection, with existing prevention and treatment medicine
Agent is compared, realize improve drug effect, the purpose of lasting period is long, environmentally friendly, be specifically related to mefentrifluconazole and
The bactericidal composition of thifluzamide.
Using above-mentioned bactericidal composition, it is equipped with auxiliary agent known to those skilled in the art, with those skilled in that art
Well known method be made suspending agent of the present invention, suspoemulsion, microcapsule suspending agent, suspension seed-coating agent, dispersible oil-suspending agent,
Wettable powder, water dispersible granules, granule.
In above-mentioned bactericidal composition, the weight ratio of mefentrifluconazole and thifluzamide is 1:50~30:1, excellent
Selecting weight ratio is 1:30~20:1, and more preferable weight ratio is 1:10~10:1.
Above-mentioned bactericidal composition has the following characteristics that 1. bactericidal effect is strong, and bactericidal effect is strong, two kinds of fungicide modes of action
With complementarity；2. two kinds of ingredients are without apparent cross resistance, effective component is novel, and the mode of action is unique；3. the use of preparation
Mode diversification can be good at playing drug effect；4. two kinds of ingredient compoundings, have good synergistic effect.
Specific embodiment
For the synergistic effect of verifying two kinds of effective component of mefentrifluconazole and thifluzamide compounding, applicant
Indoor biometrics experiment has been carried out using both ingredients first.
After the action character for analyzing two kinds of effective component first, the raw object surveyed is set to Rhizoctonia solani Kuhn by us, should
Bacterium can cause rice sheath blight disease.
The test method of indoor biometrics is referring to NY/T1156.6-2006: using growth rate method measurement medicament to rice line
The inhibiting effect of withered pathogen growth.On the basis of preliminary experiment, 10%- is reached to germ mycelial growth inhibition rate from each medicament
5 concentration are designed in 90% range, first by 95%mefentrifluconazole raw medicine and 96% thifluzamide raw medicine with methanol
The medical fluid for being made into series of concentrations for solvent is spare, then medical fluid is added to the PDA for having melted and being cooled to room temperature in 1% ratio
In culture medium, after sufficiently shaking up, pours into the culture dish (Φ 90mm) of sterilizing and band medicine plate is made, four repetitions of every processing, with
The processing that sterile water is added is blank control；With punch (Φ 5mm) picking Rhizoctonia solani Kuhn bacteria cake of sterilizing, mycelia is faced
Lower aseptic inoculation is inverted in culture in 25 DEG C of constant incubator in the center with medicine plate, uses right-angled intersection after cultivating 6d
Method measures colony diameter, calculates each medicament to the EC of pathogen50, compare the virulence and bacteriostasis of different agents.
Sun Yunpei's Method: evaluating the synergistic effect of pharmacy mix according to co-toxicity coefficient (CTC), i.e. CTC≤80 are antagonism work
Be summation action with, 80 < CTC < 120, when CTC >=120 is synergistic effect, co-toxicity coefficient according to the following formula:
The mixtures theoretical toxicity index TTI=∑ (percentage of the pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture
Rate).
The survey of table 1mefentrifluconazole and thifluzamide and its different ratio to rice sheath blight disease co-toxicity coefficient
Determine result
Analyze above-mentioned data, it can be clearly seen that when mefentrifluconazole and thifluzamide are multiple in varing proportions
The co-toxicity coefficient (CTC) of timing, formula is all larger than 120, has the synergy of different proportion to make the prevention and control capability of rice sheath blight disease
With.
By indoor biometrics experiment, verifies two kinds of effective components of mefentrifluconazole and thifluzamide and compound energy
Enough there is good synergistic effect, the following specific examples are used to further explain the present invention in detail, but the present invention is absolutely not only
It is limited to these following embodiments.Percentage is weight percentage in formula.
Formulation examples are as follows:
1 51%mefentrifluconazole thifluzamide suspending agent of embodiment
2 31%mefentrifluconazole thifluzamide suspending agent of embodiment
3 32%mefentrifluconazole thifluzamide microcapsule suspending agent of embodiment
4 24%mefentrifluconazole thifluzamide water dispersible granule of embodiment
5 35%mefentrifluconazole thifluzamide suspoemulsion of embodiment
6 30%mefentrifluconazole thifluzamide suspending agent of embodiment
7 15%mefentrifluconazole thifluzamide suspension seed-coating agent of embodiment
8 20%mefentrifluconazole thifluzamide water dispersible granule of embodiment
Oil-suspending agent can be dispersed in 9 18%mefentrifluconazole thifluzamide of embodiment
10 16%mefentrifluconazole thifluzamide suspending agent of embodiment
11 21%mefentrifluconazole thifluzamide wettable powder of embodiment
12 31%mefentrifluconazole thifluzamide suspending agent of embodiment
13 22%mefentrifluconazole thifluzamide suspending agent of embodiment
Selection above example carries out the field trial of prevention and treatment rice sheath blight disease, determines the effect of formula prevention and treatment rice sheath blight disease
Fruit；Simultaneously by the Contrast on effect with mefentrifluconazole and thifluzamide single dose, the anti-of the embodiment of the present invention is verified
Control effect.Four repetitions of each processing are tested, the random district's groups arrangement of cell processing, each plot area is 50m2, apply for the first time
For medicine when infecting in rice tillering latter stage, emphasis imposes on basal part of stem, in booting later period Shi Yici medicine again, investigation method are as follows: root
According to rice leaf sheath and blade damage symptom grading, as unit of strain, 5 points of every cell diagonal line samplings, every investigation is connected
5 clumps, totally 25 clumps, record total strain number, diseased plant number and sick series.
The preventive effect of table 2mefentrifluconazole and thifluzamide and different agents to rice sheath blight disease
From in above-mentioned data as can be seen that mefentrifluconazole and thifluzamide compound preparation are 1 before secondary medicine
It is to the preventive effect of rice sheath blight disease more than 80%, and 14 days preventive effects to rice sheath blight disease are compared more than 85% after medicine
Two kinds of single doses of mefentrifluconazole and thifluzamide, compound preparation preventive effect difference are extremely significant, it is seen that two kinds of effective components
Compounding has good synergistic effect, extends the lasting period, more longlasting to the control efficiency of rice sheath blight disease.
In conclusion the compound preparation of mefentrifluconazole and thifluzamide, can be very good to improve product
Synergistic effect has delayed drug resistance, can apply the controlling disease in crops, improves drug effect, extends the lasting period, mitigates peasant
The amount of labour, have very high practicability.The present invention it is implementable and it is unobvious violate the present invention under the premise of, different technologies scheme
Arbitrary form combination can be carried out between described technical characteristic and forms other technologies scheme.The above specific embodiment and reality
Applying example is that invention is explained in detail, but is not intended to limit the scope of the present invention, without departing from claim
Principle in modify and replace, be within the scope of protection of the invention in.
Claims (4)
1. a kind of composite bactericide, it is characterised in that: active constituent is made of mefentrifluconazole and thifluzamide,
The weight ratio of the mefentrifluconazole and thifluzamide is 1:50~30:1.
2. composite bactericide according to claim 1, it is characterised in that: the mefentrifluconazole and thiophene furan
The preferred weight ratio of amide is 1:30~20:1.
3. composite bactericide according to claim 1, it is characterised in that: the mefentrifluconazole and thiophene furan
The preferred weight ratio of amide is 1:10~10:1.
4. composite bactericide according to claim 1, it is characterised in that: suspending agent is made by active constituent and auxiliary material, hangs
Emulsion, microcapsule suspending agent, suspension seed-coating agent, dispersible oil-suspending agent, wettable powder, water dispersible granules, granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711497993.8A CN109984137A (en) | 2017-12-29 | 2017-12-29 | A kind of composite bactericide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711497993.8A CN109984137A (en) | 2017-12-29 | 2017-12-29 | A kind of composite bactericide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109984137A true CN109984137A (en) | 2019-07-09 |
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ID=67110217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711497993.8A Pending CN109984137A (en) | 2017-12-29 | 2017-12-29 | A kind of composite bactericide |
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| Country | Link |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014095994A1 (en) * | 2012-12-20 | 2014-06-26 | Basf Se | Compositions comprising a triazole compound |
-
2017
- 2017-12-29 CN CN201711497993.8A patent/CN109984137A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014095994A1 (en) * | 2012-12-20 | 2014-06-26 | Basf Se | Compositions comprising a triazole compound |
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