CN106973907A - A kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin and its application - Google Patents
A kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin and its application Download PDFInfo
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- CN106973907A CN106973907A CN201710196365.XA CN201710196365A CN106973907A CN 106973907 A CN106973907 A CN 106973907A CN 201710196365 A CN201710196365 A CN 201710196365A CN 106973907 A CN106973907 A CN 106973907A
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- Prior art keywords
- kasugarnycin
- hydroxyquinolinate
- copper
- composition pesticide
- containing copper
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- 239000000203 mixture Substances 0.000 title claims abstract description 57
- 239000000575 pesticide Substances 0.000 title claims abstract description 26
- IURRXCRWRKQLGC-UHFFFAOYSA-N copper;quinolin-8-ol Chemical compound [Cu].C1=CN=C2C(O)=CC=CC2=C1.C1=CN=C2C(O)=CC=CC2=C1 IURRXCRWRKQLGC-UHFFFAOYSA-N 0.000 title claims abstract 16
- 201000010099 disease Diseases 0.000 claims abstract description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 17
- 230000001580 bacterial effect Effects 0.000 claims abstract description 11
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 claims abstract description 10
- 241000207199 Citrus Species 0.000 claims abstract description 9
- 235000020971 citrus fruits Nutrition 0.000 claims abstract description 9
- 241001330975 Magnaporthe oryzae Species 0.000 claims abstract description 5
- 241000626572 Xanthomonas oryzae pv. oryzicola Species 0.000 claims abstract description 5
- 244000241235 Citrullus lanatus Species 0.000 claims abstract 2
- 239000004615 ingredient Substances 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 9
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 8
- 239000004563 wettable powder Substances 0.000 claims description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- 229910052802 copper Inorganic materials 0.000 claims description 4
- 239000004562 water dispersible granule Substances 0.000 claims description 4
- 241000233866 Fungi Species 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 230000000361 pesticidal effect Effects 0.000 claims description 2
- 235000013311 vegetables Nutrition 0.000 claims description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 17
- 239000003814 drug Substances 0.000 abstract description 12
- 229940079593 drug Drugs 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 10
- 230000009471 action Effects 0.000 abstract description 9
- 230000002265 prevention Effects 0.000 abstract description 6
- 238000013329 compounding Methods 0.000 abstract description 4
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- YXLXNENXOJSQEI-UHFFFAOYSA-L Oxine-copper Chemical compound [Cu+2].C1=CN=C2C([O-])=CC=CC2=C1.C1=CN=C2C([O-])=CC=CC2=C1 YXLXNENXOJSQEI-UHFFFAOYSA-L 0.000 description 60
- 241000894006 Bacteria Species 0.000 description 19
- 238000012360 testing method Methods 0.000 description 17
- 238000000034 method Methods 0.000 description 14
- 231100000419 toxicity Toxicity 0.000 description 14
- 230000001988 toxicity Effects 0.000 description 14
- 241000209094 Oryza Species 0.000 description 12
- 235000007164 Oryza sativa Nutrition 0.000 description 12
- 235000009566 rice Nutrition 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 241000219109 Citrullus Species 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 238000005259 measurement Methods 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- 244000052769 pathogen Species 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 239000000375 suspending agent Substances 0.000 description 6
- 241000589652 Xanthomonas oryzae Species 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 230000001717 pathogenic effect Effects 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 238000012216 screening Methods 0.000 description 5
- 239000005995 Aluminium silicate Substances 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 235000012211 aluminium silicate Nutrition 0.000 description 4
- 230000000843 anti-fungal effect Effects 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000009833 condensation Methods 0.000 description 3
- 230000005494 condensation Effects 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000002270 dispersing agent Substances 0.000 description 3
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- PVTHJAPFENJVNC-MHRBZPPQSA-N kasugamycin Chemical compound N[C@H]1C[C@H](NC(=N)C(O)=O)[C@@H](C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O PVTHJAPFENJVNC-MHRBZPPQSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000007711 solidification Methods 0.000 description 3
- 230000008023 solidification Effects 0.000 description 3
- 238000010257 thawing Methods 0.000 description 3
- MZSAMHOCTRNOIZ-UHFFFAOYSA-N 3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy-N-phenylaniline Chemical compound NCC1=CC(=NC(=C1)C(F)(F)F)OC=1C=C(NC2=CC=CC=C2)C=CC=1 MZSAMHOCTRNOIZ-UHFFFAOYSA-N 0.000 description 2
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- -1 Sodium dialkyl sulfate Chemical class 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000013530 defoamer Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920005646 polycarboxylate Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 239000005725 8-Hydroxyquinoline Substances 0.000 description 1
- 241000186046 Actinomyces Species 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 241001530056 Athelia rolfsii Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 206010067130 Spastic diplegia Diseases 0.000 description 1
- 241001088165 Streptomyces microaureus Species 0.000 description 1
- REAYFGLASQTHKB-UHFFFAOYSA-N [2-[3-(1H-pyrazol-4-yl)phenoxy]-6-(trifluoromethyl)pyridin-4-yl]methanamine Chemical compound N1N=CC(=C1)C=1C=C(OC2=NC(=CC(=C2)CN)C(F)(F)F)C=CC=1 REAYFGLASQTHKB-UHFFFAOYSA-N 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 230000037354 amino acid metabolism Effects 0.000 description 1
- 229940126575 aminoglycoside Drugs 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 229940111121 antirheumatic drug quinolines Drugs 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 206010008129 cerebral palsy Diseases 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 150000001879 copper Chemical class 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- JJKSAEHNIHMQKQ-UHFFFAOYSA-N copper;quinoline Chemical compound [Cu].N1=CC=CC2=CC=CC=C21 JJKSAEHNIHMQKQ-UHFFFAOYSA-N 0.000 description 1
- 230000035613 defoliation Effects 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 description 1
- 244000039328 opportunistic pathogen Species 0.000 description 1
- 229960003540 oxyquinoline Drugs 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
- 150000003248 quinolines Chemical class 0.000 description 1
- 229930185107 quinolinone Natural products 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
- A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin and its application, including copper 8-hydroxyquinolinate and kasugarnycin and usual auxiliaries, the weight ratio of copper 8-hydroxyquinolinate and kasugarnycin is (1~60)：(1~20).There is obvious synergistic effect after copper 8-hydroxyquinolinate and kasugarnycin compounding, and compound drug effective ingredient consumption is significantly reduced than exclusive use, with synergy and the features such as delay the resistance to the action of a drug, prevention and treatment range expansion, prevention effect is good, and the small and agricultural cost of dosage is low.The present composition is applied to most of fungal disease preventing and treating, especially rice blast fungus, Xanthomonas oryzae pv. oryzicola, watermelon bacterial angular leaf spot, citrus bacterial canker disease etc..
Description
Technical field
The invention belongs to technical field of pesticide, and in particular to a kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin.
Background technology
During crop growth, easily contaminated, cause harm serious, for a long time, chemical prevention is by various diseases
The main effective means of controlling disease.However, single drug and not Scientific Usage of Drugs in recent years, already lead to a variety of pathogens to working as
The preceding agricultural chemicals used generates resistance, and such as anthracnose, spot defoliation, the banded sclerotial blight resistance to the action of a drug are very universal, anti-as chemistry
The a great problem controlled.Because germ develops immunity to drugs, frequent dispenser causes peasant burden to aggravate and increasing environmental pollution again, at certain
Serious region occurs for a little diseases, and it is difficult to prevent and treat that conventional pesticide, which is used alone, and poor effect, has had a strong impact on agricultural benefit.
Therefore, to overcome the resistance to the action of a drug of germ, be badly in need of efficiently, low toxicity, safe and environment-friendly bactericide new varieties.
Copper 8-hydroxyquinolinate, english common name Oxine-copper.It is a kind of new organic copper series bactericidal agent, by 8-hydroxyquinoline
React and generate with copper sulphate, organic quinolines have double sterilization effect with mantoquita；The G- albumen of getting up early cell expression can be suppressed
The synthesis of matter, suppresses the metabolism of germ spore, and control cell divides and broken up again, has Multi-contact activity concurrently again, utilizes
The pathogen spore that chelated copper is sprouted absorbs, and spore cell is directly killed inside pathogen, so as to reach what is prevented and cured diseases
Effect.There is significant kill and inhibitory action by fungi, bacterial multiple diseases to crop.
Kasugarnycin, english common name Kasugamycin.It is a kind of broad-spectrum antibiotics bactericide.Kasugarnycin in
Aminoglycoside produced by a kind of in April, 1963 actinomyces isolated from the domestic soil in Nara County, Japan springtime sacrificial place
Antibiotics, its producing strains are streptomyces microaureus (Sterptomyces Kasugaensis).Molecular formula：C14H25N3O9·
HClH2O, molecular weight：433.84.Belong to alkalescent water-soluble antibiotics.The mechanism of action of kasugarnycin is interference pathogen
The esterase system of amino acid metabolism, destroys the biosynthesis of protein, suppresses the growth of mycelia and causes cell granulations, makes disease
Opportunistic pathogen loses breeding and infection ability, so as to reach kill pathogen, the purpose of controlling disease.Kasugarnycin is to the rice on paddy rice
Seasonal febrile diseases have excellent preventive effect and therapeutic action, in the experiment having found, kasugarnycin preventing and treating tomato leaf mildew, preventing and treating watermelon is thin
Bacterium property angular leaf spot, peach gummosis, shot hole, the disease such as shothole disease has special efficacy.
The content of the invention
Goal of the invention：The need for meeting agricultural production, the synergy produced by two kinds of active component compoundings is made full use of
The speed for acting on, improve preventive effect and delaying the germ resistance to the action of a drug to produce, the present invention proposes one kind and contains copper 8-hydroxyquinolinate and kasugarnycin
Composition pesticide, the disease for preventing and treating fruit tree, vegetables, cereal crops etc..
Technical scheme：In order to realize foregoing invention purpose, the technical solution adopted in the present invention is：
A kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin, using copper 8-hydroxyquinolinate and kasugarnycin as active ingredient, quinoline
The weight ratio of quinoline copper and kasugarnycin is (1~60)：(1~15), weight ratio preferably is (1~50)：(1~10), most preferably
Weight ratio be (1~45)：(1~5), remaining be agricultural chemicals in allow use and acceptable auxiliary element.
Composition pesticide of the present invention is prepared into any one formulation for being adapted to agriculturally use with known method, relatively good
Formulation be water dispersible granules, suspending agent, wettable powder or pulvis, active ingredient total mass fraction percentage composition is in preparation
5%~80%.
When composition pesticide of the present invention is water dispersible granules, copper 8-hydroxyquinolinate 20%-60%, kasugarnycin 2-15%, dodecane
Base sodium sulphate 1-5%, dispersant polycarboxylate 1-5%, disintegrant potassium chloride 0-3%, binding agent polyethylene glycol 4-10% are solvable
Property starch 2-20%, kaolin or diatomite complement to 100%.By above-mentioned formula in proportion dry pulverization process, granulation, drying, sieve
Preparation system is divided to produce copper 8-hydroxyquinolinate kasugamycin water-dispersion granule.
When composition pesticide of the present invention is suspending agent, copper 8-hydroxyquinolinate 30-45%, kasugarnycin 2-6%, anion and nonionic
Mixture TERSPERSE4894 2-5%, naphthalenesulfonate formaldehyde condensation compound 1-6%, propane diols 4-8%, xanthans 0.05-
0.4%, mould inhibitor 0.1-0.5%, defoamer 0.1-0.5%, water complements to 100%.
Above-mentioned formula material is disperseed in advance in proportion, then imports grinding in sand mill, xanthans is eventually adding, passes through
Allocated after high shear mixing and copper 8-hydroxyquinolinate kasugarnycin suspending agent is made.
When composition pesticide of the present invention is wettable powder or pulvis, copper 8-hydroxyquinolinate 20-60%, kasugarnycin 2-15%, ten
Sodium dialkyl sulfate 1-3%, naphthalenesulfonate formaldehyde condensation compound 1-5%, white carbon 3-8%, kaolin complements to 100%.Will be upper
State to be formulated to enter in blender after coarse crushing in proportion and be well mixed, then the i.e. obtained copper 8-hydroxyquinolinate kasugarnycin after air-flow crushing
Wettable powder.
The auxiliary agent used in composition pesticide of the present invention includes solvent, dispersant, stabilizer, emulsifying agent, antifreezing agent, thickening
Agent etc. and it is other be beneficial to the known substance that drug effect is stablized and played to active ingredient in the formulation, be all commonly use in pesticidal preparations or
Allow the various composition used, be not particularly limited, specific composition and consumption are according to recipe requirements by simply testing determination.
The present composition is applied to prevent and treat multiple kinds of crops disease, is mainly used in preventing and treating rice blast fungus, paddy rice bar
Pinta bacterium, watermelon bacterial angular leaf spot, citrus bacterial canker disease etc..
The synergistic effect principle of present composition experiment is the abundant methods of Sun Yun, i.e., being total to for built agent is calculated with poison exponent
The method of malicious coefficient.Sun Yunpei etc. thinks that it is synergistic effect that co-toxicity coefficient, which is noticeably greater than 100, is made significantly less than 100 for antagonism
With, close to 100 be summation action.
Beneficial effect：Compared with prior art, its advantage is the present invention：
1st, compounding has obvious synergistic effect, improves prevention effect；
2nd, preventing and treating spectrum is expanded；
3rd, two kinds of active ingredient compoundings, reduce Pesticide use amount, so as to reduce cost and reduce the dirt to environment
Dye；
4th, the labour for reducing repetition dispenser pays.
Embodiment
With reference to embodiment, the present invention is further illustrated.
In order that the objects, technical solutions and advantages of the present invention are more concise, present invention specific examples below
Illustrate, but the present invention is only limitted to absolutely not these examples.As described below is only the present invention preferably embodiment, is used only for retouching
State the present invention, it is impossible to be interpreted as limiting the scope of the present invention.It should be pointed out that it is all the spirit and principles in the present invention it
Interior done any modifications, equivalent substitutions and improvements etc., should be included in the scope of the protection.Therefore, it is of the invention
The protection domain of patent should be determined by the appended claims.
Biologicall test example：Copper 8-hydroxyquinolinate compounds the Toxicity Determination to rice blast fungus with kasugarnycin.
Inventor is mould with spring thunder to copper 8-hydroxyquinolinate with Wadley mixtures interaction evaluation assessment by substantial amounts of screening test
Promotor composition carries out the synergistic effect analysis of different ratio, finds in certain ratio range, copper 8-hydroxyquinolinate and kasugarnycin group
Closing rice blast fungus has synergistic function.
Process of the test：Growth selection neat and consistent, leaf age identical rice seedling, spray by set concentration above in crop
Spraying treatment is carried out on machine, places and is dried in ventilating kitchen after spraying.Rice blast pathogen spore suspension is inoculated with after 24 hours, then
Place moisturizing culture in artificial climate.After when being cultivated 10 days in artificial climate, investigation prevention effect, classification is recorded, with the state of an illness
Index calculates prevention effect, and obtains virulence regression equation and EC50, according to Wadley fungicide in mixture synergy evaluation assessments,
Calculate the ratio interacted after 2 single dose mixing.
Test result analysis：Kasugarnycin has higher bactericidal activity to rice blast with copper 8-hydroxyquinolinate mixture, and spring thunder is mould
The EC of 5 proportionings of element and copper 8-hydroxyquinolinate (1: 1,1: 3,1: 6,1: 9,1: 12)50Respectively 23.88,29.17,34.51,37.42 and
46.66mg/L, the interaction ratio of 5 proportionings is 1.24,1.35,1.32,1.31 and 1.09.It is mutual according to Wadley mixtures
The ratio of the proportioning of evaluation of effect method, kasugarnycin and copper 8-hydroxyquinolinate (1: 1,1: 3,1: 6,1: 9,1: 12) 5 between 0.5~1.5,
For summation action.Synergistic effect influence of the mixed ratio on mixture be not obvious, and mixture is to the potted plant activity of rice blast with mixture
The increase of kasugarnycin content and raise.
Measurement result shows that copper 8-hydroxyquinolinate is with kasugarnycin in proportioning 12:1~1:Between 1, with corresponding synergistic effect,
Concrete numerical value is as shown in table 1.
Table 1：Kasugarnycin, copper 8-hydroxyquinolinate joint toxicity measuring result.
The kasugarnycin of table 1, the Shenyang of copper 8-hydroxyquinolinate joint toxicity measuring result 2013
Biologicall test example：Copper 8-hydroxyquinolinate compounds the Toxicity Determination to Xanthomonas oryzae pv. oryzicola with kasugarnycin.Inventor
By substantial amounts of screening test, copper 8-hydroxyquinolinate and kasugarnycin composition are carried out not with Wadley mixtures interaction evaluation assessment
With the synergistic effect analysis of proportioning, find in certain ratio range, copper 8-hydroxyquinolinate combines Xanthomonas oryzae pv. oryzicola with kasugarnycin
With synergistic function.
Process of the test：Cultivate after 40h addition sterilized water on slant medium for examination bacterium and scrape lawn and bacterium solution is made,
Bacterium solution 1mL is added in sterile culture dish, NT culture mediums (40 DEG C to 50 DEG C of liquid temperature) 10mL of thawing is poured into.
Beaten with card punch and take filter paper dish, 15s is adsorbed in the reagent agent dilution that preparation is put into respectively, taking-up leans against it
Drop down the media surface that solidification is moved into after unnecessary decoction in walls of beaker, each 1 tablet of absorption decoction of culture dish central emissions
Paper dish, is repeated 4 times per drug concentration, and makees blank control to adsorb sterilized water, and culture dish is moved under 25 DEG C of constant temperature and cultivated.
Observation, measurement antibacterial circle diameter (mm) are taken out after 48h.Calculate bacteriostasis rate and EC50Value, uses Sun-Johnson virulence
Index calculation calculates the co-toxicity coefficient of five built agents.
Test result analysis：Copper 8-hydroxyquinolinate has preferable bacteriostatic activity to paddy rice bacterium Population of Xanthomonas Oryzae Pv, its EC50It is worth and is
3.66mg/L, kasugarnycin is poor to the Antifungal Activity in Vitro of paddy rice bacterium Population of Xanthomonas Oryzae Pv, its EC50It is worth for 524.28mg/L.Spring
Thunder mycin and copper 8-hydroxyquinolinate mixture, mixture are raised to the Antifungal Activity in Vitro of paddy rice bacterium Population of Xanthomonas Oryzae Pv with the ratio of quinolinone content
And strengthen, kasugarnycin, copper 8-hydroxyquinolinate (1:1、1:3、1:6、1:9、1:12) five supply trial ratio, co-toxicity coefficient is respectively 81.49,
84.67th, 93.75,106.10 and 104.02, the co-toxicity coefficient that kasugarnycin, copper 8-hydroxyquinolinate 5 are matched is between 80-120, performance
For summation action.For paddy rice bacterium Population of Xanthomonas Oryzae Pv, the suitable mixed ratio of kasugarnycin and copper 8-hydroxyquinolinate is kasugarnycin, quinoline
Quinoline copper (1:9-12).
Measurement result shows that copper 8-hydroxyquinolinate is with kasugarnycin in proportioning 12:1~1:Between 1, with corresponding synergistic effect.
Concrete numerical value is as shown in table 2.
Table 2：Kasugarnycin, copper 8-hydroxyquinolinate are to Xanthomonas oryzae pv. oryzicola joint toxicity measuring result.
The kasugarnycin of table 2, copper 8-hydroxyquinolinate are to paddy rice bacterium Population of Xanthomonas Oryzae Pv joint toxicity measuring result
Biologicall test example：Copper 8-hydroxyquinolinate compounds the Toxicity Determination to watermelon bacterial angular leaf spot with kasugarnycin.
Inventor is mould with spring thunder to copper 8-hydroxyquinolinate with Wadley mixtures interaction evaluation assessment by substantial amounts of screening test
Promotor composition carries out the synergistic effect analysis of different ratio, finds in certain ratio range, copper 8-hydroxyquinolinate and kasugarnycin group
Closing watermelon bacterial angular leaf spot has synergistic function.
Process of the test：Cultivate after 40h addition sterilized water on slant medium for examination bacterium and scrape lawn and bacterium solution is made,
Bacterium solution 1mL is added in sterile culture dish, NT culture mediums (40-50 DEG C of liquid temperature) 10mL of thawing is poured into.
Beaten with card punch and take filter paper dish, 15s is adsorbed in the reagent agent dilution that preparation is put into respectively, taking-up leans against it
Drop down the media surface that solidification is moved into after unnecessary decoction in walls of beaker, each 1 tablet of absorption decoction of culture dish central emissions
Paper dish, is repeated 4 times per drug concentration, and makees blank control to adsorb sterilized water, and culture dish is moved under 25 DEG C of constant temperature and cultivated.48h
Observation, measurement antibacterial circle diameter (mm) are taken out afterwards.Calculate bacteriostasis rate and EC50Value, with Sun-Johnson toxicity index calculating method meters
Calculate the co-toxicity coefficient of five built agents.
Test result analysis：Copper 8-hydroxyquinolinate, two medicaments of kasugarnycin have certain bacteriostatic activity to watermelon angular leaf spot bacterium, its
EC50Value is respectively 636.20mg/L and 975.61mg/L, the Antifungal Activity in Vitro of copper 8-hydroxyquinolinate, kasugarnycin to watermelon angular leaf spot bacterium
It is poor.Kasugarnycin, copper 8-hydroxyquinolinate (1:1、1:3、1:6、1:9、1:12) five for trials than EC50Value respectively 786.71,
741.75th, 680.26,650.62 and 641.70mg/L, co-toxicity coefficient is respectively 897.90,93.94,98.42,101.31 and
101.87.The co-toxicity coefficient that kasugarnycin, copper 8-hydroxyquinolinate 5 are matched shows as summation action between 80-120.
Measurement result shows that copper 8-hydroxyquinolinate is with kasugarnycin in proportioning 12:1~1:Between 1, with corresponding synergistic effect.
Concrete numerical value is shown in Table 3.
Table 3：Kasugarnycin, copper 8-hydroxyquinolinate are to watermelon angular leaf spot joint toxicity measuring result.
The kasugarnycin of table 3, copper 8-hydroxyquinolinate are to watermelon angular leaf spot bacterium joint toxicity measuring result
Biologicall test example：Copper 8-hydroxyquinolinate compounds the Toxicity Determination to citrus bacterial canker disease with kasugarnycin.
Inventor is mould with spring thunder to copper 8-hydroxyquinolinate with Wadley mixtures interaction evaluation assessment by substantial amounts of screening test
Promotor composition carries out the synergistic effect analysis of different ratio, finds in certain ratio range, copper 8-hydroxyquinolinate and kasugarnycin group
Closing citrus bacterial canker disease has synergistic function.
Process of the test：Cultivate after 40h addition sterilized water on slant medium for examination bacterium and scrape lawn and bacterium solution is made,
Bacterium solution 1mL is added in sterile culture dish, NT culture mediums (40-50 DEG C of liquid temperature) 10mL of thawing is poured into.Beaten with card punch and take filter
Adsorb 15s in paper dish, the reagent agent dilution that preparation is put into respectively, taking-up leans against it to drop down unnecessary decoction in walls of beaker
The media surface of solidification is moved into afterwards, and the paper dish of each 1 tablet of absorption decoction of culture dish central emissions is repeated 4 times per drug concentration,
And make blank control to adsorb sterilized water, culture dish is moved under 25 DEG C of constant temperature and cultivated.Observation is taken out after 48h, measurement inhibition zone is straight
Footpath (mm).Calculate bacteriostasis rate and EC50Value, the co-toxicity coefficient of five built agents is calculated with Sun-Johnson toxicity indexes calculating method.
Test result analysis：Copper 8-hydroxyquinolinate has preferable bacteriostatic activity to citrus processing, its EC50It is worth for 5.45mg/L,
Kasugarnycin is poor to the Antifungal Activity in Vitro of citrus processing, its EC50It is worth for 244.99mg/L.Kasugarnycin, copper 8-hydroxyquinolinate
(1:1、1:3、1:6、1:9、1:12) five supply trial ratio, EC50 values respectively 11.22,6.93,6.17,5.60,5.56mg/
L, co-toxicity coefficient is respectively 95.03,104.09,102.69,107.87 and 106.00, and co-toxicity coefficient is between 80-120, performance
For summation action.
Measurement result shows that copper 8-hydroxyquinolinate is with kasugarnycin in proportioning 12:1~1:Between 1, with corresponding synergistic effect.
Concrete numerical value is shown in Table 4.
Table 4：Kasugarnycin, copper 8-hydroxyquinolinate are to citrus processing joint toxicity measuring result.
The spring thunder Huo Su of table 4, copper 8-hydroxyquinolinate are to citrus processing joint toxicity measuring result
Any one formulation for being agriculturally adapted to use can be made in the bactericidal composition of the present invention of known method, than
Comparatively ideal formulation is water dispersible granules, suspending agent, wettable powder or pulvis.
Illustrated below with specific embodiment.Percentage in formula is mass percent.
The various preparation processing techniques of the present composition are existing industrial technology, can be adjusted according to different situations
It is whole.
Example of formulations 1：40.5+4.5% copper 8-hydroxyquinolinate kasugamycin water-dispersion granules.
Copper 8-hydroxyquinolinate 40.5%, kasugarnycin 4.5%, lauryl sodium sulfate 1-5%, dispersant polycarboxylate 1-5% collapse
Agent potassium chloride 0-3%, binding agent polyethylene glycol 4-10% are solved, soluble starch 10-20%, kaolin or diatomite are complemented to
100%.By above-mentioned formula, dry pulverization process, granulation, drying, screening preparation system produce 45% copper 8-hydroxyquinolinate kasugarnycin water in proportion
Dispersible granule.
Example of formulations 2：40.5%+4.5% copper 8-hydroxyquinolinate kasugarnycin suspending agents.
Copper 8-hydroxyquinolinate 40.5%, kasugarnycin 4.5%, anion and non-ionic complex TERSPERSE 48942-5%, naphthalene
Sulfonate and formaldehyde condensation product 1-6%, propane diols 4-8%, xanthans 0.05-0.4%, mould inhibitor 0.1-0.5%, defoamer 0.1-
0.5%, complement to 100% with water.
Above-mentioned formula material is disperseed in advance in proportion, then imports grinding in sand mill, xanthans is eventually adding, passes through
Allocated after high shear mixing and 40.5%+4.5% copper 8-hydroxyquinolinate kasugarnycin suspending agents are made.
Example of formulations 3：40.5+4.5% copper 8-hydroxyquinolinate kasugarnycin wettable powders.
Copper 8-hydroxyquinolinate 40.5%, kasugarnycin 4.5%, lauryl sodium sulfate 1-3%, naphthalenesulfonate formaldehyde condensation compound 1-
5%, white carbon 3-8%, 100% is complemented to kaolin.
It is well mixed, then is made after air-flow crushing by entering after above-mentioned formula in proportion coarse crushing in blender
40.5%+4.5% copper 8-hydroxyquinolinate kasugarnycin wettable powders.
Claims (8)
1. a kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin, a kind of pesticide combination containing copper 8-hydroxyquinolinate and kasugarnycin
Thing, it is characterised in that：The effective ingredient of the composition pesticide is the matter of copper 8-hydroxyquinolinate and kasugarnycin, copper 8-hydroxyquinolinate and kasugarnycin
Amount ratio is (1~60)：(1~15).
2. a kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin according to claim 1, it is characterised in that：Quinoline
Gross mass percentage of the quality sum of copper and kasugarnycin in composition pesticide is 5%~80%.
3. a kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin according to claim 2, it is characterised in that：It is described
Composition pesticide in also contain pesticidal preparations auxiliary element, be made and be adapted to the formulation that agriculturally uses, the formulation is to suspend
Agent, wettable powder, water dispersible granules, pulvis.
4. a kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin according to claim 3, applied to crop fungi
Preventing and treating in venereal disease evil.
5. a kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin according to claim 4, it is characterised in that：It is described
Crop is fruit tree, vegetables, field crop.
6. the composition pesticide according to claim 4 containing copper 8-hydroxyquinolinate and kasugarnycin, it is characterised in that：The fungi
Venereal disease evil is rice blast fungus, Xanthomonas oryzae pv. oryzicola, watermelon bacterial angular leaf spot, citrus bacterial canker disease.
7. a kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin according to claim 1, it is characterised in that：Quinoline
The mass ratio of copper and kasugarnycin is (1~50)：(1~10).
8. a kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin according to claim 7, it is characterised in that：Quinoline
The mass ratio of copper and kasugarnycin is (1~45)：(1~5).
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Cited By (6)
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| CN109258656A (en) * | 2018-09-30 | 2019-01-25 | 浙江海正化工股份有限公司 | Composition pesticide and its preparation method and application containing Ningnanmycin and copper 8-hydroxyquinolinate |
| CN110476988A (en) * | 2019-09-17 | 2019-11-22 | 嘉兴市世诚科技有限公司 | A kind of bactericidal composition and application thereof for preventing and treating bacterial diseases of crops |
| CN110537543A (en) * | 2019-06-04 | 2019-12-06 | 广西汇丰生物科技有限公司 | Pesticide composition containing kasugamycin and quinolinone and bactericide |
| CN113647393A (en) * | 2021-07-27 | 2021-11-16 | 惠州市银农科技股份有限公司 | Suspending agent containing kasugamycin and oxine-copper and preparation method thereof |
| WO2022175654A1 (en) * | 2021-02-17 | 2022-08-25 | UPL Corporation Limited | A synergistic agricultural composition |
| CN115067344A (en) * | 2021-03-12 | 2022-09-20 | 顺毅股份有限公司 | Oxine-copper and kasugamycin compounded pesticide suspending agent |
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| CN104542601A (en) * | 2013-10-11 | 2015-04-29 | 兴农药业（中国）有限公司 | Pesticide composition containing copper quinolate and kasugamycin and application of pesticide composition |
| CN106614599A (en) * | 2016-12-30 | 2017-05-10 | 陕西省蒲城美尔果农化有限责任公司 | Bactericidal composition containing quinoline copper and kasugamycin |
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| CN104542601A (en) * | 2013-10-11 | 2015-04-29 | 兴农药业（中国）有限公司 | Pesticide composition containing copper quinolate and kasugamycin and application of pesticide composition |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109258656A (en) * | 2018-09-30 | 2019-01-25 | 浙江海正化工股份有限公司 | Composition pesticide and its preparation method and application containing Ningnanmycin and copper 8-hydroxyquinolinate |
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| CN110476988B (en) * | 2019-09-17 | 2021-08-03 | 嘉兴市世诚科技有限公司 | A kind of bactericidal composition for preventing and treating bacterial diseases of crops and use thereof |
| WO2022175654A1 (en) * | 2021-02-17 | 2022-08-25 | UPL Corporation Limited | A synergistic agricultural composition |
| CN115067344A (en) * | 2021-03-12 | 2022-09-20 | 顺毅股份有限公司 | Oxine-copper and kasugamycin compounded pesticide suspending agent |
| CN115067344B (en) * | 2021-03-12 | 2024-03-12 | 顺毅股份有限公司 | Pesticide suspending agent compounded by copper quinolinate and kasugamycin |
| CN113647393A (en) * | 2021-07-27 | 2021-11-16 | 惠州市银农科技股份有限公司 | Suspending agent containing kasugamycin and oxine-copper and preparation method thereof |
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